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Your search keyword '"Kim, Eunha"' showing total 22 results
Start Over Author "Kim, Eunha" Publisher springer science and business media llc
22 results on '"Kim, Eunha"'

4. Maternal immune activation in mice disrupts proteostasis in the fetal brain

Author

Kalish, Brian T., Kim, Eunha, Finander, Benjamin, Duffy, Erin E., Kim, Hyunju, Gilman, Casey K., Yim, Yeong Shin, Tong, Lilin, Kaufman, Randal J., Griffith, Eric C., Choi, Gloria B., Greenberg, Michael E., Huh, Jun R., Kalish, Brian T., Kim, Eunha, Finander, Benjamin, Duffy, Erin E., Kim, Hyunju, Gilman, Casey K., Yim, Yeong Shin, Tong, Lilin, Kaufman, Randal J., Griffith, Eric C., Choi, Gloria B., Greenberg, Michael E., and Huh, Jun R.

Abstract

© 2020, The Author(s), under exclusive licence to Springer Nature America, Inc. Maternal infection and inflammation during pregnancy are associated with neurodevelopmental disorders in offspring, but little is understood about the molecular mechanisms underlying this epidemiologic phenomenon. Here, we leveraged single-cell RNA sequencing to profile transcriptional changes in the mouse fetal brain in response to maternal immune activation (MIA) and identified perturbations in cellular pathways associated with mRNA translation, ribosome biogenesis and stress signaling. We found that MIA activates the integrated stress response (ISR) in male, but not female, MIA offspring in an interleukin-17a-dependent manner, which reduced global mRNA translation and altered nascent proteome synthesis. Moreover, blockade of ISR activation prevented the behavioral abnormalities as well as increased cortical neural activity in MIA male offspring. Our data suggest that sex-specific activation of the ISR leads to maternal inflammation-associated neurodevelopmental disorders.

Published
2022

5. Human gut bacteria produce ΤΗ17-modulating bile acid metabolites

Author

Paik, Donggi, primary, Yao, Lina, additional, Zhang, Yancong, additional, Bae, Sena, additional, D’Agostino, Gabriel D., additional, Zhang, Minghao, additional, Kim, Eunha, additional, Franzosa, Eric A., additional, Avila-Pacheco, Julian, additional, Bisanz, Jordan E., additional, Rakowski, Christopher K., additional, Vlamakis, Hera, additional, Xavier, Ramnik J., additional, Turnbaugh, Peter J., additional, Longman, Randy S., additional, Krout, Michael R., additional, Clish, Clary B., additional, Rastinejad, Fraydoon, additional, Huttenhower, Curtis, additional, Huh, Jun R., additional, and Devlin, A. Sloan, additional

Published
2022
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6. Maternal immune activation in mice disrupts proteostasis in the fetal brain

Author

Kalish, Brian T, Kim, Eunha, Finander, Benjamin, Duffy, Erin E, Kim, Hyunju, Gilman, Casey K, Yim, Yeong Shin, Tong, Lilin, Kaufman, Randal J, Griffith, Eric C, Choi, Gloria B, Greenberg, Michael E, Huh, Jun R, Kalish, Brian T, Kim, Eunha, Finander, Benjamin, Duffy, Erin E, Kim, Hyunju, Gilman, Casey K, Yim, Yeong Shin, Tong, Lilin, Kaufman, Randal J, Griffith, Eric C, Choi, Gloria B, Greenberg, Michael E, and Huh, Jun R

Abstract

© 2020, The Author(s), under exclusive licence to Springer Nature America, Inc. Maternal infection and inflammation during pregnancy are associated with neurodevelopmental disorders in offspring, but little is understood about the molecular mechanisms underlying this epidemiologic phenomenon. Here, we leveraged single-cell RNA sequencing to profile transcriptional changes in the mouse fetal brain in response to maternal immune activation (MIA) and identified perturbations in cellular pathways associated with mRNA translation, ribosome biogenesis and stress signaling. We found that MIA activates the integrated stress response (ISR) in male, but not female, MIA offspring in an interleukin-17a-dependent manner, which reduced global mRNA translation and altered nascent proteome synthesis. Moreover, blockade of ISR activation prevented the behavioral abnormalities as well as increased cortical neural activity in MIA male offspring. Our data suggest that sex-specific activation of the ISR leads to maternal inflammation-associated neurodevelopmental disorders.

Published
2021

7. Maternal immune activation in mice disrupts proteostasis in the fetal brain

Author

Kalish, Brian T., primary, Kim, Eunha, additional, Finander, Benjamin, additional, Duffy, Erin E., additional, Kim, Hyunju, additional, Gilman, Casey K., additional, Yim, Yeong Shin, additional, Tong, Lilin, additional, Kaufman, Randal J., additional, Griffith, Eric C., additional, Choi, Gloria B., additional, Greenberg, Michael E., additional, and Huh, Jun R., additional

Published
2020
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9. Author Correction: Bile acid metabolites control TH17 and Treg cell differentiation

Author

Hang, Saiyu, primary, Paik, Donggi, additional, Yao, Lina, additional, Kim, Eunha, additional, Trinath, Jamma, additional, Lu, Jingping, additional, Ha, Soyoung, additional, Nelson, Brandon N., additional, Kelly, Samantha P., additional, Wu, Lin, additional, Zheng, Ye, additional, Longman, Randy S., additional, Rastinejad, Fraydoon, additional, Devlin, A. Sloan, additional, Krout, Michael R., additional, Fischbach, Michael A., additional, Littman, Dan R., additional, and Huh, Jun R., additional

Published
2020
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10. Genomic profiling of 553 uncharacterized neurodevelopment patients reveals a high proportion of recessive pathogenic variant carriers in an outbred population

Author

Lee, Youngha, primary, Park, Soojin, additional, Lee, Jin Sook, additional, Kim, Soo Yeon, additional, Cho, Jaeso, additional, Yoo, Yongjin, additional, Lee, Sangmoon, additional, Yoo, Taekyeong, additional, Lee, Moses, additional, Seo, Jieun, additional, Lee, Jeongeun, additional, Kneissl, Jana, additional, Lee, Jean, additional, Jeon, Hyoungseok, additional, Jeon, Eun Young, additional, Hong, Sung Eun, additional, Kim, Eunha, additional, Kim, Hyuna, additional, Kim, Woo Joong, additional, Kim, Jon Soo, additional, Ko, Jung Min, additional, Cho, Anna, additional, Lim, Byung Chan, additional, Kim, Won Seop, additional, Choi, Murim, additional, and Chae, Jong-Hee, additional

Published
2020
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11. Bile acid metabolites control TH17 and Treg cell differentiation

Author

Hang, Saiyu, primary, Paik, Donggi, additional, Yao, Lina, additional, Kim, Eunha, additional, Trinath, Jamma, additional, Lu, Jingping, additional, Ha, Soyoung, additional, Nelson, Brandon N., additional, Kelly, Samantha P., additional, Wu, Lin, additional, Zheng, Ye, additional, Longman, Randy S., additional, Rastinejad, Fraydoon, additional, Devlin, A. Sloan, additional, Krout, Michael R., additional, Fischbach, Michael A., additional, Littman, Dan R., additional, and Huh, Jun R., additional

Published
2019
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22. G-TRACE: rapid Gal4-based cell lineage analysis in Drosophila

Author

Evans, Cory J, primary, Olson, John M, additional, Ngo, Kathy T, additional, Kim, Eunha, additional, Lee, Noemi E, additional, Kuoy, Edward, additional, Patananan, Alexander N, additional, Sitz, Daniel, additional, Tran, PhuongThao, additional, Do, Minh-Tu, additional, Yackle, Kevin, additional, Cespedes, Albert, additional, Hartenstein, Volker, additional, Call, Gerald B, additional, and Banerjee, Utpal, additional

Published
2009
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