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31 results on '"Longo V."'

1. Fasting mimicking diet in mice delays cancer growth and reduces immunotherapy-associated cardiovascular and systemic side effects

Author

Cortellino, S., primary, Quagliariello, V., additional, Delfanti, G., additional, Blaževitš, O., additional, Chiodoni, C., additional, Maurea, N., additional, Di Mauro, A., additional, Tatangelo, F., additional, Pisati, F., additional, Shmahala, A., additional, Lazzeri, S., additional, Spagnolo, V., additional, Visco, E., additional, Tripodo, C., additional, Casorati, G., additional, Dellabona, P., additional, and Longo, V. D., additional

Published
2023
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7. L’iposomatismo congenito dovuto a deficit del recettore per il GH è associato nell’uomo a una drastica riduzione dell’incidenza di tumori, diabete mellito e invecchiamento cellulare

Author

Guevara-Aguirre, J., primary, Balasubramanian, P., additional, Guevara-Aguirre, M., additional, Wei, M., additional, Madia, F., additional, Cheng, C. W., additional, Hwang, D., additional, Martin-Montalvo, A., additional, Saavedra, J., additional, Ingles, S., additional, de Cabo, R., additional, Cohen, P., additional, Longo, V. D., additional, and Arvat, Emanuela, additional

Published
2011
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24. Abstracts

Author

Brink, F. G., primary, Vaccari, Andrea, additional, Cugurra, Franco, additional, Mazzanti, L., additional, Crema, A., additional, Frigo, G. M., additional, Tacca, M., additional, Lecchini, S., additional, Beani, L., additional, Bianchi, C., additional, Gandini, A., additional, Lualdi, P., additional, Bella, D., additional, Rossini, L., additional, Sardi, A., additional, Baldoli, E., additional, Caravaggi, A. M., additional, Kyncl, J., additional, Mauz, G., additional, Kreye, V. A. W., additional, Tubaro, E., additional, Bulgini, M. J., additional, Biagi, G. L., additional, Barbaro, A. M., additional, Guerra, M. C., additional, Hümpel, J. -E., additional, Zetler, G., additional, Stern, P., additional, Bianco, P. L., additional, Fanciullacci, M., additional, Franchi, G., additional, Sicuteri, F., additional, Rovati, A. L., additional, Casula, P. L., additional, Meldolesi, J., additional, Angelucci, L., additional, Linari, G., additional, Soldani, G., additional, Pacini, S., additional, Pascale, V., additional, Mantovani, P., additional, Fregnan, G. B., additional, GlÄsser, A. H., additional, Jahrreiss, R., additional, Habermann, E., additional, Breithaupt, H., additional, Rübsamen, K., additional, Walsch, P., additional, Lankisch, P. G., additional, Vogt, W., additional, Rudinger, J., additional, Krejčí, I., additional, Pliška, V., additional, Poláček, I., additional, Möhring, J., additional, Brekner, Hanna, additional, Schömig, A., additional, Möhring, BÄrbel, additional, Philippu, A., additional, Przuntek, H., additional, Pecile, A., additional, Felici, M., additional, Müller, E. E., additional, Muller, E. E., additional, Cocchi, D., additional, Scapagnini, U., additional, Look, G. R., additional, Moberg, G. P., additional, Preziosi, P., additional, Ganong, W. F., additional, Fraschini, F., additional, Vargiu, L., additional, Spano, P. F., additional, Marquardt, H., additional, Zedeck, M. S., additional, Sternberg, S. S., additional, Fleisher, M., additional, Hamilton, L. D., additional, Classen, H. -G., additional, Marquardt, P., additional, SpÄth, M., additional, Schumacher, K. -A., additional, Bernauer, W., additional, Hahn, F., additional, Wissler, J., additional, Nimptsch, P., additional, Filipowski, P., additional, Gjuriš, V., additional, Wolf, D., additional, Moroni, F., additional, Buiatti, E., additional, Mannaioni, P. F., additional, Periti, P., additional, Lorenz, W., additional, Schauer, A., additional, Reimann, H. J., additional, Guidotti, A., additional, Meyer, R., additional, Doenicke, A., additional, Schmal, A., additional, Hutzel, M., additional, Werle, E., additional, Bertaccini, G., additional, Impicciatore, M., additional, Mossini, F., additional, Frontini, E., additional, Giani, G., additional, Nicolin, A., additional, Olivani, P., additional, Dietmann, K., additional, Schieck, A., additional, Kornalik, F., additional, Chiarra, A., additional, Piccinini, F., additional, Villani, F., additional, Caspary, W. F., additional, Nell, G., additional, Forth, W., additional, Overhoff, H., additional, Pfleger, K., additional, Rummel, W., additional, Agsten, M., additional, Voth, D., additional, Possner, R., additional, Förschler, M. -L., additional, KÄvenheim, W., additional, Kurz, H., additional, Wirth, K., additional, Bodem, G., additional, Dengler, H. J., additional, Rietbrock, N., additional, Plato, H. v., additional, Bergmann, K. v., additional, Abshagen, U., additional, Kewitz, H., additional, Hengstmann, J. H., additional, Konen, W., additional, Konen, C., additional, Backmann, H., additional, Haschemian, A., additional, Kemper, F., additional, Morgenroth, K., additional, Winterhoff, H., additional, Mascherpa, P., additional, Strauer, B. E., additional, Westberg, C., additional, Tauchert, M., additional, Juhran, W., additional, Ledda, F., additional, Giotti, A., additional, Turnheim, K., additional, Stühlinger, W., additional, Kraupp, O., additional, Trendelenburg, U., additional, Haeusler, G., additional, Brandt, W., additional, Reiter, M., additional, Nakamura, J., additional, Gerold, M., additional, Thoenen, H., additional, Boksay, I., additional, Bollmann, V., additional, Kukovetz, W. R., additional, Klein, W. W., additional, Pöch, G., additional, Lüdtke, A. H., additional, Braga, P. C., additional, Ferri, S., additional, Magnoni, V., additional, Romano, A., additional, Bartsch, W., additional, Heinz, N., additional, Furlanello, F., additional, Ferrari, M., additional, Sava, C., additional, Maragno, I., additional, Bergamaschi, M., additional, Fuccella, L. M., additional, Mandelli, V., additional, Tommasini, R., additional, Turba, C., additional, Usardi, M., additional, Lehr, E., additional, Gesmundo, F., additional, Susanna, A., additional, Paroli, E., additional, Carpi, A., additional, Cartoni, C., additional, Basso, P., additional, Giardini, V., additional, Marmo, E., additional, Brogi, M., additional, Bossa, R., additional, Fioroni, G., additional, Galatulas, I., additional, Pomarelli, P., additional, Henderson, P. Th., additional, Remmer, H., additional, Casals, J., additional, Petruch, F., additional, Schüppel, R., additional, Forti, G. Cantelli, additional, Fracasso, M. E., additional, Berti, T., additional, Maccari, M., additional, Gatti, M. T., additional, Losert, W., additional, Kraaz, W., additional, Jahn, P., additional, Rilke, A., additional, Cascio, G., additional, Mantia, G., additional, Leone, F., additional, Datz, B., additional, Vetter, J., additional, Brade, W., additional, Schönhöfer, P. S., additional, Skidmore, I. F., additional, Bourne, H. R., additional, Vapaatalo, H., additional, Bieck, P., additional, Westermann, E., additional, Stork, H., additional, Schmidt, F. H., additional, Riemenschneider, H., additional, Willig, F., additional, May, B., additional, Leinweber, W., additional, Poser, W., additional, Panten, U., additional, Hasselblatt, A., additional, Klissiunis, N., additional, Mykoniatis, M., additional, Lengsfeld, H., additional, Gey, K. F., additional, Bianchini, P., additional, Mantovani, V., additional, LoMarco, E., additional, Bufalina, L., additional, Guidi, G., additional, Osima, B., additional, Casetta, R., additional, Casarini, A., additional, Mann, E., additional, Pepeu, G., additional, Ruffi, A., additional, Mulas, A., additional, Pleul, O., additional, Lipparini, F., additional, Loizzo, A., additional, Carolis, Scotti, additional, Marino, A., additional, Girone, E., additional, Battista, O., additional, Marino, V., additional, Florio, V., additional, Longo, V. G., additional, Gogolák, G., additional, Stumpf, Ch., additional, Pavan, P., additional, Dross, K., additional, Bianchi, A., additional, Caprio, F., additional, Kuschinsky, K., additional, Carlo, R., additional, Mandel, P., additional, Rosa, M., additional, Willoughby, D. A., additional, Sorrentino, L., additional, Capasso, F., additional, Sandow, J., additional, Alpermann, H., additional, Metzger, H., additional, Vogel, H. G., additional, Velo, G. P., additional, Capelli, A., additional, Martinelli, G., additional, Bertoni, F., additional, Karzel, K., additional, Peters, H. D., additional, Hack, G., additional, Fleming, K., additional, Kazda, S., additional, Lamprecht, F., additional, Miksche, L., additional, Orth, H., additional, Philippi, A., additional, Schmidt, D., additional, Schneider, D., additional, Soell, G., additional, Taugner, R., additional, Hammersen, G., additional, Rosenthal, J., additional, Fülgraff, G., additional, Meiforth, A., additional, Sudhoff, D., additional, Zimmermann, E., additional, Knebel, L., additional, Barzaghi, F., additional, Riva, M., additional, Mantegazza, P., additional, Chiesara, E., additional, Edwards, K. D. G., additional, Morini, M., additional, Bilone, F., additional, Ortolani, L., additional, Barbieri, A., additional, Bertelli, A., additional, Cerrati, A., additional, Bizzi, A., additional, Codegoni, A. M., additional, Medea, A., additional, Tacconi, M. T., additional, Garattini, S., additional, Bonaccorsi, A., additional, Cotillo, P., additional, and Babulova, A., additional

Published
1971
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30. Co-carcinogenic effects of vitamin E in prostate

Author

Alessio Papi, Antonello Lorenzini, Silvia Cirillo, Marco Lucarini, Silvia Marchionni, Sandra Filippi, Enzo Spisni, Andrea Vornoli, Vincenzo Longo, Clara Della Croce, Donatella Canistro, Paola Franchi, Francesca Rotondo, Cristina Zanzi, Moreno Paolini, Fabio Vivarelli, Vivarelli F., Canistro D., Cirillo S., Papi A., Spisni E., Vornoli A., Croce C.M.D., Longo V., Franchi P., Filippi S., Lucarini M., Zanzi C., Rotondo F., Lorenzini A., Marchionni S., and Paolini M.

Subjects
Male, 0301 basic medicine, medicine.medical_treatment, medicine.disease_cause, carcinogenesis, prostate, Mice, Prostate cancer, 0302 clinical medicine, Cytochrome P-450 Enzyme System, Prostate, Vitamin E, Multidisciplinary, biology, Chemistry, 3T3 Cells, Up-Regulation, Gene Expression Regulation, Neoplastic, Cell Transformation, Neoplastic, medicine.anatomical_structure, Medicine, DNA damage, Science, Article, Cell Line, 03 medical and health sciences, Benzo(a)pyrene, medicine, Animals, Humans, Micronuclei, Chromosome-Defective, Carcinogen, Gene Expression Profiling, Prostatic Neoplasms, Cancer, Cytochrome P450, Neoplasms, Experimental, medicine.disease, Rats, Oxidative Stress, 030104 developmental biology, Risk factors, Dietary Supplements, Carcinogens, biology.protein, Cancer research, Lipid Peroxidation, Reactive Oxygen Species, 030217 neurology & neurosurgery, Oxidative stress, DNA Damage
Abstract

A large number of basic researches and observational studies suggested the cancer preventive activity of vitamin E, but large-scale human intervention trials have yielded disappointing results and actually showed a higher incidence of prostate cancer although the mechanisms underlying the increased risk remain largely unknown. Here we show through in vitro and in vivo studies that vitamin E produces a marked inductive effect on carcinogen-bioactivating enzymes and a pro-oxidant status promoting both DNA damage and cell transformation frequency. First, we found that vitamin E in the human prostate epithelial RWPE-1 cell line has the remarkable ability to upregulate the expression of various phase-I activating cytochrome P450 (CYP) enzymes, including activators of polycyclic aromatic hydrocarbons (PAHs), giving rise to supraphysiological levels of reactive oxygen species. Furthermore, our rat model confirmed that vitamin E in the prostate has a powerful booster effect on CYP enzymes associated with the generation of oxidative stress, thereby favoring lipid-derived electrophile spread that covalently modifies proteins. We show that vitamin E not only causes DNA damage but also promotes cell transformation frequency induced by the PAH-prototype benzo[a]pyrene. Our findings might explain why dietary supplementation with vitamin E increases the prostate cancer risk among healthy men.

Published
2019

31. In silico characterization of the neural alpha tubulin gene promoter of the sea urchin embryo Paracentrotus lividus by phylogenetic footprinting

Author

Maria Antonietta Ragusa, Marco Emanuele, Salvatore Costa, Fabrizio Gianguzza, Valeria Longo, Ragusa M.A., Longo V., Emanuele M, Costa S, and Gianguzza F

Subjects
Embryo, Nonmammalian, Microinjections, Sequence analysis, Green Fluorescent Proteins, DNA Footprinting, Nerve Tissue Proteins, Settore BIO/11 - Biologia Molecolare, Phylogenetic footprinting, Paracentrotus lividus, Genes, Reporter, Tubulin, Genetics, Animals, Promoter Regions, Genetic, Molecular Biology, Gene, DNA Primers, Expressed Sequence Tags, Comparative genomics, Binding Sites, biology, Gene Transfer Techniques, Computational Biology, Molecular Sequence Annotation, Promoter, Genomics, General Medicine, Sea urchin, Neural development, Gene expression, Phylogenetic footprint, Cis-regulatory analysis, biology.organism_classification, Gene Expression Regulation, Regulatory sequence, Paracentrotus, Orthologous Gene
Abstract

During Paracentrotus lividus sea urchin embryo development one alpha and one beta tubulin genes are expressed specifically in the neural cells and they are early end output of the gene regulatory network that specifies the neural commitment. In this paper we have used a comparative genomics approach to identify con- served regulatory elements in the P. lividus neural alpha tubulin gene. To this purpose, we have first isolated a genomic clone containing the entire gene plus 4.5 Kb of 5 0 upstream sequences. Then, we have shown by gene transfer experiments that its non-coding region drives the spatio- temporal gene expression corresponding substantially to that of the endogenous gene. In addition, we have identified by genome and EST sequence analysis the S. purpuratus alpha tubulin orthologous gene and we propose a revised annotation of some tubulin family members. Moreover, by computational techniques we delineate at least three puta- tive regulatory regions located both in the upstream region and in the first intron containing putative binding sites for Forkhead and Nkx transcription factor families.

Published
2011

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