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43 results on '"Levine, Douglas A."'

3. Endometrial cancer

Author

Makker, Vicky, primary, MacKay, Helen, additional, Ray-Coquard, Isabelle, additional, Levine, Douglas A., additional, Westin, Shannon N., additional, Aoki, Daisuke, additional, and Oaknin, Ana, additional

Published
2021
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6. Adult height is associated with increased risk of ovarian cancer: a Mendelian randomisation study

Author

Dixon-Suen, Suzanne C, Nagle, Christina M, Thrift, Aaron P, Pharoah, Paul DP, Ewing, Ailith, Pearce, Celeste Leigh, Zheng, Wei, Australian Ovarian Cancer Study Group, Chenevix-Trench, Georgia, Fasching, Peter A, Beckmann, Matthias W, Lambrechts, Diether, Vergote, Ignace, Lambrechts, Sandrina, Van Nieuwenhuysen, Els, Rossing, Mary Anne, Doherty, Jennifer A, Wicklund, Kristine G, Chang-Claude, Jenny, Jung, Audrey Y, Moysich, Kirsten B, Odunsi, Kunle, Goodman, Marc T, Wilkens, Lynne R, Thompson, Pamela J, Shvetsov, Yurii B, Dörk, Thilo, Park-Simon, Tjoung-Won, Hillemanns, Peter, Bogdanova, Natalia, Butzow, Ralf, Nevanlinna, Heli, Pelttari, Liisa M, Leminen, Arto, Modugno, Francesmary, Ness, Roberta B, Edwards, Robert P, Kelley, Joseph L, Heitz, Florian, du Bois, Andreas, Harter, Philipp, Schwaab, Ira, Karlan, Beth Y, Lester, Jenny, Orsulic, Sandra, Rimel, Bobbie J, Kjær, Susanne K, Høgdall, Estrid, Jensen, Allan, Goode, Ellen L, Fridley, Brooke L, Cunningham, Julie M, Winham, Stacey J, Giles, Graham G, Bruinsma, Fiona, Milne, Roger L, Southey, Melissa C, Hildebrandt, Michelle AT, Wu, Xifeng, Lu, Karen H, Liang, Dong, Levine, Douglas A, Bisogna, Maria, Schildkraut, Joellen M, Berchuck, Andrew, Cramer, Daniel W, Terry, Kathryn L, Bandera, Elisa V, Olson, Sara H, Salvesen, Helga B, Thomsen, Liv Cecilie Vestrheim, Kopperud, Reidun K, Bjorge, Line, Kiemeney, Lambertus A, Massuger, Leon FAG, Pejovic, Tanja, Bruegl, Amanda, Cook, Linda S, Le, Nhu D, Swenerton, Kenneth D, Brooks-Wilson, Angela, Kelemen, Linda E, Lubiński, Jan, Huzarski, Tomasz, Gronwald, Jacek, Menkiszak, Janusz, Wentzensen, Nicolas, Brinton, Louise, Yang, Hannah, Lissowska, Jolanta, Høgdall, Claus K, Lundvall, Lene, Song, Honglin, Tyrer, Jonathan P, Campbell, Ian, Eccles, Diana, Paul, James, Glasspool, Rosalind, Siddiqui, Nadeem, Whittemore, Alice S, Sieh, Weiva, McGuire, Valerie, Rothstein, Joseph H, Narod, Steven A, Phelan, Catherine, Risch, Harvey A, McLaughlin, John R, Anton-Culver, Hoda, Ziogas, Argyrios, Menon, Usha, Gayther, Simon A, Ramus, Susan J, Gentry-Maharaj, Aleksandra, Wu, Anna H, Pike, Malcolm C, Tseng, Chiu-Chen, Kupryjanczyk, Jolanta, Dansonka-Mieszkowska, Agnieszka, Budzilowska, Agnieszka, Rzepecka, Iwona K, Webb, Penelope M, Ovarian Cancer Association Consortium, Dixon-Suen, Suzanne C [0000-0003-3714-8386], Zheng, Wei [0000-0003-1226-070X], Brinton, Louise [0000-0003-3853-8562], Glasspool, Rosalind [0000-0002-5000-1680], and Apollo - University of Cambridge Repository

Subjects
Adult, Aged, 80 and over, Ovarian Neoplasms, Adolescent, Geography, Carcinoma, Ovarian Epithelial, Mendelian Randomization Analysis, Middle Aged, Body Height, Young Adult, Risk Factors, Case-Control Studies, Humans, Female, Genetic Predisposition to Disease, Aged
Abstract

BACKGROUND: Observational studies suggest greater height is associated with increased ovarian cancer risk, but cannot exclude bias and/or confounding as explanations for this. Mendelian randomisation (MR) can provide evidence which may be less prone to bias. METHODS: We pooled data from 39 Ovarian Cancer Association Consortium studies (16,395 cases; 23,003 controls). We applied two-stage predictor-substitution MR, using a weighted genetic risk score combining 609 single-nucleotide polymorphisms. Study-specific odds ratios (OR) and 95% confidence intervals (CI) for the association between genetically predicted height and risk were pooled using random-effects meta-analysis. RESULTS: Greater genetically predicted height was associated with increased ovarian cancer risk overall (pooled-OR (pOR) = 1.06; 95% CI: 1.01-1.11 per 5 cm increase in height), and separately for invasive (pOR = 1.06; 95% CI: 1.01-1.11) and borderline (pOR = 1.15; 95% CI: 1.02-1.29) tumours. CONCLUSIONS: Women with a genetic propensity to being taller have increased risk of ovarian cancer. This suggests genes influencing height are involved in pathways promoting ovarian carcinogenesis.

Published
2018

7. Chromatin-informed inference of transcriptional programs in gynecologic and basal breast cancers

Author

Osmanbeyoglu, Hatice U., primary, Shimizu, Fumiko, additional, Rynne-Vidal, Angela, additional, Alonso-Curbelo, Direna, additional, Chen, Hsuan-An, additional, Wen, Hannah Y., additional, Yeung, Tsz-Lun, additional, Jelinic, Petar, additional, Razavi, Pedram, additional, Lowe, Scott W., additional, Mok, Samuel C., additional, Chiosis, Gabriela, additional, Levine, Douglas A., additional, and Leslie, Christina S., additional

Published
2019
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8. Publisher Correction: Shared heritability and functional enrichment across six solid cancers

Author

Jiang, Xia, primary, Finucane, Hilary K., additional, Schumacher, Fredrick R., additional, Schmit, Stephanie L., additional, Tyrer, Jonathan P., additional, Han, Younghun, additional, Michailidou, Kyriaki, additional, Lesseur, Corina, additional, Kuchenbaecker, Karoline B., additional, Dennis, Joe, additional, Conti, David V., additional, Casey, Graham, additional, Gaudet, Mia M., additional, Huyghe, Jeroen R., additional, Albanes, Demetrius, additional, Aldrich, Melinda C., additional, Andrew, Angeline S., additional, Andrulis, Irene L., additional, Anton-Culver, Hoda, additional, Antoniou, Antonis C., additional, Antonenkova, Natalia N., additional, Arnold, Susanne M., additional, Aronson, Kristan J., additional, Arun, Banu K., additional, Bandera, Elisa V., additional, Barkardottir, Rosa B., additional, Barnes, Daniel R., additional, Batra, Jyotsna, additional, Beckmann, Matthias W., additional, Benitez, Javier, additional, Benlloch, Sara, additional, Berchuck, Andrew, additional, Berndt, Sonja I., additional, Bickeböller, Heike, additional, Bien, Stephanie A., additional, Blomqvist, Carl, additional, Boccia, Stefania, additional, Bogdanova, Natalia V., additional, Bojesen, Stig E., additional, Bolla, Manjeet K., additional, Brauch, Hiltrud, additional, Brenner, Hermann, additional, Brenton, James D., additional, Brook, Mark N., additional, Brunet, Joan, additional, Brunnström, Hans, additional, Buchanan, Daniel D., additional, Burwinkel, Barbara, additional, Butzow, Ralf, additional, Cadoni, Gabriella, additional, Caldés, Trinidad, additional, Caligo, Maria A., additional, Campbell, Ian, additional, Campbell, Peter T., additional, Cancel-Tassin, Géraldine, additional, Cannon-Albright, Lisa, additional, Campa, Daniele, additional, Caporaso, Neil, additional, Carvalho, André L., additional, Chan, Andrew T., additional, Chang-Claude, Jenny, additional, Chanock, Stephen J., additional, Chen, Chu, additional, Christiani, David C., additional, Claes, Kathleen B. M., additional, Claessens, Frank, additional, Clements, Judith, additional, Collée, J. Margriet, additional, Correa, Marcia Cruz, additional, Couch, Fergus J., additional, Cox, Angela, additional, Cunningham, Julie M., additional, Cybulski, Cezary, additional, Czene, Kamila, additional, Daly, Mary B., additional, deFazio, Anna, additional, Devilee, Peter, additional, Diez, Orland, additional, Gago-Dominguez, Manuela, additional, Donovan, Jenny L., additional, Dörk, Thilo, additional, Duell, Eric J., additional, Dunning, Alison M., additional, Dwek, Miriam, additional, Eccles, Diana M., additional, Edlund, Christopher K., additional, Edwards, Digna R. Velez, additional, Ellberg, Carolina, additional, Evans, D. Gareth, additional, Fasching, Peter A., additional, Ferris, Robert L., additional, Liloglou, Triantafillos, additional, Figueiredo, Jane C., additional, Fletcher, Olivia, additional, Fortner, Renée T., additional, Fostira, Florentia, additional, Franceschi, Silvia, additional, Friedman, Eitan, additional, Gallinger, Steven J., additional, Ganz, Patricia A., additional, Garber, Judy, additional, García-Sáenz, José A., additional, Gayther, Simon A., additional, Giles, Graham G., additional, Godwin, Andrew K., additional, Goldberg, Mark S., additional, Goldgar, David E., additional, Goode, Ellen L., additional, Goodman, Marc T., additional, Goodman, Gary, additional, Grankvist, Kjell, additional, Greene, Mark H., additional, Gronberg, Henrik, additional, Gronwald, Jacek, additional, Guénel, Pascal, additional, Håkansson, Niclas, additional, Hall, Per, additional, Hamann, Ute, additional, Hamdy, Freddie C., additional, Hamilton, Robert J., additional, Hampe, Jochen, additional, Haugen, Aage, additional, Heitz, Florian, additional, Herrero, Rolando, additional, Hillemanns, Peter, additional, Hoffmeister, Michael, additional, Høgdall, Estrid, additional, Hong, Yun-Chul, additional, Hopper, John L., additional, Houlston, Richard, additional, Hulick, Peter J., additional, Hunter, David J., additional, Huntsman, David G., additional, Idos, Gregory, additional, Imyanitov, Evgeny N., additional, Ingles, Sue Ann, additional, Isaacs, Claudine, additional, Jakubowska, Anna, additional, James, Paul, additional, Jenkins, Mark A., additional, Johansson, Mattias, additional, Johansson, Mikael, additional, John, Esther M., additional, Joshi, Amit D., additional, Kaneva, Radka, additional, Karlan, Beth Y., additional, Kelemen, Linda E., additional, Kühl, Tabea, additional, Khaw, Kay-Tee, additional, Khusnutdinova, Elza, additional, Kibel, Adam S., additional, Kiemeney, Lambertus A., additional, Kim, Jeri, additional, Kjaer, Susanne K., additional, Knight, Julia A., additional, Kogevinas, Manolis, additional, Kote-Jarai, Zsofia, additional, Koutros, Stella, additional, Kristensen, Vessela N., additional, Kupryjanczyk, Jolanta, additional, Lacko, Martin, additional, Lam, Stephan, additional, Lambrechts, Diether, additional, Landi, Maria Teresa, additional, Lazarus, Philip, additional, Le, Nhu D., additional, Lee, Eunjung, additional, Lejbkowicz, Flavio, additional, Lenz, Heinz-Josef, additional, Leslie, Goska, additional, Lessel, Davor, additional, Lester, Jenny, additional, Levine, Douglas A., additional, Li, Li, additional, Li, Christopher I., additional, Lindblom, Annika, additional, Lindor, Noralane M., additional, Liu, Geoffrey, additional, Loupakis, Fotios, additional, Lubiński, Jan, additional, Maehle, Lovise, additional, Maier, Christiane, additional, Mannermaa, Arto, additional, Marchand, Loic Le, additional, Margolin, Sara, additional, May, Taymaa, additional, McGuffog, Lesley, additional, Meindl, Alfons, additional, Middha, Pooja, additional, Miller, Austin, additional, Milne, Roger L., additional, MacInnis, Robert J., additional, Modugno, Francesmary, additional, Montagna, Marco, additional, Moreno, Victor, additional, Moysich, Kirsten B., additional, Mucci, Lorelei, additional, Muir, Kenneth, additional, Mulligan, Anna Marie, additional, Nathanson, Katherine L., additional, Neal, David E., additional, Ness, Andrew R., additional, Neuhausen, Susan L., additional, Nevanlinna, Heli, additional, Newcomb, Polly A., additional, Newcomb, Lisa F., additional, Nielsen, Finn Cilius, additional, Nikitina-Zake, Liene, additional, Nordestgaard, Børge G., additional, Nussbaum, Robert L., additional, Offit, Kenneth, additional, Olah, Edith, additional, Olama, Ali Amin Al, additional, Olopade, Olufunmilayo I., additional, Olshan, Andrew F., additional, Olsson, Håkan, additional, Osorio, Ana, additional, Pandha, Hardev, additional, Park, Jong Y., additional, Pashayan, Nora, additional, Parsons, Michael T., additional, Pejovic, Tanja, additional, Penney, Kathryn L., additional, Peters, Wilbert H. M., additional, Phelan, Catherine M., additional, Phipps, Amanda I., additional, Plaseska-Karanfilska, Dijana, additional, Pring, Miranda, additional, Prokofyeva, Darya, additional, Radice, Paolo, additional, Stefansson, Kari, additional, Ramus, Susan J., additional, Raskin, Leon, additional, Rennert, Gad, additional, Rennert, Hedy S., additional, van Rensburg, Elizabeth J., additional, Riggan, Marjorie J., additional, Risch, Harvey A., additional, Risch, Angela, additional, Roobol, Monique J., additional, Rosenstein, Barry S., additional, Rossing, Mary Anne, additional, De Ruyck, Kim, additional, Saloustros, Emmanouil, additional, Sandler, Dale P., additional, Sawyer, Elinor J., additional, Schabath, Matthew B., additional, Schleutker, Johanna, additional, Schmidt, Marjanka K., additional, Setiawan, V. Wendy, additional, Shen, Hongbing, additional, Siegel, Erin M., additional, Sieh, Weiva, additional, Singer, Christian F., additional, Slattery, Martha L., additional, Sorensen, Karina Dalsgaard, additional, Southey, Melissa C., additional, Spurdle, Amanda B., additional, Stanford, Janet L., additional, Stevens, Victoria L., additional, Stintzing, Sebastian, additional, Stone, Jennifer, additional, Sundfeldt, Karin, additional, Sutphen, Rebecca, additional, Swerdlow, Anthony J., additional, Tajara, Eloiza H., additional, Tangen, Catherine M., additional, Tardon, Adonina, additional, Taylor, Jack A., additional, Teare, M. Dawn, additional, Teixeira, Manuel R., additional, Terry, Mary Beth, additional, Terry, Kathryn L., additional, Thibodeau, Stephen N., additional, Thomassen, Mads, additional, Bjørge, Line, additional, Tischkowitz, Marc, additional, Toland, Amanda E., additional, Torres, Diana, additional, Townsend, Paul A., additional, Travis, Ruth C., additional, Tung, Nadine, additional, Tworoger, Shelley S., additional, Ulrich, Cornelia M., additional, Usmani, Nawaid, additional, Vachon, Celine M., additional, Van Nieuwenhuysen, Els, additional, Vega, Ana, additional, Aguado-Barrera, Miguel Elías, additional, Wang, Qin, additional, Webb, Penelope M., additional, Weinberg, Clarice R., additional, Weinstein, Stephanie, additional, Weissler, Mark C., additional, Weitzel, Jeffrey N., additional, West, Catharine M. L., additional, White, Emily, additional, Whittemore, Alice S., additional, Wichmann, H-Erich, additional, Wiklund, Fredrik, additional, Winqvist, Robert, additional, Wolk, Alicja, additional, Woll, Penella, additional, Woods, Michael, additional, Wu, Anna H., additional, Wu, Xifeng, additional, Yannoukakos, Drakoulis, additional, Zheng, Wei, additional, Zienolddiny, Shanbeh, additional, Ziogas, Argyrios, additional, Zorn, Kristin K., additional, Lane, Jacqueline M., additional, Saxena, Richa, additional, Thomas, Duncan, additional, Hung, Rayjean J., additional, Diergaarde, Brenda, additional, McKay, James, additional, Peters, Ulrike, additional, Hsu, Li, additional, García-Closas, Montserrat, additional, Eeles, Rosalind A., additional, Chenevix-Trench, Georgia, additional, Brennan, Paul J., additional, Haiman, Christopher A., additional, Simard, Jacques, additional, Easton, Douglas F., additional, Gruber, Stephen B., additional, Pharoah, Paul D. P., additional, Price, Alkes L., additional, Pasaniuc, Bogdan, additional, Amos, Christopher I., additional, Kraft, Peter, additional, and Lindström, Sara, additional

Published
2019
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9. MAGENTA (Making Genetic testing accessible): a prospective randomized controlled trial comparing online genetic education and telephone genetic counseling for hereditary cancer genetic testing

Author

Rayes, Nadine, primary, Bowen, Deborah J., additional, Coffin, Tara, additional, Nebgen, Denise, additional, Peterson, Christine, additional, Munsell, Mark F., additional, Gavin, Kathleen, additional, Lechner, Rebecca, additional, Crase, Jamie, additional, Polinsky, Deborah, additional, Romero, Iris, additional, Blank, Stephanie V., additional, Levine, Douglas A., additional, Norquist, Barbara M., additional, Swisher, Elizabeth M., additional, and Lu, Karen H., additional

Published
2019
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10. CDK4/6 inhibitors target SMARCA4-determined cyclin D1 deficiency in hypercalcemic small cell carcinoma of the ovary

Author

Xue, Yibo, primary, Meehan, Brian, additional, Macdonald, Elizabeth, additional, Venneti, Sriram, additional, Wang, Xue Qing D., additional, Witkowski, Leora, additional, Jelinic, Petar, additional, Kong, Tim, additional, Martinez, Daniel, additional, Morin, Geneviève, additional, Firlit, Michelle, additional, Abedini, Atefeh, additional, Johnson, Radia M., additional, Cencic, Regina, additional, Patibandla, Jay, additional, Chen, Hongbo, additional, Papadakis, Andreas I., additional, Auguste, Aurelie, additional, de Rink, Iris, additional, Kerkhoven, Ron M., additional, Bertos, Nicholas, additional, Gotlieb, Walter H., additional, Clarke, Blaise A., additional, Leary, Alexandra, additional, Witcher, Michael, additional, Guiot, Marie-Christine, additional, Pelletier, Jerry, additional, Dostie, Josée, additional, Park, Morag, additional, Judkins, Alexander R., additional, Hass, Ralf, additional, Levine, Douglas A., additional, Rak, Janusz, additional, Vanderhyden, Barbara, additional, Foulkes, William D., additional, and Huang, Sidong, additional

Published
2019
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11. Shared heritability and functional enrichment across six solid cancers

Author

Jiang, Xia, primary, Finucane, Hilary K., additional, Schumacher, Fredrick R., additional, Schmit, Stephanie L., additional, Tyrer, Jonathan P., additional, Han, Younghun, additional, Michailidou, Kyriaki, additional, Lesseur, Corina, additional, Kuchenbaecker, Karoline B., additional, Dennis, Joe, additional, Conti, David V., additional, Casey, Graham, additional, Gaudet, Mia M., additional, Huyghe, Jeroen R., additional, Albanes, Demetrius, additional, Aldrich, Melinda C., additional, Andrew, Angeline S., additional, Andrulis, Irene L., additional, Anton-Culver, Hoda, additional, Antoniou, Antonis C., additional, Antonenkova, Natalia N., additional, Arnold, Susanne M., additional, Aronson, Kristan J., additional, Arun, Banu K., additional, Bandera, Elisa V., additional, Barkardottir, Rosa B., additional, Barnes, Daniel R., additional, Batra, Jyotsna, additional, Beckmann, Matthias W., additional, Benitez, Javier, additional, Benlloch, Sara, additional, Berchuck, Andrew, additional, Berndt, Sonja I., additional, Bickeböller, Heike, additional, Bien, Stephanie A., additional, Blomqvist, Carl, additional, Boccia, Stefania, additional, Bogdanova, Natalia V., additional, Bojesen, Stig E., additional, Bolla, Manjeet K., additional, Brauch, Hiltrud, additional, Brenner, Hermann, additional, Brenton, James D., additional, Brook, Mark N., additional, Brunet, Joan, additional, Brunnström, Hans, additional, Buchanan, Daniel D., additional, Burwinkel, Barbara, additional, Butzow, Ralf, additional, Cadoni, Gabriella, additional, Caldés, Trinidad, additional, Caligo, Maria A., additional, Campbell, Ian, additional, Campbell, Peter T., additional, Cancel-Tassin, Géraldine, additional, Cannon-Albright, Lisa, additional, Campa, Daniele, additional, Caporaso, Neil, additional, Carvalho, André L., additional, Chan, Andrew T., additional, Chang-Claude, Jenny, additional, Chanock, Stephen J., additional, Chen, Chu, additional, Christiani, David C., additional, Claes, Kathleen B. M., additional, Claessens, Frank, additional, Clements, Judith, additional, Collée, J. Margriet, additional, Correa, Marcia Cruz, additional, Couch, Fergus J., additional, Cox, Angela, additional, Cunningham, Julie M., additional, Cybulski, Cezary, additional, Czene, Kamila, additional, Daly, Mary B., additional, deFazio, Anna, additional, Devilee, Peter, additional, Diez, Orland, additional, Gago-Dominguez, Manuela, additional, Donovan, Jenny L., additional, Dörk, Thilo, additional, Duell, Eric J., additional, Dunning, Alison M., additional, Dwek, Miriam, additional, Eccles, Diana M., additional, Edlund, Christopher K., additional, Edwards, Digna R Velez, additional, Ellberg, Carolina, additional, Evans, D. Gareth, additional, Fasching, Peter A., additional, Ferris, Robert L., additional, Liloglou, Triantafillos, additional, Figueiredo, Jane C., additional, Fletcher, Olivia, additional, Fortner, Renée T., additional, Fostira, Florentia, additional, Franceschi, Silvia, additional, Friedman, Eitan, additional, Gallinger, Steven J., additional, Ganz, Patricia A., additional, Garber, Judy, additional, García-Sáenz, José A., additional, Gayther, Simon A., additional, Giles, Graham G., additional, Godwin, Andrew K., additional, Goldberg, Mark S., additional, Goldgar, David E., additional, Goode, Ellen L., additional, Goodman, Marc T., additional, Goodman, Gary, additional, Grankvist, Kjell, additional, Greene, Mark H., additional, Gronberg, Henrik, additional, Gronwald, Jacek, additional, Guénel, Pascal, additional, Håkansson, Niclas, additional, Hall, Per, additional, Hamann, Ute, additional, Hamdy, Freddie C., additional, Hamilton, Robert J., additional, Hampe, Jochen, additional, Haugen, Aage, additional, Heitz, Florian, additional, Herrero, Rolando, additional, Hillemanns, Peter, additional, Hoffmeister, Michael, additional, Høgdall, Estrid, additional, Hong, Yun-Chul, additional, Hopper, John L., additional, Houlston, Richard, additional, Hulick, Peter J., additional, Hunter, David J., additional, Huntsman, David G., additional, Idos, Gregory, additional, Imyanitov, Evgeny N., additional, Ingles, Sue Ann, additional, Isaacs, Claudine, additional, Jakubowska, Anna, additional, James, Paul, additional, Jenkins, Mark A., additional, Johansson, Mattias, additional, Johansson, Mikael, additional, John, Esther M., additional, Joshi, Amit D., additional, Kaneva, Radka, additional, Karlan, Beth Y., additional, Kelemen, Linda E., additional, Kühl, Tabea, additional, Khaw, Kay-Tee, additional, Khusnutdinova, Elza, additional, Kibel, Adam S., additional, Kiemeney, Lambertus A., additional, Kim, Jeri, additional, Kjaer, Susanne K., additional, Knight, Julia A., additional, Kogevinas, Manolis, additional, Kote-Jarai, Zsofia, additional, Koutros, Stella, additional, Kristensen, Vessela N., additional, Kupryjanczyk, Jolanta, additional, Lacko, Martin, additional, Lam, Stephan, additional, Lambrechts, Diether, additional, Landi, Maria Teresa, additional, Lazarus, Philip, additional, Le, Nhu D., additional, Lee, Eunjung, additional, Lejbkowicz, Flavio, additional, Lenz, Heinz-Josef, additional, Leslie, Goska, additional, Lessel, Davor, additional, Lester, Jenny, additional, Levine, Douglas A., additional, Li, Li, additional, Li, Christopher I., additional, Lindblom, Annika, additional, Lindor, Noralane M., additional, Liu, Geoffrey, additional, Loupakis, Fotios, additional, Lubiński, Jan, additional, Maehle, Lovise, additional, Maier, Christiane, additional, Mannermaa, Arto, additional, Marchand, Loic Le, additional, Margolin, Sara, additional, May, Taymaa, additional, McGuffog, Lesley, additional, Meindl, Alfons, additional, Middha, Pooja, additional, Miller, Austin, additional, Milne, Roger L., additional, MacInnis, Robert J., additional, Modugno, Francesmary, additional, Montagna, Marco, additional, Moreno, Victor, additional, Moysich, Kirsten B., additional, Mucci, Lorelei, additional, Muir, Kenneth, additional, Mulligan, Anna Marie, additional, Nathanson, Katherine L., additional, Neal, David E., additional, Ness, Andrew R., additional, Neuhausen, Susan L., additional, Nevanlinna, Heli, additional, Newcomb, Polly A., additional, Newcomb, Lisa F., additional, Nielsen, Finn Cilius, additional, Nikitina-Zake, Liene, additional, Nordestgaard, Børge G., additional, Nussbaum, Robert L., additional, Offit, Kenneth, additional, Olah, Edith, additional, Olama, Ali Amin Al, additional, Olopade, Olufunmilayo I., additional, Olshan, Andrew F., additional, Olsson, Håkan, additional, Osorio, Ana, additional, Pandha, Hardev, additional, Park, Jong Y., additional, Pashayan, Nora, additional, Parsons, Michael T., additional, Pejovic, Tanja, additional, Penney, Kathryn L., additional, Peters, Wilbert H M., additional, Phelan, Catherine M., additional, Phipps, Amanda I., additional, Plaseska-Karanfilska, Dijana, additional, Pring, Miranda, additional, Prokofyeva, Darya, additional, Radice, Paolo, additional, Stefansson, Kari, additional, Ramus, Susan J., additional, Raskin, Leon, additional, Rennert, Gad, additional, Rennert, Hedy S., additional, van Rensburg, Elizabeth J., additional, Riggan, Marjorie J., additional, Risch, Harvey A., additional, Risch, Angela, additional, Roobol, Monique J., additional, Rosenstein, Barry S., additional, Rossing, Mary Anne, additional, De Ruyck, Kim, additional, Saloustros, Emmanouil, additional, Sandler, Dale P., additional, Sawyer, Elinor J., additional, Schabath, Matthew B., additional, Schleutker, Johanna, additional, Schmidt, Marjanka K., additional, Setiawan, V. Wendy, additional, Shen, Hongbing, additional, Siegel, Erin M., additional, Sieh, Weiva, additional, Singer, Christian F., additional, Slattery, Martha L., additional, Sorensen, Karina Dalsgaard, additional, Southey, Melissa C., additional, Spurdle, Amanda B., additional, Stanford, Janet L., additional, Stevens, Victoria L., additional, Stintzing, Sebastian, additional, Stone, Jennifer, additional, Sundfeldt, Karin, additional, Sutphen, Rebecca, additional, Swerdlow, Anthony J., additional, Tajara, Eloiza H., additional, Tangen, Catherine M., additional, Tardon, Adonina, additional, Taylor, Jack A., additional, Teare, M. Dawn, additional, Teixeira, Manuel R., additional, Terry, Mary Beth, additional, Terry, Kathryn L., additional, Thibodeau, Stephen N., additional, Thomassen, Mads, additional, Bjørge, Line, additional, Tischkowitz, Marc, additional, Toland, Amanda E., additional, Torres, Diana, additional, Townsend, Paul A., additional, Travis, Ruth C., additional, Tung, Nadine, additional, Tworoger, Shelley S., additional, Ulrich, Cornelia M., additional, Usmani, Nawaid, additional, Vachon, Celine M., additional, Van Nieuwenhuysen, Els, additional, Vega, Ana, additional, Aguado-Barrera, Miguel Elías, additional, Wang, Qin, additional, Webb, Penelope M., additional, Weinberg, Clarice R., additional, Weinstein, Stephanie, additional, Weissler, Mark C., additional, Weitzel, Jeffrey N., additional, West, Catharine M. L., additional, White, Emily, additional, Whittemore, Alice S., additional, Wichmann, H-Erich, additional, Wiklund, Fredrik, additional, Winqvist, Robert, additional, Wolk, Alicja, additional, Woll, Penella, additional, Woods, Michael, additional, Wu, Anna H., additional, Wu, Xifeng, additional, Yannoukakos, Drakoulis, additional, Zheng, Wei, additional, Zienolddiny, Shanbeh, additional, Ziogas, Argyrios, additional, Zorn, Kristin K., additional, Lane, Jacqueline M., additional, Saxena, Richa, additional, Thomas, Duncan, additional, Hung, Rayjean J., additional, Diergaarde, Brenda, additional, McKay, James, additional, Peters, Ulrike, additional, Hsu, Li, additional, García-Closas, Montserrat, additional, Eeles, Rosalind A., additional, Chenevix-Trench, Georgia, additional, Brennan, Paul J., additional, Haiman, Christopher A., additional, Simard, Jacques, additional, Easton, Douglas F., additional, Gruber, Stephen B., additional, Pharoah, Paul D. P., additional, Price, Alkes L., additional, Pasaniuc, Bogdan, additional, Amos, Christopher I., additional, Kraft, Peter, additional, and Lindström, Sara, additional

Published
2019
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14. Platelets reduce anoikis and promote metastasis by activating YAP1 signaling

Author

Haemmerle, Monika, primary, Taylor, Morgan L., additional, Gutschner, Tony, additional, Pradeep, Sunila, additional, Cho, Min Soon, additional, Sheng, Jianting, additional, Lyons, Yasmin M., additional, Nagaraja, Archana S., additional, Dood, Robert L., additional, Wen, Yunfei, additional, Mangala, Lingegowda S., additional, Hansen, Jean M., additional, Rupaimoole, Rajesha, additional, Gharpure, Kshipra M., additional, Rodriguez-Aguayo, Cristian, additional, Yim, Sun Young, additional, Lee, Ju-Seog, additional, Ivan, Cristina, additional, Hu, Wei, additional, Lopez-Berestein, Gabriel, additional, Wong, Stephen T., additional, Karlan, Beth Y., additional, Levine, Douglas A., additional, Liu, Jinsong, additional, Afshar-Kharghan, Vahid, additional, and Sood, Anil K., additional

Published
2017
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16. A novel representation of inter-site tumour heterogeneity from pre-treatment computed tomography textures classifies ovarian cancers by clinical outcome

Author

Vargas, Hebert Alberto, primary, Veeraraghavan, Harini, additional, Micco, Maura, additional, Nougaret, Stephanie, additional, Lakhman, Yulia, additional, Meier, Andreas A., additional, Sosa, Ramon, additional, Soslow, Robert A., additional, Levine, Douglas A., additional, Weigelt, Britta, additional, Aghajanian, Carol, additional, Hricak, Hedvig, additional, Deasy, Joseph, additional, Snyder, Alexandra, additional, and Sala, Evis, additional

Published
2017
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17. Enrichment of putative PAX8 target genes at serous epithelial ovarian cancer susceptibility loci

Author

Kar, Siddhartha P, primary, Adler, Emily, additional, Tyrer, Jonathan, additional, Hazelett, Dennis, additional, Anton-Culver, Hoda, additional, Bandera, Elisa V, additional, Beckmann, Matthias W, additional, Berchuck, Andrew, additional, Bogdanova, Natalia, additional, Brinton, Louise, additional, Butzow, Ralf, additional, Campbell, Ian, additional, Carty, Karen, additional, Chang-Claude, Jenny, additional, Cook, Linda S, additional, Cramer, Daniel W, additional, Cunningham, Julie M, additional, Dansonka-Mieszkowska, Agnieszka, additional, Doherty, Jennifer Anne, additional, Dörk, Thilo, additional, Dürst, Matthias, additional, Eccles, Diana, additional, Fasching, Peter A, additional, Flanagan, James, additional, Gentry-Maharaj, Aleksandra, additional, Glasspool, Rosalind, additional, Goode, Ellen L, additional, Goodman, Marc T, additional, Gronwald, Jacek, additional, Heitz, Florian, additional, Hildebrandt, Michelle A T, additional, Høgdall, Estrid, additional, Høgdall, Claus K, additional, Huntsman, David G, additional, Jensen, Allan, additional, Karlan, Beth Y, additional, Kelemen, Linda E, additional, Kiemeney, Lambertus A, additional, Kjaer, Susanne K, additional, Kupryjanczyk, Jolanta, additional, Lambrechts, Diether, additional, Levine, Douglas A, additional, Li, Qiyuan, additional, Lissowska, Jolanta, additional, Lu, Karen H, additional, Lubiński, Jan, additional, Massuger, Leon F A G, additional, McGuire, Valerie, additional, McNeish, Iain, additional, Menon, Usha, additional, Modugno, Francesmary, additional, Monteiro, Alvaro N, additional, Moysich, Kirsten B, additional, Ness, Roberta B, additional, Nevanlinna, Heli, additional, Paul, James, additional, Pearce, Celeste L, additional, Pejovic, Tanja, additional, Permuth, Jennifer B, additional, Phelan, Catherine, additional, Pike, Malcolm C, additional, Poole, Elizabeth M, additional, Ramus, Susan J, additional, Risch, Harvey A, additional, Rossing, Mary Anne, additional, Salvesen, Helga B, additional, Schildkraut, Joellen M, additional, Sellers, Thomas A, additional, Sherman, Mark, additional, Siddiqui, Nadeem, additional, Sieh, Weiva, additional, Song, Honglin, additional, Southey, Melissa, additional, Terry, Kathryn L, additional, Tworoger, Shelley S, additional, Walsh, Christine, additional, Wentzensen, Nicolas, additional, Whittemore, Alice S, additional, Wu, Anna H, additional, Yang, Hannah, additional, Zheng, Wei, additional, Ziogas, Argyrios, additional, Freedman, Matthew L, additional, Gayther, Simon A, additional, Pharoah, Paul D P, additional, and Lawrenson, Kate, additional

Published
2017
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19. Impact of Obesity on Sentinel Lymph Node Mapping in Patients with Newly Diagnosed Uterine Cancer Undergoing Robotic Surgery

Author

Eriksson, Ane Gerda Zahl, primary, Montovano, Margaret, additional, Beavis, Anna, additional, Soslow, Robert A., additional, Zhou, Qin, additional, Abu-Rustum, Nadeem R., additional, Gardner, Ginger J., additional, Zivanovic, Oliver, additional, Barakat, Richard R., additional, Brown, Carol L., additional, Levine, Douglas A., additional, Sonoda, Yukio, additional, Leitao, Mario M., additional, and Jewell, Elizabeth L., additional

Published
2016
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20. Impact of Robotic Platforms on Surgical Approach and Costs in the Management of Morbidly Obese Patients with Newly Diagnosed Uterine Cancer

Author

Leitao, Mario M., primary, Narain, Wazim R., additional, Boccamazzo, Donna, additional, Sioulas, Vasileios, additional, Cassella, Danielle, additional, Ducie, Jennifer A., additional, Eriksson, Ane Gerda Z., additional, Sonoda, Yukio, additional, Chi, Dennis S., additional, Brown, Carol L., additional, Levine, Douglas A., additional, Jewell, Elizabeth L., additional, Zivanovic, Oliver, additional, Barakat, Richard R., additional, Abu-Rustum, Nadeem R., additional, and Gardner, Ginger J., additional

Published
2016
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21. Is It Time to Centralize Ovarian Cancer Care in the United States?

Author

Cowan, Renee A., primary, O’Cearbhaill, Roisin E., additional, Gardner, Ginger J., additional, Levine, Douglas A., additional, Roche, Kara Long, additional, Sonoda, Yukio, additional, Zivanovic, Oliver, additional, Tew, William P., additional, Sala, Evis, additional, Lakhman, Yulia, additional, Vargas Alvarez, Hebert A., additional, Sarasohn, Debra M., additional, Mironov, Svetlana, additional, Abu-Rustum, Nadeem R., additional, and Chi, Dennis S., additional

Published
2015
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22. Rethinking ovarian cancer II: reducing mortality from high-grade serous ovarian cancer

Author

Bowtell, David D., primary, Böhm, Steffen, additional, Ahmed, Ahmed A., additional, Aspuria, Paul-Joseph, additional, Bast, Robert C., additional, Beral, Valerie, additional, Berek, Jonathan S., additional, Birrer, Michael J., additional, Blagden, Sarah, additional, Bookman, Michael A., additional, Brenton, James D., additional, Chiappinelli, Katherine B., additional, Martins, Filipe Correia, additional, Coukos, George, additional, Drapkin, Ronny, additional, Edmondson, Richard, additional, Fotopoulou, Christina, additional, Gabra, Hani, additional, Galon, Jérôme, additional, Gourley, Charlie, additional, Heong, Valerie, additional, Huntsman, David G., additional, Iwanicki, Marcin, additional, Karlan, Beth Y., additional, Kaye, Allyson, additional, Lengyel, Ernst, additional, Levine, Douglas A., additional, Lu, Karen H., additional, McNeish, Iain A., additional, Menon, Usha, additional, Narod, Steven A., additional, Nelson, Brad H., additional, Nephew, Kenneth P., additional, Pharoah, Paul, additional, Powell, Daniel J., additional, Ramos, Pilar, additional, Romero, Iris L., additional, Scott, Clare L., additional, Sood, Anil K., additional, Stronach, Euan A., additional, and Balkwill, Frances R., additional

Published
2015
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25. Recurrent SMARCA4 mutations in small cell carcinoma of the ovary

Author

Jelinic, Petar, primary, Mueller, Jennifer J, additional, Olvera, Narciso, additional, Dao, Fanny, additional, Scott, Sasinya N, additional, Shah, Ronak, additional, Gao, JianJiong, additional, Schultz, Nikolaus, additional, Gonen, Mithat, additional, Soslow, Robert A, additional, Berger, Michael F, additional, and Levine, Douglas A, additional

Published
2014
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26. Inferring tumour purity and stromal and immune cell admixture from expression data

Author

Yoshihara, Kosuke, primary, Shahmoradgoli, Maria, additional, Martínez, Emmanuel, additional, Vegesna, Rahulsimham, additional, Kim, Hoon, additional, Torres-Garcia, Wandaliz, additional, Treviño, Victor, additional, Shen, Hui, additional, Laird, Peter W., additional, Levine, Douglas A., additional, Carter, Scott L., additional, Getz, Gad, additional, Stemke-Hale, Katherine, additional, Mills, Gordon B., additional, and Verhaak, Roel G.W., additional

Published
2013
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28. Absolute quantification of somatic DNA alterations in human cancer

Author

Carter, Scott L, primary, Cibulskis, Kristian, additional, Helman, Elena, additional, McKenna, Aaron, additional, Shen, Hui, additional, Zack, Travis, additional, Laird, Peter W, additional, Onofrio, Robert C, additional, Winckler, Wendy, additional, Weir, Barbara A, additional, Beroukhim, Rameen, additional, Pellman, David, additional, Levine, Douglas A, additional, Lander, Eric S, additional, Meyerson, Matthew, additional, and Getz, Gad, additional

Published
2012
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29. Rethinking ovarian cancer: recommendations for improving outcomes

Author

Vaughan, Sebastian, primary, Coward, Jermaine I., additional, Bast, Robert C., additional, Berchuck, Andy, additional, Berek, Jonathan S., additional, Brenton, James D., additional, Coukos, George, additional, Crum, Christopher C., additional, Drapkin, Ronny, additional, Etemadmoghadam, Dariush, additional, Friedlander, Michael, additional, Gabra, Hani, additional, Kaye, Stan B., additional, Lord, Chris J., additional, Lengyel, Ernst, additional, Levine, Douglas A., additional, McNeish, Iain A., additional, Menon, Usha, additional, Mills, Gordon B., additional, Nephew, Kenneth P., additional, Oza, Amit M., additional, Sood, Anil K., additional, Stronach, Euan A., additional, Walczak, Henning, additional, Bowtell, David D., additional, and Balkwill, Frances R., additional

Published
2011
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30. Resistance to therapy caused by intragenic deletion in BRCA2

Author

Edwards, Stacey L., primary, Brough, Rachel, additional, Lord, Christopher J., additional, Natrajan, Rachael, additional, Vatcheva, Radost, additional, Levine, Douglas A., additional, Boyd, Jeff, additional, Reis-Filho, Jorge S., additional, and Ashworth, Alan, additional

Published
2008
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31. Network modeling links breast cancer susceptibility and centrosome dysfunction

Author

Pujana, Miguel Angel, primary, Han, Jing-Dong J, additional, Starita, Lea M, additional, Stevens, Kristen N, additional, Tewari, Muneesh, additional, Ahn, Jin Sook, additional, Rennert, Gad, additional, Moreno, Víctor, additional, Kirchhoff, Tomas, additional, Gold, Bert, additional, Assmann, Volker, additional, ElShamy, Wael M, additional, Rual, Jean-François, additional, Levine, Douglas, additional, Rozek, Laura S, additional, Gelman, Rebecca S, additional, Gunsalus, Kristin C, additional, Greenberg, Roger A, additional, Sobhian, Bijan, additional, Bertin, Nicolas, additional, Venkatesan, Kavitha, additional, Ayivi-Guedehoussou, Nono, additional, Solé, Xavier, additional, Hernández, Pilar, additional, Lázaro, Conxi, additional, Nathanson, Katherine L, additional, Weber, Barbara L, additional, Cusick, Michael E, additional, Hill, David E, additional, Offit, Kenneth, additional, Livingston, David M, additional, Gruber, Stephen B, additional, Parvin, Jeffrey D, additional, and Vidal, Marc, additional

Published
2007
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32. Heterogenic Loss of the Wild-Type BRCA Allele in Human Breast Tumorigenesis

Author

King, Tari A., primary, Li, Weiwei, additional, Brogi, Edi, additional, Yee, Cindy J., additional, Gemignani, Mary L., additional, Olvera, Narciso, additional, Levine, Douglas A., additional, Norton, Larry, additional, Robson, Mark E., additional, Offit, Kenneth, additional, Borgen, Patrick I., additional, and Boyd, Jeff, additional

Published
2007
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35. Adult height is associated with increased risk of ovarian cancer: a Mendelian randomisation study

Author

Dixon-Suen, Suzanne C, Nagle, Christina M, Thrift, Aaron P, Pharoah, Paul DP, Ewing, Ailith, Pearce, Celeste Leigh, Zheng, Wei, Australian Ovarian Cancer Study Group, Chenevix-Trench, Georgia, Fasching, Peter A, Beckmann, Matthias W, Lambrechts, Diether, Vergote, Ignace, Lambrechts, Sandrina, Van Nieuwenhuysen, Els, Rossing, Mary Anne, Doherty, Jennifer A, Wicklund, Kristine G, Chang-Claude, Jenny, Jung, Audrey Y, Moysich, Kirsten B, Odunsi, Kunle, Goodman, Marc T, Wilkens, Lynne R, Thompson, Pamela J, Shvetsov, Yurii B, Dörk, Thilo, Park-Simon, Tjoung-Won, Hillemanns, Peter, Bogdanova, Natalia, Butzow, Ralf, Nevanlinna, Heli, Pelttari, Liisa M, Leminen, Arto, Modugno, Francesmary, Ness, Roberta B, Edwards, Robert P, Kelley, Joseph L, Heitz, Florian, Du Bois, Andreas, Harter, Philipp, Schwaab, Ira, Karlan, Beth Y, Lester, Jenny, Orsulic, Sandra, Rimel, Bobbie J, Kjær, Susanne K, Høgdall, Estrid, Jensen, Allan, Goode, Ellen L, Fridley, Brooke L, Cunningham, Julie M, Winham, Stacey J, Giles, Graham G, Bruinsma, Fiona, Milne, Roger L, Southey, Melissa C, Hildebrandt, Michelle AT, Wu, Xifeng, Lu, Karen H, Liang, Dong, Levine, Douglas A, Bisogna, Maria, Schildkraut, Joellen M, Berchuck, Andrew, Cramer, Daniel W, Terry, Kathryn L, Bandera, Elisa V, Olson, Sara H, Salvesen, Helga B, Thomsen, Liv Cecilie Vestrheim, Kopperud, Reidun K, Bjorge, Line, Kiemeney, Lambertus A, Massuger, Leon FAG, Pejovic, Tanja, Bruegl, Amanda, Cook, Linda S, Le, Nhu D, Swenerton, Kenneth D, Brooks-Wilson, Angela, Kelemen, Linda E, Lubiński, Jan, Huzarski, Tomasz, Gronwald, Jacek, Menkiszak, Janusz, Wentzensen, Nicolas, Brinton, Louise, Yang, Hannah, Lissowska, Jolanta, Høgdall, Claus K, Lundvall, Lene, Song, Honglin, Tyrer, Jonathan P, Campbell, Ian, Eccles, Diana, Paul, James, Glasspool, Rosalind, Siddiqui, Nadeem, Whittemore, Alice S, Sieh, Weiva, McGuire, Valerie, Rothstein, Joseph H, Narod, Steven A, Phelan, Catherine, Risch, Harvey A, McLaughlin, John R, Anton-Culver, Hoda, Ziogas, Argyrios, Menon, Usha, Gayther, Simon A, Ramus, Susan J, Gentry-Maharaj, Aleksandra, Wu, Anna H, Pike, Malcolm C, Tseng, Chiu-Chen, Kupryjanczyk, Jolanta, Dansonka-Mieszkowska, Agnieszka, Budzilowska, Agnieszka, Rzepecka, Iwona K, Webb, Penelope M, and Ovarian Cancer Association Consortium

Subjects
Adult, Aged, 80 and over, Ovarian Neoplasms, Adolescent, Geography, Carcinoma, Ovarian Epithelial, Mendelian Randomization Analysis, Middle Aged, Body Height, 3. Good health, Young Adult, Risk Factors, Case-Control Studies, Humans, Female, Genetic Predisposition to Disease, Aged
Abstract

BACKGROUND: Observational studies suggest greater height is associated with increased ovarian cancer risk, but cannot exclude bias and/or confounding as explanations for this. Mendelian randomisation (MR) can provide evidence which may be less prone to bias. METHODS: We pooled data from 39 Ovarian Cancer Association Consortium studies (16,395 cases; 23,003 controls). We applied two-stage predictor-substitution MR, using a weighted genetic risk score combining 609 single-nucleotide polymorphisms. Study-specific odds ratios (OR) and 95% confidence intervals (CI) for the association between genetically predicted height and risk were pooled using random-effects meta-analysis. RESULTS: Greater genetically predicted height was associated with increased ovarian cancer risk overall (pooled-OR (pOR) = 1.06; 95% CI: 1.01-1.11 per 5 cm increase in height), and separately for invasive (pOR = 1.06; 95% CI: 1.01-1.11) and borderline (pOR = 1.15; 95% CI: 1.02-1.29) tumours. CONCLUSIONS: Women with a genetic propensity to being taller have increased risk of ovarian cancer. This suggests genes influencing height are involved in pathways promoting ovarian carcinogenesis.

36. Shared heritability and functional enrichment across six solid cancers

Author

Jiang, Xia, Finucane, Hilary K, Schumacher, Fredrick R, Schmit, Stephanie L, Tyrer, Jonathan P, Han, Younghun, Michailidou, Kyriaki, Lesseur, Corina, Kuchenbaecker, Karoline B, Dennis, Joe, Conti, David V, Casey, Graham, Gaudet, Mia M, Huyghe, Jeroen R, Albanes, Demetrius, Aldrich, Melinda C, Andrew, Angeline S, Andrulis, Irene L, Anton-Culver, Hoda, Antoniou, Antonis C, Antonenkova, Natalia N, Arnold, Susanne M, Aronson, Kristan J, Arun, Banu K, Bandera, Elisa V, Barkardottir, Rosa B, Barnes, Daniel R, Batra, Jyotsna, Beckmann, Matthias W, Benitez, Javier, Benlloch, Sara, Berchuck, Andrew, Berndt, Sonja I, Bickeböller, Heike, Bien, Stephanie A, Blomqvist, Carl, Boccia, Stefania, Bogdanova, Natalia V, Bojesen, Stig E, Bolla, Manjeet K, Brauch, Hiltrud, Brenner, Hermann, Brenton, James D, Brook, Mark N, Brunet, Joan, Brunnström, Hans, Buchanan, Daniel D, Burwinkel, Barbara, Butzow, Ralf, Cadoni, Gabriella, Caldés, Trinidad, Caligo, Maria A, Campbell, Ian, Campbell, Peter T, Cancel-Tassin, Géraldine, Cannon-Albright, Lisa, Campa, Daniele, Caporaso, Neil, Carvalho, André L, Chan, Andrew T, Chang-Claude, Jenny, Chanock, Stephen J, Chen, Chu, Christiani, David C, Claes, Kathleen BM, Claessens, Frank, Clements, Judith, Collée, J Margriet, Correa, Marcia Cruz, Couch, Fergus J, Cox, Angela, Cunningham, Julie M, Cybulski, Cezary, Czene, Kamila, Daly, Mary B, DeFazio, Anna, Devilee, Peter, Diez, Orland, Gago-Dominguez, Manuela, Donovan, Jenny L, Dörk, Thilo, Duell, Eric J, Dunning, Alison M, Dwek, Miriam, Eccles, Diana M, Edlund, Christopher K, Edwards, Digna R Velez, Ellberg, Carolina, Evans, D Gareth, Fasching, Peter A, Ferris, Robert L, Liloglou, Triantafillos, Figueiredo, Jane C, Fletcher, Olivia, Fortner, Renée T, Fostira, Florentia, Franceschi, Silvia, Friedman, Eitan, Gallinger, Steven J, Ganz, Patricia A, Garber, Judy, García-Sáenz, José A, Gayther, Simon A, Giles, Graham G, Godwin, Andrew K, Goldberg, Mark S, Goldgar, David E, Goode, Ellen L, Goodman, Marc T, Goodman, Gary, Grankvist, Kjell, Greene, Mark H, Gronberg, Henrik, Gronwald, Jacek, Guénel, Pascal, Håkansson, Niclas, Hall, Per, Hamann, Ute, Hamdy, Freddie C, Hamilton, Robert J, Hampe, Jochen, Haugen, Aage, Heitz, Florian, Herrero, Rolando, Hillemanns, Peter, Hoffmeister, Michael, Høgdall, Estrid, Hong, Yun-Chul, Hopper, John L, Houlston, Richard, Hulick, Peter J, Hunter, David J, Huntsman, David G, Idos, Gregory, Imyanitov, Evgeny N, Ingles, Sue Ann, Isaacs, Claudine, Jakubowska, Anna, James, Paul, Jenkins, Mark A, Johansson, Mattias, Johansson, Mikael, John, Esther M, Joshi, Amit D, Kaneva, Radka, Karlan, Beth Y, Kelemen, Linda E, Kühl, Tabea, Khaw, Kay-Tee, Khusnutdinova, Elza, Kibel, Adam S, Kiemeney, Lambertus A, Kim, Jeri, Kjaer, Susanne K, Knight, Julia A, Kogevinas, Manolis, Kote-Jarai, Zsofia, Koutros, Stella, Kristensen, Vessela N, Kupryjanczyk, Jolanta, Lacko, Martin, Lam, Stephan, Lambrechts, Diether, Landi, Maria Teresa, Lazarus, Philip, Le, Nhu D, Lee, Eunjung, Lejbkowicz, Flavio, Lenz, Heinz-Josef, Leslie, Goska, Lessel, Davor, Lester, Jenny, Levine, Douglas A, Li, Li, Li, Christopher I, Lindblom, Annika, Lindor, Noralane M, Liu, Geoffrey, Loupakis, Fotios, Lubiński, Jan, Maehle, Lovise, Maier, Christiane, Mannermaa, Arto, Marchand, Loic Le, Margolin, Sara, May, Taymaa, McGuffog, Lesley, Meindl, Alfons, Middha, Pooja, Miller, Austin, Milne, Roger L, MacInnis, Robert J, Modugno, Francesmary, Montagna, Marco, Moreno, Victor, Moysich, Kirsten B, Mucci, Lorelei, Muir, Kenneth, Mulligan, Anna Marie, Nathanson, Katherine L, Neal, David E, Ness, Andrew R, Neuhausen, Susan L, Nevanlinna, Heli, Newcomb, Polly A, Newcomb, Lisa F, Nielsen, Finn Cilius, Nikitina-Zake, Liene, Nordestgaard, Børge G, Nussbaum, Robert L, Offit, Kenneth, Olah, Edith, Olama, Ali Amin Al, Olopade, Olufunmilayo I, Olshan, Andrew F, Olsson, Håkan, Osorio, Ana, Pandha, Hardev, Park, Jong Y, Pashayan, Nora, Parsons, Michael T, Pejovic, Tanja, Penney, Kathryn L, Peters, Wilbert HM, Phelan, Catherine M, Phipps, Amanda I, Plaseska-Karanfilska, Dijana, Pring, Miranda, Prokofyeva, Darya, Radice, Paolo, Stefansson, Kari, Ramus, Susan J, Raskin, Leon, Rennert, Gad, Rennert, Hedy S, Van Rensburg, Elizabeth J, Riggan, Marjorie J, Risch, Harvey A, Risch, Angela, Roobol, Monique J, Rosenstein, Barry S, Rossing, Mary Anne, De Ruyck, Kim, Saloustros, Emmanouil, Sandler, Dale P, Sawyer, Elinor J, Schabath, Matthew B, Schleutker, Johanna, Schmidt, Marjanka K, Setiawan, V Wendy, Shen, Hongbing, Siegel, Erin M, Sieh, Weiva, Singer, Christian F, Slattery, Martha L, Sorensen, Karina Dalsgaard, Southey, Melissa C, Spurdle, Amanda B, Stanford, Janet L, Stevens, Victoria L, Stintzing, Sebastian, Stone, Jennifer, Sundfeldt, Karin, Sutphen, Rebecca, Swerdlow, Anthony J, Tajara, Eloiza H, Tangen, Catherine M, Tardon, Adonina, Taylor, Jack A, Teare, M Dawn, Teixeira, Manuel R, Terry, Mary Beth, Terry, Kathryn L, Thibodeau, Stephen N, Thomassen, Mads, Bjørge, Line, Tischkowitz, Marc, Toland, Amanda E, Torres, Diana, Townsend, Paul A, Travis, Ruth C, Tung, Nadine, Tworoger, Shelley S, Ulrich, Cornelia M, Usmani, Nawaid, Vachon, Celine M, Van Nieuwenhuysen, Els, Vega, Ana, Aguado-Barrera, Miguel Elías, Wang, Qin, Webb, Penelope M, Weinberg, Clarice R, Weinstein, Stephanie, Weissler, Mark C, Weitzel, Jeffrey N, West, Catharine ML, White, Emily, Whittemore, Alice S, Wichmann, H-Erich, Wiklund, Fredrik, Winqvist, Robert, Wolk, Alicja, Woll, Penella, Woods, Michael, Wu, Anna H, Wu, Xifeng, Yannoukakos, Drakoulis, Zheng, Wei, Zienolddiny, Shanbeh, Ziogas, Argyrios, Zorn, Kristin K, Lane, Jacqueline M, Saxena, Richa, Thomas, Duncan, Hung, Rayjean J, Diergaarde, Brenda, McKay, James, Peters, Ulrike, Hsu, Li, García-Closas, Montserrat, Eeles, Rosalind A, Chenevix-Trench, Georgia, Brennan, Paul J, Haiman, Christopher A, Simard, Jacques, Easton, Douglas F, Gruber, Stephen B, Pharoah, Paul DP, Price, Alkes L, Pasaniuc, Bogdan, Amos, Christopher I, Kraft, Peter, and Lindström, Sara

Subjects
Male, Ovarian Neoplasms, Lung Neoplasms, Mental Disorders, Smoking, Inheritance Patterns, Prostatic Neoplasms, Breast Neoplasms, Polymorphism, Single Nucleotide, White People, 3. Good health, Neoplasm Proteins, Phenotype, Head and Neck Neoplasms, Case-Control Studies, Humans, Female, Genetic Predisposition to Disease, Colorectal Neoplasms, Genome-Wide Association Study
Abstract

Quantifying the genetic correlation between cancers can provide important insights into the mechanisms driving cancer etiology. Using genome-wide association study summary statistics across six cancer types based on a total of 296,215 cases and 301,319 controls of European ancestry, here we estimate the pair-wise genetic correlations between breast, colorectal, head/neck, lung, ovary and prostate cancer, and between cancers and 38 other diseases. We observed statistically significant genetic correlations between lung and head/neck cancer (rg = 0.57, p = 4.6 × 10-8), breast and ovarian cancer (rg = 0.24, p = 7 × 10-5), breast and lung cancer (rg = 0.18, p =1.5 × 10-6) and breast and colorectal cancer (rg = 0.15, p = 1.1 × 10-4). We also found that multiple cancers are genetically correlated with non-cancer traits including smoking, psychiatric diseases and metabolic characteristics. Functional enrichment analysis revealed a significant excess contribution of conserved and regulatory regions to cancer heritability. Our comprehensive analysis of cross-cancer heritability suggests that solid tumors arising across tissues share in part a common germline genetic basis.

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