22 results on '"Johnstone, R. W."'
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2. A pharmacogenomic approach validates AG-221 as an effective and on-target therapy in IDH2 mutant AML
3. HDAC3 activity is required for initiation of leukemogenesis in acute promyelocytic leukemia
4. The SMAC mimetic, LCL-161, reduces survival in aggressive MYC-driven lymphoma while promoting susceptibility to endotoxic shock
5. A genome scale RNAi screen identifies GLI1 as a novel gene regulating vorinostat sensitivity
6. Scribble acts as an oncogene in Eμ-myc-driven lymphoma
7. A functional genomics screen identifies PCAF and ADA3 as regulators of human granzyme B-mediated apoptosis and Bid cleavage
8. CDK9 inhibition by dinaciclib potently suppresses Mcl-1 to induce durable apoptotic responses in aggressive MYC-driven B-cell lymphoma in vivo
9. The role of p21waf1/cip1 and p27Kip1 in HDACi-mediated tumor cell death and cell cycle arrest in the Eμ-myc model of B-cell lymphoma
10. Preclinical screening of histone deacetylase inhibitors combined with ABT-737, rhTRAIL/MD5-1 or 5-azacytidine using syngeneic Vk*MYC multiple myeloma
11. HDAC inhibitors induce tumor-cell-selective pro-apoptotic transcriptional responses
12. Thalidomide-analogue biology: immunological, molecular and epigenetic targets in cancer therapy
13. Translation inhibitors induce cell death by multiple mechanisms and Mcl-1 reduction is only a minor contributor
14. Induction of autophagy does not alter the anti-tumor effects of HDAC inhibitors
15. Granzyme B triggers a prolonged pressure to die in Bcl-2 overexpressing cells, defining a window of opportunity for effective treatment with ABT-737
16. Non-uniform residual stress assembly for free-space optical systems
17. Cell death research, on an island girt by sea
18. Histone deacetylase inhibitors are unable to synergize with ABT-737 in killing primary chronic lymphocytic leukaemia cells in vitro
19. Efficacy of CHK inhibitors as single agents in MYC-driven lymphoma cells
20. Blocking granule-mediated death by primary human NK cells requires both protection of mitochondria and inhibition of caspase activity
21. Mutational analysis of P-glycoprotein: suppression of caspase activation in the absence of ATP-dependent drug efflux
22. P-glycoprotein inhibits caspase-8 activation but not formation of the death inducing signal complex (disc) following Fas ligation
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