11 results on '"Jingzhou Chen"'
Search Results
2. Use of CoNi-ZIF (zeolitic imidazolate framework)-derived bimetal-doped nitrogen-rich porous carbon composite transition metal oxides in lithium–sulfur batteries
- Author
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Wangjun Feng, Yueping Niu, Xiaoping Zheng, Wenxiao Su, Jingzhou Chen, and Li Zhang
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Electrical and Electronic Engineering ,Condensed Matter Physics ,Atomic and Molecular Physics, and Optics ,Electronic, Optical and Magnetic Materials - Published
- 2023
3. ZIF-67-derived cobalt-based sulfate CoSO4/carbon nanotube nanocomposites as host material for high-performance lithium–sulfur battery cathode
- Author
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Wangjun Feng, Wei Zhao, Jingzhou Chen, and Zhaoyu Huang
- Subjects
Nanocomposite ,Materials science ,General Chemical Engineering ,General Engineering ,General Physics and Astronomy ,chemistry.chemical_element ,Lithium–sulfur battery ,Carbon nanotube ,Electrochemistry ,Cathode ,law.invention ,chemistry.chemical_compound ,chemistry ,Chemical engineering ,law ,General Materials Science ,Cobalt ,Faraday efficiency ,Polysulfide - Abstract
Lithium-sulfur batteries (LSBs) are considered the most likely replacement for conventional lithium–ion batteries in next-generation high-energy output solutions based on their high specific capacity (1675 mAh g−1) and high-energy density (2600 Wh kg−1). But, there are some problems that need to be solved urgently. In this work, an environmentally friendly, green, and low-cost ZIF-67-derived cobalt-based sulfate material (CoSO4) combined with carbon nanotubes was proposed as a sulfur host material. Experiments show that the addition of CoSO4 can significantly enhance the transformation of polysulfide and suppress the shuttle effect. The best performance is the CNT-CoSO4-2/S, which has an initial capacity of 1356.9 mAh g−1 at 0.1 C current density. Furthermore, long-term cycle test was carried out at a current density of 0.2 C; the coulombic efficiency was above 98.63% after 200 cycles. This work demonstrates the potential of cobalt-based sulfates as cathode materials for lithium–sulfur batteries.
- Published
- 2021
4. Structural, magnetic, optical, and impedance properties of SrxCo1−xFe2O4 nanoparticles prepared by sol–gel method
- Author
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Jingzhou Chen, Zhaxi Suonan, Yanchun Zhang, Aimin Sun, and Liqiong Shao
- Subjects
Materials science ,Scanning electron microscope ,Spinel ,Analytical chemistry ,engineering.material ,Coercivity ,Condensed Matter Physics ,Atomic and Molecular Physics, and Optics ,Electronic, Optical and Magnetic Materials ,X-ray photoelectron spectroscopy ,engineering ,Electrical and Electronic Engineering ,Fourier transform infrared spectroscopy ,Spectroscopy ,Absorption (electromagnetic radiation) ,Sol-gel - Abstract
Sr2+ ions-substituted cobalt ferrite having the composition formula SrxCo1−xFe2O4 (x = 0.05, 0.10, 0.15, and 0.20) was synthesized with sol–gel method. X-ray diffraction (XRD) patterns proved that the samples had a spinel structure. The Fourier-transform infrared (FTIR) spectra showed that the samples have two characteristic bands about the intrinsic vibrations of spinel ferrite. The morphology and chemical elements were tested by scanning electron microscope (SEM) and energy-dispersive spectrometer (EDS). The elemental state of annealed samples was examined by X-ray photoelectron spectroscopy (XPS). The magnetic data showed the coercivity increased from 954.33 Oe to 1545.54 Oe when the Sr2+ ions content increased. The optical absorption properties of annealed samples were investigated by UV–Vis spectroscopy. Complex impedance spectroscopy showed that grain resistance of Sr0.10Co0.90Fe2O4 sample was 443.9 Ω.
- Published
- 2021
5. Application of ZIF-8 coated with titanium dioxide in cathode material of lithium-sulfur battery
- Author
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Wei Zhao, Wangjun Feng, Zhaojiao Shi, Xuan Wang, and Jingzhou Chen
- Subjects
Battery (electricity) ,Materials science ,chemistry.chemical_element ,Sintering ,Lithium–sulfur battery ,02 engineering and technology ,010402 general chemistry ,021001 nanoscience & nanotechnology ,Condensed Matter Physics ,Electrochemistry ,01 natural sciences ,Sulfur ,0104 chemical sciences ,chemistry.chemical_compound ,Adsorption ,chemistry ,Chemical engineering ,Specific surface area ,Titanium dioxide ,General Materials Science ,Electrical and Electronic Engineering ,0210 nano-technology - Abstract
Lithium-sulfur batteries have become a potential candidate for a new generation of energy storage devices due to their extremely high theoretical capacity, but their shuttle effect and poor conductivity of sulfur and final discharge products hinder their commercial development. In this paper, ZIF-8 material with a large specific surface area was successfully prepared with metallic zinc as the central atom and dimethylimidazole. After sintering at 800 °C, the mesoporous carbon material was obtained, which increased its physical adsorption of sulfur. At the same time, titanium dioxide was coated on the mesoporous carbon material to obtain a core-shell structure with a specific surface area of up to 556.1 m2/g. The titanium dioxide coating well inhibits the occurrence of the shuttle effect and at the same time improves the cycle stability of the lithium-sulfur battery. The specific discharge capacity of the battery reaches 1351 mAh/g at 0.1 C.
- Published
- 2021
6. Low Serum Uric Acid Levels Promote Hypertensive Intracerebral Hemorrhage by Disrupting the Smooth Muscle Cell-Elastin Contractile Unit and Upregulating the Erk1/2-MMP Axis
- Author
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Weihua Song, Jingzhou Chen, Congxia Bai, Hao Li, Yinhui Zhang, Jing Ge, Yingying Sun, Hongyan Wen, Rutai Hui, Tianlong Liu, Haochen Xu, Ning Xiao, and Li Song
- Subjects
0301 basic medicine ,medicine.medical_specialty ,Matrix metalloproteinase ,Pathogenesis ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,Downregulation and upregulation ,Internal medicine ,Medicine ,cardiovascular diseases ,Stroke ,Intracerebral hemorrhage ,biology ,business.industry ,General Neuroscience ,medicine.disease ,Angiotensin II ,nervous system diseases ,030104 developmental biology ,Endocrinology ,chemistry ,biology.protein ,Uric acid ,Neurology (clinical) ,Cardiology and Cardiovascular Medicine ,business ,Elastin ,030217 neurology & neurosurgery - Abstract
Intracerebral hemorrhage (ICH) is a catastrophic stroke with high mortality, and the mechanism underlying ICH is largely unknown. Previous studies have shown that high serum uric acid (SUA) levels are an independent risk factor for hypertension, cardiovascular disease (CVD), and ischemic stroke. However, our metabolomics data showed that SUA levels were lower in recurrent intracerebral hemorrhage (R-ICH) patients than in ICH patients, indicating that lower SUA might contribute to ICH. In this study, we confirmed the association between low SUA levels and the risk for recurrence of ICH and for cardiac-cerebral vascular mortality in hypertensive patients. To determine the mechanism by which low SUA effects ICH pathogenesis, we developed the first low SUA mouse model and conducted transcriptome profiling of the cerebrovasculature of ICH mice. When combining these assessments with pathological morphology, we found that low SUA levels led to ICH in mice with angiotensin II (Ang II)-induced hypertension and aggravated the pathological progression of ICH. In vitro, our results showed that p-Erk1/2-MMP axis were involved in the low UA-induce degradation of elastin, and that physiological concentrations of UA and p-Erk1/2-specific inhibitor exerted a protective role. This is the first report describing to the disruption of the smooth muscle cell (SMC)-elastin contractile units in ICH. Most importantly, we revealed that the upregulation of the p-Erk1/2-MMP axis, which promotes the degradation of elastin, plays a vital role in mediating low SUA levels to exacerbate cerebrovascular rupture during the ICH process.
- Published
- 2020
7. Investigation of novel metabolites potentially involved in the pathogenesis of coronary heart disease using a UHPLC-QTOF/MS-based metabolomics approach
- Author
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Dong Zhang, Changzhe Chen, Yuejin Yang, Yinxiao Bai, Jielin Pu, Chenxi Song, Yanyan Zhao, Yiping Li, Jingzhou Chen, Yang Wang, Yuan He, and Kefei Dou
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Male ,0301 basic medicine ,China ,medicine.medical_specialty ,Lithocholic acid ,Linoleic acid ,lcsh:Medicine ,Coronary Disease ,030204 cardiovascular system & hematology ,Pharmacology ,Gastroenterology ,Mass Spectrometry ,Article ,Palmitic acid ,Pathogenesis ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,Metabolomics ,Asian People ,Internal medicine ,Humans ,Medicine ,Carnitine ,lcsh:Science ,Chromatography, High Pressure Liquid ,Aged ,Multidisciplinary ,business.industry ,Uhplc qtof ms ,lcsh:R ,Middle Aged ,Coronary heart disease ,030104 developmental biology ,chemistry ,lcsh:Q ,Female ,business ,Biomarkers ,medicine.drug - Abstract
Coronary heart disease (CHD) is associated with complex metabolic disorders, but its molecular aetiology remains unclear. Using a novel nontargeted metabolomics approach, we explored the global metabolic perturbation profile for CHD. Blood samples from 150 patients with severe obstructive CHD and 150 angiographically normal controls were collected. Metabolic fingerprinting was performed by ultra-high performance liquid chromatography coupled to quadruple time-of-flight mass spectrometry (UHPLC-QTOF/MS) technique. After adjusting for CHD traditional risk factors and metabolic batch, a comprehensive list of 105 metabolites was found to be significantly altered in CHD patients. Among the metabolites identified, six metabolites were discovered to have the strongest correlation with CHD after adjusting for multiple testing: palmitic acid (β = 0.205; p
- Published
- 2017
8. The C-1021T polymorphism of dopamine β-hydroxylase is not associated with orthostatic hypotension in a Chinese population
- Author
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Kai Sun, Yang Zheng, Na Lu, Lin Meng, Rutai Hui, Yi Yang, Jingzhou Chen, Ye Yuan, and X Cong
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Adult ,Male ,China ,medicine.medical_specialty ,Population ,Diastole ,Blood Pressure ,Dopamine beta-Hydroxylase ,Polymorphism, Single Nucleotide ,Hypotension, Orthostatic ,Orthostatic vital signs ,Asian People ,Dopamine ,Internal medicine ,Genotype ,Internal Medicine ,medicine ,Humans ,education ,Allele frequency ,Chinese population ,education.field_of_study ,business.industry ,Middle Aged ,Cross-Sectional Studies ,Blood pressure ,Endocrinology ,Hypertension ,Female ,business ,medicine.drug - Abstract
To explore the association between the dopamine β-hydroxylase (DBH) gene C-1021T polymorphism and the occurrence of orthostatic hypotension (OH) in Chinese patients, the DBH C-1021T polymorphism was genotyped in 317 patients with OH and 664 age- and sex-matched controls with orthostatic normotension. All subjects underwent an upright posture study for the measurement of orthostatic blood pressure. OH was defined as a drop in blood pressure of 20/10 mm Hg or more within 3 min of assuming the upright posture. The allele frequency of the DBH C-1021T polymorphism in the orthostatic hypotensive group was similar to the orthostatic normotensive group (17.4 versus 14.9%, P>0.05). No statistical significant association was found between the distribution of the C-1021T genotypes and the risk of OH in both the orthostatic hypotensive and orthostatic normotensive groups even after adjustment for demographic parameters. Among the three different genotypes, blood pressure levels did not significantly differ in the general population in this study. The changes in orthostatic systolic or diastolic blood pressures among the different genotype groups were not detected (all P>0.05). The C-1021T polymorphism of the DBH was not associated with orthostatic hypotensive risk in a Chinese population.
- Published
- 2014
9. A functional variant of the collagen type III alpha1 gene modify risk of sporadic intracranial aneurysms
- Author
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Yuhua Jiang, Yufang Zhu, Kai Sun, Hui Yu, Youxiang Li, Liming Luan, Weihua Song, Qi Pang, Jingzhou Chen, Peng Jiang, Kejia Lou, and Rutai Hui
- Subjects
Male ,China ,medicine.medical_specialty ,Genotype ,Population ,Biology ,Polymorphism, Single Nucleotide ,Gastroenterology ,Gene Frequency ,Polymorphism (computer science) ,Internal medicine ,Genetics ,medicine ,Humans ,SNP ,Genetic Predisposition to Disease ,Allele ,education ,Allele frequency ,Stroke ,Alleles ,Genetic Association Studies ,Genetics (clinical) ,Intracerebral hemorrhage ,education.field_of_study ,Genetic Variation ,Intracranial Aneurysm ,Odds ratio ,Middle Aged ,medicine.disease ,Collagen Type III ,Female - Abstract
Abnormalities in type III collagen in the arterial walls cause certain familial intracranial aneurysms (IAs); however, it remains unknown whether COL3A1 variants contribute to the risk of sporadic IAs. To study whether COL3A1 variants are associated with sporadic IAs, the association of COL3A1 variants with sporadic IAs was tested in 298 cases and 488 controls, replicated in an independent population of 192 cases and 1,690 controls, and further verified in 633 patients with intra-cerebral hemorrhage, 1,074 hypertensives, and 1,883 controls. We found that allele A of SNP rs1800255 conferred a 1.71-fold increased risk for IAs (adjusted odds ratio: OR = 1.71, 95% confidence interval: CI 1.19-2.45, P = 0.004) and results in an amino acid change of Ala698Thr, which led to a lower thermal stability of the peptide. These results were confirmed in the independent study. The associations were independent of the presence of hemorrhagic stroke and hypertension. These results support the view that the functional variant of COL3A1 is genetic risk factors for IAs in the Chinese population.
- Published
- 2012
10. A Functional Variant of IC53 Correlates with the Late Onset of Colorectal Cancer
- Author
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Yinhui Zhang, Ziyu Li, Jiafu Ji, Yi Shi, Yan Song, Tao Yang, Kai Sun, Yisong Zhen, Ying Hu, Yu Han, Jingzhou Chen, Gui-guo Zhang, Hui Yu, Rutai Hui, Xiaojian Wang, and Kejia Lou
- Subjects
Male ,Oncology ,Integrins ,medicine.medical_specialty ,Genotype ,Colorectal cancer ,Transplantation, Heterologous ,Cell ,Mice, Nude ,Cell Cycle Proteins ,Nerve Tissue Proteins ,Late onset ,Polymorphism, Single Nucleotide ,Article ,Mice ,Phosphatidylinositol 3-Kinases ,Internal medicine ,Genetics ,medicine ,Animals ,Humans ,Age of Onset ,Phosphorylation ,Molecular Biology ,Genetics (clinical) ,Aged ,Mice, Inbred BALB C ,business.industry ,Tumor Suppressor Proteins ,Intracellular Signaling Peptides and Proteins ,Middle Aged ,HCT116 Cells ,medicine.disease ,Molecular medicine ,Transplantation ,MicroRNAs ,medicine.anatomical_structure ,NIH 3T3 Cells ,Molecular Medicine ,Adenocarcinoma ,Female ,RNA Interference ,Age of onset ,Colorectal Neoplasms ,business ,HT29 Cells ,Proto-Oncogene Proteins c-akt ,Neoplasm Transplantation - Abstract
The IC53 gene was reported to be upregulated in the colon adenocarcinoma cell line SW480. Here, we show that the expression level of IC53 is positively correlated with the grade and depth of invasion in adenocarcinoma of the colon. Injection of IC53 stably transfected HCT-116 cells into athymic nude mice promoted tumor growth. Furthermore, overexpression of IC53 increased cell invasive growth, which could be dramatically prevented by knocking down IC53 with siRNA. The effects of IC53 on cell-invasive growth were mediated by upregulation of integrins, activation of phosphatidylinositol 3-kinase and phosphorylation of Akt. A single-nucleotide polymorphism rs2737 in the IC53 gene created a potential microRNA379 target site, and microRNA379 expression inhibited IC53 translation. Among 222 patients with colorectal cancer, the C/C rs2737 genotype was associated with late onset of colorectal cancer (median age 63.0 versus 55.3 years, P = 0.003). The frequency of the C/C rs2737 genotype was much lower in patients who developed colorectal cancer below the age of 45 years than in individuals over age 45 years (10.8% versus 26.6%, P = 0.039). These data indicated that IC53 is a positive mediator for colon cancer progression, and IC53-rs2737 may serve as protection from the onset of colorectal cancer.
- Published
- 2011
11. A functional variant in promoter region of platelet-derived growth factor-D is probably associated with intracerebral hemorrhage
- Author
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Kai Sun, Jingzhou Chen, Yibo Wang, Rutai Hui, and Yongyi Bai
- Subjects
Male ,medicine.medical_specialty ,Genotype ,Immunology ,Short Report ,Single-nucleotide polymorphism ,Biology ,Polymorphism, Single Nucleotide ,Gastroenterology ,Statistics, Nonparametric ,lcsh:RC346-429 ,Cellular and Molecular Neuroscience ,Asian People ,Polymorphism (computer science) ,Internal medicine ,medicine ,Humans ,risk factors ,Genetic Predisposition to Disease ,genetics ,cardiovascular diseases ,Promoter Regions, Genetic ,Stroke ,lcsh:Neurology. Diseases of the nervous system ,Aged ,Cerebral Hemorrhage ,Platelet-Derived Growth Factor ,Intracerebral hemorrhage ,Lymphokines ,General Neuroscience ,Hazard ratio ,Odds ratio ,Middle Aged ,medicine.disease ,intracerebral hemorrhage ,Confidence interval ,Logistic Models ,Neurology ,Stroke, Lacunar ,Female ,Platelet-derived growth factor D ,Follow-Up Studies - Abstract
Background Platelet-derived growth factor D (PDGF-D) plays an important role in angiogenesis, vessel remodeling, inflammation and repair in response to injury. We hypothesized that genetic variation in PDGFD gene might alter the susceptibility to stroke. Findings We determined the genotypes of a single nucleotide polymorphism (SNP) (-858A/C, rs3809021) in 1484 patients with stroke (654 cerebral thrombosis, 419 lacunar infarction, 411 intracerebral hemorrhage [ICH]) and 1528 control subjects from an unrelated Chinese Han population and followed the stroke patients up for a median of 4.5 years. The -858AA genotype showed significantly increased risk of ICH (dominant model: odds ratio [OR] 1.29, 95% confidence interval [CI] 1.00-1.68, P = 0.05; additive model: OR 1.24, 95% CI 1.01-1.52, P = 0.04) than wild-type genotype. Further analyses showed that -858AA genotype conferred about 2-fold increase in risk of non-hypertensive ICH (dominant model: OR 2.1, 95%CI 1.34-3.29, P = 0.001; additive model: OR 1.75, 95% CI 1.24-2.46, P = 0.001). After a median follow-up of 4.5 years, -858AA genotype was associated with a reduced risk of ICH recurrence (dominant model: adjusted hazard ratio [HR] 0.09, 95%CI 0.01-0.74, P = 0.025; additive model: HR 0.21, 95% CI 0.04-1.16, P = 0.073) in non-hypertensive patients. Conclusions The -858AA genotype is probably associated with risk for non-hypertensive ICH. Further studies should be conducted to reveal the role of PDGF-D at various stages of ICH development--beneficial, or deleterious.
- Published
- 2012
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