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8 results on '"Johnson, Randi K"'

1. Multi-omics in nasal epithelium reveals three axes of dysregulation for asthma risk in the African Diaspora populations

Author

Szczesny, Brooke, primary, Boorgula, Meher Preethi, additional, Chavan, Sameer, additional, Campbell, Monica, additional, Johnson, Randi K., additional, Kammers, Kai, additional, Thompson, Emma E., additional, Cox, Madison S., additional, Shankar, Gautam, additional, Cox, Corey, additional, Morin, Andréanne, additional, Lorizio, Wendy, additional, Daya, Michelle, additional, Kelada, Samir N. P., additional, Beaty, Terri H., additional, Doumatey, Ayo P., additional, Cruz, Alvaro A., additional, Watson, Harold, additional, Naureckas, Edward T., additional, Giles, B. Louise, additional, Arinola, Ganiyu A., additional, Sogaolu, Olumide, additional, Falade, Adegoke G., additional, Hansel, Nadia N., additional, Yang, Ivana V., additional, Olopade, Christopher O., additional, Rotimi, Charles N., additional, Landis, R. Clive, additional, Figueiredo, Camila A., additional, Altman, Matthew C., additional, Kenny, Eimear, additional, Ruczinski, Ingo, additional, Liu, Andrew H., additional, Ober, Carole, additional, Taub, Margaret A., additional, Barnes, Kathleen C., additional, and Mathias, Rasika A., additional

Published
2024
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2. Second international consensus report on gaps and opportunities for the clinical translation of precision diabetes medicine

Author

Tobias, Deirdre K., primary, Merino, Jordi, additional, Ahmad, Abrar, additional, Aiken, Catherine, additional, Benham, Jamie L., additional, Bodhini, Dhanasekaran, additional, Clark, Amy L., additional, Colclough, Kevin, additional, Corcoy, Rosa, additional, Cromer, Sara J., additional, Duan, Daisy, additional, Felton, Jamie L., additional, Francis, Ellen C., additional, Gillard, Pieter, additional, Gingras, Véronique, additional, Gaillard, Romy, additional, Haider, Eram, additional, Hughes, Alice, additional, Ikle, Jennifer M., additional, Jacobsen, Laura M., additional, Kahkoska, Anna R., additional, Kettunen, Jarno L. T., additional, Kreienkamp, Raymond J., additional, Lim, Lee-Ling, additional, Männistö, Jonna M. E., additional, Massey, Robert, additional, Mclennan, Niamh-Maire, additional, Miller, Rachel G., additional, Morieri, Mario Luca, additional, Most, Jasper, additional, Naylor, Rochelle N., additional, Ozkan, Bige, additional, Patel, Kashyap Amratlal, additional, Pilla, Scott J., additional, Prystupa, Katsiaryna, additional, Raghavan, Sridharan, additional, Rooney, Mary R., additional, Schön, Martin, additional, Semnani-Azad, Zhila, additional, Sevilla-Gonzalez, Magdalena, additional, Svalastoga, Pernille, additional, Takele, Wubet Worku, additional, Tam, Claudia Ha-ting, additional, Thuesen, Anne Cathrine B., additional, Tosur, Mustafa, additional, Wallace, Amelia S., additional, Wang, Caroline C., additional, Wong, Jessie J., additional, Yamamoto, Jennifer M., additional, Young, Katherine, additional, Amouyal, Chloé, additional, Andersen, Mette K., additional, Bonham, Maxine P., additional, Chen, Mingling, additional, Cheng, Feifei, additional, Chikowore, Tinashe, additional, Chivers, Sian C., additional, Clemmensen, Christoffer, additional, Dabelea, Dana, additional, Dawed, Adem Y., additional, Deutsch, Aaron J., additional, Dickens, Laura T., additional, DiMeglio, Linda A., additional, Dudenhöffer-Pfeifer, Monika, additional, Evans-Molina, Carmella, additional, Fernández-Balsells, María Mercè, additional, Fitipaldi, Hugo, additional, Fitzpatrick, Stephanie L., additional, Gitelman, Stephen E., additional, Goodarzi, Mark O., additional, Grieger, Jessica A., additional, Guasch-Ferré, Marta, additional, Habibi, Nahal, additional, Hansen, Torben, additional, Huang, Chuiguo, additional, Harris-Kawano, Arianna, additional, Ismail, Heba M., additional, Hoag, Benjamin, additional, Johnson, Randi K., additional, Jones, Angus G., additional, Koivula, Robert W., additional, Leong, Aaron, additional, Leung, Gloria K. W., additional, Libman, Ingrid M., additional, Liu, Kai, additional, Long, S. Alice, additional, Lowe, William L., additional, Morton, Robert W., additional, Motala, Ayesha A., additional, Onengut-Gumuscu, Suna, additional, Pankow, James S., additional, Pathirana, Maleesa, additional, Pazmino, Sofia, additional, Perez, Dianna, additional, Petrie, John R., additional, Powe, Camille E., additional, Quinteros, Alejandra, additional, Jain, Rashmi, additional, Ray, Debashree, additional, Ried-Larsen, Mathias, additional, Saeed, Zeb, additional, Santhakumar, Vanessa, additional, Kanbour, Sarah, additional, Sarkar, Sudipa, additional, Monaco, Gabriela S. F., additional, Scholtens, Denise M., additional, Selvin, Elizabeth, additional, Sheu, Wayne Huey-Herng, additional, Speake, Cate, additional, Stanislawski, Maggie A., additional, Steenackers, Nele, additional, Steck, Andrea K., additional, Stefan, Norbert, additional, Støy, Julie, additional, Taylor, Rachael, additional, Tye, Sok Cin, additional, Ukke, Gebresilasea Gendisha, additional, Urazbayeva, Marzhan, additional, Van der Schueren, Bart, additional, Vatier, Camille, additional, Wentworth, John M., additional, Hannah, Wesley, additional, White, Sara L., additional, Yu, Gechang, additional, Zhang, Yingchai, additional, Zhou, Shao J., additional, Beltrand, Jacques, additional, Polak, Michel, additional, Aukrust, Ingvild, additional, de Franco, Elisa, additional, Flanagan, Sarah E., additional, Maloney, Kristin A., additional, McGovern, Andrew, additional, Molnes, Janne, additional, Nakabuye, Mariam, additional, Njølstad, Pål Rasmus, additional, Pomares-Millan, Hugo, additional, Provenzano, Michele, additional, Saint-Martin, Cécile, additional, Zhang, Cuilin, additional, Zhu, Yeyi, additional, Auh, Sungyoung, additional, de Souza, Russell, additional, Fawcett, Andrea J., additional, Gruber, Chandra, additional, Mekonnen, Eskedar Getie, additional, Mixter, Emily, additional, Sherifali, Diana, additional, Eckel, Robert H., additional, Nolan, John J., additional, Philipson, Louis H., additional, Brown, Rebecca J., additional, Billings, Liana K., additional, Boyle, Kristen, additional, Costacou, Tina, additional, Dennis, John M., additional, Florez, Jose C., additional, Gloyn, Anna L., additional, Gomez, Maria F., additional, Gottlieb, Peter A., additional, Greeley, Siri Atma W., additional, Griffin, Kurt, additional, Hattersley, Andrew T., additional, Hirsch, Irl B., additional, Hivert, Marie-France, additional, Hood, Korey K., additional, Josefson, Jami L., additional, Kwak, Soo Heon, additional, Laffel, Lori M., additional, Lim, Siew S., additional, Loos, Ruth J. F., additional, Ma, Ronald C. W., additional, Mathieu, Chantal, additional, Mathioudakis, Nestoras, additional, Meigs, James B., additional, Misra, Shivani, additional, Mohan, Viswanathan, additional, Murphy, Rinki, additional, Oram, Richard, additional, Owen, Katharine R., additional, Ozanne, Susan E., additional, Pearson, Ewan R., additional, Perng, Wei, additional, Pollin, Toni I., additional, Pop-Busui, Rodica, additional, Pratley, Richard E., additional, Redman, Leanne M., additional, Redondo, Maria J., additional, Reynolds, Rebecca M., additional, Semple, Robert K., additional, Sherr, Jennifer L., additional, Sims, Emily K., additional, Sweeting, Arianne, additional, Tuomi, Tiinamaija, additional, Udler, Miriam S., additional, Vesco, Kimberly K., additional, Vilsbøll, Tina, additional, Wagner, Robert, additional, Rich, Stephen S., additional, and Franks, Paul W., additional

Published
2023
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4. Predictors of oxylipins in a healthy pediatric population

Author

Buckner, Teresa, primary, Vanderlinden, Lauren A., additional, Johnson, Randi K., additional, DeFelice, Brian C., additional, Carry, Patrick M., additional, Seifert, Jennifer, additional, Waugh, Kathleen, additional, Dong, Fran, additional, Fiehn, Oliver, additional, Clare-Salzler, Michael, additional, Rewers, Marian, additional, and Norris, Jill M., additional

Published
2020
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6. Longitudinal DNA methylation differences precede type 1 diabetes

Author

Johnson, Randi K., primary, Vanderlinden, Lauren A., additional, Dong, Fran, additional, Carry, Patrick M., additional, Seifert, Jennifer, additional, Waugh, Kathleen, additional, Shorrosh, Hanan, additional, Fingerlin, Tasha, additional, Frohnert, Brigitte I., additional, Yang, Ivana V., additional, Kechris, Katerina, additional, Rewers, Marian, additional, and Norris, Jill M., additional

Published
2020
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7. Metabolite-related dietary patterns and the development of islet autoimmunity

Author

Johnson, Randi K., Vanderlinden, Lauren, DeFelice, Brian C., Kechris, Katerina, Uusitalo, Ulla, Fiehn, Oliver, Sontag, Marci, Crume, Tessa, Beyerlein, Andreas, Lernmark, Åke, Toppari, Jorma, Ziegler, Anette-G., She, Jin-Xiong, Hagopian, William, Rewers, Marian, Akolkar, Beena, Krischer, Jeffrey, Virtanen, Suvi M., Norris, Jill M., TEDDY study group, Yhteiskuntatieteiden tiedekunta - Faculty of Social Sciences, and Tampere University

Subjects
Male, 0301 basic medicine, Epidemiology, type 1 diabetes, Metabolite, The Environmental Determinants of Diabetes in the Young, lcsh:Medicine, Autoimmunity, medicine.disease_cause, chemistry.chemical_compound, 0302 clinical medicine, Risk Factors, lcsh:Science, Child, Pediatric, Multidisciplinary, Diabetes, Sisätaudit - Internal medicine, 3. Good health, ddc, Type 1 diabetes, Child, Preschool, Female, epidemiology, Child Nutritional Physiological Phenomena, Type 1, TEDDY Study Group, 030209 endocrinology & metabolism, Biology, Autoimmune Disease, Article, Islets of Langerhans, 03 medical and health sciences, Metabolomics, Lipidomics, Diabetes Mellitus, medicine, Humans, Seroconversion, Preschool, Metabolic and endocrine, Nutrition, Autoantibodies, Prevention, lcsh:R, Case-control study, Infant, Lipid Metabolism, medicine.disease, Diabetes Mellitus, Type 1, Early Diagnosis, 030104 developmental biology, chemistry, Case-Control Studies, Immunology, lcsh:Q, Follow-Up Studies
Abstract

The role of diet in type 1 diabetes development is poorly understood. Metabolites, which reflect dietary response, may help elucidate this role. We explored metabolomics and lipidomics differences between 352 cases of islet autoimmunity (IA) and controls in the TEDDY (The Environmental Determinants of Diabetes in the Young) study. We created dietary patterns reflecting pre-IA metabolite differences between groups and examined their association with IA. Secondary outcomes included IA cases positive for multiple autoantibodies (mAb+). The association of 853 plasma metabolites with outcomes was tested at seroconversion to IA, just prior to seroconversion, and during infancy. Key compounds in enriched metabolite sets were used to create dietary patterns reflecting metabolite composition, which were then tested for association with outcomes in the nested case-control subset and the full TEDDY cohort. Unsaturated phosphatidylcholines, sphingomyelins, phosphatidylethanolamines, glucosylceramides, and phospholipid ethers in infancy were inversely associated with mAb+ risk, while dicarboxylic acids were associated with an increased risk. An infancy dietary pattern representing higher levels of unsaturated phosphatidylcholines and phospholipid ethers, and lower sphingomyelins was protective for mAb+ in the nested case-control study only. Characterization of this high-risk infant metabolomics profile may help shape the future of early diagnosis or prevention efforts.

Published
2018
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