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Start Over Author "Lim, Geok-Hoon" Publisher springer science and business media llc
12 results on '"Lim, Geok-Hoon"'

1. Alterations to DNA methylation patterns induced by chemotherapy treatment are associated with negative impacts on the olfactory pathway

Author

Ho, Peh Joo, primary, Khng, Alexis Jiaying, additional, Tan, Benita Kiat-Tee, additional, Lim, Geok Hoon, additional, Tan, Su-Ming, additional, Tan, Veronique Kiak Mien, additional, Tan, Ryan Shea Ying Cong, additional, Lim, Elaine Hsuen, additional, Iau, Philip Tsau-Choong, additional, Chew, Ying Jia, additional, Lim, Yi Ying, additional, Hartman, Mikael, additional, Tan, Ern Yu, additional, and Li, Jingmei, additional

Published
2023
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3. Mammography screening is associated with more favourable breast cancer tumour characteristics and better overall survival: case-only analysis of 3739 Asian breast cancer patients

Author

Lim, Zi Lin, primary, Ho, Peh Joo, additional, Khng, Alexis Jiaying, additional, Yeoh, Yen Shing, additional, Ong, Amanda Tse Woon, additional, Tan, Benita Kiat Tee, additional, Tan, Ern Yu, additional, Tan, Su-Ming, additional, Lim, Geok Hoon, additional, Lee, Jung Ah, additional, Tan, Veronique Kiak-Mien, additional, Hu, Jesse, additional, Li, Jingmei, additional, and Hartman, Mikael, additional

Published
2022
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4. Relevance of the MHC region for breast cancer susceptibility in Asians

Author

Ho, Peh Joo, primary, Khng, Alexis Jiaying, additional, Tan, Benita Kiat-Tee, additional, Tan, Ern Yu, additional, Tan, Su-Ming, additional, Tan, Veronique Kiak Mien, additional, Lim, Geok Hoon, additional, Aronson, Kristan J., additional, Chan, Tsun L., additional, Choi, Ji-Yeob, additional, Dennis, Joe, additional, Ho, Weang-Kee, additional, Hou, Ming-Feng, additional, Ito, Hidemi, additional, Iwasaki, Motoki, additional, John, Esther M., additional, Kang, Daehee, additional, Kim, Sung-Won, additional, Kurian, Allison W., additional, Kwong, Ava, additional, Lophatananon, Artitaya, additional, Matsuo, Keitaro, additional, Mohd-Taib, Nur Aishah, additional, Muir, Kenneth, additional, Murphy, Rachel A., additional, Park, Sue K., additional, Shen, Chen-Yang, additional, Shu, Xiao-Ou, additional, Teo, Soo Hwang, additional, Wang, Qin, additional, Yamaji, Taiki, additional, Zheng, Wei, additional, Bolla, Manjeet K., additional, Dunning, Alison M., additional, Easton, Douglas F., additional, Pharoah, Paul D. P., additional, Hartman, Mikael, additional, and Li, Jingmei, additional

Published
2022
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5. Overlap of high-risk individuals predicted by family history, and genetic and non-genetic breast cancer risk prediction models: implications for risk stratification

Author

Ho, Peh Joo, primary, Ho, Weang Kee, additional, Khng, Alexis J., additional, Yeoh, Yen Shing, additional, Tan, Benita Kiat-Tee, additional, Tan, Ern Yu, additional, Lim, Geok Hoon, additional, Tan, Su-Ming, additional, Tan, Veronique Kiak Mien, additional, Yip, Cheng-Har, additional, Mohd-Taib, Nur-Aishah, additional, Wong, Fuh Yong, additional, Lim, Elaine Hsuen, additional, Ngeow, Joanne, additional, Chay, Wen Yee, additional, Leong, Lester Chee Hao, additional, Yong, Wei Sean, additional, Seah, Chin Mui, additional, Tang, Siau Wei, additional, Ng, Celene Wei Qi, additional, Yan, Zhiyan, additional, Lee, Jung Ah, additional, Rahmat, Kartini, additional, Islam, Tania, additional, Hassan, Tiara, additional, Tai, Mei-Chee, additional, Khor, Chiea Chuen, additional, Yuan, Jian-Min, additional, Koh, Woon-Puay, additional, Sim, Xueling, additional, Dunning, Alison M., additional, Bolla, Manjeet K., additional, Antoniou, Antonis C., additional, Teo, Soo-Hwang, additional, Li, Jingmei, additional, and Hartman, Mikael, additional

Published
2022
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6. HER2 expression, copy number variation and survival outcomes in HER2-low non-metastatic breast cancer: an international multicentre cohort study and TCGA-METABRIC analysis

Author

Tan, Ryan Shea Ying Cong, primary, Ong, Whee Sze, additional, Lee, Kyung-Hun, additional, Lim, Abner Herbert, additional, Park, Seri, additional, Park, Yeon Hee, additional, Lin, Ching-Hung, additional, Lu, Yen-Shen, additional, Ono, Makiko, additional, Ueno, Takayuki, additional, Naito, Yoichi, additional, Onishi, Tatsuya, additional, Lim, Geok-Hoon, additional, Tan, Su-Ming, additional, Lee, Han-Byoel, additional, Ryu, Han Suk, additional, Han, Wonshik, additional, Tan, Veronique Kiak Mien, additional, Wong, Fuh-Yong, additional, Im, Seock-Ah, additional, Tan, Puay Hoon, additional, Chan, Jason Yongsheng, additional, and Yap, Yoon-Sim, additional

Published
2022
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7. Germline breast cancer susceptibility genes, tumor characteristics, and survival

Author

Ho, Peh Joo, primary, Khng, Alexis J., additional, Loh, Hui Wen, additional, Ho, Weang-Kee, additional, Yip, Cheng Har, additional, Mohd-Taib, Nur Aishah, additional, Tan, Veronique Kiak Mien, additional, Tan, Benita Kiat-Tee, additional, Tan, Su-Ming, additional, Tan, Ern Yu, additional, Lim, Swee Ho, additional, Jamaris, Suniza, additional, Sim, Yirong, additional, Wong, Fuh Yong, additional, Ngeow, Joanne, additional, Lim, Elaine Hsuen, additional, Tai, Mei Chee, additional, Wijaya, Eldarina Azfar, additional, Lee, Soo Chin, additional, Chan, Ching Wan, additional, Buhari, Shaik Ahmad, additional, Chan, Patrick M. Y., additional, Chen, Juliana J. C., additional, Seah, Jaime Chin Mui, additional, Lee, Wai Peng, additional, Mok, Chi Wei, additional, Lim, Geok Hoon, additional, Woo, Evan, additional, Kim, Sung-Won, additional, Lee, Jong Won, additional, Lee, Min Hyuk, additional, Park, Sue K., additional, Dunning, Alison M., additional, Easton, Douglas F., additional, Schmidt, Marjanka K., additional, Teo, Soo-Hwang, additional, Li, Jingmei, additional, and Hartman, Mikael, additional

Published
2021
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8. Outcomes of Stage I and II Breast Cancer with Nodal Micrometastases Treated with Mastectomy without Axillary Therapy

Author

Lim, Sue Zann, primary, Kusumawidjaja, Grace, additional, Mohd Ishak, Hanis Mariyah, additional, Tan, Benita Kiat Tee, additional, Tan, Si Ying, additional, Hamzah, Julie Liana, additional, Madhukumar, Preetha, additional, Yong, Wei Sean, additional, Wong, Chow Yin, additional, Sim, Yirong, additional, Lim, Geok Hoon, additional, Lim, Swee Ho, additional, Tan, Su-Ming, additional, Wong, Fuh Yong, additional, and Tan, Veronique Kiak Mien, additional

Published
2021
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9. European polygenic risk score for prediction of breast cancer shows similar performance in Asian women

Author

Ho, Weang-Kee, primary, Tan, Min-Min, additional, Mavaddat, Nasim, additional, Tai, Mei-Chee, additional, Mariapun, Shivaani, additional, Li, Jingmei, additional, Ho, Peh-Joo, additional, Dennis, Joe, additional, Tyrer, Jonathan P., additional, Bolla, Manjeet K., additional, Michailidou, Kyriaki, additional, Wang, Qin, additional, Kang, Daehee, additional, Choi, Ji-Yeob, additional, Jamaris, Suniza, additional, Shu, Xiao-Ou, additional, Yoon, Sook-Yee, additional, Park, Sue K., additional, Kim, Sung-Won, additional, Shen, Chen-Yang, additional, Yu, Jyh-Cherng, additional, Tan, Ern Yu, additional, Chan, Patrick Mun Yew, additional, Muir, Kenneth, additional, Lophatananon, Artitaya, additional, Wu, Anna H., additional, Stram, Daniel O., additional, Matsuo, Keitaro, additional, Ito, Hidemi, additional, Chan, Ching Wan, additional, Ngeow, Joanne, additional, Yong, Wei Sean, additional, Lim, Swee Ho, additional, Lim, Geok Hoon, additional, Kwong, Ava, additional, Chan, Tsun L., additional, Tan, Su Ming, additional, Seah, Jaime, additional, John, Esther M., additional, Kurian, Allison W., additional, Koh, Woon-Puay, additional, Khor, Chiea Chuen, additional, Iwasaki, Motoki, additional, Yamaji, Taiki, additional, Tan, Kiak Mien Veronique, additional, Tan, Kiat Tee Benita, additional, Spinelli, John J., additional, Aronson, Kristan J., additional, Hasan, Siti Norhidayu, additional, Rahmat, Kartini, additional, Vijayananthan, Anushya, additional, Sim, Xueling, additional, Pharoah, Paul D. P., additional, Zheng, Wei, additional, Dunning, Alison M., additional, Simard, Jacques, additional, van Dam, Rob Martinus, additional, Yip, Cheng-Har, additional, Taib, Nur Aishah Mohd, additional, Hartman, Mikael, additional, Easton, Douglas F., additional, Teo, Soo-Hwang, additional, and Antoniou, Antonis C., additional

Published
2020
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12. European polygenic risk score for prediction of breast cancer shows similar performance in Asian women

Author

Ho, Weang-Kee, Tan, Min-Min, Mavaddat, Nasim, Tai, Mei-Chee, Mariapun, Shivaani, Li, Jingmei, Ho, Peh-Joo, Dennis, Joe, Tyrer, Jonathan P, Bolla, Manjeet K, Michailidou, Kyriaki, Wang, Qin, Kang, Daehee, Choi, Ji-Yeob, Jamaris, Suniza, Shu, Xiao-Ou, Yoon, Sook-Yee, Park, Sue K, Kim, Sung-Won, Shen, Chen-Yang, Yu, Jyh-Cherng, Tan, Ern Yu, Chan, Patrick Mun Yew, Muir, Kenneth, Lophatananon, Artitaya, Wu, Anna H, Stram, Daniel O, Matsuo, Keitaro, Ito, Hidemi, Chan, Ching Wan, Ngeow, Joanne, Yong, Wei Sean, Lim, Swee Ho, Lim, Geok Hoon, Kwong, Ava, Chan, Tsun L, Tan, Su Ming, Seah, Jaime, John, Esther M, Kurian, Allison W, Koh, Woon-Puay, Khor, Chiea Chuen, Iwasaki, Motoki, Yamaji, Taiki, Tan, Kiak Mien Veronique, Tan, Kiat Tee Benita, Spinelli, John J, Aronson, Kristan J, Hasan, Siti Norhidayu, Rahmat, Kartini, Vijayananthan, Anushya, Sim, Xueling, Pharoah, Paul DP, Zheng, Wei, Dunning, Alison M, Simard, Jacques, Van Dam, Rob Martinus, Yip, Cheng-Har, Taib, Nur Aishah Mohd, Hartman, Mikael, Easton, Douglas F, Teo, Soo-Hwang, and Antoniou, Antonis C

Subjects
Adult, Risk, Multifactorial Inheritance, Asia, Breast Neoplasms, Middle Aged, Prognosis, Polymorphism, Single Nucleotide, 3. Good health, Europe, Case-Control Studies, Odds Ratio, Humans, Female, Genetic Predisposition to Disease, Aged, Genome-Wide Association Study
Abstract

Polygenic risk scores (PRS) have been shown to predict breast cancer risk in European women, but their utility in Asian women is unclear. Here we evaluate the best performing PRSs for European-ancestry women using data from 17,262 breast cancer cases and 17,695 controls of Asian ancestry from 13 case-control studies, and 10,255 Chinese women from a prospective cohort (413 incident breast cancers). Compared to women in the middle quintile of the risk distribution, women in the highest 1% of PRS distribution have a ~2.7-fold risk and women in the lowest 1% of PRS distribution has ~0.4-fold risk of developing breast cancer. There is no evidence of heterogeneity in PRS performance in Chinese, Malay and Indian women. A PRS developed for European-ancestry women is also predictive of breast cancer risk in Asian women and can help in developing risk-stratified screening programmes in Asia.

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