1. The impact of bacteremia on lipoprotein concentrations and patient’s outcome: a retrospective analysis
- Author
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Günter Weiss, Jasmin Rabensteiner, Cornelia Lass-Floerl, Fabian Lunger, Manfred Fille, Ivan Tancevski, Katharina Kurz, Dorothea Orth-Hoeller, Rosa Bellmann-Weiler, Alex Pizzini, Lukas Lunger, Robert Krause, and Christoph Tschurtschenthaler
- Subjects
0301 basic medicine ,Microbiology (medical) ,medicine.medical_specialty ,HDL ,Lipoproteins ,030106 microbiology ,Gram species ,Bacteremia ,LDL ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,Medical microbiology ,Internal medicine ,Plasma lipids ,Retrospective analysis ,Humans ,Medicine ,030212 general & internal medicine ,Lipoprotein ,Triglycerides ,Gram-Positive Bacterial Infections ,Aged ,Retrospective Studies ,Aged, 80 and over ,Triglyceride ,business.industry ,General Medicine ,Middle Aged ,medicine.disease ,Icu admission ,Intensive Care Units ,C-Reactive Protein ,Cross-Sectional Studies ,Infectious Diseases ,chemistry ,Relative risk ,Multivariate Analysis ,Original Article ,lipids (amino acids, peptides, and proteins) ,Gram-Negative Bacterial Infections ,business - Abstract
Bacteremia is a major clinical challenge requiring early treatment. Metabolic alterations occur during bacteremia, and accordingly plasma concentrations of lipoproteins LDL-C and HDL-C are substantially changed. We questioned whether bacteremia with Gram-negative versus Gram-positive bacteria causes contrasting changes of lipoprotein levels in order to differentiate between the 2-g stain types and if there is a relation with outcome parameters namely ICU-admission, 30-day mortality, duration of hospitalization. This is a retrospective dual-center cross-sectional study, including 258 patients with bacteremia. Plasma lipid levels were analyzed within 48 h to positive blood culture. Upon admission, HDL-C, LDL-C, and total cholesterol (p = 0.99) in plasma did not significantly differ between patients with Gram-negative and Gram-positive bacteremia, while significantly higher triglyceride concentrations were found in Gram-negative bacteremia (p
- Published
- 2019
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