1. Efficacy of anakinra in gouty arthritis: a retrospective study of 40 cases
- Author
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Lauren Brunier, Sébastien Ottaviani, Elisabeth Palazzo, Thomas Bardin, Yannick Allanore, Maxime Dougados, Philippe Dieudé, Hang-Korng Ea, Pascal Richette, Ghislaine Gill, Anna Molto, Olivier Meyer, Frédéric Lioté, and Severine Neveu
- Subjects
Male ,medicine.medical_specialty ,Time Factors ,Visual analogue scale ,Immunology ,Arthritis ,03 medical and health sciences ,gout ,0302 clinical medicine ,Rheumatology ,Recurrence ,Internal medicine ,medicine ,Humans ,Immunology and Allergy ,Adverse effect ,Aged ,Pain Measurement ,Retrospective Studies ,030304 developmental biology ,030203 arthritis & rheumatology ,0303 health sciences ,Anakinra ,biology ,IL-1 ,Arthritis, Gouty ,business.industry ,C-reactive protein ,Retrospective cohort study ,Middle Aged ,Staphylococcal Infections ,medicine.disease ,3. Good health ,Gout ,Surgery ,Interleukin 1 Receptor Antagonist Protein ,C-Reactive Protein ,Treatment Outcome ,arthritis ,Antirheumatic Agents ,biology.protein ,Female ,business ,Research Article ,anakinra ,Follow-Up Studies ,medicine.drug - Abstract
Introduction Gout is a common arthritis that occurs particularly in patients who frequently have associated comorbidities that limit the use of conventional therapies. The main mechanism of crystal-induced inflammation is interleukin-1 production by activation of the inflammasome. We aimed to evaluate the efficacy and tolerance of anakinra in gouty patients. Methods We conducted a multicenter retrospective review of patients receiving anakinra for gouty arthritis. We reviewed the response to treatment, adverse events and relapses. Results We examined data for 40 gouty patients (32 men; mean age 60.0 ± 13.9 years) receiving anakinra. Mean disease duration was 8.7 ± 8.7 years. All patients showed contraindications to and/or failure of at least two conventional therapies. Most (36; 90%) demonstrated good response to anakinra. Median pain on a 100-mm visual analog scale was rapidly decreased (73.5 (70.0 to 80.0) to 25.0 (20.0 to 32.5) mm, P
- Published
- 2013
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