26 results on '"Justice, Anne"'
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2. Implicating genes, pleiotropy, and sexual dimorphism at blood lipid loci through multi-ancestry meta-analysis
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Kanoni, Stavroula, primary, Graham, Sarah E., additional, Wang, Yuxuan, additional, Surakka, Ida, additional, Ramdas, Shweta, additional, Zhu, Xiang, additional, Clarke, Shoa L., additional, Bhatti, Konain Fatima, additional, Vedantam, Sailaja, additional, Winkler, Thomas W., additional, Locke, Adam E., additional, Marouli, Eirini, additional, Zajac, Greg J. M., additional, Wu, Kuan-Han H., additional, Ntalla, Ioanna, additional, Hui, Qin, additional, Klarin, Derek, additional, Hilliard, Austin T., additional, Wang, Zeyuan, additional, Xue, Chao, additional, Thorleifsson, Gudmar, additional, Helgadottir, Anna, additional, Gudbjartsson, Daniel F., additional, Holm, Hilma, additional, Olafsson, Isleifur, additional, Hwang, Mi Yeong, additional, Han, Sohee, additional, Akiyama, Masato, additional, Sakaue, Saori, additional, Terao, Chikashi, additional, Kanai, Masahiro, additional, Zhou, Wei, additional, Brumpton, Ben M., additional, Rasheed, Humaira, additional, Havulinna, Aki S., additional, Veturi, Yogasudha, additional, Pacheco, Jennifer Allen, additional, Rosenthal, Elisabeth A., additional, Lingren, Todd, additional, Feng, QiPing, additional, Kullo, Iftikhar J., additional, Narita, Akira, additional, Takayama, Jun, additional, Martin, Hilary C., additional, Hunt, Karen A., additional, Trivedi, Bhavi, additional, Haessler, Jeffrey, additional, Giulianini, Franco, additional, Bradford, Yuki, additional, Miller, Jason E., additional, Campbell, Archie, additional, Lin, Kuang, additional, Millwood, Iona Y., additional, Rasheed, Asif, additional, Hindy, George, additional, Faul, Jessica D., additional, Zhao, Wei, additional, Weir, David R., additional, Turman, Constance, additional, Huang, Hongyan, additional, Graff, Mariaelisa, additional, Choudhury, Ananyo, additional, Sengupta, Dhriti, additional, Mahajan, Anubha, additional, Brown, Michael R., additional, Zhang, Weihua, additional, Yu, Ketian, additional, Schmidt, Ellen M., additional, Pandit, Anita, additional, Gustafsson, Stefan, additional, Yin, Xianyong, additional, Luan, Jian’an, additional, Zhao, Jing-Hua, additional, Matsuda, Fumihiko, additional, Jang, Hye-Mi, additional, Yoon, Kyungheon, additional, Medina-Gomez, Carolina, additional, Pitsillides, Achilleas, additional, Hottenga, Jouke Jan, additional, Wood, Andrew R., additional, Ji, Yingji, additional, Gao, Zishan, additional, Haworth, Simon, additional, Yousri, Noha A., additional, Mitchell, Ruth E., additional, Chai, Jin Fang, additional, Aadahl, Mette, additional, Bjerregaard, Anne A., additional, Yao, Jie, additional, Manichaikul, Ani, additional, Hwu, Chii-Min, additional, Hung, Yi-Jen, additional, Warren, Helen R., additional, Ramirez, Julia, additional, Bork-Jensen, Jette, additional, Kårhus, Line L., additional, Goel, Anuj, additional, Sabater-Lleal, Maria, additional, Noordam, Raymond, additional, Mauro, Pala, additional, Matteo, Floris, additional, McDaid, Aaron F., additional, Marques-Vidal, Pedro, additional, Wielscher, Matthias, additional, Trompet, Stella, additional, Sattar, Naveed, additional, Møllehave, Line T., additional, Munz, Matthias, additional, Zeng, Lingyao, additional, Huang, Jianfeng, additional, Yang, Bin, additional, Poveda, Alaitz, additional, Kurbasic, Azra, additional, Lamina, Claudia, additional, Forer, Lukas, additional, Scholz, Markus, additional, Galesloot, Tessel E., additional, Bradfield, Jonathan P., additional, Ruotsalainen, Sanni E., additional, Daw, EWarwick, additional, Zmuda, Joseph M., additional, Mitchell, Jonathan S., additional, Fuchsberger, Christian, additional, Christensen, Henry, additional, Brody, Jennifer A., additional, Vazquez-Moreno, Miguel, additional, Feitosa, Mary F., additional, Wojczynski, Mary K., additional, Wang, Zhe, additional, Preuss, Michael H., additional, Mangino, Massimo, additional, Christofidou, Paraskevi, additional, Verweij, Niek, additional, Benjamins, Jan W., additional, Engmann, Jorgen, additional, Tsao, Noah L., additional, Verma, Anurag, additional, Slieker, Roderick C., additional, Lo, Ken Sin, additional, Zilhao, Nuno R., additional, Le, Phuong, additional, Kleber, Marcus E., additional, Delgado, Graciela E., additional, Huo, Shaofeng, additional, Ikeda, Daisuke D., additional, Iha, Hiroyuki, additional, Yang, Jian, additional, Liu, Jun, additional, Demirkan, Ayşe, additional, Leonard, Hampton L., additional, Marten, Jonathan, additional, Frank, Mirjam, additional, Schmidt, Börge, additional, Smyth, Laura J., additional, Cañadas-Garre, Marisa, additional, Wang, Chaolong, additional, Nakatochi, Masahiro, additional, Wong, Andrew, additional, Hutri-Kähönen, Nina, additional, Sim, Xueling, additional, Xia, Rui, additional, Huerta-Chagoya, Alicia, additional, Fernandez-Lopez, Juan Carlos, additional, Lyssenko, Valeriya, additional, Nongmaithem, Suraj S., additional, Bayyana, Swati, additional, Stringham, Heather M., additional, Irvin, Marguerite R., additional, Oldmeadow, Christopher, additional, Kim, Han-Na, additional, Ryu, Seungho, additional, Timmers, Paul R. H. J., additional, Arbeeva, Liubov, additional, Dorajoo, Rajkumar, additional, Lange, Leslie A., additional, Prasad, Gauri, additional, Lorés-Motta, Laura, additional, Pauper, Marc, additional, Long, Jirong, additional, Li, Xiaohui, additional, Theusch, Elizabeth, additional, Takeuchi, Fumihiko, additional, Spracklen, Cassandra N., additional, Loukola, Anu, additional, Bollepalli, Sailalitha, additional, Warner, Sophie C., additional, Wang, Ya Xing, additional, Wei, Wen B., additional, Nutile, Teresa, additional, Ruggiero, Daniela, additional, Sung, Yun Ju, additional, Chen, Shufeng, additional, Liu, Fangchao, additional, Yang, Jingyun, additional, Kentistou, Katherine A., additional, Banas, Bernhard, additional, Nardone, Giuseppe Giovanni, additional, Meidtner, Karina, additional, Bielak, Lawrence F., additional, Smith, Jennifer A., additional, Hebbar, Prashantha, additional, Farmaki, Aliki-Eleni, additional, Hofer, Edith, additional, Lin, Maoxuan, additional, Concas, Maria Pina, additional, Vaccargiu, Simona, additional, van der Most, Peter J., additional, Pitkänen, Niina, additional, Cade, Brian E., additional, van der Laan, Sander W., additional, Chitrala, Kumaraswamy Naidu, additional, Weiss, Stefan, additional, Bentley, Amy R., additional, Doumatey, Ayo P., additional, Adeyemo, Adebowale A., additional, Lee, Jong Young, additional, Petersen, Eva R. B., additional, Nielsen, Aneta A., additional, Choi, Hyeok Sun, additional, Nethander, Maria, additional, Freitag-Wolf, Sandra, additional, Southam, Lorraine, additional, Rayner, Nigel W., additional, Wang, Carol A., additional, Lin, Shih-Yi, additional, Wang, Jun-Sing, additional, Couture, Christian, additional, Lyytikäinen, Leo-Pekka, additional, Nikus, Kjell, additional, Cuellar-Partida, Gabriel, additional, Vestergaard, Henrik, additional, Hidalgo, Bertha, additional, Giannakopoulou, Olga, additional, Cai, Qiuyin, additional, Obura, Morgan O., additional, van Setten, Jessica, additional, Li, Xiaoyin, additional, Liang, Jingjing, additional, Tang, Hua, additional, Terzikhan, Natalie, additional, Shin, Jae Hun, additional, Jackson, Rebecca D., additional, Reiner, Alexander P., additional, Martin, Lisa Warsinger, additional, Chen, Zhengming, additional, Li, Liming, additional, Kawaguchi, Takahisa, additional, Thiery, Joachim, additional, Bis, Joshua C., additional, Launer, Lenore J., additional, Li, Huaixing, additional, Nalls, Mike A., additional, Raitakari, Olli T., additional, Ichihara, Sahoko, additional, Wild, Sarah H., additional, Nelson, Christopher P., additional, Campbell, Harry, additional, Jäger, Susanne, additional, Nabika, Toru, additional, Al-Mulla, Fahd, additional, Niinikoski, Harri, additional, Braund, Peter S., additional, Kolcic, Ivana, additional, Kovacs, Peter, additional, Giardoglou, Tota, additional, Katsuya, Tomohiro, additional, de Kleijn, Dominique, additional, de Borst, Gert J., additional, Kim, Eung Kweon, additional, Adams, Hieab H. H., additional, Ikram, M. Arfan, additional, Zhu, Xiaofeng, additional, Asselbergs, Folkert W., additional, Kraaijeveld, Adriaan O., additional, Beulens, Joline W. J., additional, Shu, Xiao-Ou, additional, Rallidis, Loukianos S., additional, Pedersen, Oluf, additional, Hansen, Torben, additional, Mitchell, Paul, additional, Hewitt, Alex W., additional, Kähönen, Mika, additional, Pérusse, Louis, additional, Bouchard, Claude, additional, Tönjes, Anke, additional, Chen, Yii-Der Ida, additional, Pennell, Craig E., additional, Mori, Trevor A., additional, Lieb, Wolfgang, additional, Franke, Andre, additional, Ohlsson, Claes, additional, Mellström, Dan, additional, Cho, Yoon Shin, additional, Lee, Hyejin, additional, Yuan, Jian-Min, additional, Koh, Woon-Puay, additional, Rhee, Sang Youl, additional, Woo, Jeong-Taek, additional, Heid, Iris M., additional, Stark, Klaus J., additional, Zimmermann, Martina E., additional, Völzke, Henry, additional, Homuth, Georg, additional, Evans, Michele K., additional, Zonderman, Alan B., additional, Polasek, Ozren, additional, Pasterkamp, Gerard, additional, Hoefer, Imo E., additional, Redline, Susan, additional, Pahkala, Katja, additional, Oldehinkel, Albertine J., additional, Snieder, Harold, additional, Biino, Ginevra, additional, Schmidt, Reinhold, additional, Schmidt, Helena, additional, Bandinelli, Stefania, additional, Dedoussis, George, additional, Thanaraj, Thangavel Alphonse, additional, Kardia, Sharon L. R., additional, Peyser, Patricia A., additional, Kato, Norihiro, additional, Schulze, Matthias B., additional, Girotto, Giorgia, additional, Böger, Carsten A., additional, Jung, Bettina, additional, Joshi, Peter K., additional, Bennett, David A., additional, De Jager, Philip L., additional, Lu, Xiangfeng, additional, Mamakou, Vasiliki, additional, Brown, Morris, additional, Caulfield, Mark J., additional, Munroe, Patricia B., additional, Guo, Xiuqing, additional, Ciullo, Marina, additional, Jonas, Jost B., additional, Samani, Nilesh J., additional, Kaprio, Jaakko, additional, Pajukanta, Päivi, additional, Tusié-Luna, Teresa, additional, Aguilar-Salinas, Carlos A., additional, Adair, Linda S., additional, Bechayda, Sonny Augustin, additional, de Silva, H. Janaka, additional, Wickremasinghe, Ananda R., additional, Krauss, Ronald M., additional, Wu, Jer-Yuarn, additional, Zheng, Wei, additional, Hollander, Anneke Iden, additional, Bharadwaj, Dwaipayan, additional, Correa, Adolfo, additional, Wilson, James G., additional, Lind, Lars, additional, Heng, Chew-Kiat, additional, Nelson, Amanda E., additional, Golightly, Yvonne M., additional, Wilson, James F., additional, Penninx, Brenda, additional, Kim, Hyung-Lae, additional, Attia, John, additional, Scott, Rodney J., additional, Rao, D. C., additional, Arnett, Donna K., additional, Hunt, Steven C., additional, Walker, Mark, additional, Koistinen, Heikki A., additional, Chandak, Giriraj R., additional, Mercader, Josep M., additional, Costanzo, Maria C., additional, Jang, Dongkeun, additional, Burtt, Noël P., additional, Villalpando, Clicerio Gonzalez, additional, Orozco, Lorena, additional, Fornage, Myriam, additional, Tai, EShyong, additional, van Dam, Rob M., additional, Lehtimäki, Terho, additional, Chaturvedi, Nish, additional, Yokota, Mitsuhiro, additional, Liu, Jianjun, additional, Reilly, Dermot F., additional, McKnight, Amy Jayne, additional, Kee, Frank, additional, Jöckel, Karl-Heinz, additional, McCarthy, Mark I., additional, Palmer, Colin N. A., additional, Vitart, Veronique, additional, Hayward, Caroline, additional, Simonsick, Eleanor, additional, van Duijn, Cornelia M., additional, Jin, Zi-Bing, additional, Qu, Jia, additional, Hishigaki, Haretsugu, additional, Lin, Xu, additional, März, Winfried, additional, Gudnason, Vilmundur, additional, Tardif, Jean-Claude, additional, Lettre, Guillaume, additional, Hart, Leen M.‘t, additional, Elders, Petra J. M., additional, Damrauer, Scott M., additional, Kumari, Meena, additional, Kivimaki, Mika, additional, van der Harst, Pim, additional, Spector, Tim D., additional, Loos, Ruth J. F., additional, Province, Michael A., additional, Parra, Esteban J., additional, Cruz, Miguel, additional, Psaty, Bruce M., additional, Brandslund, Ivan, additional, Pramstaller, Peter P., additional, Rotimi, Charles N., additional, Christensen, Kaare, additional, Ripatti, Samuli, additional, Widén, Elisabeth, additional, Hakonarson, Hakon, additional, Grant, Struan F. A., additional, Kiemeney, Lambertus A. L. M., additional, de Graaf, Jacqueline, additional, Loeffler, Markus, additional, Kronenberg, Florian, additional, Gu, Dongfeng, additional, Erdmann, Jeanette, additional, Schunkert, Heribert, additional, Franks, Paul W., additional, Linneberg, Allan, additional, Jukema, J. Wouter, additional, Khera, Amit V., additional, Männikkö, Minna, additional, Jarvelin, Marjo-Riitta, additional, Kutalik, Zoltan, additional, Francesco, Cucca, additional, Mook-Kanamori, Dennis O., additional, van Dijk, Ko Willems, additional, Watkins, Hugh, additional, Strachan, David P., additional, Grarup, Niels, additional, Sever, Peter, additional, Poulter, Neil, additional, Chuang, Lee-Ming, additional, Rotter, Jerome I., additional, Dantoft, Thomas M., additional, Karpe, Fredrik, additional, Neville, Matt J., additional, Timpson, Nicholas J., additional, Cheng, Ching-Yu, additional, Wong, Tien-Yin, additional, Khor, Chiea Chuen, additional, Li, Hengtong, additional, Sabanayagam, Charumathi, additional, Peters, Annette, additional, Gieger, Christian, additional, Hattersley, Andrew T., additional, Pedersen, Nancy L., additional, Magnusson, Patrik K. E., additional, Boomsma, Dorret I., additional, Willemsen, Allegonda H. M., additional, Cupples, LAdrienne, additional, van Meurs, Joyce B. J., additional, Ghanbari, Mohsen, additional, Gordon-Larsen, Penny, additional, Huang, Wei, additional, Kim, Young Jin, additional, Tabara, Yasuharu, additional, Wareham, Nicholas J., additional, Langenberg, Claudia, additional, Zeggini, Eleftheria, additional, Kuusisto, Johanna, additional, Laakso, Markku, additional, Ingelsson, Erik, additional, Abecasis, Goncalo, additional, Chambers, John C., additional, Kooner, Jaspal S., additional, de Vries, Paul S., additional, Morrison, Alanna C., additional, Hazelhurst, Scott, additional, Ramsay, Michèle, additional, North, Kari E., additional, Daviglus, Martha, additional, Kraft, Peter, additional, Martin, Nicholas G., additional, Whitfield, John B., additional, Abbas, Shahid, additional, Saleheen, Danish, additional, Walters, Robin G., additional, Holmes, Michael V., additional, Black, Corri, additional, Smith, Blair H., additional, Baras, Aris, additional, Justice, Anne E., additional, Buring, Julie E., additional, Ridker, Paul M., additional, Chasman, Daniel I., additional, Kooperberg, Charles, additional, Tamiya, Gen, additional, Yamamoto, Masayuki, additional, van Heel, David A., additional, Trembath, Richard C., additional, Wei, Wei-Qi, additional, Jarvik, Gail P., additional, Namjou, Bahram, additional, Hayes, M. Geoffrey, additional, Ritchie, Marylyn D., additional, Jousilahti, Pekka, additional, Salomaa, Veikko, additional, Hveem, Kristian, additional, Åsvold, Bjørn Olav, additional, Kubo, Michiaki, additional, Kamatani, Yoichiro, additional, Okada, Yukinori, additional, Murakami, Yoshinori, additional, Kim, Bong-Jo, additional, Thorsteinsdottir, Unnur, additional, Stefansson, Kari, additional, Zhang, Jifeng, additional, Chen, YEugene, additional, Ho, Yuk-Lam, additional, Lynch, Julie A., additional, Rader, Daniel J., additional, Tsao, Philip S., additional, Chang, Kyong-Mi, additional, Cho, Kelly, additional, O’Donnell, Christopher J., additional, Gaziano, John M., additional, Wilson, Peter W. F., additional, Frayling, Timothy M., additional, Hirschhorn, Joel N., additional, Kathiresan, Sekar, additional, Mohlke, Karen L., additional, Sun, Yan V., additional, Morris, Andrew P., additional, Boehnke, Michael, additional, Brown, Christopher D., additional, Natarajan, Pradeep, additional, Deloukas, Panos, additional, Willer, Cristen J., additional, Assimes, Themistocles L., additional, and Peloso, Gina M., additional
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- 2022
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3. Rare genetic variants explain missing heritability in smoking
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Jang, Seon-Kyeong, primary, Evans, Luke, additional, Fialkowski, Allison, additional, Arnett, Donna K., additional, Ashley-Koch, Allison E., additional, Barnes, Kathleen C., additional, Becker, Diane M., additional, Bis, Joshua C., additional, Blangero, John, additional, Bleecker, Eugene R., additional, Boorgula, Meher Preethi, additional, Bowden, Donald W., additional, Brody, Jennifer A., additional, Cade, Brian E., additional, Jenkins, Brenda W. Campbell, additional, Carson, April P., additional, Chavan, Sameer, additional, Cupples, L. Adrienne, additional, Custer, Brian, additional, Damrauer, Scott M., additional, David, Sean P., additional, de Andrade, Mariza, additional, Dinardo, Carla L., additional, Fingerlin, Tasha E., additional, Fornage, Myriam, additional, Freedman, Barry I., additional, Garrett, Melanie E., additional, Gharib, Sina A., additional, Glahn, David C., additional, Haessler, Jeffrey, additional, Heckbert, Susan R., additional, Hokanson, John E., additional, Hou, Lifang, additional, Hwang, Shih-Jen, additional, Hyman, Matthew C., additional, Judy, Renae, additional, Justice, Anne E., additional, Kaplan, Robert C., additional, Kardia, Sharon L. R., additional, Kelly, Shannon, additional, Kim, Wonji, additional, Kooperberg, Charles, additional, Levy, Daniel, additional, Lloyd-Jones, Donald M., additional, Loos, Ruth J. F., additional, Manichaikul, Ani W., additional, Gladwin, Mark T., additional, Martin, Lisa Warsinger, additional, Nouraie, Mehdi, additional, Melander, Olle, additional, Meyers, Deborah A., additional, Montgomery, Courtney G., additional, North, Kari E., additional, Oelsner, Elizabeth C., additional, Palmer, Nicholette D., additional, Payton, Marinelle, additional, Peljto, Anna L., additional, Peyser, Patricia A., additional, Preuss, Michael, additional, Psaty, Bruce M., additional, Qiao, Dandi, additional, Rader, Daniel J., additional, Rafaels, Nicholas, additional, Redline, Susan, additional, Reed, Robert M., additional, Reiner, Alexander P., additional, Rich, Stephen S., additional, Rotter, Jerome I., additional, Schwartz, David A., additional, Shadyab, Aladdin H., additional, Silverman, Edwin K., additional, Smith, Nicholas L., additional, Smith, J. Gustav, additional, Smith, Albert V., additional, Smith, Jennifer A., additional, Tang, Weihong, additional, Taylor, Kent D., additional, Telen, Marilyn J., additional, Vasan, Ramachandran S., additional, Gordeuk, Victor R., additional, Wang, Zhe, additional, Wiggins, Kerri L., additional, Yanek, Lisa R., additional, Yang, Ivana V., additional, Young, Kendra A., additional, Young, Kristin L., additional, Zhang, Yingze, additional, Liu, Dajiang J., additional, Keller, Matthew C., additional, and Vrieze, Scott, additional
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- 2022
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4. Within-sibship genome-wide association analyses decrease bias in estimates of direct genetic effects
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Howe, Laurence J, Nivard, Michel G, Morris, Tim T, Hansen, Ailin F, Rasheed, Humaira, Cho, Yoonsu, Chittoor, Geetha, Ahlskog, Rafael, Lind, Penelope A, Palviainen, Teemu, Van Der Zee, Matthijs D, Cheesman, Rosa, Mangino, Massimo, Wang, Yunzhang, Li, Shuai, Klaric, Lucija, Ratliff, Scott M, Bielak, Lawrence F, Nygaard, Marianne, Giannelis, Alexandros, Willoughby, Emily A, Reynolds, Chandra A, Balbona, Jared V, Andreassen, Ole A, Ask, Helga, Baras, Aris, Bauer, Christopher R, Boomsma, Dorret I, Campbell, Archie, Campbell, Harry, Chen, Zhengming, Christofidou, Paraskevi, Corfield, Elizabeth, Dahm, Christina C, Dokuru, Deepika R, Evans, Luke M, De Geus, Eco JC, Giddaluru, Sudheer, Gordon, Scott D, Harden, K Paige, Hill, W David, Hughes, Amanda, Kerr, Shona M, Kim, Yongkang, Kweon, Hyeokmoon, Latvala, Antti, Lawlor, Deborah A, Li, Liming, Lin, Kuang, Magnus, Per, Magnusson, Patrik KE, Mallard, Travis T, Martikainen, Pekka, Mills, Melinda C, Njølstad, Pål Rasmus, Overton, John D, Pedersen, Nancy L, Porteous, David J, Reid, Jeffrey, Silventoinen, Karri, Southey, Melissa C, Stoltenberg, Camilla, Tucker-Drob, Elliot M, Wright, Margaret J, Social Science Genetic Association Consortium, Within Family Consortium, Hewitt, John K, Keller, Matthew C, Stallings, Michael C, Lee, James J, Christensen, Kaare, Kardia, Sharon LR, Peyser, Patricia A, Smith, Jennifer A, Wilson, James F, Hopper, John L, Hägg, Sara, Spector, Tim D, Pingault, Jean-Baptiste, Plomin, Robert, Havdahl, Alexandra, Bartels, Meike, Martin, Nicholas G, Oskarsson, Sven, Justice, Anne E, Millwood, Iona Y, Hveem, Kristian, Naess, Øyvind, Willer, Cristen J, Åsvold, Bjørn Olav, Koellinger, Philipp D, Kaprio, Jaakko, Medland, Sarah E, Walters, Robin G, Benjamin, Daniel J, Turley, Patrick, Evans, David M, Davey Smith, George, Hayward, Caroline, Brumpton, Ben, Hemani, Gibran, Davies, Neil M, Howe, Laurence J [0000-0002-2819-9686], Nivard, Michel G [0000-0003-2015-1888], Morris, Tim T [0000-0001-8178-6815], Rasheed, Humaira [0000-0002-3331-5864], Cho, Yoonsu [0000-0001-6118-6652], Lind, Penelope A [0000-0002-3887-2598], Palviainen, Teemu [0000-0002-7847-8384], van der Zee, Matthijs D [0000-0003-4076-9167], Mangino, Massimo [0000-0002-2167-7470], Wang, Yunzhang [0000-0003-1165-3595], Klaric, Lucija [0000-0003-3105-8929], Bielak, Lawrence F [0000-0002-3443-8030], Nygaard, Marianne [0000-0003-0703-2665], Giannelis, Alexandros [0000-0003-4587-0336], Willoughby, Emily A [0000-0001-7559-1544], Reynolds, Chandra A [0000-0001-6502-7173], Balbona, Jared V [0000-0003-4466-248X], Andreassen, Ole A [0000-0002-4461-3568], Ask, Helga [0000-0003-0149-5319], Baras, Aris [0000-0002-6830-3396], Boomsma, Dorret I [0000-0002-7099-7972], Campbell, Archie [0000-0003-0198-5078], Chen, Zhengming [0000-0001-6423-105X], Corfield, Elizabeth [0000-0002-0119-157X], Evans, Luke M [0000-0002-7458-1720], Gordon, Scott D [0000-0001-7623-328X], Harden, K Paige [0000-0002-1557-6737], Hughes, Amanda [0000-0001-5896-7650], Kerr, Shona M [0000-0002-4137-1495], Kweon, Hyeokmoon [0000-0002-3649-0457], Lawlor, Deborah A [0000-0002-6793-2262], Magnusson, Patrik KE [0000-0002-7315-7899], Mallard, Travis T [0000-0002-3265-3001], Martikainen, Pekka [0000-0001-9374-1438], Njølstad, Pål Rasmus [0000-0003-0304-6728], Porteous, David J [0000-0003-1249-6106], Reid, Jeffrey [0000-0001-8645-4713], Southey, Melissa C [0000-0002-6313-9005], Stoltenberg, Camilla [0000-0002-8747-1985], Tucker-Drob, Elliot M [0000-0001-5599-6237], Wright, Margaret J [0000-0001-7133-4970], Keller, Matthew C [0000-0002-6075-9882], Lee, James J [0000-0001-6547-5128], Christensen, Kaare [0000-0002-5429-5292], Peyser, Patricia A [0000-0002-9717-8459], Smith, Jennifer A [0000-0002-3575-5468], Wilson, James F [0000-0001-5751-9178], Hägg, Sara [0000-0002-2452-1500], Spector, Tim D [0000-0002-9795-0365], Plomin, Robert [0000-0002-0756-3629], Havdahl, Alexandra [0000-0002-9268-0423], Bartels, Meike [0000-0002-9667-7555], Oskarsson, Sven [0000-0001-8698-2866], Willer, Cristen J [0000-0001-5645-4966], Åsvold, Bjørn Olav [0000-0003-3837-2101], Koellinger, Philipp D [0000-0001-7413-0412], Kaprio, Jaakko [0000-0002-3716-2455], Walters, Robin G [0000-0002-9179-0321], Benjamin, Daniel J [0000-0002-2642-5416], Evans, David M [0000-0003-0663-4621], Davey Smith, George [0000-0002-1407-8314], Hayward, Caroline [0000-0002-9405-9550], Brumpton, Ben [0000-0002-3058-1059], Hemani, Gibran [0000-0003-0920-1055], Davies, Neil M [0000-0002-2460-0508], and Apollo - University of Cambridge Repository
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Multifactorial Inheritance ,Phenotype ,631/208/205/2138 ,article ,Humans ,631/208/457 ,Mendelian Randomization Analysis ,Polymorphism, Single Nucleotide ,Genome-Wide Association Study - Abstract
Funder: Jacobs Foundation; doi: https://doi.org/10.13039/501100003986, Estimates from genome-wide association studies (GWAS) of unrelated individuals capture effects of inherited variation (direct effects), demography (population stratification, assortative mating) and relatives (indirect genetic effects). Family-based GWAS designs can control for demographic and indirect genetic effects, but large-scale family datasets have been lacking. We combined data from 178,086 siblings from 19 cohorts to generate population (between-family) and within-sibship (within-family) GWAS estimates for 25 phenotypes. Within-sibship GWAS estimates were smaller than population estimates for height, educational attainment, age at first birth, number of children, cognitive ability, depressive symptoms and smoking. Some differences were observed in downstream SNP heritability, genetic correlations and Mendelian randomization analyses. For example, the within-sibship genetic correlation between educational attainment and body mass index attenuated towards zero. In contrast, analyses of most molecular phenotypes (for example, low-density lipoprotein-cholesterol) were generally consistent. We also found within-sibship evidence of polygenic adaptation on taller height. Here, we illustrate the importance of family-based GWAS data for phenotypes influenced by demographic and indirect genetic effects.
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- 2022
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5. Associations between DNA methylation and BMI vary by metabolic health status: a potential link to disparate cardiovascular outcomes
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Do, Whitney L., primary, Nguyen, Steve, additional, Yao, Jie, additional, Guo, Xiuqing, additional, Whitsel, Eric A., additional, Demerath, Ellen, additional, Rotter, Jerome I., additional, Rich, Stephen S., additional, Lange, Leslie, additional, Ding, Jingzhong, additional, Van Den Berg, David, additional, Liu, Yongmei, additional, Justice, Anne E., additional, Guan, Weihua, additional, Horvath, Steve, additional, Assimes, Themistocles L., additional, Bhatti, Parveen, additional, Jordahl, Kristina, additional, Shadyab, Aladdin, additional, Valencia, Celina I., additional, Stein, Aryeh D., additional, Smith, Alicia, additional, Staimez, Lisa R., additional, Conneely, Karen, additional, and Narayan, K. M. Venkat, additional
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- 2021
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6. Genetic determinants of metabolic biomarkers and their associations with cardiometabolic traits in Hispanic/Latino adolescents
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Kim, Daeeun, primary, Justice, Anne E., additional, Chittoor, Geetha, additional, Blanco, Estela, additional, Burrows, Raquel, additional, Graff, Mariaelisa, additional, Howard, Annie Green, additional, Wang, Yujie, additional, Rohde, Rebecca, additional, Buchanan, Victoria L., additional, Voruganti, V. Saroja, additional, Almeida, Marcio, additional, Peralta, Juan, additional, Lehman, Donna M., additional, Curran, Joanne E., additional, Comuzzie, Anthony G., additional, Duggirala, Ravindranath, additional, Blangero, John, additional, Albala, Cecilia, additional, Santos, José L., additional, Angel, Bárbara, additional, Lozoff, Betsy, additional, Gahagan, Sheila, additional, and North, Kari E., additional
- Published
- 2021
- Full Text
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7. Exome-wide evaluation of rare coding variants using electronic health records identifies new gene–phenotype associations
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Park, Joseph, primary, Lucas, Anastasia M., additional, Zhang, Xinyuan, additional, Chaudhary, Kumardeep, additional, Cho, Judy H., additional, Nadkarni, Girish, additional, Dobbyn, Amanda, additional, Chittoor, Geetha, additional, Josyula, Navya S., additional, Katz, Nathan, additional, Breeyear, Joseph H., additional, Ahmadmehrabi, Shadi, additional, Drivas, Theodore G., additional, Chavali, Venkata R. M., additional, Fasolino, Maria, additional, Sawada, Hisashi, additional, Daugherty, Alan, additional, Li, Yanming, additional, Zhang, Chen, additional, Bradford, Yuki, additional, Weaver, JoEllen, additional, Verma, Anurag, additional, Judy, Renae L., additional, Kember, Rachel L., additional, Overton, John D., additional, Reid, Jeffrey G., additional, Ferreira, Manuel A. R., additional, Li, Alexander H., additional, Baras, Aris, additional, LeMaire, Scott A., additional, Shen, Ying H., additional, Naji, Ali, additional, Kaestner, Klaus H., additional, Vahedi, Golnaz, additional, Edwards, Todd L., additional, Chen, Jinbo, additional, Damrauer, Scott M., additional, Justice, Anne E., additional, Do, Ron, additional, Ritchie, Marylyn D., additional, and Rader, Daniel J., additional
- Published
- 2021
- Full Text
- View/download PDF
8. Genetic analyses of diverse populations improves discovery for complex traits
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Wojcik, Genevieve L., primary, Graff, Mariaelisa, additional, Nishimura, Katherine K., additional, Tao, Ran, additional, Haessler, Jeffrey, additional, Gignoux, Christopher R., additional, Highland, Heather M., additional, Patel, Yesha M., additional, Sorokin, Elena P., additional, Avery, Christy L., additional, Belbin, Gillian M., additional, Bien, Stephanie A., additional, Cheng, Iona, additional, Cullina, Sinead, additional, Hodonsky, Chani J., additional, Hu, Yao, additional, Huckins, Laura M., additional, Jeff, Janina, additional, Justice, Anne E., additional, Kocarnik, Jonathan M., additional, Lim, Unhee, additional, Lin, Bridget M., additional, Lu, Yingchang, additional, Nelson, Sarah C., additional, Park, Sung-Shim L., additional, Poisner, Hannah, additional, Preuss, Michael H., additional, Richard, Melissa A., additional, Schurmann, Claudia, additional, Setiawan, Veronica W., additional, Sockell, Alexandra, additional, Vahi, Karan, additional, Verbanck, Marie, additional, Vishnu, Abhishek, additional, Walker, Ryan W., additional, Young, Kristin L., additional, Zubair, Niha, additional, Acuña-Alonso, Victor, additional, Ambite, Jose Luis, additional, Barnes, Kathleen C., additional, Boerwinkle, Eric, additional, Bottinger, Erwin P., additional, Bustamante, Carlos D., additional, Caberto, Christian, additional, Canizales-Quinteros, Samuel, additional, Conomos, Matthew P., additional, Deelman, Ewa, additional, Do, Ron, additional, Doheny, Kimberly, additional, Fernández-Rhodes, Lindsay, additional, Fornage, Myriam, additional, Hailu, Benyam, additional, Heiss, Gerardo, additional, Henn, Brenna M., additional, Hindorff, Lucia A., additional, Jackson, Rebecca D., additional, Laurie, Cecelia A., additional, Laurie, Cathy C., additional, Li, Yuqing, additional, Lin, Dan-Yu, additional, Moreno-Estrada, Andres, additional, Nadkarni, Girish, additional, Norman, Paul J., additional, Pooler, Loreall C., additional, Reiner, Alexander P., additional, Romm, Jane, additional, Sabatti, Chiara, additional, Sandoval, Karla, additional, Sheng, Xin, additional, Stahl, Eli A., additional, Stram, Daniel O., additional, Thornton, Timothy A., additional, Wassel, Christina L., additional, Wilkens, Lynne R., additional, Winkler, Cheryl A., additional, Yoneyama, Sachi, additional, Buyske, Steven, additional, Haiman, Christopher A., additional, Kooperberg, Charles, additional, Le Marchand, Loic, additional, Loos, Ruth J. F., additional, Matise, Tara C., additional, North, Kari E., additional, Peters, Ulrike, additional, Kenny, Eimear E., additional, and Carlson, Christopher S., additional
- Published
- 2019
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9. Complex patterns of direct and indirect association between the transcription Factor-7 like 2 gene, body mass index and type 2 diabetes diagnosis in adulthood in the Hispanic Community Health Study/Study of Latinos
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Fernández-Rhodes, Lindsay, primary, Howard, Annie Green, additional, Graff, Mariaelisa, additional, Isasi, Carmen R., additional, Highland, Heather M., additional, Young, Kristin L., additional, Parra, Esteban, additional, Below, Jennifer E., additional, Qi, Qibin, additional, Kaplan, Robert C., additional, Justice, Anne E., additional, Papanicolaou, George, additional, Laurie, Cathy C., additional, Grant, Struan F. A., additional, Haiman, Christopher, additional, Loos, Ruth J. F., additional, and North, Kari E., additional
- Published
- 2018
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- View/download PDF
10. Direct and indirect genetic effects on triglycerides through omics and correlated phenotypes
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Justice, Anne E., primary, Howard, Annie Green, additional, Fernández-Rhodes, Lindsay, additional, Graff, Misa, additional, Tao, Ran, additional, and North, Kari E., additional
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- 2018
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- View/download PDF
11. Causal modeling in a multi-omic setting: insights from GAW20
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Auerbach, Jonathan, primary, Howey, Richard, additional, Jiang, Lai, additional, Justice, Anne, additional, Li, Liming, additional, Oualkacha, Karim, additional, Sayols-Baixeras, Sergi, additional, and Aslibekyan, Stella W., additional
- Published
- 2018
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12. Characterization of the contribution of shared environmental and genetic factors to metabolic syndrome methylation heritability and familial correlations
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Fernández-Rhodes, Lindsay, primary, Howard, Annie Green, additional, Tao, Ran, additional, Young, Kristin L., additional, Graff, Mariaelisa, additional, Aiello, Allison E., additional, North, Kari E., additional, and Justice, Anne E., additional
- Published
- 2018
- Full Text
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13. Genome-wide meta-analysis of macronutrient intake of 91,114 European ancestry participants from the cohorts for heart and aging research in genomic epidemiology consortium
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Merino, Jordi, primary, Dashti, Hassan S., additional, Li, Sherly X., additional, Sarnowski, Chloé, additional, Justice, Anne E., additional, Graff, Misa, additional, Papoutsakis, Constantina, additional, Smith, Caren E., additional, Dedoussis, George V., additional, Lemaitre, Rozenn N., additional, Wojczynski, Mary K., additional, Männistö, Satu, additional, Ngwa, Julius S., additional, Kho, Minjung, additional, Ahluwalia, Tarunveer S., additional, Pervjakova, Natalia, additional, Houston, Denise K., additional, Bouchard, Claude, additional, Huang, Tao, additional, Orho-Melander, Marju, additional, Frazier-Wood, Alexis C., additional, Mook-Kanamori, Dennis O., additional, Pérusse, Louis, additional, Pennell, Craig E., additional, de Vries, Paul S., additional, Voortman, Trudy, additional, Li, Olivia, additional, Kanoni, Stavroula, additional, Rose, Lynda M., additional, Lehtimäki, Terho, additional, Zhao, Jing Hua, additional, Feitosa, Mary F., additional, Luan, Jian’an, additional, McKeown, Nicola M., additional, Smith, Jennifer A., additional, Hansen, Torben, additional, Eklund, Niina, additional, Nalls, Mike A., additional, Rankinen, Tuomo, additional, Huang, Jinyan, additional, Hernandez, Dena G., additional, Schulz, Christina-Alexandra, additional, Manichaikul, Ani, additional, Li-Gao, Ruifang, additional, Vohl, Marie-Claude, additional, Wang, Carol A., additional, van Rooij, Frank J. A., additional, Shin, Jean, additional, Kalafati, Ioanna P., additional, Day, Felix, additional, Ridker, Paul M., additional, Kähönen, Mika, additional, Siscovick, David S., additional, Langenberg, Claudia, additional, Zhao, Wei, additional, Astrup, Arne, additional, Knekt, Paul, additional, Garcia, Melissa, additional, Rao, D. C., additional, Qi, Qibin, additional, Ferrucci, Luigi, additional, Ericson, Ulrika, additional, Blangero, John, additional, Hofman, Albert, additional, Pausova, Zdenka, additional, Mikkilä, Vera, additional, Wareham, Nick J., additional, Kardia, Sharon L. R, additional, Pedersen, Oluf, additional, Jula, Antti, additional, Curran, Joanne E., additional, Zillikens, M. Carola, additional, Viikari, Jorma S., additional, Forouhi, Nita G., additional, Ordovás, José M., additional, Lieske, John C., additional, Rissanen, Harri, additional, Uitterlinden, André G., additional, Raitakari, Olli T., additional, Kiefte-de Jong, Jessica C., additional, Dupuis, Josée, additional, Rotter, Jerome I., additional, North, Kari E., additional, Scott, Robert A., additional, Province, Michael A., additional, Perola, Markus, additional, Cupples, L. Adrienne, additional, Turner, Stephen T., additional, Sørensen, Thorkild I. A., additional, Salomaa, Veikko, additional, Liu, Yongmei, additional, Sung, Yun J., additional, Qi, Lu, additional, Bandinelli, Stefania, additional, Rich, Stephen S., additional, de Mutsert, Renée, additional, Tremblay, Angelo, additional, Oddy, Wendy H., additional, Franco, Oscar H., additional, Paus, Tomas, additional, Florez, Jose C., additional, Deloukas, Panos, additional, Lyytikäinen, Leo-Pekka, additional, Chasman, Daniel I., additional, Chu, Audrey Y., additional, and Tanaka, Toshiko, additional
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- 2018
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14. Genetic architecture of lipid traits in the Hispanic community health study/study of Latinos
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Graff, Mariaelisa, primary, Emery, Leslie S., additional, Justice, Anne E., additional, Parra, Esteban, additional, Below, Jennifer E., additional, Palmer, Nicholette D., additional, Gao, Chuan, additional, Duan, Qing, additional, Valladares-Salgado, Adan, additional, Cruz, Miguel, additional, Morrison, Alanna C., additional, Boerwinkle, Eric, additional, Whitsel, Eric A., additional, Kooperberg, Charles, additional, Reiner, Alex, additional, Li, Yun, additional, Rodriguez, Carlos Jose, additional, Talavera, Gregory A., additional, Langefeld, Carl D., additional, Wagenknecht, Lynne E., additional, Norris, Jill M., additional, Taylor, Kent D., additional, Papanicolaou, George, additional, Kenny, Eimear, additional, Loos, Ruth J. F., additional, Chen, Yii-Der Ida, additional, Laurie, Cathy, additional, Sofer, Tamar, additional, and North, Kari E., additional
- Published
- 2017
- Full Text
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15. Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits
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Justice, Anne E., primary, Winkler, Thomas W., additional, Feitosa, Mary F., additional, Graff, Misa, additional, Fisher, Virginia A., additional, Young, Kristin, additional, Barata, Llilda, additional, Deng, Xuan, additional, Czajkowski, Jacek, additional, Hadley, David, additional, Ngwa, Julius S., additional, Ahluwalia, Tarunveer S., additional, Chu, Audrey Y., additional, Heard-Costa, Nancy L., additional, Lim, Elise, additional, Perez, Jeremiah, additional, Eicher, John D., additional, Kutalik, Zoltán, additional, Xue, Luting, additional, Mahajan, Anubha, additional, Renström, Frida, additional, Wu, Joseph, additional, Qi, Qibin, additional, Ahmad, Shafqat, additional, Alfred, Tamuno, additional, Amin, Najaf, additional, Bielak, Lawrence F., additional, Bonnefond, Amelie, additional, Bragg, Jennifer, additional, Cadby, Gemma, additional, Chittani, Martina, additional, Coggeshall, Scott, additional, Corre, Tanguy, additional, Direk, Nese, additional, Eriksson, Joel, additional, Fischer, Krista, additional, Gorski, Mathias, additional, Neergaard Harder, Marie, additional, Horikoshi, Momoko, additional, Huang, Tao, additional, Huffman, Jennifer E., additional, Jackson, Anne U., additional, Justesen, Johanne Marie, additional, Kanoni, Stavroula, additional, Kinnunen, Leena, additional, Kleber, Marcus E., additional, Komulainen, Pirjo, additional, Kumari, Meena, additional, Lim, Unhee, additional, Luan, Jian'an, additional, Lyytikäinen, Leo-Pekka, additional, Mangino, Massimo, additional, Manichaikul, Ani, additional, Marten, Jonathan, additional, Middelberg, Rita P. S., additional, Müller-Nurasyid, Martina, additional, Navarro, Pau, additional, Pérusse, Louis, additional, Pervjakova, Natalia, additional, Sarti, Cinzia, additional, Smith, Albert Vernon, additional, Smith, Jennifer A., additional, Stančáková, Alena, additional, Strawbridge, Rona J., additional, Stringham, Heather M., additional, Sung, Yun Ju, additional, Tanaka, Toshiko, additional, Teumer, Alexander, additional, Trompet, Stella, additional, van der Laan, Sander W., additional, van der Most, Peter J., additional, Van Vliet-Ostaptchouk, Jana V., additional, Vedantam, Sailaja L., additional, Verweij, Niek, additional, Vink, Jacqueline M., additional, Vitart, Veronique, additional, Wu, Ying, additional, Yengo, Loic, additional, Zhang, Weihua, additional, Hua Zhao, Jing, additional, Zimmermann, Martina E., additional, Zubair, Niha, additional, Abecasis, Gonçalo R., additional, Adair, Linda S., additional, Afaq, Saima, additional, Afzal, Uzma, additional, Bakker, Stephan J. L., additional, Bartz, Traci M., additional, Beilby, John, additional, Bergman, Richard N., additional, Bergmann, Sven, additional, Biffar, Reiner, additional, Blangero, John, additional, Boerwinkle, Eric, additional, Bonnycastle, Lori L., additional, Bottinger, Erwin, additional, Braga, Daniele, additional, Buckley, Brendan M., additional, Buyske, Steve, additional, Campbell, Harry, additional, Chambers, John C., additional, Collins, Francis S., additional, Curran, Joanne E., additional, de Borst, Gert J., additional, de Craen, Anton J. M., additional, de Geus, Eco J. C., additional, Dedoussis, George, additional, Delgado, Graciela E., additional, den Ruijter, Hester M., additional, Eiriksdottir, Gudny, additional, Eriksson, Anna L., additional, Esko, Tõnu, additional, Faul, Jessica D., additional, Ford, Ian, additional, Forrester, Terrence, additional, Gertow, Karl, additional, Gigante, Bruna, additional, Glorioso, Nicola, additional, Gong, Jian, additional, Grallert, Harald, additional, Grammer, Tanja B., additional, Grarup, Niels, additional, Haitjema, Saskia, additional, Hallmans, Göran, additional, Hamsten, Anders, additional, Hansen, Torben, additional, Harris, Tamara B., additional, Hartman, Catharina A., additional, Hassinen, Maija, additional, Hastie, Nicholas D., additional, Heath, Andrew C., additional, Hernandez, Dena, additional, Hindorff, Lucia, additional, Hocking, Lynne J., additional, Hollensted, Mette, additional, Holmen, Oddgeir L., additional, Homuth, Georg, additional, Jan Hottenga, Jouke, additional, Huang, Jie, additional, Hung, Joseph, additional, Hutri-Kähönen, Nina, additional, Ingelsson, Erik, additional, James, Alan L., additional, Jansson, John-Olov, additional, Jarvelin, Marjo-Riitta, additional, Jhun, Min A., additional, Jørgensen, Marit E., additional, Juonala, Markus, additional, Kähönen, Mika, additional, Karlsson, Magnus, additional, Koistinen, Heikki A., additional, Kolcic, Ivana, additional, Kolovou, Genovefa, additional, Kooperberg, Charles, additional, Krämer, Bernhard K., additional, Kuusisto, Johanna, additional, Kvaløy, Kirsti, additional, Lakka, Timo A., additional, Langenberg, Claudia, additional, Launer, Lenore J., additional, Leander, Karin, additional, Lee, Nanette R., additional, Lind, Lars, additional, Lindgren, Cecilia M., additional, Linneberg, Allan, additional, Lobbens, Stephane, additional, Loh, Marie, additional, Lorentzon, Mattias, additional, Luben, Robert, additional, Lubke, Gitta, additional, Ludolph-Donislawski, Anja, additional, Lupoli, Sara, additional, Madden, Pamela A. F., additional, Männikkö, Reija, additional, Marques-Vidal, Pedro, additional, Martin, Nicholas G., additional, McKenzie, Colin A., additional, McKnight, Barbara, additional, Mellström, Dan, additional, Menni, Cristina, additional, Montgomery, Grant W., additional, Musk, AW, additional, Narisu, Narisu, additional, Nauck, Matthias, additional, Nolte, Ilja M., additional, Oldehinkel, Albertine J., additional, Olden, Matthias, additional, Ong, Ken K., additional, Padmanabhan, Sandosh, additional, Peyser, Patricia A., additional, Pisinger, Charlotta, additional, Porteous, David J., additional, Raitakari, Olli T., additional, Rankinen, Tuomo, additional, Rao, D. C., additional, Rasmussen-Torvik, Laura J., additional, Rawal, Rajesh, additional, Rice, Treva, additional, Ridker, Paul M., additional, Rose, Lynda M., additional, Bien, Stephanie A., additional, Rudan, Igor, additional, Sanna, Serena, additional, Sarzynski, Mark A., additional, Sattar, Naveed, additional, Savonen, Kai, additional, Schlessinger, David, additional, Scholtens, Salome, additional, Schurmann, Claudia, additional, Scott, Robert A., additional, Sennblad, Bengt, additional, Siemelink, Marten A., additional, Silbernagel, Günther, additional, Slagboom, P Eline, additional, Snieder, Harold, additional, Staessen, Jan A., additional, Stott, David J., additional, Swertz, Morris A., additional, Swift, Amy J., additional, Taylor, Kent D., additional, Tayo, Bamidele O., additional, Thorand, Barbara, additional, Thuillier, Dorothee, additional, Tuomilehto, Jaakko, additional, Uitterlinden, Andre G., additional, Vandenput, Liesbeth, additional, Vohl, Marie-Claude, additional, Völzke, Henry, additional, Vonk, Judith M., additional, Waeber, Gérard, additional, Waldenberger, Melanie, additional, Westendorp, R. G. J., additional, Wild, Sarah, additional, Willemsen, Gonneke, additional, Wolffenbuttel, Bruce H. R., additional, Wong, Andrew, additional, Wright, Alan F., additional, Zhao, Wei, additional, Zillikens, M Carola, additional, Baldassarre, Damiano, additional, Balkau, Beverley, additional, Bandinelli, Stefania, additional, Böger, Carsten A., additional, Boomsma, Dorret I., additional, Bouchard, Claude, additional, Bruinenberg, Marcel, additional, Chasman, Daniel I., additional, Chen, Yii-DerIda, additional, Chines, Peter S., additional, Cooper, Richard S., additional, Cucca, Francesco, additional, Cusi, Daniele, additional, Faire, Ulf de, additional, Ferrucci, Luigi, additional, Franks, Paul W., additional, Froguel, Philippe, additional, Gordon-Larsen, Penny, additional, Grabe, Hans- Jörgen, additional, Gudnason, Vilmundur, additional, Haiman, Christopher A., additional, Hayward, Caroline, additional, Hveem, Kristian, additional, Johnson, Andrew D., additional, Wouter Jukema, J, additional, Kardia, Sharon L. R., additional, Kivimaki, Mika, additional, Kooner, Jaspal S., additional, Kuh, Diana, additional, Laakso, Markku, additional, Lehtimäki, Terho, additional, Marchand, Loic Le, additional, März, Winfried, additional, McCarthy, Mark I., additional, Metspalu, Andres, additional, Morris, Andrew P., additional, Ohlsson, Claes, additional, Palmer, Lyle J., additional, Pasterkamp, Gerard, additional, Pedersen, Oluf, additional, Peters, Annette, additional, Peters, Ulrike, additional, Polasek, Ozren, additional, Psaty, Bruce M., additional, Qi, Lu, additional, Rauramaa, Rainer, additional, Smith, Blair H., additional, Sørensen, Thorkild I. A., additional, Strauch, Konstantin, additional, Tiemeier, Henning, additional, Tremoli, Elena, additional, van der Harst, Pim, additional, Vestergaard, Henrik, additional, Vollenweider, Peter, additional, Wareham, Nicholas J., additional, Weir, David R., additional, Whitfield, John B., additional, Wilson, James F., additional, Tyrrell, Jessica, additional, Frayling, Timothy M., additional, Barroso, Inês, additional, Boehnke, Michael, additional, Deloukas, Panagiotis, additional, Fox, Caroline S., additional, Hirschhorn, Joel N., additional, Hunter, David J., additional, Spector, Tim D., additional, Strachan, David P., additional, van Duijn, Cornelia M., additional, Heid, Iris M., additional, Mohlke, Karen L., additional, Marchini, Jonathan, additional, Loos, Ruth J. F., additional, Kilpeläinen, Tuomas O., additional, Liu, Ching-Ti, additional, Borecki, Ingrid B., additional, North, Kari E., additional, and Cupples, L Adrienne, additional
- Published
- 2017
- Full Text
- View/download PDF
16. A principal component meta-analysis on multiple anthropometric traits identifies novel loci for body shape
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Ried, Janina S., primary, Jeff M., Janina, additional, Chu, Audrey Y., additional, Bragg-Gresham, Jennifer L., additional, van Dongen, Jenny, additional, Huffman, Jennifer E., additional, Ahluwalia, Tarunveer S., additional, Cadby, Gemma, additional, Eklund, Niina, additional, Eriksson, Joel, additional, Esko, Tõnu, additional, Feitosa, Mary F., additional, Goel, Anuj, additional, Gorski, Mathias, additional, Hayward, Caroline, additional, Heard-Costa, Nancy L., additional, Jackson, Anne U., additional, Jokinen, Eero, additional, Kanoni, Stavroula, additional, Kristiansson, Kati, additional, Kutalik, Zoltán, additional, Lahti, Jari, additional, Luan, Jian'an, additional, Mägi, Reedik, additional, Mahajan, Anubha, additional, Mangino, Massimo, additional, Medina-Gomez, Carolina, additional, Monda, Keri L., additional, Nolte, Ilja M., additional, Pérusse, Louis, additional, Prokopenko, Inga, additional, Qi, Lu, additional, Rose, Lynda M., additional, Salvi, Erika, additional, Smith, Megan T., additional, Snieder, Harold, additional, Stančáková, Alena, additional, Ju Sung, Yun, additional, Tachmazidou, Ioanna, additional, Teumer, Alexander, additional, Thorleifsson, Gudmar, additional, van der Harst, Pim, additional, Walker, Ryan W., additional, Wang, Sophie R., additional, Wild, Sarah H., additional, Willems, Sara M., additional, Wong, Andrew, additional, Zhang, Weihua, additional, Albrecht, Eva, additional, Couto Alves, Alexessander, additional, Bakker, Stephan J. L., additional, Barlassina, Cristina, additional, Bartz, Traci M., additional, Beilby, John, additional, Bellis, Claire, additional, Bergman, Richard N., additional, Bergmann, Sven, additional, Blangero, John, additional, Blüher, Matthias, additional, Boerwinkle, Eric, additional, Bonnycastle, Lori L., additional, Bornstein, Stefan R., additional, Bruinenberg, Marcel, additional, Campbell, Harry, additional, Chen, Yii-Der Ida, additional, Chiang, Charleston W. K., additional, Chines, Peter S., additional, Collins, Francis S, additional, Cucca, Fracensco, additional, Cupples, L Adrienne, additional, D’Avila, Francesca, additional, de Geus, Eco J .C., additional, Dedoussis, George, additional, Dimitriou, Maria, additional, Döring, Angela, additional, Eriksson, Johan G., additional, Farmaki, Aliki-Eleni, additional, Farrall, Martin, additional, Ferreira, Teresa, additional, Fischer, Krista, additional, Forouhi, Nita G., additional, Friedrich, Nele, additional, Gjesing, Anette Prior, additional, Glorioso, Nicola, additional, Graff, Mariaelisa, additional, Grallert, Harald, additional, Grarup, Niels, additional, Gräßler, Jürgen, additional, Grewal, Jagvir, additional, Hamsten, Anders, additional, Harder, Marie Neergaard, additional, Hartman, Catharina A., additional, Hassinen, Maija, additional, Hastie, Nicholas, additional, Hattersley, Andrew Tym, additional, Havulinna, Aki S., additional, Heliövaara, Markku, additional, Hillege, Hans, additional, Hofman, Albert, additional, Holmen, Oddgeir, additional, Homuth, Georg, additional, Hottenga, Jouke-Jan, additional, Hui, Jennie, additional, Husemoen, Lise Lotte, additional, Hysi, Pirro G., additional, Isaacs, Aaron, additional, Ittermann, Till, additional, Jalilzadeh, Shapour, additional, James, Alan L., additional, Jørgensen, Torben, additional, Jousilahti, Pekka, additional, Jula, Antti, additional, Marie Justesen, Johanne, additional, Justice, Anne E., additional, Kähönen, Mika, additional, Karaleftheri, Maria, additional, Tee Khaw, Kay, additional, Keinanen-Kiukaanniemi, Sirkka M., additional, Kinnunen, Leena, additional, Knekt, Paul B., additional, Koistinen, Heikki A., additional, Kolcic, Ivana, additional, Kooner, Ishminder K., additional, Koskinen, Seppo, additional, Kovacs, Peter, additional, Kyriakou, Theodosios, additional, Laitinen, Tomi, additional, Langenberg, Claudia, additional, Lewin, Alexandra M., additional, Lichtner, Peter, additional, Lindgren, Cecilia M., additional, Lindström, Jaana, additional, Linneberg, Allan, additional, Lorbeer, Roberto, additional, Lorentzon, Mattias, additional, Luben, Robert, additional, Lyssenko, Valeriya, additional, Männistö, Satu, additional, Manunta, Paolo, additional, Leach, Irene Mateo, additional, McArdle, Wendy L., additional, Mcknight, Barbara, additional, Mohlke, Karen L., additional, Mihailov, Evelin, additional, Milani, Lili, additional, Mills, Rebecca, additional, Montasser, May E., additional, Morris, Andrew P., additional, Müller, Gabriele, additional, Musk, Arthur W., additional, Narisu, Narisu, additional, Ong, Ken K., additional, Oostra, Ben A., additional, Osmond, Clive, additional, Palotie, Aarno, additional, Pankow, James S., additional, Paternoster, Lavinia, additional, Penninx, Brenda W., additional, Pichler, Irene, additional, Pilia, Maria G., additional, Polašek, Ozren, additional, Pramstaller, Peter P., additional, Raitakari, Olli T, additional, Rankinen, Tuomo, additional, Rao, D. C., additional, Rayner, Nigel W., additional, Ribel-Madsen, Rasmus, additional, Rice, Treva K., additional, Richards, Marcus, additional, Ridker, Paul M., additional, Rivadeneira, Fernando, additional, Ryan, Kathy A., additional, Sanna, Serena, additional, Sarzynski, Mark A., additional, Scholtens, Salome, additional, Scott, Robert A., additional, Sebert, Sylvain, additional, Southam, Lorraine, additional, Sparsø, Thomas Hempel, additional, Steinthorsdottir, Valgerdur, additional, Stirrups, Kathleen, additional, Stolk, Ronald P., additional, Strauch, Konstantin, additional, Stringham, Heather M., additional, Swertz, Morris A., additional, Swift, Amy J., additional, Tönjes, Anke, additional, Tsafantakis, Emmanouil, additional, van der Most, Peter J., additional, Van Vliet-Ostaptchouk, Jana V., additional, Vandenput, Liesbeth, additional, Vartiainen, Erkki, additional, Venturini, Cristina, additional, Verweij, Niek, additional, Viikari, Jorma S., additional, Vitart, Veronique, additional, Vohl, Marie-Claude, additional, Vonk, Judith M., additional, Waeber, Gérard, additional, Widén, Elisabeth, additional, Willemsen, Gonneke, additional, Wilsgaard, Tom, additional, Winkler, Thomas W., additional, Wright, Alan F., additional, Yerges-Armstrong, Laura M., additional, Hua Zhao, Jing, additional, Carola Zillikens, M., additional, Boomsma, Dorret I., additional, Bouchard, Claude, additional, Chambers, John C., additional, Chasman, Daniel I., additional, Cusi, Daniele, additional, Gansevoort, Ron T., additional, Gieger, Christian, additional, Hansen, Torben, additional, Hicks, Andrew A., additional, Hu, Frank, additional, Hveem, Kristian, additional, Jarvelin, Marjo-Riitta, additional, Kajantie, Eero, additional, Kooner, Jaspal S., additional, Kuh, Diana, additional, Kuusisto, Johanna, additional, Laakso, Markku, additional, Lakka, Timo A., additional, Lehtimäki, Terho, additional, Metspalu, Andres, additional, Njølstad, Inger, additional, Ohlsson, Claes, additional, Oldehinkel, Albertine J., additional, Palmer, Lyle J., additional, Pedersen, Oluf, additional, Perola, Markus, additional, Peters, Annette, additional, Psaty, Bruce M., additional, Puolijoki, Hannu, additional, Rauramaa, Rainer, additional, Rudan, Igor, additional, Salomaa, Veikko, additional, Schwarz, Peter E. H., additional, Shudiner, Alan R., additional, Smit, Jan H., additional, Sørensen, Thorkild I. A., additional, Spector, Timothy D., additional, Stefansson, Kari, additional, Stumvoll, Michael, additional, Tremblay, Angelo, additional, Tuomilehto, Jaakko, additional, Uitterlinden, André G., additional, Uusitupa, Matti, additional, Völker, Uwe, additional, Vollenweider, Peter, additional, Wareham, Nicholas J., additional, Watkins, Hugh, additional, Wilson, James F., additional, Zeggini, Eleftheria, additional, Abecasis, Goncalo R., additional, Boehnke, Michael, additional, Borecki, Ingrid B., additional, Deloukas, Panos, additional, van Duijn, Cornelia M., additional, Fox, Caroline, additional, Groop, Leif C., additional, Heid, Iris M., additional, Hunter, David J., additional, Kaplan, Robert C., additional, McCarthy, Mark I., additional, North, Kari E., additional, O'Connell, Jeffrey R., additional, Schlessinger, David, additional, Thorsteinsdottir, Unnur, additional, Strachan, David P., additional, Frayling, Timothy, additional, Hirschhorn, Joel N., additional, Müller-Nurasyid, Martina, additional, and Loos, Ruth J. F., additional
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- 2016
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17. Comparison of 2 models for gene–environment interactions: an example of simulated gene–medication interactions on systolic blood pressure in family-based data
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Fernández-Rhodes, Lindsay, primary, Hodonsky, Chani J., additional, Graff, Mariaelisa, additional, Love, Shelly-Ann M., additional, Howard, Annie Green, additional, Seyerle, Amanda A., additional, Avery, Christy L., additional, Chittoor, Geetha, additional, Franceschini, Nora, additional, Voruganti, V. Saroja, additional, Young, Kristin, additional, O’Connell, Jeffrey R., additional, North, Kari E., additional, and Justice, Anne E., additional
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- 2016
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18. Genome-wide association of trajectories of systolic blood pressure change
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Justice, Anne E., primary, Howard, Annie Green, additional, Chittoor, Geetha, additional, Fernandez-Rhodes, Lindsay, additional, Graff, Misa, additional, Voruganti, V. Saroja, additional, Diao, Guoqing, additional, Love, Shelly-Ann M., additional, Franceschini, Nora, additional, O’Connell, Jeffrey R., additional, Avery, Christy L., additional, Young, Kristin L., additional, and North, Kari E., additional
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- 2016
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19. Longitudinal analytical approaches to genetic data
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Chiu, Yen-Feng, primary, Justice, Anne E., additional, and Melton, Phillip E., additional
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- 2016
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20. New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk
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Lu, Yingchang, primary, Day, Felix R., additional, Gustafsson, Stefan, additional, Buchkovich, Martin L., additional, Na, Jianbo, additional, Bataille, Veronique, additional, Cousminer, Diana L., additional, Dastani, Zari, additional, Drong, Alexander W., additional, Esko, Tõnu, additional, Evans, David M., additional, Falchi, Mario, additional, Feitosa, Mary F., additional, Ferreira, Teresa, additional, Hedman, Åsa K., additional, Haring, Robin, additional, Hysi, Pirro G., additional, Iles, Mark M., additional, Justice, Anne E., additional, Kanoni, Stavroula, additional, Lagou, Vasiliki, additional, Li, Rui, additional, Li, Xin, additional, Locke, Adam, additional, Lu, Chen, additional, Mägi, Reedik, additional, Perry, John R. B., additional, Pers, Tune H., additional, Qi, Qibin, additional, Sanna, Marianna, additional, Schmidt, Ellen M., additional, Scott, William R., additional, Shungin, Dmitry, additional, Teumer, Alexander, additional, Vinkhuyzen, Anna A. E., additional, Walker, Ryan W., additional, Westra, Harm-Jan, additional, Zhang, Mingfeng, additional, Zhang, Weihua, additional, Zhao, Jing Hua, additional, Zhu, Zhihong, additional, Afzal, Uzma, additional, Ahluwalia, Tarunveer Singh, additional, Bakker, Stephan J. L., additional, Bellis, Claire, additional, Bonnefond, Amélie, additional, Borodulin, Katja, additional, Buchman, Aron S., additional, Cederholm, Tommy, additional, Choh, Audrey C., additional, Choi, Hyung Jin, additional, Curran, Joanne E., additional, de Groot, Lisette C. P. G. M., additional, De Jager, Philip L., additional, Dhonukshe-Rutten, Rosalie A. M., additional, Enneman, Anke W., additional, Eury, Elodie, additional, Evans, Daniel S., additional, Forsen, Tom, additional, Friedrich, Nele, additional, Fumeron, Frédéric, additional, Garcia, Melissa E., additional, Gärtner, Simone, additional, Han, Bok-Ghee, additional, Havulinna, Aki S., additional, Hayward, Caroline, additional, Hernandez, Dena, additional, Hillege, Hans, additional, Ittermann, Till, additional, Kent, Jack W., additional, Kolcic, Ivana, additional, Laatikainen, Tiina, additional, Lahti, Jari, additional, Leach, Irene Mateo, additional, Lee, Christine G., additional, Lee, Jong-Young, additional, Liu, Tian, additional, Liu, Youfang, additional, Lobbens, Stéphane, additional, Loh, Marie, additional, Lyytikäinen, Leo-Pekka, additional, Medina-Gomez, Carolina, additional, Michaëlsson, Karl, additional, Nalls, Mike A., additional, Nielson, Carrie M., additional, Oozageer, Laticia, additional, Pascoe, Laura, additional, Paternoster, Lavinia, additional, Polašek, Ozren, additional, Ripatti, Samuli, additional, Sarzynski, Mark A., additional, Shin, Chan Soo, additional, Narančić, Nina Smolej, additional, Spira, Dominik, additional, Srikanth, Priya, additional, Steinhagen-Thiessen, Elisabeth, additional, Sung, Yun Ju, additional, Swart, Karin M. A., additional, Taittonen, Leena, additional, Tanaka, Toshiko, additional, Tikkanen, Emmi, additional, van der Velde, Nathalie, additional, van Schoor, Natasja M., additional, Verweij, Niek, additional, Wright, Alan F., additional, Yu, Lei, additional, Zmuda, Joseph M., additional, Eklund, Niina, additional, Forrester, Terrence, additional, Grarup, Niels, additional, Jackson, Anne U., additional, Kristiansson, Kati, additional, Kuulasmaa, Teemu, additional, Kuusisto, Johanna, additional, Lichtner, Peter, additional, Luan, Jian'an, additional, Mahajan, Anubha, additional, Männistö, Satu, additional, Palmer, Cameron D., additional, Ried, Janina S., additional, Scott, Robert A., additional, Stancáková, Alena, additional, Wagner, Peter J., additional, Demirkan, Ayse, additional, Döring, Angela, additional, Gudnason, Vilmundur, additional, Kiel, Douglas P., additional, Kühnel, Brigitte, additional, Mangino, Massimo, additional, Mcknight, Barbara, additional, Menni, Cristina, additional, O'Connell, Jeffrey R., additional, Oostra, Ben A., additional, Shuldiner, Alan R., additional, Song, Kijoung, additional, Vandenput, Liesbeth, additional, van Duijn, Cornelia M., additional, Vollenweider, Peter, additional, White, Charles C., additional, Boehnke, Michael, additional, Boettcher, Yvonne, additional, Cooper, Richard S., additional, Forouhi, Nita G., additional, Gieger, Christian, additional, Grallert, Harald, additional, Hingorani, Aroon, additional, Jørgensen, Torben, additional, Jousilahti, Pekka, additional, Kivimaki, Mika, additional, Kumari, Meena, additional, Laakso, Markku, additional, Langenberg, Claudia, additional, Linneberg, Allan, additional, Luke, Amy, additional, Mckenzie, Colin A., additional, Palotie, Aarno, additional, Pedersen, Oluf, additional, Peters, Annette, additional, Strauch, Konstantin, additional, Tayo, Bamidele O., additional, Wareham, Nicholas J., additional, Bennett, David A., additional, Bertram, Lars, additional, Blangero, John, additional, Blüher, Matthias, additional, Bouchard, Claude, additional, Campbell, Harry, additional, Cho, Nam H., additional, Cummings, Steven R., additional, Czerwinski, Stefan A., additional, Demuth, Ilja, additional, Eckardt, Rahel, additional, Eriksson, Johan G., additional, Ferrucci, Luigi, additional, Franco, Oscar H., additional, Froguel, Philippe, additional, Gansevoort, Ron T., additional, Hansen, Torben, additional, Harris, Tamara B., additional, Hastie, Nicholas, additional, Heliövaara, Markku, additional, Hofman, Albert, additional, Jordan, Joanne M., additional, Jula, Antti, additional, Kähönen, Mika, additional, Kajantie, Eero, additional, Knekt, Paul B., additional, Koskinen, Seppo, additional, Kovacs, Peter, additional, Lehtimäki, Terho, additional, Lind, Lars, additional, Liu, Yongmei, additional, Orwoll, Eric S., additional, Osmond, Clive, additional, Perola, Markus, additional, Pérusse, Louis, additional, Raitakari, Olli T., additional, Rankinen, Tuomo, additional, Rao, D. C., additional, Rice, Treva K., additional, Rivadeneira, Fernando, additional, Rudan, Igor, additional, Salomaa, Veikko, additional, Sørensen, Thorkild I. A., additional, Stumvoll, Michael, additional, Tönjes, Anke, additional, Towne, Bradford, additional, Tranah, Gregory J., additional, Tremblay, Angelo, additional, Uitterlinden, André G., additional, van der Harst, Pim, additional, Vartiainen, Erkki, additional, Viikari, Jorma S., additional, Vitart, Veronique, additional, Vohl, Marie-Claude, additional, Völzke, Henry, additional, Walker, Mark, additional, Wallaschofski, Henri, additional, Wild, Sarah, additional, Wilson, James F., additional, Yengo, Loïc, additional, Bishop, D. Timothy, additional, Borecki, Ingrid B., additional, Chambers, John C., additional, Cupples, L. Adrienne, additional, Dehghan, Abbas, additional, Deloukas, Panos, additional, Fatemifar, Ghazaleh, additional, Fox, Caroline, additional, Furey, Terrence S., additional, Franke, Lude, additional, Han, Jiali, additional, Hunter, David J., additional, Karjalainen, Juha, additional, Karpe, Fredrik, additional, Kaplan, Robert C., additional, Kooner, Jaspal S., additional, McCarthy, Mark I., additional, Murabito, Joanne M., additional, Morris, Andrew P., additional, Bishop, Julia A. N., additional, North, Kari E., additional, Ohlsson, Claes, additional, Ong, Ken K., additional, Prokopenko, Inga, additional, Richards, J. Brent, additional, Schadt, Eric E., additional, Spector, Tim D., additional, Widén, Elisabeth, additional, Willer, Cristen J., additional, Yang, Jian, additional, Ingelsson, Erik, additional, Mohlke, Karen L., additional, Hirschhorn, Joel N., additional, Pospisilik, John Andrew, additional, Zillikens, M. Carola, additional, Lindgren, Cecilia, additional, Kilpeläinen, Tuomas Oskari, additional, and Loos, Ruth J. F., additional
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- 2016
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21. Population genetic differentiation of height and body mass index across Europe
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Robinson, Matthew R, primary, Hemani, Gibran, additional, Medina-Gomez, Carolina, additional, Mezzavilla, Massimo, additional, Esko, Tonu, additional, Shakhbazov, Konstantin, additional, Powell, Joseph E, additional, Vinkhuyzen, Anna, additional, Berndt, Sonja I, additional, Gustafsson, Stefan, additional, Justice, Anne E, additional, Kahali, Bratati, additional, Locke, Adam E, additional, Pers, Tune H, additional, Vedantam, Sailaja, additional, Wood, Andrew R, additional, van Rheenen, Wouter, additional, Andreassen, Ole A, additional, Gasparini, Paolo, additional, Metspalu, Andres, additional, Berg, Leonard H van den, additional, Veldink, Jan H, additional, Rivadeneira, Fernando, additional, Werge, Thomas M, additional, Abecasis, Goncalo R, additional, Boomsma, Dorret I, additional, Chasman, Daniel I, additional, de Geus, Eco J C, additional, Frayling, Timothy M, additional, Hirschhorn, Joel N, additional, Hottenga, Jouke Jan, additional, Ingelsson, Erik, additional, Loos, Ruth J F, additional, Magnusson, Patrik K E, additional, Martin, Nicholas G, additional, Montgomery, Grant W, additional, North, Kari E, additional, Pedersen, Nancy L, additional, Spector, Timothy D, additional, Speliotes, Elizabeth K, additional, Goddard, Michael E, additional, Yang, Jian, additional, and Visscher, Peter M, additional
- Published
- 2015
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22. Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture
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Berndt, Sonja I, primary, Gustafsson, Stefan, additional, Mägi, Reedik, additional, Ganna, Andrea, additional, Wheeler, Eleanor, additional, Feitosa, Mary F, additional, Justice, Anne E, additional, Monda, Keri L, additional, Croteau-Chonka, Damien C, additional, Day, Felix R, additional, Esko, Tõnu, additional, Fall, Tove, additional, Ferreira, Teresa, additional, Gentilini, Davide, additional, Jackson, Anne U, additional, Luan, Jian'an, additional, Randall, Joshua C, additional, Vedantam, Sailaja, additional, Willer, Cristen J, additional, Winkler, Thomas W, additional, Wood, Andrew R, additional, Workalemahu, Tsegaselassie, additional, Hu, Yi-Juan, additional, Lee, Sang Hong, additional, Liang, Liming, additional, Lin, Dan-Yu, additional, Min, Josine L, additional, Neale, Benjamin M, additional, Thorleifsson, Gudmar, additional, Yang, Jian, additional, Albrecht, Eva, additional, Amin, Najaf, additional, Bragg-Gresham, Jennifer L, additional, Cadby, Gemma, additional, den Heijer, Martin, additional, Eklund, Niina, additional, Fischer, Krista, additional, Goel, Anuj, additional, Hottenga, Jouke-Jan, additional, Huffman, Jennifer E, additional, Jarick, Ivonne, additional, Johansson, Åsa, additional, Johnson, Toby, additional, Kanoni, Stavroula, additional, Kleber, Marcus E, additional, König, Inke R, additional, Kristiansson, Kati, additional, Kutalik, Zoltán, additional, Lamina, Claudia, additional, Lecoeur, Cecile, additional, Li, Guo, additional, Mangino, Massimo, additional, McArdle, Wendy L, additional, Medina-Gomez, Carolina, additional, Müller-Nurasyid, Martina, additional, Ngwa, Julius S, additional, Nolte, Ilja M, additional, Paternoster, Lavinia, additional, Pechlivanis, Sonali, additional, Perola, Markus, additional, Peters, Marjolein J, additional, Preuss, Michael, additional, Rose, Lynda M, additional, Shi, Jianxin, additional, Shungin, Dmitry, additional, Smith, Albert Vernon, additional, Strawbridge, Rona J, additional, Surakka, Ida, additional, Teumer, Alexander, additional, Trip, Mieke D, additional, Tyrer, Jonathan, additional, Van Vliet-Ostaptchouk, Jana V, additional, Vandenput, Liesbeth, additional, Waite, Lindsay L, additional, Zhao, Jing Hua, additional, Absher, Devin, additional, Asselbergs, Folkert W, additional, Atalay, Mustafa, additional, Attwood, Antony P, additional, Balmforth, Anthony J, additional, Basart, Hanneke, additional, Beilby, John, additional, Bonnycastle, Lori L, additional, Brambilla, Paolo, additional, Bruinenberg, Marcel, additional, Campbell, Harry, additional, Chasman, Daniel I, additional, Chines, Peter S, additional, Collins, Francis S, additional, Connell, John M, additional, Cookson, William O, additional, de Faire, Ulf, additional, de Vegt, Femmie, additional, Dei, Mariano, additional, Dimitriou, Maria, additional, Edkins, Sarah, additional, Estrada, Karol, additional, Evans, David M, additional, Farrall, Martin, additional, Ferrario, Marco M, additional, Ferrières, Jean, additional, Franke, Lude, additional, Frau, Francesca, additional, Gejman, Pablo V, additional, Grallert, Harald, additional, Grönberg, Henrik, additional, Gudnason, Vilmundur, additional, Hall, Alistair S, additional, Hall, Per, additional, Hartikainen, Anna-Liisa, additional, Hayward, Caroline, additional, Heard-Costa, Nancy L, additional, Heath, Andrew C, additional, Hebebrand, Johannes, additional, Homuth, Georg, additional, Hu, Frank B, additional, Hunt, Sarah E, additional, Hyppönen, Elina, additional, Iribarren, Carlos, additional, Jacobs, Kevin B, additional, Jansson, John-Olov, additional, Jula, Antti, additional, Kähönen, Mika, additional, Kathiresan, Sekar, additional, Kee, Frank, additional, Khaw, Kay-Tee, additional, Kivimäki, Mika, additional, Koenig, Wolfgang, additional, Kraja, Aldi T, additional, Kumari, Meena, additional, Kuulasmaa, Kari, additional, Kuusisto, Johanna, additional, Laitinen, Jaana H, additional, Lakka, Timo A, additional, Langenberg, Claudia, additional, Launer, Lenore J, additional, Lind, Lars, additional, Lindström, Jaana, additional, Liu, Jianjun, additional, Liuzzi, Antonio, additional, Lokki, Marja-Liisa, additional, Lorentzon, Mattias, additional, Madden, Pamela A, additional, Magnusson, Patrik K, additional, Manunta, Paolo, additional, Marek, Diana, additional, März, Winfried, additional, Leach, Irene Mateo, additional, McKnight, Barbara, additional, Medland, Sarah E, additional, Mihailov, Evelin, additional, Milani, Lili, additional, Montgomery, Grant W, additional, Mooser, Vincent, additional, Mühleisen, Thomas W, additional, Munroe, Patricia B, additional, Musk, Arthur W, additional, Narisu, Narisu, additional, Navis, Gerjan, additional, Nicholson, George, additional, Nohr, Ellen A, additional, Ong, Ken K, additional, Oostra, Ben A, additional, Palmer, Colin N A, additional, Palotie, Aarno, additional, Peden, John F, additional, Pedersen, Nancy, additional, Peters, Annette, additional, Polasek, Ozren, additional, Pouta, Anneli, additional, Pramstaller, Peter P, additional, Prokopenko, Inga, additional, Pütter, Carolin, additional, Radhakrishnan, Aparna, additional, Raitakari, Olli, additional, Rendon, Augusto, additional, Rivadeneira, Fernando, additional, Rudan, Igor, additional, Saaristo, Timo E, additional, Sambrook, Jennifer G, additional, Sanders, Alan R, additional, Sanna, Serena, additional, Saramies, Jouko, additional, Schipf, Sabine, additional, Schreiber, Stefan, additional, Schunkert, Heribert, additional, Shin, So-Youn, additional, Signorini, Stefano, additional, Sinisalo, Juha, additional, Skrobek, Boris, additional, Soranzo, Nicole, additional, Stančáková, Alena, additional, Stark, Klaus, additional, Stephens, Jonathan C, additional, Stirrups, Kathleen, additional, Stolk, Ronald P, additional, Stumvoll, Michael, additional, Swift, Amy J, additional, Theodoraki, Eirini V, additional, Thorand, Barbara, additional, Tregouet, David-Alexandre, additional, Tremoli, Elena, additional, Van der Klauw, Melanie M, additional, van Meurs, Joyce B J, additional, Vermeulen, Sita H, additional, Viikari, Jorma, additional, Virtamo, Jarmo, additional, Vitart, Veronique, additional, Waeber, Gérard, additional, Wang, Zhaoming, additional, Widén, Elisabeth, additional, Wild, Sarah H, additional, Willemsen, Gonneke, additional, Winkelmann, Bernhard R, additional, Witteman, Jacqueline C M, additional, Wolffenbuttel, Bruce H R, additional, Wong, Andrew, additional, Wright, Alan F, additional, Zillikens, M Carola, additional, Amouyel, Philippe, additional, Boehm, Bernhard O, additional, Boerwinkle, Eric, additional, Boomsma, Dorret I, additional, Caulfield, Mark J, additional, Chanock, Stephen J, additional, Cupples, L Adrienne, additional, Cusi, Daniele, additional, Dedoussis, George V, additional, Erdmann, Jeanette, additional, Eriksson, Johan G, additional, Franks, Paul W, additional, Froguel, Philippe, additional, Gieger, Christian, additional, Gyllensten, Ulf, additional, Hamsten, Anders, additional, Harris, Tamara B, additional, Hengstenberg, Christian, additional, Hicks, Andrew A, additional, Hingorani, Aroon, additional, Hinney, Anke, additional, Hofman, Albert, additional, Hovingh, Kees G, additional, Hveem, Kristian, additional, Illig, Thomas, additional, Jarvelin, Marjo-Riitta, additional, Jöckel, Karl-Heinz, additional, Keinanen-Kiukaanniemi, Sirkka M, additional, Kiemeney, Lambertus A, additional, Kuh, Diana, additional, Laakso, Markku, additional, Lehtimäki, Terho, additional, Levinson, Douglas F, additional, Martin, Nicholas G, additional, Metspalu, Andres, additional, Morris, Andrew D, additional, Nieminen, Markku S, additional, Njølstad, Inger, additional, Ohlsson, Claes, additional, Oldehinkel, Albertine J, additional, Ouwehand, Willem H, additional, Palmer, Lyle J, additional, Penninx, Brenda, additional, Power, Chris, additional, Province, Michael A, additional, Psaty, Bruce M, additional, Qi, Lu, additional, Rauramaa, Rainer, additional, Ridker, Paul M, additional, Ripatti, Samuli, additional, Salomaa, Veikko, additional, Samani, Nilesh J, additional, Snieder, Harold, additional, Sørensen, Thorkild I A, additional, Spector, Timothy D, additional, Stefansson, Kari, additional, Tönjes, Anke, additional, Tuomilehto, Jaakko, additional, Uitterlinden, André G, additional, Uusitupa, Matti, additional, van der Harst, Pim, additional, Vollenweider, Peter, additional, Wallaschofski, Henri, additional, Wareham, Nicholas J, additional, Watkins, Hugh, additional, Wichmann, H-Erich, additional, Wilson, James F, additional, Abecasis, Goncalo R, additional, Assimes, Themistocles L, additional, Barroso, Inês, additional, Boehnke, Michael, additional, Borecki, Ingrid B, additional, Deloukas, Panos, additional, Fox, Caroline S, additional, Frayling, Timothy, additional, Groop, Leif C, additional, Haritunian, Talin, additional, Heid, Iris M, additional, Hunter, David, additional, Kaplan, Robert C, additional, Karpe, Fredrik, additional, Moffatt, Miriam F, additional, Mohlke, Karen L, additional, O'Connell, Jeffrey R, additional, Pawitan, Yudi, additional, Schadt, Eric E, additional, Schlessinger, David, additional, Steinthorsdottir, Valgerdur, additional, Strachan, David P, additional, Thorsteinsdottir, Unnur, additional, van Duijn, Cornelia M, additional, Visscher, Peter M, additional, Di Blasio, Anna Maria, additional, Hirschhorn, Joel N, additional, Lindgren, Cecilia M, additional, Morris, Andrew P, additional, Meyre, David, additional, Scherag, André, additional, McCarthy, Mark I, additional, Speliotes, Elizabeth K, additional, North, Kari E, additional, Loos, Ruth J F, additional, and Ingelsson, Erik, additional
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- 2013
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23. A principal component meta-analysis on multiple anthropometric traits identifies novel loci for body shape
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Ried, Janina S, Jeff M, Janina, Chu, Audrey Y, Bragg-Gresham, Jennifer L, Van Dongen, Jenny, Huffman, Jennifer E, Ahluwalia, Tarunveer S, Cadby, Gemma, Eklund, Niina, Eriksson, Joel, Esko, Tõnu, Feitosa, Mary F, Goel, Anuj, Gorski, Mathias, Hayward, Caroline, Heard-Costa, Nancy L, Jackson, Anne U, Jokinen, Eero, Kanoni, Stavroula, Kristiansson, Kati, Kutalik, Zoltán, Lahti, Jari, Luan, Jian'an, Mägi, Reedik, Mahajan, Anubha, Mangino, Massimo, Medina-Gomez, Carolina, Monda, Keri L, Nolte, Ilja M, Pérusse, Louis, Prokopenko, Inga, Qi, Lu, Rose, Lynda M, Salvi, Erika, Smith, Megan T, Snieder, Harold, Stančáková, Alena, Ju Sung, Yun, Tachmazidou, Ioanna, Teumer, Alexander, Thorleifsson, Gudmar, Van Der Harst, Pim, Walker, Ryan W, Wang, Sophie R, Wild, Sarah H, Willems, Sara M, Wong, Andrew, Zhang, Weihua, Albrecht, Eva, Couto Alves, Alexessander, Bakker, Stephan JL, Barlassina, Cristina, Bartz, Traci M, Beilby, John, Bellis, Claire, Bergman, Richard N, Bergmann, Sven, Blangero, John, Blüher, Matthias, Boerwinkle, Eric, Bonnycastle, Lori L, Bornstein, Stefan R, Bruinenberg, Marcel, Campbell, Harry, Chen, Yii-Der Ida, Chiang, Charleston WK, Chines, Peter S, Collins, Francis S, Cucca, Fracensco, Cupples, L Adrienne, D'Avila, Francesca, De Geus, Eco JC, Dedoussis, George, Dimitriou, Maria, Döring, Angela, Eriksson, Johan G, Farmaki, Aliki-Eleni, Farrall, Martin, Ferreira, Teresa, Fischer, Krista, Forouhi, Nita G, Friedrich, Nele, Gjesing, Anette Prior, Glorioso, Nicola, Graff, Mariaelisa, Grallert, Harald, Grarup, Niels, Gräßler, Jürgen, Grewal, Jagvir, Hamsten, Anders, Harder, Marie Neergaard, Hartman, Catharina A, Hassinen, Maija, Hastie, Nicholas, Hattersley, Andrew Tym, Havulinna, Aki S, Heliövaara, Markku, Hillege, Hans, Hofman, Albert, Holmen, Oddgeir, Homuth, Georg, Hottenga, Jouke-Jan, Hui, Jennie, Husemoen, Lise Lotte, Hysi, Pirro G, Isaacs, Aaron, Ittermann, Till, Jalilzadeh, Shapour, James, Alan L, Jørgensen, Torben, Jousilahti, Pekka, Jula, Antti, Marie Justesen, Johanne, Justice, Anne E, Kähönen, Mika, Karaleftheri, Maria, Tee Khaw, Kay, Keinanen-Kiukaanniemi, Sirkka M, Kinnunen, Leena, Knekt, Paul B, Koistinen, Heikki A, Kolcic, Ivana, Kooner, Ishminder K, Koskinen, Seppo, Kovacs, Peter, Kyriakou, Theodosios, Laitinen, Tomi, Langenberg, Claudia, Lewin, Alexandra M, Lichtner, Peter, Lindgren, Cecilia M, Lindström, Jaana, Linneberg, Allan, Lorbeer, Roberto, Lorentzon, Mattias, Luben, Robert, Lyssenko, Valeriya, Männistö, Satu, Manunta, Paolo, Leach, Irene Mateo, McArdle, Wendy L, Mcknight, Barbara, Mohlke, Karen L, Mihailov, Evelin, Milani, Lili, Mills, Rebecca, Montasser, May E, Morris, Andrew P, Müller, Gabriele, Musk, Arthur W, Narisu, Narisu, Ong, Ken K, Oostra, Ben A, Osmond, Clive, Palotie, Aarno, Pankow, James S, Paternoster, Lavinia, Penninx, Brenda W, Pichler, Irene, Pilia, Maria G, Polašek, Ozren, Pramstaller, Peter P, Raitakari, Olli T, Rankinen, Tuomo, Rao, DC, Rayner, Nigel W, Ribel-Madsen, Rasmus, Rice, Treva K, Richards, Marcus, Ridker, Paul M, Rivadeneira, Fernando, Ryan, Kathy A, Sanna, Serena, Sarzynski, Mark A, Scholtens, Salome, Scott, Robert A, Sebert, Sylvain, Southam, Lorraine, Sparsø, Thomas Hempel, Steinthorsdottir, Valgerdur, Stirrups, Kathleen, Stolk, Ronald P, Strauch, Konstantin, Stringham, Heather M, Swertz, Morris A, Swift, Amy J, Tönjes, Anke, Tsafantakis, Emmanouil, Van Der Most, Peter J, Van Vliet-Ostaptchouk, Jana V, Vandenput, Liesbeth, Vartiainen, Erkki, Venturini, Cristina, Verweij, Niek, Viikari, Jorma S, Vitart, Veronique, Vohl, Marie-Claude, Vonk, Judith M, Waeber, Gérard, Widén, Elisabeth, Willemsen, Gonneke, Wilsgaard, Tom, Winkler, Thomas W, Wright, Alan F, Yerges-Armstrong, Laura M, Hua Zhao, Jing, Zillikens, M Carola, Boomsma, Dorret I, Bouchard, Claude, Chambers, John C, Chasman, Daniel I, Cusi, Daniele, Gansevoort, Ron T, Gieger, Christian, Hansen, Torben, Hicks, Andrew A, Hu, Frank, Hveem, Kristian, Jarvelin, Marjo-Riitta, Kajantie, Eero, Kooner, Jaspal S, Kuh, Diana, Kuusisto, Johanna, Laakso, Markku, Lakka, Timo A, Lehtimäki, Terho, Metspalu, Andres, Njølstad, Inger, Ohlsson, Claes, Oldehinkel, Albertine J, Palmer, Lyle J, Pedersen, Oluf, Perola, Markus, Peters, Annette, Psaty, Bruce M, Puolijoki, Hannu, Rauramaa, Rainer, Rudan, Igor, Salomaa, Veikko, Schwarz, Peter EH, Shudiner, Alan R, Smit, Jan H, Sørensen, Thorkild IA, Spector, Timothy D, Stefansson, Kari, Stumvoll, Michael, Tremblay, Angelo, Tuomilehto, Jaakko, Uitterlinden, André G, Uusitupa, Matti, Völker, Uwe, Vollenweider, Peter, Wareham, Nicholas J, Watkins, Hugh, Wilson, James F, Zeggini, Eleftheria, Abecasis, Goncalo R, Boehnke, Michael, Borecki, Ingrid B, Deloukas, Panos, Van Duijn, Cornelia M, Fox, Caroline, Groop, Leif C, Heid, Iris M, Hunter, David J, Kaplan, Robert C, McCarthy, Mark I, North, Kari E, O'Connell, Jeffrey R, Schlessinger, David, Thorsteinsdottir, Unnur, Strachan, David P, Frayling, Timothy, Hirschhorn, Joel N, Müller-Nurasyid, Martina, and Loos, Ruth JF
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2. Zero hunger ,Principal Component Analysis ,Anthropometry ,Genotype ,Models, Genetic ,Body Size ,Humans ,Genome-Wide Association Study - Abstract
Large consortia have revealed hundreds of genetic loci associated with anthropometric traits, one trait at a time. We examined whether genetic variants affect body shape as a composite phenotype that is represented by a combination of anthropometric traits. We developed an approach that calculates averaged PCs (AvPCs) representing body shape derived from six anthropometric traits (body mass index, height, weight, waist and hip circumference, waist-to-hip ratio). The first four AvPCs explain >99% of the variability, are heritable, and associate with cardiometabolic outcomes. We performed genome-wide association analyses for each body shape composite phenotype across 65 studies and meta-analysed summary statistics. We identify six novel loci: LEMD2 and CD47 for AvPC1, RPS6KA5/C14orf159 and GANAB for AvPC3, and ARL15 and ANP32 for AvPC4. Our findings highlight the value of using multiple traits to define complex phenotypes for discovery, which are not captured by single-trait analyses, and may shed light onto new pathways.
24. Protein-coding variants implicate novel genes related to lipid homeostasis contributing to body-fat distribution
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Justice, Anne E, Karaderi, Tugce, Highland, Heather M, Young, Kristin L, Graff, Mariaelisa, Lu, Yingchang, Turcot, Valérie, Auer, Paul L, Fine, Rebecca S, Guo, Xiuqing, Schurmann, Claudia, Lempradl, Adelheid, Marouli, Eirini, Mahajan, Anubha, Winkler, Thomas W, Locke, Adam E, Medina-Gomez, Carolina, Esko, Tõnu, Vedantam, Sailaja, Giri, Ayush, Lo, Ken Sin, Alfred, Tamuno, Mudgal, Poorva, Ng, Maggie CY, Heard-Costa, Nancy L, Feitosa, Mary F, Manning, Alisa K, Willems, Sara M, Sivapalaratnam, Suthesh, Abecasis, Goncalo, Alam, Dewan S, Allison, Matthew, Amouyel, Philippe, Arzumanyan, Zorayr, Balkau, Beverley, Bastarache, Lisa, Bergmann, Sven, Bielak, Lawrence F, Blüher, Matthias, Boehnke, Michael, Boeing, Heiner, Boerwinkle, Eric, Böger, Carsten A, Bork-Jensen, Jette, Bottinger, Erwin P, Bowden, Donald W, Brandslund, Ivan, Broer, Linda, Burt, Amber A, Butterworth, Adam S, Caulfield, Mark J, Cesana, Giancarlo, Chambers, John C, Chasman, Daniel I, Chen, Yii-Der Ida, Chowdhury, Rajiv, Christensen, Cramer, Chu, Audrey Y, Collins, Francis S, Cook, James P, Cox, Amanda J, Crosslin, David S, Danesh, John, De Bakker, Paul IW, Denus, Simon De, Mutsert, Renée De, Dedoussis, George, Demerath, Ellen W, Dennis, Joe G, Denny, Josh C, Di Angelantonio, Emanuele, Dörr, Marcus, Drenos, Fotios, Dubé, Marie-Pierre, Dunning, Alison M, Easton, Douglas F, Elliott, Paul, Evangelou, Evangelos, Farmaki, Aliki-Eleni, Feng, Shuang, Ferrannini, Ele, Ferrieres, Jean, Florez, Jose C, Fornage, Myriam, Fox, Caroline S, Franks, Paul W, Friedrich, Nele, Gan, Wei, Gandin, Ilaria, Gasparini, Paolo, Giedraitis, Vilmantas, Girotto, Giorgia, Gorski, Mathias, Grallert, Harald, Grarup, Niels, Grove, Megan L, Gustafsson, Stefan, Haessler, Jeff, Hansen, Torben, Hattersley, Andrew T, Hayward, Caroline, Heid, Iris M, Holmen, Oddgeir L, Hovingh, G Kees, Howson, Joanna MM, Hu, Yao, Hung, Yi-Jen, Hveem, Kristian, Ikram, M Arfan, Ingelsson, Erik, Jackson, Anne U, Jarvik, Gail P, Jia, Yucheng, Jørgensen, Torben, Jousilahti, Pekka, Justesen, Johanne M, Kahali, Bratati, Karaleftheri, Maria, Kardia, Sharon LR, Karpe, Fredrik, Kee, Frank, Kitajima, Hidetoshi, Komulainen, Pirjo, Kooner, Jaspal S, Kovacs, Peter, Krämer, Bernhard K, Kuulasmaa, Kari, Kuusisto, Johanna, Laakso, Markku, Lakka, Timo A, Lamparter, David, Lange, Leslie A, Langenberg, Claudia, Larson, Eric B, Lee, Nanette R, Lee, Wen-Jane, Lehtimäki, Terho, Lewis, Cora E, Li, Huaixing, Li, Jin, Li-Gao, Ruifang, Lin, Li-An, Lin, Xu, Lind, Lars, Lindström, Jaana, Linneberg, Allan, Liu, Ching-Ti, Liu, Dajiang J, Luan, Jian'an, Lyytikäinen, Leo-Pekka, MacGregor, Stuart, Mägi, Reedik, Männistö, Satu, Marenne, Gaëlle, Marten, Jonathan, Masca, Nicholas GD, McCarthy, Mark I, Meidtner, Karina, Mihailov, Evelin, Moilanen, Leena, Moitry, Marie, Mook-Kanamori, Dennis O, Morgan, Anna, Morris, Andrew P, Müller-Nurasyid, Martina, Munroe, Patricia B, Narisu, Narisu, Nelson, Christopher P, Neville, Matt, Ntalla, Ioanna, O'Connell, Jeffrey R, Owen, Katharine R, Pedersen, Oluf, Peloso, Gina M, Pennell, Craig E, Perola, Markus, Perry, James A, Perry, John RB, Pers, Tune H, Ewing, Ailith, Polasek, Ozren, Raitakari, Olli T, Rasheed, Asif, Raulerson, Chelsea K, Rauramaa, Rainer, Reilly, Dermot F, Reiner, Alex P, Ridker, Paul M, Rivas, Manuel A, Robertson, Neil R, Robino, Antonietta, Rudan, Igor, Ruth, Katherine S, Saleheen, Danish, Salomaa, Veikko, Samani, Nilesh J, Schreiner, Pamela J, Schulze, Matthias B, Scott, Robert A, Segura-Lepe, Marcelo, Sim, Xueling, Slater, Andrew J, Small, Kerrin S, Smith, Blair H, Smith, Jennifer A, Southam, Lorraine, Spector, Timothy D, Speliotes, Elizabeth K, Stefansson, Kari, Steinthorsdottir, Valgerdur, Stirrups, Kathleen E, Strauch, Konstantin, Stringham, Heather M, Stumvoll, Michael, Sun, Liang, Surendran, Praveen, Swart, Karin MA, Tardif, Jean-Claude, Taylor, Kent D, Teumer, Alexander, Thompson, Deborah J, Thorleifsson, Gudmar, Thorsteinsdottir, Unnur, Thuesen, Betina H, Tönjes, Anke, Torres, Mina, Tsafantakis, Emmanouil, Tuomilehto, Jaakko, Uitterlinden, André G, Uusitupa, Matti, Van Duijn, Cornelia M, Vanhala, Mauno, Varma, Rohit, Vermeulen, Sita H, Vestergaard, Henrik, Vitart, Veronique, Vogt, Thomas F, Vuckovic, Dragana, Wagenknecht, Lynne E, Walker, Mark, Wallentin, Lars, Wang, Feijie, Wang, Carol A, Wang, Shuai, Wareham, Nicholas J, Warren, Helen R, Waterworth, Dawn M, Wessel, Jennifer, White, Harvey D, Willer, Cristen J, Wilson, James G, Wood, Andrew R, Wu, Ying, Yaghootkar, Hanieh, Yao, Jie, Yerges-Armstrong, Laura M, Young, Robin, Zeggini, Eleftheria, Zhan, Xiaowei, Zhang, Weihua, Zhao, Jing Hua, Zhao, Wei, Zheng, He, Zhou, Wei, Zillikens, M Carola, Rivadeneira, Fernando, Borecki, Ingrid B, Pospisilik, J Andrew, Deloukas, Panos, Frayling, Timothy M, Lettre, Guillaume, Mohlke, Karen L, Rotter, Jerome I, Kutalik, Zoltán, Hirschhorn, Joel N, Cupples, L Adrienne, Loos, Ruth JF, North, Kari E, Lindgren, Cecilia M, CHD Exome+ Consortium, Cohorts For Heart And Aging Research In Genomic Epidemiology (CHARGE) Consortium, EPIC-CVD Consortium, ExomeBP Consortium, Global Lipids Genetic Consortium, GoT2D Genes Consortium, InterAct, ReproGen Consortium, T2D-Genes Consortium, and MAGIC Investigators
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2. Zero hunger ,Male ,Waist-Hip Ratio ,Genetic Variation ,Proteins ,Lipids ,Body Mass Index ,Gene Frequency ,Risk Factors ,Case-Control Studies ,Animals ,Body Fat Distribution ,Homeostasis ,Humans ,Drosophila ,Exome ,Female ,Genetic Predisposition to Disease ,Genome-Wide Association Study - Abstract
Body-fat distribution is a risk factor for adverse cardiovascular health consequences. We analyzed the association of body-fat distribution, assessed by waist-to-hip ratio adjusted for body mass index, with 228,985 predicted coding and splice site variants available on exome arrays in up to 344,369 individuals from five major ancestries (discovery) and 132,177 European-ancestry individuals (validation). We identified 15 common (minor allele frequency, MAF ≥5%) and nine low-frequency or rare (MAF
25. Trans-ancestry meta-analyses identify rare and common variants associated with blood pressure and hypertension
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Surendran, Praveen, Drenos, Fotios, Young, Robin, Warren, Helen, Cook, James P, Manning, Alisa K, Grarup, Niels, Sim, Xueling, Barnes, Daniel R, Witkowska, Kate, Staley, James R, Tragante, Vinicius, Tukiainen, Taru, Yaghootkar, Hanieh, Masca, Nicholas, Freitag, Daniel F, Ferreira, Teresa, Giannakopoulou, Olga, Tinker, Andrew, Harakalova, Magdalena, Mihailov, Evelin, Liu, Chunyu, Kraja, Aldi T, Fallgaard Nielsen, Sune, Rasheed, Asif, Samuel, Maria, Zhao, Wei, Bonnycastle, Lori L, Jackson, Anne U, Narisu, Narisu, Swift, Amy J, Southam, Lorraine, Marten, Jonathan, Huyghe, Jeroen R, Stančáková, Alena, Fava, Cristiano, Ohlsson, Therese, Matchan, Angela, Stirrups, Kathleen E, Bork-Jensen, Jette, Gjesing, Anette P, Kontto, Jukka, Perola, Markus, Shaw-Hawkins, Susan, Havulinna, Aki S, Zhang, He, Donnelly, Louise A, Groves, Christopher J, Rayner, N William, Neville, Matt J, Robertson, Neil R, Yiorkas, Andrianos M, Herzig, Karl-Heinz, Kajantie, Eero, Zhang, Weihua, Willems, Sara M, Lannfelt, Lars, Malerba, Giovanni, Soranzo, Nicole, Trabetti, Elisabetta, Verweij, Niek, Evangelou, Evangelos, Moayyeri, Alireza, Vergnaud, Anne-Claire, Nelson, Christopher P, Poveda, Alaitz, Varga, Tibor V, Caslake, Muriel, De Craen, Anton Jm, Trompet, Stella, Luan, Jian'an, Scott, Robert A, Harris, Sarah E, Liewald, David Cm, Marioni, Riccardo, Menni, Cristina, Farmaki, Aliki-Eleni, Hallmans, Göran, Renström, Frida, Huffman, Jennifer E, Hassinen, Maija, Burgess, Stephen, Vasan, Ramachandran S, Felix, Janine F, CHARGE-Heart Failure Consortium, Uria-Nickelsen, Maria, Malarstig, Anders, Reily, Dermot F, Hoek, Maarten, Vogt, Thomas, Lin, Honghuang, Lieb, Wolfgang, EchoGen Consortium, Traylor, Matthew, Markus, Hugh F, METASTROKE Consortium, Highland, Heather M, Justice, Anne E, Marouli, Eirini, GIANT Consortium, Lindström, Jaana, Uusitupa, Matti, Komulainen, Pirjo, Lakka, Timo A, Rauramaa, Rainer, Polasek, Ozren, Rudan, Igor, Rolandsson, Olov, Franks, Paul W, Dedoussis, George, Spector, Timothy D, EPIC-InterAct Consortium, Jousilahti, Pekka, Männistö, Satu, Deary, Ian J, Starr, John M, Langenberg, Claudia, Wareham, Nick J, Brown, Morris J, Dominiczak, Anna F, Connell, John M, Jukema, J Wouter, Sattar, Naveed, Ford, Ian, Packard, Chris J, Esko, Tõnu, Mägi, Reedik, Metspalu, Andres, De Boer, Rudolf A, Van Der Meer, Peter, Van Der Harst, Pim, Lifelines Cohort Study, Gambaro, Giovanni, Ingelsson, Erik, Lind, Lars, De Bakker, Paul Iw, Numans, Mattijs E, Brandslund, Ivan, Christensen, Cramer, Petersen, Eva Rb, Korpi-Hyövälti, Eeva, Oksa, Heikki, Chambers, John C, Kooner, Jaspal S, Blakemore, Alexandra If, Franks, Steve, Jarvelin, Marjo-Riitta, Husemoen, Lise L, Linneberg, Allan, Skaaby, Tea, Thuesen, Betina, Karpe, Fredrik, Tuomilehto, Jaakko, Doney, Alex Sf, Morris, Andrew D, Palmer, Colin Na, Holmen, Oddgeir Lingaas, Hveem, Kristian, Willer, Cristen J, Tuomi, Tiinamaija, Groop, Leif, Käräjämäki, AnneMari, Palotie, Aarno, Ripatti, Samuli, Salomaa, Veikko, Alam, Dewan S, Shafi Majumder, Abdulla Al, Di Angelantonio, Emanuele, Chowdhury, Rajiv, McCarthy, Mark I, Poulter, Neil, Stanton, Alice V, Sever, Peter, Amouyel, Philippe, Arveiler, Dominique, Blankenberg, Stefan, Ferrières, Jean, Kee, Frank, Kuulasmaa, Kari, Müller-Nurasyid, Martina, Veronesi, Giovanni, Virtamo, Jarmo, Deloukas, Panos, Wellcome Trust Case Control Consortium, Elliott, Paul, Understanding Society Scientific Group, Zeggini, Eleftheria, Kathiresan, Sekar, Melander, Olle, Kuusisto, Johanna, Laakso, Markku, Padmanabhan, Sandosh, Porteous, David, Hayward, Caroline, Scotland, Generation, Collins, Francis S, Mohlke, Karen L, Hansen, Torben, Pedersen, Oluf, Boehnke, Michael, Stringham, Heather M, EPIC-CVD Consortium, Frossard, Philippe, Newton-Cheh, Christopher, CHARGE+ Exome Chip Blood Pressure Consortium, Tobin, Martin D, Nordestgaard, Børge Grønne, T2D-GENES Consortium, GoT2DGenes Consortium, ExomeBP Consortium, CHD Exome+ Consortium, Caulfield, Mark J, Mahajan, Anubha, Morris, Andrew P, Tomaszewski, Maciej, Samani, Nilesh J, Saleheen, Danish, Asselbergs, Folkert W, Lindgren, Cecilia M, Danesh, John, Wain, Louise V, Butterworth, Adam S, Howson, Joanna Mm, and Munroe, Patricia B
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Genotype ,Hypertension ,Genetic Variation ,Humans ,Blood Pressure ,Genetic Predisposition to Disease ,3. Good health ,Genome-Wide Association Study - Abstract
High blood pressure is a major risk factor for cardiovascular disease and premature death. However, there is limited knowledge on specific causal genes and pathways. To better understand the genetics of blood pressure, we genotyped 242,296 rare, low-frequency and common genetic variants in up to 192,763 individuals and used ∼155,063 samples for independent replication. We identified 30 new blood pressure- or hypertension-associated genetic regions in the general population, including 3 rare missense variants in RBM47, COL21A1 and RRAS with larger effects (>1.5 mm Hg/allele) than common variants. Multiple rare nonsense and missense variant associations were found in A2ML1, and a low-frequency nonsense variant in ENPEP was identified. Our data extend the spectrum of allelic variation underlying blood pressure traits and hypertension, provide new insights into the pathophysiology of hypertension and indicate new targets for clinical intervention.
26. Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity
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Turcot, Valérie, Lu, Yingchang, Highland, Heather M, Schurmann, Claudia, Justice, Anne E, Fine, Rebecca S, Bradfield, Jonathan P, Esko, Tõnu, Giri, Ayush, Graff, Mariaelisa, Guo, Xiuqing, Hendricks, Audrey E, Karaderi, Tugce, Lempradl, Adelheid, Locke, Adam E, Mahajan, Anubha, Marouli, Eirini, Sivapalaratnam, Suthesh, Young, Kristin L, Alfred, Tamuno, Feitosa, Mary F, Masca, Nicholas GD, Manning, Alisa K, Medina-Gomez, Carolina, Mudgal, Poorva, Ng, Maggie CY, Reiner, Alex P, Vedantam, Sailaja, Willems, Sara M, Winkler, Thomas W, Abecasis, Gonçalo, Aben, Katja K, Alam, Dewan S, Alharthi, Sameer E, Allison, Matthew, Amouyel, Philippe, Asselbergs, Folkert W, Auer, Paul L, Balkau, Beverley, Bang, Lia E, Barroso, Inês, Bastarache, Lisa, Benn, Marianne, Bergmann, Sven, Bielak, Lawrence F, Blüher, Matthias, Boehnke, Michael, Boeing, Heiner, Boerwinkle, Eric, Böger, Carsten A, Bork-Jensen, Jette, Bots, Michiel L, Bottinger, Erwin P, Bowden, Donald W, Brandslund, Ivan, Breen, Gerome, Brilliant, Murray H, Broer, Linda, Brumat, Marco, Burt, Amber A, Butterworth, Adam S, Campbell, Peter T, Cappellani, Stefania, Carey, David J, Catamo, Eulalia, Caulfield, Mark J, Chambers, John C, Chasman, Daniel I, Chen, Yii-Der I, Chowdhury, Rajiv, Christensen, Cramer, Chu, Audrey Y, Cocca, Massimiliano, Collins, Francis S, Cook, James P, Corley, Janie, Corominas Galbany, Jordi, Cox, Amanda J, Crosslin, David S, Cuellar-Partida, Gabriel, D'Eustacchio, Angela, Danesh, John, Davies, Gail, Bakker, Paul IW, Groot, Mark CH, Mutsert, Renée, Deary, Ian J, Dedoussis, George, Demerath, Ellen W, Heijer, Martin, Hollander, Anneke I, Ruijter, Hester M, Dennis, Joe G, Denny, Josh C, Di Angelantonio, Emanuele, Drenos, Fotios, Du, Mengmeng, Dubé, Marie-Pierre, Dunning, Alison M, Easton, Douglas F, Edwards, Todd L, Ellinghaus, David, Ellinor, Patrick T, Elliott, Paul, Evangelou, Evangelos, Farmaki, Aliki-Eleni, Farooqi, I Sadaf, Faul, Jessica D, Fauser, Sascha, Feng, Shuang, Ferrannini, Ele, Ferrieres, Jean, 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2. Zero hunger ,Adult ,Male ,Genetic Variation ,Proteins ,Syndrome ,Body Mass Index ,Gene Frequency ,Animals ,Humans ,Drosophila ,Female ,Obesity ,Energy Intake ,Energy Metabolism - Abstract
Genome-wide association studies (GWAS) have identified >250 loci for body mass index (BMI), implicating pathways related to neuronal biology. Most GWAS loci represent clusters of common, noncoding variants from which pinpointing causal genes remains challenging. Here we combined data from 718,734 individuals to discover rare and low-frequency (minor allele frequency (MAF) < 5%) coding variants associated with BMI. We identified 14 coding variants in 13 genes, of which 8 variants were in genes (ZBTB7B, ACHE, RAPGEF3, RAB21, ZFHX3, ENTPD6, ZFR2 and ZNF169) newly implicated in human obesity, 2 variants were in genes (MC4R and KSR2) previously observed to be mutated in extreme obesity and 2 variants were in GIPR. The effect sizes of rare variants are ~10 times larger than those of common variants, with the largest effect observed in carriers of an MC4R mutation introducing a stop codon (p.Tyr35Ter, MAF = 0.01%), who weighed ~7 kg more than non-carriers. Pathway analyses based on the variants associated with BMI confirm enrichment of neuronal genes and provide new evidence for adipocyte and energy expenditure biology, widening the potential of genetically supported therapeutic targets in obesity.
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