1. Comparison of survival between radiation therapy and trans-oral laser microsurgery for early glottic cancer patients; a retrospective cohort study
- Author
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Kevin Higgins, Justin Lee, R. J. De Santis, Danny Enepekides, Ian Poon, and Irene Karam
- Subjects
Adult ,Male ,Early glottic cancer ,Glottis ,Microsurgery ,medicine.medical_specialty ,medicine.medical_treatment ,Population ,Urology ,Laryngectomy ,03 medical and health sciences ,0302 clinical medicine ,medicine ,Humans ,Original Research Article ,030223 otorhinolaryngology ,education ,Laryngeal Neoplasms ,Survival rate ,Survival analysis ,Aged ,Retrospective Studies ,Aged, 80 and over ,5-year survival ,education.field_of_study ,Chemotherapy ,T2 ,T1 ,business.industry ,Cancer ,Retrospective cohort study ,Middle Aged ,medicine.disease ,Survival Analysis ,Surgery ,Survival Rate ,Trans-oral laser microsurgery ,Radiation therapy ,Plastic surgery ,Otorhinolaryngology ,030220 oncology & carcinogenesis ,Female ,Laser Therapy ,business - Abstract
The literature reports various treatment methodologies, such as trans-oral laser microsurgery, radiation therapy, total/partial laryngectomies, and concurrent radiation chemotherapy for patients with early larynx cancer. However, at the forefront of early glottis treatment is trans-oral laser microsurgery and radiation therapy, likely due to better functional and survival outcomes. Here we conduct the largest Canadian head-to-head comparison of consecutive patients treated with either radiation therapy or trans-oral laser microsurgery. Additionally, we compare these two treatments and their 5-year survival rates post treatment to add to the existing literature. Charts of patients who were diagnosed with early glottic cancer between 2006 and 2013 were reviewed. Seventy-five patients were identified, and split into 2 groups based on their primary treatment, trans-oral laser microsurgery and radiation therapy. Kaplan–Meier survival curves, life-tables, and the log-rank statistic were reported to determine if there was a difference between the two treatment groups and their disease-specific survival, disease-free survival, and total laryngectomy-free survival. Additionally, each different survival analysis was stratified by potential confounding variables, to help conclude which treatment is more efficacious in this population. The 5-year disease-specific survival rate is 93.3 % σ = 0.063 and 90.8 % σ = 0.056 for patients treated with trans-oral laser microsurgery and radiation therapy, respectively (χ 2
- Published
- 2016