1. Impact of Amerind ancestry and FADS genetic variation on omega-3 deficiency and cardiometabolic traits in Hispanic populations
- Author
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Yii-Der Ida Chen, Lindsay M. Reynolds, Robert C. Kaplan, Chaojie Yang, Michael C. Seeds, Martha L. Daviglus, Lyn M. Steffen, Brian Hallmark, Floyd H. Chilton, Michael Y. Tsai, Stephen S. Rich, Alexis C. Wood, Laurel Johnstone, Jin Choul Chai, Chandra Tontsch, Ingo Ruczinski, Timothy D. O’Connor, Lawrence J. Mandarino, Sarah A. Blomquist, Rasika A. Mathias, Rozenn N. Lemaitre, Qibin Qi, Dawn K. Coletta, Amanda M. Fretts, and Ani Manichaikul
- Subjects
Fatty Acid Desaturases ,0301 basic medicine ,Heredity ,QH301-705.5 ,Genetic genealogy ,Medicine (miscellaneous) ,Single-nucleotide polymorphism ,030204 cardiovascular system & hematology ,Biology ,Article ,General Biochemistry, Genetics and Molecular Biology ,03 medical and health sciences ,0302 clinical medicine ,Fatty Acids, Omega-3 ,Genetic variation ,Genotype ,medicine ,Humans ,SNP ,Hispanic population ,Longitudinal Studies ,Biology (General) ,Genetic association study ,Genetics ,chemistry.chemical_classification ,Genetic Variation ,Hispanic or Latino ,medicine.disease ,United States ,030104 developmental biology ,Risk factors ,chemistry ,Multigene Family ,Indians, North American ,Heritable quantitative trait ,lipids (amino acids, peptides, and proteins) ,General Agricultural and Biological Sciences ,Dyslipidemia ,Polyunsaturated fatty acid - Abstract
Long chain polyunsaturated fatty acids (LC-PUFAs) have critical signaling roles that regulate dyslipidemia and inflammation. Genetic variation in the FADS gene cluster accounts for a large portion of interindividual differences in circulating and tissue levels of LC-PUFAs, with the genotypes most strongly predictive of low LC-PUFA levels at strikingly higher frequencies in Amerind ancestry populations. In this study, we examined relationships between genetic ancestry and FADS variation in 1102 Hispanic American participants from the Multi-Ethnic Study of Atherosclerosis. We demonstrate strong negative associations between Amerind genetic ancestry and LC-PUFA levels. The FADS rs174537 single nucleotide polymorphism (SNP) accounted for much of the AI ancestry effect on LC-PUFAs, especially for low levels of n-3 LC-PUFAs. Rs174537 was also strongly associated with several metabolic, inflammatory and anthropomorphic traits including circulating triglycerides (TGs) and E-selectin in MESA Hispanics. Our study demonstrates that Amerind ancestry provides a useful and readily available tool to identify individuals most likely to have FADS-related n-3 LC-PUFA deficiencies and associated cardiovascular risk., Yang et al. examine whether genetic ancestry is associated with genetic variation in fatty acid desaturases and plasma phospholipid levels of long chain polyunsaturated fatty acids (LC-PUFAs) in Hispanic Americans. They find strong associations between Amerind genetic ancestry and LC-PUFA levels; and report that the well-known FADS rs174537 variant was associated with several metabolic, inflammatory and anthropomorphic traits including circulating triglycerides.
- Published
- 2021