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Background Diabetic is one of the fundamental persuasive of diabetic nephropathy and significantly sparks off kidney diseases and end stage renal failure globally. Method The current research was carried out to evaluate hypoglycemic potential and nephroprotective effect of ethanolic extract of Mikania scandens leaves by using alloxan-induced diabetic nephropathy (DN) mice. The mice were intraperitoneally treated with (200 mg/kg) Mikania scandens leaves extract and standard (120 mg/kg) metformin HCL solution up to 22 days. During this treatment period, we collected blood for evaluation of different types of parameters such as blood glucose level body weight at 0, 15, 22th days, serum creatinine, uric acid, total protein were estimated at the end of the experiment (day 22). Result Mikania scandens leaves extract significantly (p 50. The plant has high LC50 dose thus cytotoxicity has ensued at massive amount and safe to administer. Conclusion Lowering of serum creatinine, uric acid and total protein recommend that the ethanolic extract of Mikania scandens possess potent nephroprotective activity and assure the traditional avail of this plant in the management of diabetes nephropathy.

Strengthening of Reinforced Concrete Beam (RCB) for enhancing its flexural performance is a very popular technique to increase the structural life span. Optimization of the construction and strengthening cost without compromising the target strength and service life of a structure is now a matter of challenge for researchers. The wire mesh and geotextile materials possesses some good properties, such as cost-effectiveness, high strength-to-weight ratio, significant flexural performance, and compatibility with concrete, thus can be used as strengthening material. This experimental study aimed to investigate wire mesh and geotextile as strengthening materials for RCBs to enhance their flexural capacity. Three different types of strengthening configuration were used for each type of strengthening material. In order to examine the effectiveness of the wire mesh and geotextile as strengthening material, three point bending tests were done. This experimental results showed that the beams wrapped using wire mesh could enhance the flexural performance and reduce the deflection of RCBs without damage up to the reliable limit. Moreover, wire mesh layer in the tension face and U-wrapping system were proven as the effective configuration in the strengthening technique. The nonwoven geotextile strengthened-beams also had a moderate strength compared with wire mesh strengthened-beams. Nevertheless, the RCBs were found to be more flexible in nature, having a grip on concrete after failure occurred in concrete crushing when wrapped with geotextile layer. Therefore, RCB strengthening by incorporating wire mesh and geotextile materials is sustainable in terms of structural integrity and economic aspect.