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2 results on '"Ko Ebata"'

1. Successful treatment by on-demand glecaprevir and pibrentasvir for hepatitis C flare during R-CHOP in patients with diffuse large B-cell lymphoma: a case report

Author

Koji Hirata, Takashi Sasaki, Mariko Ozasa, Ko Ebata, Masatoshi Takano, Naoya Sakamoto, Sae Nakajima, Shihori Tsukamoto, Masaki Katagiri, Goki Suda, Shinjiro Takahash, and Machiko Umemura

Subjects
Cyclopropanes, Male, Aminoisobutyric Acids, Pyrrolidines, Sustained Virologic Response, Case Report, Hepacivirus, Infectious and parasitic diseases, RC109-216, Direct-acting antiviral, medicine.disease_cause, Gastroenterology, 0302 clinical medicine, Medical microbiology, immune system diseases, hemic and lymphatic diseases, Antineoplastic Combined Chemotherapy Protocols, Sulfonamides, Hepatitis C virus, Pibrentasvir, Hepatitis C, Middle Aged, Viral Load, Direct-acting antiviral, hepatitis C flare, Infectious Diseases, Vincristine, 030220 oncology & carcinogenesis, RNA, Viral, 030211 gastroenterology & hepatology, Lymphoma, Large B-Cell, Diffuse, Rituximab, medicine.medical_specialty, Genotype, Proline, Lactams, Macrocyclic, Antiviral Agents, hepatitis C flare, 03 medical and health sciences, Leucine, Glecaprevir, Quinoxalines, Internal medicine, medicine, Humans, Cyclophosphamide, business.industry, medicine.disease, Lymphoma, Discontinuation, Doxorubicin, Prednisone, Benzimidazoles, business, Diffuse large B-cell lymphoma
Abstract

Background In patients with hepatitis C virus (HCV) and malignant lymphoma, hepatitis C flare during R-CHOP can result in discontinuation of treatment. However, appropriate therapeutic strategies for managing hepatitis C flare during R-CHOP have not been established, and this issue is complicated by conflicting results regarding the use of direct-acting antivirals in patients with uncontrolled malignancies. Case presentation We report the first case of effective and safe treatment with on-demand 8-week glecaprevir and pibrentasvir for hepatitis C flare during R-CHOP in a patient with diffuse large B-cell lymphoma (DLBCL). The patient completed five additional courses of R-CHOP without hepatic toxicity. A complete response of DLBCL and a sustained virological response were observed at 24 weeks after glecaprevir and pibrentasvir completion. Conclusion On-demand, direct-acting antivirals could be a novel strategy for managing hepatitis C flare during R-CHOP.

Published
2021

2. Intestinal Lymphatic Endothelial Cells Produce R-Spondin3

Author

Ko Ebata, Toshihiko Iwanaga, Daigo Hashimoto, Shunsuke Kimura, Emi Yokoyama, Masahiro Onozawa, Takeshi Kondo, Takahiro Tateno, Eiko Hayase, Kosuke Yoshioka, Junichi Sugita, Takahide Ara, Takanori Teshima, Hiroyuki Ohigashi, Shuichiro Takahashi, and Reiki Ogasawara

Subjects
0301 basic medicine, Science, government.form_of_government, Graft vs Host Disease, Biology, Article, Receptors, G-Protein-Coupled, Mice, 03 medical and health sciences, Intestinal mucosa, medicine, Animals, Humans, Transplantation, Homologous, Intestinal Mucosa, Autocrine signalling, Lamina propria, Multidisciplinary, Gene Expression Profiling, fungi, Hematopoietic Stem Cell Transplantation, LGR5, Wnt signaling pathway, Endothelial Cells, Cell biology, Transplantation, Autocrine Communication, Disease Models, Animal, Lymphatic Endothelium, 030104 developmental biology, medicine.anatomical_structure, government, Medicine, Female, Endothelium, Lymphatic, Stem cell, Thrombospondins
Abstract

The R-Spondin (R-Spo) family regulates WNT signaling and stimulates the proliferation and differentiation of intestinal stem cells (ISCs). R-Spo plays a critical role in maintaining intestinal homeostasis, but endogenous producers of R-Spo in the intestine remain to be investigated. We found that R-Spo3 was the major R-Spo family member produced in the intestine and it was predominantly produced by CD45−CD90+CD31+ lymphatic endothelial cells (LECs) in the lamina propria of the intestinal mucosa. Transcriptome analysis demonstrated that LECs highly expressed R-Spo receptor, Lgr5, suggesting an autocrine stimulatory loop in LECs. LECs were significantly reduced in number, and their R-Spo3 production was impaired in intestinal graft-versus-host disease (GVHD) after allogeneic hematopoietic stem cell transplantation. The impaired production of R-Spo3 in the intestine may be a novel mechanism of delayed tissue repair and defective mucosal defense in intestinal GVHD. We demonstrate a novel role of intestinal LECs in producing R-Spondin3 to maintain intestinal homeostasis.

Published
2018

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