1. An inverse association between serum leptin concentration and reported alcohol intake in patients with manifest vascular disease
- Author
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Jan Filipovsky, Otto Mayer, Jan Bruthans, Jana Hrbková, M. Galovcova, J. Simon, Jindra Vrzalova, Renata Cifkova, and 2nd Department of Internal Medicine
- Subjects
Leptin ,Male ,medicine.medical_specialty ,Inverse Association ,Alcohol Drinking ,Medicine (miscellaneous) ,030209 endocrinology & metabolism ,Alcohol ,Coronary Artery Disease ,030204 cardiovascular system & hematology ,Central nervous system disease ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,Risk Factors ,Internal medicine ,Humans ,Medicine ,In patient ,EUROASPIRE ,coronary heart disease ,Stroke ,Aged ,2. Zero hunger ,Nutrition and Dietetics ,Ethanol ,business.industry ,Vascular disease ,digestive, oral, and skin physiology ,Middle Aged ,medicine.disease ,stroke ,3. Good health ,Cerebrovascular Disorders ,Cross-Sectional Studies ,Endocrinology ,chemistry ,Female ,Alcohol intake ,business ,secondary prevention ,hormones, hormone substitutes, and hormone antagonists ,alcohol intake - Abstract
International audience; Background/Objectives: It has been reported that alcohol stimulates appetite. We aimed to establish the association between leptin, as a major food intake regulating factor, and alcohol intake in patients with chronic manifest coronary artery or cerebrovascular disease. Subjects/Methods: A cross-sectional study of 820 subjects after acute coronary syndrome, coronary revascularisation or after first ischemic stroke. (Czech part of EUROASPIRE III surveys). Leptin concentration were evaluated among predefined categories of reported weekly alcohol intake: abstainers, light drinkers (up to 2 drinks weekly, 1-44 g of pure alcohol), mild regular drinkers (3-14 drinks weekly, 45-308 g) and moderate or heavy drinkers (more than 15 drinks, ≥ 309 g of alcohol). Results: The leptin showed a clear negative trend among alcohol intake categories. Mild regular drinkers showed significantly lower leptin [9.3(8.2)ng/mL], than abstainers [18.7(18.7) ng/mL, p
- Published
- 2010
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