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Your search keyword '"Loretelli, C."' showing total 5 results
Start Over Author "Loretelli, C." Publisher springer science and business media llc
5 results on '"Loretelli, C."'

1. Anti-inflammatory effects of diet and caloric restriction in metabolic syndrome

Author

Montefusco, L., primary, D’Addio, F., additional, Loretelli, C., additional, Ben Nasr, M., additional, Garziano, M., additional, Rossi, A., additional, Pastore, I., additional, Plebani, L., additional, Lunati, M. E., additional, Bolla, A. M., additional, Porta, M. D., additional, Piuri, G., additional, Rocchio, F., additional, Abdelsalam, A., additional, Assi, E., additional, Barichella, M., additional, Maestroni, A., additional, Usuelli, V., additional, Loreggian, L., additional, Muzio, F., additional, Zuccotti, G. V., additional, Cazzola, R., additional, and Fiorina, P., additional

Published
2021
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2. VEGF and VEGFR polymorphisms affect clinical outcome in advanced renal cell carcinoma patients receiving first-line sunitinib

Author

Scartozzi, M, primary, Bianconi, M, additional, Faloppi, L, additional, Loretelli, C, additional, Bittoni, A, additional, Del Prete, M, additional, Giampieri, R, additional, Maccaroni, E, additional, Nicoletti, S, additional, Burattini, L, additional, Minardi, D, additional, Muzzonigro, G, additional, Montironi, R, additional, and Cascinu, S, additional

Published
2012
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5. Embryonic stem cell extracts improve wound healing in diabetic mice

Author

Vera Usuelli, Alessandro Sannino, Francesca D'Addio, Saja S. Scherer, Cristian Loretelli, Paolo Fiorina, Ahmed Abdelsalam, Emma Assi, Giorgio Giatsidis, Alessandro Valderrama-Vasquez, Gian Vincenzo Zuccotti, Giorgio Pietramaggiori, Luca Salvatore, Moufida Ben Nasr, Basset El Essawy, Dennis P. Orgill, Roberto Bassi, Luca Lancerotto, Elio Ippolito, Marta Madaghiele, Loretelli, C., Ben Nasr, M., Giatsidis, G., Bassi, R., Lancerotto, L., D'Addio, F., Valderrama-Vasquez, A., Scherer, S. S., Salvatore, L., Madaghiele, M., Abdelsalam, A., Ippolito, E., Assi, E., Usuelli, V., El Essawy, B., Sannino, A., Pietramaggiori, G., Zuccotti, G. V., Orgill, D. P., and Fiorina, P.

Subjects
Male, musculoskeletal diseases, Contraction (grammar), Type 1 diabete, Proteome, Angiogenesis, Endocrinology, Diabetes and Metabolism, Mice, Transgenic, 030209 endocrinology & metabolism, 030204 cardiovascular system & hematology, Pharmacology, Diabete, Diabetes Mellitus, Experimental, Mice, 03 medical and health sciences, 0302 clinical medicine, Endocrinology, In vivo, Diabetes mellitus, Internal Medicine, medicine, 3T3 Cell, Wound Healing, Type 1 diabetes, Neovascularization, Pathologic, Animal, business.industry, Proteomic, Stem cell extract, General Medicine, medicine.disease, Embryonic stem cell, Immunity, Innate, In vitro, Cell Extract, Wound healing, business, human activities
Abstract

Aims/hypothesis: Impaired wound healing significantly impacts morbidity and mortality in diabetic patients, necessitating the development of novel treatments to improve the wound healing process. We here investigated the topical use of acellular embryonic stem cell extracts (EXTs) in wound healing in diabetic db/db mice. Methods: Wounds were induced in diabetic db/db mice, which were subsequently treated with EXTs, with 3T3 fibroblast cell line protein extracts (3T3XTs) or with saline as a control. Pathology and mechanistic assays were then performed. Results: The in vivo topical administration of EXTs facilitates wound closure, contraction and re-epithelialization. Moreover, EXTs reduced the number of wound-infiltrating CD45+ inflammatory cells and increased the rate of repair and of angiogenesis as compared to controls. Interestingly, the EXT effect was partly enhanced by the use of a collagen-based biocompatible scaffold. In vivo, topical administration of EXTs increased the percentage of regulatory T cells in the wounded tissue, while in vitro EXT treatment reduced T cell-mediated IFN-γ production. Proteomic screening revealed 82 proteins differentially segregating in EXTs as compared to 3T3 extracts, with APEX1 identified as a key player for the observed immunomodulatory effect of EXTs. Conclusions: EXTs are endowed with immunoregulatory and anti-inflammatory properties; their use improves wound healing in diabetic preclinical models.

Published
2020
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