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Your search keyword '"Koralnik, Igor J."' showing total 27 results
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27 results on '"Koralnik, Igor J."'

1. Characterizing Epstein-Barr virus infection of the central nervous system in Zambian adults living with HIV

Author

Musukuma-Chifulo, Kalo, primary, Ghebremichael, Musie, additional, Chilyabanyama, Obvious Nchimunya, additional, Bates, Matthew, additional, Munsaka, Sody, additional, Simuyandi, Michelo, additional, Chisenga, Caroline, additional, Tembo, John, additional, Sinkala, Edford, additional, Koralnik, Igor J., additional, Dang, Xin, additional, Chilengi, Roma, additional, and Siddiqi, Omar K., additional

Published
2023
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3. JC virus infection of meningeal and choroid plexus cells in patients with progressive multifocal leukoencephalopathy

Author

McGovern Institute for Brain Research at MIT, Corbridge, Sarah M., Rice, Richard C., Bean, Linda A., Wüthrich, Christian, Dang, Xin, Nicholson, Daniel A., Koralnik, Igor J., McGovern Institute for Brain Research at MIT, Corbridge, Sarah M., Rice, Richard C., Bean, Linda A., Wüthrich, Christian, Dang, Xin, Nicholson, Daniel A., and Koralnik, Igor J.

Abstract

JC virus (JCV) can cause a lytic infection of oligodendrocytes and astrocytes in the central nervous system (CNS) leading to progressive multifocal leukoencephalopathy (PML). JCV can also infect meningeal and choroid plexus cells causing JCV meningitis (JCVM). Whether JCV also infects meningeal and choroid plexus cells in PML patients and other immunosuppressed individuals with no overt symptoms of meningitis remains unknown. We therefore analyzed archival formalin-fixed, paraffin-embedded brain samples from PML patients, and HIV-seropositive and seronegative control subjects by immunohistochemistry for the presence of JCV early regulatory T Ag and JCV VP1 late capsid protein. In meninges, we detected JCV T Ag in 11/48 (22.9%) and JCV VP1 protein in 8/48 (16.7%) PML patients. In choroid plexi, we detected JCV T Ag in 1/7 (14.2%) and JCV VP1 protein in 1/8 (12.5%) PML patients. Neither JCV T Ag nor VP1 protein could be detected in meninges or choroid plexus of HIV-seropositive and HIV-seronegative control subjects without PML. In addition, examination of underlying cerebellar cortex of PML patients revealed JCV-infected cells in the molecular layer, including GAD 67+ interneurons, but not in HIV-seropositive and HIV-seronegative control subjects without PML. Our findings suggest that productive JCV infection of meningeal cells and choroid plexus cells also occurs in PML patients without signs or symptoms of meningitis. The phenotypic characterization of JCV-infected neurons in the molecular layer deserves further study. This data provides new insight into JCV pathogenesis in the CNS.

Published
2022

4. Persistent viral RNA shedding of SARS-CoV-2 is associated with delirium incidence and six-month mortality in hospitalized COVID-19 patients

Author

Batra, Ayush, primary, Clark, Jeffrey R., additional, Kang, Anthony K., additional, Ali, Sareen, additional, Patel, Tulsi R., additional, Shlobin, Nathan A., additional, Hoffman, Steven C., additional, Lim, Patrick H., additional, Orban, Zachary S., additional, Visvabharathy, Lavanya, additional, Graham, Edith L., additional, Sullivan, David P., additional, Muller, William A., additional, Chou, Sherry H.-Y., additional, Ungvári, Zoltán, additional, Koralnik, Igor J., additional, and Liotta, Eric M., additional

Published
2022
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5. JC virus infection of meningeal and choroid plexus cells in patients with progressive multifocal leukoencephalopathy

Author

McGovern Institute for Brain Research at MIT, Corbridge, Sarah M., Rice, Richard C., Bean, Linda A., Wüthrich, Christian, Dang, Xin, Nicholson, Daniel A., Koralnik, Igor J., McGovern Institute for Brain Research at MIT, Corbridge, Sarah M., Rice, Richard C., Bean, Linda A., Wüthrich, Christian, Dang, Xin, Nicholson, Daniel A., and Koralnik, Igor J.

Abstract

JC virus (JCV) can cause a lytic infection of oligodendrocytes and astrocytes in the central nervous system (CNS) leading to progressive multifocal leukoencephalopathy (PML). JCV can also infect meningeal and choroid plexus cells causing JCV meningitis (JCVM). Whether JCV also infects meningeal and choroid plexus cells in PML patients and other immunosuppressed individuals with no overt symptoms of meningitis remains unknown. We therefore analyzed archival formalin-fixed, paraffin-embedded brain samples from PML patients, and HIV-seropositive and seronegative control subjects by immunohistochemistry for the presence of JCV early regulatory T Ag and JCV VP1 late capsid protein. In meninges, we detected JCV T Ag in 11/48 (22.9%) and JCV VP1 protein in 8/48 (16.7%) PML patients. In choroid plexi, we detected JCV T Ag in 1/7 (14.2%) and JCV VP1 protein in 1/8 (12.5%) PML patients. Neither JCV T Ag nor VP1 protein could be detected in meninges or choroid plexus of HIV-seropositive and HIV-seronegative control subjects without PML. In addition, examination of underlying cerebellar cortex of PML patients revealed JCV-infected cells in the molecular layer, including GAD 67+ interneurons, but not in HIV-seropositive and HIV-seronegative control subjects without PML. Our findings suggest that productive JCV infection of meningeal cells and choroid plexus cells also occurs in PML patients without signs or symptoms of meningitis. The phenotypic characterization of JCV-infected neurons in the molecular layer deserves further study. This data provides new insight into JCV pathogenesis in the CNS.

Published
2021

14. JC virus granule cell neuronopathy in the setting of chronic lymphopenia treated with recombinant interleukin-7

Author

Soleimani-Meigooni, David N., primary, Schwetye, Katherine E., additional, Angeles, Maria Reyes, additional, Ryschkewitsch, Caroline F., additional, Major, Eugene O., additional, Dang, Xin, additional, Koralnik, Igor J., additional, Schmidt, Robert E., additional, Clifford, David B., additional, Kuhlmann, F. Matthew, additional, and Bucelli, Robert C., additional

Published
2016
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15. Recurrence of progressive multifocal leukoencephalopathy despite immune recovery in two HIV seropositive individuals

Author

Crossley, Kate M., primary, Agnihotri, Shruti, additional, Chaganti, Joga, additional, Rodriguez, Michael L., additional, McNally, Leon Patrick, additional, Venna, Nagagopal, additional, Turbett, Sarah E., additional, Gutman, Matthew, additional, Morey, Adrienne, additional, Koralnik, Igor J., additional, and Brew, Bruce J., additional

Published
2016
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23. Characterization of lymphocytic infiltrates in progressive multifocal leukoencephalopathy: Co-localization of CD8+T cells with JCV-infected glial cells

Author

Wüthrich, Christian, primary, Kesari, Santosh, additional, Kim, Woong-Ki, additional, Williams, Kenneth, additional, Gelman, Rebecca, additional, Elmeric, Derek, additional, De Girolami, Umberto, additional, Joseph, Jeffrey T, additional, Hedley-Whyte, Tessa, additional, and Koralnik, Igor J, additional

Published
2006
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24. Identification of T lymphocytes in simian immunodeficiency virus encephalitis: Distribution of CD8+T cells in association with central nervous system vessels and virus

Author

Kim, Woong-Ki, primary, Corey, Sarah, additional, Chesney, Gillian, additional, Knight, Heather, additional, Klumpp, Sherry, additional, Wüthrich, Christian, additional, Letvin, Norman L, additional, Koralnik, Igor J, additional, Lackner, Andrew, additional, Veasey, Ronald S, additional, and Williams, Kenneth, additional

Published
2004
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