1. Structure-activity relationship studies of isoquinolinone type anticancer agent
- Author
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You Na Lee, Byung-Ho Chung, Joon Yeol Lee, Sang-Un Choi, Joon Suck Park, Won-Jea Cho, Chong-Ock Lee, Seung Hoon Cheon, Bo-Gil Choi, and Hyo Yi
- Subjects
Magnetic Resonance Spectroscopy ,Chemistry ,Organic Chemistry ,Pharmacology toxicology ,Antineoplastic Agents ,Pharmacology ,Isoquinolines ,In vitro ,Structure-Activity Relationship ,Cell culture ,Drug Discovery ,Tumor Cells, Cultured ,Humans ,Molecular Medicine ,Structure–activity relationship ,Indicators and Reagents ,Drug Screening Assays, Antitumor ,Cytotoxicity ,Human cancer - Abstract
Substituted isoquinolin-1-ones (1) were synthesized to test their in vitro anticancer activity. 3-Biphenyl-N-methylisoquinolin-1-one (7) showed the most potent anticancer activity against five different human cancer cell lines.
- Published
- 2001
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