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Subthreshold premenstrual symptoms can be impairing even if the diagnostic criteria for premenstrual dysphoric disorder (PMDD) are not reached. Previous research suggests shared psychological risk factors without a clear differentiation of premenstrual syndrome (PMS) from PMDD. This study focuses on a sample with a wide range of premenstrual symptoms not reaching PMDD-criteria and aims to investigate within-person associations of premenstrual symptoms with daily rumination and perceived stress during the late luteal phase as well as cycle-phase specific associations of habitual mindfulness including present-moment-awareness and acceptance with premenstrual symptoms and impairment. Fifty-six naturally cycling women with self-reported premenstrual symptoms completed an online diary on premenstrual symptoms, rumination and perceived stress over two consecutive menstrual cycles, and baseline questionnaires on habitual present-moment-awareness and acceptance. Multilevel analyses revealed cycle-related variations in premenstrual symptoms and impairment (all ps ps p ≤ .018). Higher habitual present-moment-awareness was linked to lower premenstrual symptom and impairment levels toward the late luteal phase whereas higher habitual acceptance was associated with lower premenstrual functional impairment (p ≤ .015). Premenstrual symptom increases during the late luteal phase in women with PMS seem to be linked to increased daily rumination and perceived stress. Trait present-moment-awareness and acceptance in turn seem to reflect protective factors against premenstrual distress and may represent useful targets for interventions.

Psychological stress and physical activity are interrelated, constituting a relevant association to human health, especially in children. However, the association’s nature remains elusive, i.e., why psychological stress predicts both decreased and increased physical activity. To test whether effects vary as a function of the level of analyses, we derived intensive longitudinal data via accelerometers and stress questionnaires from 74 children across 7 days as they went about their daily routines (n = 513 assessments). Multilevel modelling analyses revealed that between children, higher psychological stress predicted decreased physical activity (standardized beta coefficient = −0.14; p = 0.046). Concurrently, within those children, higher psychological stress predicted increased physical activity across days (standardized beta coefficient = 0.09; p = 0.015). Translated to practice, children who experienced more stress than others moved less, but children were more active on days when they experienced heightened stress. This suggests that the analyses level is crucial to the understanding of the association between psychological stress and physical activity and should be considered to receive unequivocal results. If replicated, e.g., including high-frequency sampling and experimental manipulation in everyday life for in-depth insights on underlying mechanisms and causality, our findings may be translated to individually tailored (digital) prevention and intervention strategies which target children’s distress-feelings despite impairing their heightened physical activity in stressful situations and identify tipping points of chronic stress phases. Therefore, we especially call for more intensive longitudinal data approaches to tackle thus far neglected within-subject issues in the field of physical activity, sport and exercise research.

Psychiatric morbidity is high in cities, so identifying potential modifiable urban protective factors is important. We show that exposure to urban green space improves well-being in naturally behaving male and female city dwellers, particularly in districts with higher psychiatric incidence and fewer green resources. Higher green-related affective benefit was related to lower prefrontal activity during negative-emotion processing, which suggests that urban green space exposure may compensate for reduced neural regulatory capacity. Tost et al. show that urban green space exposure improves well-being, particularly in people dwelling in relatively deprived areas and showing less prefrontal activity during emotion processing, a neural signature that is linked to mental health risk.

Aufgrund der hohen Pravalenz bei Alkoholabhangigen und der anspruchsvollen und zeitaufwendigen Diagnostik der Aufmerksamkeitsdefizit‑/Hyperaktivitatsstorung (ADHS) wird ein routinemasiges Screening mit Selbstbeurteilungsfragebogen empfohlen. Die psychometrischen Eigenschaften solcher Fragebogen wurden in dieser Patientengruppe bisher kaum untersucht. Bei 402 alkoholabhangigen Patienten in der stationaren Entwohnung wurden die psychometrischen Eigenschaften der ADHS-Selbstbeurteilungsskala (ADHS-SB) und der Wender Utah Rating Scale in der deutschen Kurzversion (WURS-k) untersucht. Bei 85 dieser Patienten war in einer ausfuhrlichen standardisierten Diagnostik eine Erwachsenen-ADHS festgestellt worden. Die ADHS-SB zeigte bei einem Cut-off von ≥15 die besten psychometrischen Eigenschaften (Sensitivitat 75,3 %, Spezifitat 94,0 %, positiver Vorhersagewert [PPV] 77,1 %, negativer Vorhersagewert [NPV] 93,4 %). Die WURS-k zeigte bei dem etablierten Cut-off von ≥30, aber auch bei niedrigeren Cut-offs, keine zufriedenstellenden Ergebnisse mit im Vergleich zur ADHS-SB vielen falsch-positiven Screeningergebnissen. Die Kombination beider Instrumente (ADHS-SB ≥ 15 und/oder WURS-k ≥ 30) zeigte eine hohe Sensitivitat (86,9 %), die jedoch mit einer erhohten Anzahl an falsch-positiven Screeningergebnissen einherging (Spezifitat 87,7 %, PPV 65,2 %). Die ADHS-SB ist geeignet zum routinemasigen ADHS-Screening bei Alkoholabhangigen. Fur eine bessere Sensitivitat sollte ein niedrigerer Cut-off von ≥15 verwendet werden. Die WURS-k ist fur das alleinige ADHS-Screening bei Alkoholabhangigen nicht zu empfehlen. Soll eine moglichst hohe Sensitivitat bei ausreichender Spezifitat erreicht werden, ist eine Kombination von ADHS-SB und WURS-k moglich.

Mind wandering is often thought to have adverse consequences such as to deteriorate mood. However, more recent findings suggest that the effect of mind wandering on mood may depend on the specific thought contents that occur during mind-wandering episodes and may be influenced by trait-like interindividual differences. The current study examined prospective effects of mind wandering (MW) on mood in daily life as well as possible moderating effects of dispositional mindfulness and rumination. Forty-three university students aged 19 to 32 (61% women) filled out questionnaires on trait mindfulness and rumination. Subsequently, they underwent 5 days of electronic ambulatory assessment of MW and positive and negative affect in daily life ten times a day. Prospective models revealed positive effects of MW on mood, and negative affect was lowest when thoughts during MW were most pleasant. Although dispositional rumination and mindfulness significantly affected mood in daily life, no moderating effects of these traits were identified on the association between MW and mood. These results suggest that mind wandering is not a negative phenomenon per se but instead has adaptive consequences that can lead to mood improvements. Our findings highlight the importance of accounting for the thought content of mind-wandering episodes when investigating the functional outcomes of a wandering mind. Given that mind wandering frequently takes place in everyday life, interventions that encourage individuals to shift the content of their mind-wandering experiences towards pleasant topics may have an important impact particularly for clinical populations.

Several studies in patients with schizophrenia reported a marked reduction in sleep spindle activity. To investigate whether the reduction may be linked to genetic risk of the illness, we analysed sleep spindle activity in healthy volunteers, patients with schizophrenia and first-degree relatives, who share an enriched set of schizophrenia susceptibility genes. We further investigated the correlation of spindle activity with cognitive function in first-degree relatives and whether spindle abnormalities affect both fast (12-15 Hz) and slow (9-12 Hz) sleep spindles. We investigated fast and slow sleep spindle activity during non-rapid eye movement sleep in a total of 47 subjects comprising 17 patients with schizophrenia, 13 healthy first-degree relatives and 17 healthy volunteers. Groups were balanced for age, gender, years of education and estimated verbal IQ. A subsample of relatives received additional testing for memory performance. Compared to healthy volunteers, fast spindle density was reduced in patients with schizophrenia and healthy first-degree relatives following a pattern consistent with an assumed genetic load for schizophrenia. The deficit in spindle density was specific to fast spindles and was associated with decreased memory performance. Our findings indicate familial occurrence of this phenotype and thus support the hypothesis that deficient spindle activity relates to genetic liability for schizophrenia. Furthermore, spindle reductions predict impaired cognitive function and are specific to fast spindles. This physiological marker should be further investigated as an intermediate phenotype of schizophrenia. It could also constitute a target for drug development, especially with regard to cognitive dysfunction.

Mesocorticolimbic reactivity to alcohol-associated cues has been shown to be associated with relapse to renewed drinking and to be decreased by cue-exposure-based extinction training (CET). Evidence from preclinical studies suggests that the extinction of conditioned alcohol-seeking behavior might be facilitated by drugs increasing N-methyl-d-aspartate (NMDA) receptor-associated memory consolidation. In this study, we assessed the efficacy of CET treatment supplemented with the partial NMDA-receptor agonist d-cycloserine (DCS) at reducing mesolimbic cue reactivity (CR), craving, and relapse risk in alcoholism. In a randomized, placebo-controlled, double-blind study, we recruited 76 recently detoxified abstinent alcohol-dependent patients. Thirty-two (16 DCS, 16 placebo) patients showed cue-induced ventral-striatal activation measured with functional magnetic resonance imaging (fMRI) prior to treatment and were thus included in the efficacy analyses. After inpatient detoxification, patients underwent nine sessions of CET spaced over 3 weeks, receiving either 50 mg DCS or placebo 1 h prior to each CET session. FMRI was conducted before treatment and 3 weeks after treatment onset. Following treatment with CET plus DCS, cue-induced brain activation in the ventral and dorsal striatum was decreased compared to treatment with CET plus placebo. Elevated posttreatment ventral striatal CR and increased craving (assessed using the Obsessive Compulsive Drinking Scale) were associated with increased relapse risk. DCS was shown to augment the effect of CET for alcohol-dependent subjects. The interaction between craving and ventral-striatal CR on treatment outcome suggests that CET might be especially effective in patients exhibiting both high craving and elevated CR.

To benchmark outcomes of a German breast cancer network with the Surveillance Epidemiology and End Results programme (SEER) of the USA from a longitudinal point of view. All women receiving primary breast cancer therapy of three hospitals in a rural district of Marburg-Biedenkopf (Germany) of time intervals 1996–1997 and 2003–2004 were used to define local benchmark objects. Data from SEER-programme contributed longitudinal benchmark objects from national level (1988–2004). All benchmark objects were compared with the time-fixed benchmark reference of SEER (2004). Stage distributions and 5-year relative survival ratios were combined to estimate standardized screening-, case-mix-, work-up-, treatment- and relative overall performance index. From the entry cohort of 877 German women, 97.7 % of the patients accounted for the institutional sample (N = 857) and 65.8 % accounted for the regional sample (N = 577). Stage distributions, relative survival ratios and indices of the German breast cancer network improved over time. Developed indices converged with SEER (2004). Effectiveness gap between one exemplary German breast cancer network and international benchmark defined by SEER has been closed. Reasons are manifold, and further research is recommended.