557 results on '"In, Tae-sung"'
Search Results
2. Centrosome amplification and aneuploidy driven by the HIV-1-induced Vpr•VprBP•Plk4 complex in CD4+ T cells
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Park, Jung-Eun, primary, Kim, Tae-Sung, additional, Zeng, Yan, additional, Mikolaj, Melissa, additional, Il Ahn, Jong, additional, Alam, Muhammad S., additional, Monnie, Christina M., additional, Shi, Victoria, additional, Zhou, Ming, additional, Chun, Tae-Wook, additional, Maldarelli, Frank, additional, Narayan, Kedar, additional, Ahn, Jinwoo, additional, Ashwell, Jonathan D., additional, Strebel, Klaus, additional, and Lee, Kyung S., additional
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- 2024
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3. The Efficacy and Safety of an Indocyanine Green-Macroaggregated Albumin-Hyaluronic Acid Mixture (LuminoMark™) for Surgical Localization of Recurrent Thyroid Cancer
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Kim, Seok-ki, primary, Seok, Jungirl, additional, Lee, Chang Yoon, additional, Ryu, Chang Hwan, additional, Choi, Sung Yong, additional, Park, Seog Yun, additional, Lee, Young Ki, additional, Hwangbo, Yul, additional, Lee, Eun Kyung, additional, Lee, You Jin, additional, Park, Sohyun, additional, Kim, Tae Sung, additional, Kim, Tae Hyun, additional, Ryu, Junsun, additional, and Jung, Yuh-Seog, additional
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- 2024
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4. Liquid chromatography-tandem mass spectrometry for pharmacokinetics evaluation of AZD5305, a selective PARP1 inhibitor, in mice
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Lee, Gi Ju, primary, Kim, Jin Woo, additional, Choi, Hae-In, additional, Choi, Jin Young, additional, Cho, Kwan Hyung, additional, and Koo, Tae-Sung, additional
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- 2023
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5. Repurposing and computational design of PARP inhibitors as SARS-CoV-2 inhibitors
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Rampogu, Shailima, primary, Jung, Tae Sung, additional, Ha, Min Woo, additional, and Lee, Keun Woo, additional
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- 2023
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6. Silicone ring tourniquet could be a substitute for a conventional tourniquet in total knee arthroplasty with a longer surgical field: a prospective comparative study in simultaneous total knee arthroplasty
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Lee, Tae sung, primary, Park, Kwan Kyu, additional, Cho, Byung Woo, additional, Lee, Woo-Suk, additional, and Kwon, Hyuck Min, additional
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- 2023
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7. FDG metabolic parameter-based models for predicting recurrence after upfront surgery in synchronous colorectal cancer liver metastasis
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Hyo Sang Lee, Hyun Woo Kwon, Seok-Byung Lim, Jin Cheon Kim, Chang Sik Yu, Yong Sang Hong, Tae Won Kim, Minyoung Oh, Sangwon Han, Jae Hwan Oh, Sohyun Park, Tae-Sung Kim, Seok-ki Kim, Hyun Joo Kim, Jae Young Kwak, Ho-Suk Oh, Sungeun Kim, Jung-Myun Kwak, Ji Sung Lee, and Jae Seung Kim
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Radiology, Nuclear Medicine and imaging ,General Medicine - Abstract
This study aimed to develop and validate post- and preoperative models for predicting recurrence after curative-intent surgery using an FDG PET-CT metabolic parameter to improve the prognosis of patients with synchronous colorectal cancer liver metastasis (SCLM).In this retrospective multicenter study, consecutive patients with resectable SCLM underwent upfront surgery between 2006 and 2015 (development cohort) and between 2006 and 2017 (validation cohort). In the development cohort, we developed and internally validated the post- and preoperative models using multivariable Cox regression with an FDG metabolic parameter (metastasis-to-primary-tumor uptake ratio [M/P ratio]) and clinicopathological variables as predictors. In the validation cohort, the models were externally validated for discrimination, calibration, and clinical usefulness. Model performance was compared with that of Fong's clinical risk score (FCRS).A total of 374 patients (59.1 ± 10.5 years, 254 men) belonged in the development cohort and 151 (60.3 ± 12.0 years, 94 men) in the validation cohort. The M/P ratio and nine clinicopathological predictors were included in the models. Both postoperative and preoperative models showed significantly higher discrimination than FCRS (p.05) in the external validation (time-dependent AUC = 0.76 [95% CI 0.68-0.84] and 0.76 [0.68-0.84] vs. 0.65 [0.57-0.74], respectively). Calibration plots and decision curve analysis demonstrated that both models were well calibrated and clinically useful. The developed models are presented as a web-based calculator ( https://cpmodel.shinyapps.io/SCLM/ ) and nomograms.FDG metabolic parameter-based prognostic models are well-calibrated recurrence prediction models with good discriminative power. They can be used for accurate risk stratification in patients with SCLM.• In this multicenter study, we developed and validated prediction models for recurrence in patients with resectable synchronous colorectal cancer liver metastasis using a metabolic parameter from FDG PET-CT. • The developed models showed good predictive performance on external validation, significantly exceeding that of a pre-existing model. • The models may be utilized for accurate patient risk stratification, thereby aiding in therapeutic decision-making.
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- 2022
8. Silicone ring tourniquet could be a substitute for a conventional tourniquet in total knee arthroplasty with a longer surgical field: a prospective comparative study in simultaneous total knee arthroplasty
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Tae sung Lee, Kwan Kyu Park, Byung Woo Cho, Woo-Suk Lee, and Hyuck Min Kwon
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Rheumatology ,Orthopedics and Sports Medicine - Abstract
Introduction This study aimed to compare the clinical outcomes of silicon ring tourniquets and conventional pneumatic tourniquets in total knee arthroplasty (TKA). The study compared the operation time, total bleeding amount, length from the tourniquet distal end to the patella superior pole (L_TP), and complications related to the two tourniquet application methods and attempted to determine whether the silicon ring tourniquet has advantages over conventional pneumatic tourniquets. Materials and methods This prospective comparative study included 30 patients who underwent bilateral simultaneous TKA for degenerative osteoarthritis in August to December 2021. All patients underwent TKA on one side with a conventional pneumatic tourniquet, while TKA on the other side with a silicon ring tourniquet. The primary outcomes were the L_TP, operation time, tourniquet time, total bleeding amount, total drainage amount, and postoperative visual analog scale (VAS) score of the tourniquet applied site at 6, 24, and 48 h postoperatively. The secondary outcome was tourniquet-related complications in both groups. Results L_TP was significantly longer in the silicon ring tourniquet group compared with that in the pneumatic tourniquet group (20.22 ± 2.74 cm versus 15.12 ± 2.40, p Conclusions Silicon ring tourniquet application resulted in better clinical outcomes than conventional pneumatic tourniquets in TKA. Because we can obtain a wider surgical field using silicon ring tourniquets without complications, silicon ring tourniquets could be a substitute for conventional pneumatic tourniquets in total knee arthroplasty or distal femoral surgeries.
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- 2023
9. Effect of Physicochemical Properties of Slag on the Removal Rate of Alumina Inclusions in the Ruhrstahl–Heraeus (RH) Refining Conditions
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Tae Sung Kim, Jian Yang, and Joo Hyun Park
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Mechanics of Materials ,Materials Chemistry ,Metals and Alloys ,Condensed Matter Physics - Published
- 2022
10. Graphene/MoS2/SiOx memristive synapses for linear weight update
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Adithi Krishnaprasad, Durjoy Dev, Mashiyat Sumaiya Shawkat, Ricardo Martinez-Martinez, Molla Manjurul Islam, Hee-Suk Chung, Tae-Sung Bae, Yeonwoong Jung, and Tania Roy
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Mechanics of Materials ,Mechanical Engineering ,General Materials Science ,General Chemistry ,Condensed Matter Physics - Abstract
Memristors for neuromorphic computing have gained prominence over the years for implementing synapses and neurons due to their nano-scale footprint and reduced complexity. Several demonstrations show two-dimensional (2D) materials as a promising platform for the realization of transparent, flexible, ultra-thin memristive synapses. However, unsupervised learning in a spiking neural network (SNN) facilitated by linearity and symmetry in synaptic weight update has not been explored thoroughly using the 2D materials platform. Here, we demonstrate that graphene/MoS2/SiOx/Ni synapses exhibit ideal linearity and symmetry when subjected to identical input pulses, which is essential for their role in online training of neural networks. The linearity in weight update holds for a range of pulse width, amplitude and number of applied pulses. Our work illustrates that the mechanism of switching in MoS2-based synapses is through conductive filaments governed by Poole-Frenkel emission. We demonstrate that the graphene/MoS2/SiOx/Ni synapses, when integrated with a MoS2-based leaky integrate-and-fire neuron, can control the spiking of the neuron efficiently. This work establishes 2D MoS2 as a viable platform for all-memristive SNNs.
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- 2023
11. Microsatellite Instability and Effectiveness of Adjuvant Treatment in pT1N1 Gastric Cancer: A Multicohort Study
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Hyunki Kim, Ji Yeong An, Sung Hoon Noh, Tae Sung Sohn, Yoon Young Choi, Kyoung-Mee Kim, Namkee Oh, Jae Ho Cheong, and Jeeyun Lee
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medicine.medical_specialty ,medicine.medical_treatment ,Gastroenterology ,Stomach Neoplasms ,Surgical oncology ,Internal medicine ,Humans ,Medicine ,Survival rate ,Neoplasm Staging ,Retrospective Studies ,Univariate analysis ,business.industry ,Hazard ratio ,Cancer ,Microsatellite instability ,Retrospective cohort study ,Prognosis ,medicine.disease ,digestive system diseases ,Oncology ,Chemotherapy, Adjuvant ,Microsatellite Instability ,Surgery ,Neoplasm Recurrence, Local ,business ,Adjuvant - Abstract
Microsatellite status is a prognostic biomarker in advanced gastric cancer. This retrospective study aimed to investigate the usefulness of microsatellite status in predicting prognosis and response to adjuvant treatment in pT1N1 gastric cancer. Among 875 patients who underwent radical gastrectomy for pT1N1 gastric cancer at two tertiary hospitals, 838 with available microsatellite instability (MSI) data were included and classified into two groups according to microsatellite status: microsatellite stable (MSS) and MSI-high (MSI-H). Recurrence-free survival rate and risk factors for tumor recurrence were analyzed. Of 838 gastric cancer patients, 100 (11.9%) were MSI-H and 307 (36.6%) received adjuvant treatment. During median follow-up of 70 months, 42 (5.0%) patients experienced gastric cancer recurrence; hematogenous recurrences were the most common (45.2%). Recurrence-free survival was similar in the MSS and MSI-H groups (p = 0.27), and adjuvant treatment did not show an oncological benefit over surgery alone for pT1N1 gastric cancer (p = 0.53). On univariate analysis, age, operation period, and Lauren classification were significantly associated with tumor recurrence, while adjuvant treatment and MSI status were not associated with tumor recurrence. On multivariate analysis, MSI status was not associated with tumor recurrence, and adjuvant treatment worsened the tumor recurrence risk [hazard ratio (HR) 2.373, 95% confidence interval (CI) 1.125–5.006, p = 0.023). MSI status may not be a prognostic factor for tumor recurrence or a predictor of response to adjuvant treatment in pT1N1 gastric cancer patients. Considering that the effect of adjuvant treatment to decrease the risk of tumor recurrence is not clear, it may not be indicated in pT1N1 patients.
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- 2021
12. Bioanalysis of alpelisib using liquid chromatography–tandem mass spectrometry and application to pharmacokinetic study
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Seop Lee, Min-Soo Kim, Jong-Woo Jeong, Jung-woo Chae, Tae-Sung Koo, Han-Joo Maeng, Suk-Jae Chung, Kyeong-Ryoon Lee, and Yoon-Jee Chae
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General Physics and Astronomy ,General Materials Science ,General Chemistry ,General Biochemistry, Genetics and Molecular Biology ,General Environmental Science - Abstract
Alpelisib is the first alpha-specific phosphatidylinositol-3-kinase (PI3K) inhibitor indicated for the treatment of hormone receptor-positive, human epidermal growth factor receptor 2-negative, PI3K catalytic subunit alpha-mutated, advanced, or metastatic breast cancer. Substantial attempts have been made to extend its clinical use to other types of cancer. Analytical methods proven to accurately quantify alpelisib would improve the reliability of the preclinical and clinical data of alpelisib. Therefore, we developed and validated a quantification method based on liquid chromatography–tandem mass spectrometry for alpelisib in mouse and human plasma samples. Alpelisib and an internal standard (IS; enzalutamide) were separated from endogenous substances using an XTerra MS C18 column with a linear gradient of 0.1% formic acid in water and 0.1% formic acid in acetonitrile. Multiple reaction monitoring transitions for alpelisib and the IS were m/z 442.1 > 328.0 and m/z 465.0 > 209.1, respectively. The calibration curve for alpelisib was confirmed to be linear in the range of 1–2000 ng/mL in both mouse and human plasma. The intra- and inter-day accuracy and precision met the acceptance criteria, and no significant matrix effects were observed. Alpelisib was stable under various storage and handling conditions, and the carryover effect was overcome using the injection loop flushing method. We successfully used this assay to study the in vitro metabolic profiles and in vivo pharmacokinetics of alpelisib in mice. Here, to the best of our knowledge, we report for the first time a valid quantitative method for alpelisib in mouse and human plasma, which could aid in providing valuable pharmacokinetic information on alpelisib to increase its clinical availability.
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- 2022
13. FDG metabolic parameter-based models for predicting recurrence after upfront surgery in synchronous colorectal cancer liver metastasis
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Lee, Hyo Sang, primary, Kwon, Hyun Woo, additional, Lim, Seok-Byung, additional, Kim, Jin Cheon, additional, Yu, Chang Sik, additional, Hong, Yong Sang, additional, Kim, Tae Won, additional, Oh, Minyoung, additional, Han, Sangwon, additional, Oh, Jae Hwan, additional, Park, Sohyun, additional, Kim, Tae-Sung, additional, Kim, Seok-ki, additional, Kim, Hyun Joo, additional, Kwak, Jae Young, additional, Oh, Ho-Suk, additional, Kim, Sungeun, additional, Kwak, Jung-Myun, additional, Lee, Ji Sung, additional, and Kim, Jae Seung, additional
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- 2022
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14. Bioanalysis of alpelisib using liquid chromatography–tandem mass spectrometry and application to pharmacokinetic study
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Lee, Seop, primary, Kim, Min-Soo, additional, Jeong, Jong-Woo, additional, Chae, Jung-woo, additional, Koo, Tae-Sung, additional, Maeng, Han-Joo, additional, Chung, Suk-Jae, additional, Lee, Kyeong-Ryoon, additional, and Chae, Yoon-Jee, additional
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- 2022
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15. Changes in working status after cancer diagnosis and socio-demographic, clinical, work-related, and psychological factors associated with it
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Kang, Danbee, primary, Bae, Ka Ryeong, additional, Kim, Ho Young, additional, Ahn, Yeojin, additional, Kim, Nayeon, additional, Shim, Youngmog, additional, Sohn, Tae Sung, additional, Lee, Woo Yong, additional, Baek, Ji Hyun, additional, Kweon, Sun-Seog, additional, and Cho, Juhee, additional
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- 2022
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16. Mechanical Properties of PP/Glass Fiber/Kenaf/Bamboo Fiber-reinforced Hybrid Composite
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Tae Sung Park, Eun Young Park, Su Kyoung Lee, and Seung Kook An
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Polypropylene ,Bamboo ,Materials science ,Polymers and Plastics ,biology ,General Chemical Engineering ,Composite number ,Glass fiber ,02 engineering and technology ,General Chemistry ,Molding (process) ,010402 general chemistry ,021001 nanoscience & nanotechnology ,biology.organism_classification ,01 natural sciences ,Kenaf ,0104 chemical sciences ,chemistry.chemical_compound ,chemistry ,Ultimate tensile strength ,Fiber ,Composite material ,0210 nano-technology - Abstract
The present study deals with the effect of hybrid ratio on the mechanical properties and thermal properties of kenaf, bamboo fiber-reinforced hybrid polypropylene (PP) composites. The present work deals with the fabricating and characterization of PP/glass fiber/kenaf/bamboo fiber-reinforced composite. The composite of PP reinforced with kenaf, bamboo fiber and kenaf/bamboo fiber was made using injection molding technique. Different fiber loadings of 100, 75, 50, 25, 0 wt% kenaf/bamboo composites were also prepared. Scanning electron microscopy (SEM) were performed for non-mixed fiber and mixed compounds. By observing FE_SEM, the random directionality of fiber direction was reduced as the KF content increased, thus improving the physical characteristic value. Moreover, since the kenaf and bamboo were mixed with the pp, PP/glass fiber/kenaf/bamboo fiber-reinforced composite had better physical, morphological and mechanical properties. However, variations in tensile and impact properties depend on the mixing ratio. The mechanical properties of PP/glass fiber/kenaf/bamboo fiber-reinforced composite compared with those of non-mixed stand-alone were also measured. The mechanical properties were higher when 75 wt% kenaf/bamboo fibers were mixed. And the calculation of the volume fraction also showed the tendency of increasing mechanical properties according to the increasing proportion of fibers.
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- 2021
17. Effect of Physicochemical Properties of Slag on the Removal Rate of Alumina Inclusions in the Ruhrstahl–Heraeus (RH) Refining Conditions
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Kim, Tae Sung, primary, Yang, Jian, additional, and Park, Joo Hyun, additional
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- 2022
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18. Author Correction: Improved device efficiency and lifetime of perovskite light-emitting diodes by size-controlled polyvinylpyrrolidone-capped gold nanoparticles with dipole formation
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Chang Min Lee, Dong Hyun Choi, Amjad Islam, Dong Hyun Kim, Tae Wook Kim, Geon‑Woo Jeong, Hyun Woo Cho, Min Jae Park, Syed Hamad Ullah Shah, Hyung Ju Chae, Kyoung-Ho Kim, Muhammad Sujak, Jae Woo Lee, Donghyun Kim, Chul Hoon Kim, Hyun Jae Lee, Tae‑Sung Bae, Seung Min Yu, Jong Sung Jin, Yong‑Cheol Kang, Juyun Park, Myungkwan Song, Chang‑Su Kim, Sung Tae Shin, and Seung Yoon Ryu
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Multidisciplinary - Published
- 2022
19. Improvement of osseointegration of Ti–6Al–4V ELI alloy orthodontic mini-screws through anodization, cyclic pre-calcification, and heat treatments
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Im, Changkyun, primary, Park, Je-Hyeok, additional, Jeon, Young-Mi, additional, Kim, Jong-Ghee, additional, Jang, Yong-Seok, additional, Lee, Min-Ho, additional, Jeon, Woo-Yong, additional, Kim, Jun-Min, additional, and Bae, Tae-Sung, additional
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- 2022
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20. Author Correction: Improved device efficiency and lifetime of perovskite light-emitting diodes by size-controlled polyvinylpyrrolidone-capped gold nanoparticles with dipole formation
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Lee, Chang Min, primary, Choi, Dong Hyun, additional, Islam, Amjad, additional, Kim, Dong Hyun, additional, Kim, Tae Wook, additional, Jeong, Geon‑Woo, additional, Cho, Hyun Woo, additional, Park, Min Jae, additional, Shah, Syed Hamad Ullah, additional, Chae, Hyung Ju, additional, Kim, Kyoung-Ho, additional, Sujak, Muhammad, additional, Lee, Jae Woo, additional, Kim, Donghyun, additional, Kim, Chul Hoon, additional, Lee, Hyun Jae, additional, Bae, Tae‑Sung, additional, Yu, Seung Min, additional, Jin, Jong Sung, additional, Kang, Yong‑Cheol, additional, Park, Juyun, additional, Song, Myungkwan, additional, Kim, Chang‑Su, additional, Shin, Sung Tae, additional, and Ryu, Seung Yoon, additional
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- 2022
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21. Improved device efficiency and lifetime of perovskite light-emitting diodes by size-controlled polyvinylpyrrolidone-capped gold nanoparticles with dipole formation
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Lee, Chang Min, primary, Choi, Dong Hyun, additional, Islam, Amjad, additional, Kim, Dong Hyun, additional, Kim, Tae Wook, additional, Jeong, Geon-Woo, additional, Cho, Hyun Woo, additional, Park, Min Jae, additional, Shah, Syed Hamad Ullah, additional, Chae, Hyung Ju, additional, Kim, Kyoung-Ho, additional, Sujak, Muhammad, additional, Lee, Jae Woo, additional, Kim, Donghyun, additional, Kim, Chul Hoon, additional, Lee, Hyun Jae, additional, Bae, Tae-Sung, additional, Yu, Seung Min, additional, Jin, Jong Sung, additional, Kang, Yong-Cheol, additional, Park, Juyun, additional, Song, Myungkwan, additional, Kim, Chang-Su, additional, Shin, Sung Tae, additional, and Ryu, Seung Yoon, additional
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- 2022
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22. Early experience of laparoscopic resection and comparison with open surgery for gastric gastrointestinal stromal tumor: a multicenter retrospective study
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Park, Shin-Hoo, primary, Lee, Hyuk-Joon, additional, Kim, Min-Chan, additional, Yook, Jeong-Hwan, additional, Sohn, Tae-Sung, additional, Hyung, Woo-Jin, additional, Ryu, Seung-Wan, additional, Kurokawa, Yukinori, additional, Kim, Young-Woo, additional, Han, Sang-Uk, additional, Kim, Hyung-Ho, additional, Park, Do-Joong, additional, Kim, Wook, additional, Lee, Sang-Il, additional, Cho, Haruhiko, additional, Cho, Gyu-Seok, additional, Kim, Jin-Jo, additional, Kim, Ki-Han, additional, Yoo, Moon-Won, additional, and Yang, Han-Kwang, additional
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- 2022
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23. Adjuvant Chemotherapy vs. Surgery Alone for pT3N0M0 Gastric Cancer
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Jae Moon Bae, Sung Kim, Minseo Kang, Jun Ho Lee, Min-Gew Choi, Tae Sung Sohn, Ji Yeong An, and Ho Geun Youn
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medicine.medical_specialty ,Adjuvant chemotherapy ,medicine.medical_treatment ,Tegafur ,Gastroenterology ,03 medical and health sciences ,0302 clinical medicine ,Gastrectomy ,Stomach Neoplasms ,Surgical oncology ,Internal medicine ,Antineoplastic Combined Chemotherapy Protocols ,medicine ,Humans ,In patient ,Significant risk ,Neoplasm Staging ,Retrospective Studies ,Tumor size ,business.industry ,Cancer ,medicine.disease ,Oxonic Acid ,Oncology ,Chemotherapy, Adjuvant ,030220 oncology & carcinogenesis ,030211 gastroenterology & hepatology ,Surgery ,Neoplasm Recurrence, Local ,business ,Adjuvant ,medicine.drug - Abstract
As both the role and clinical application of adjuvant chemotherapy (CTx) for pT3N0M0 gastric cancer after curative gastrectomy have fluctuated chronologically, the oncological benefit of adjuvant CTx in patients should be elucidated. Between 2000 and 2018, 1083 patients underwent radical gastrectomy for pT3N0M0 gastric cancer and were subsequently divided into two groups: the surgery-alone group (n = 471) and the adjuvant CTx group (n = 612). Chronological changes in adjuvant CTx and various chemotherapeutic regimens were evaluated and disease-free survival was compared between the two groups. Risk factors for tumor recurrence were also analyzed. The proportion of patients in the surgery-alone group was more than 60% until 2001, whereas in the CTx group this increased to over 80%, especially after publication of the American Joint Committee on Cancer (AJCC) 7th edition staging manual. The main chemotherapeutic agents were tegafur-uracil (UFT) and 5-fluorouracil with leucovorin until 2008, whereas tegafur/gimeracil/oteracil (TS-1) has been the main agent since 2009. The 5-year disease-free survival was 89.2% in the surgery-alone group and 89.9% in the CTx group, which was not significantly different (p = 0.694). In multivariate analysis, larger tumor size (≥ 4.5 cm) and venous invasion were significant risk factors for tumor recurrence. In addition, adjuvant CTx did not improve the oncological outcome, even in the large tumor size group (p = 0.760) and the venous invasion group (p = 0.753). As adjuvant CTx did not show any oncological benefit in pT3N0M0 gastric cancer in this large-scale study, it might be unnecessary for these patients after curative gastrectomy.
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- 2020
24. Effect of CaF2 on Phosphorus Refining from Molten Steel by Electric Arc Furnace Slag using Direct Reduced Iron (DRI) as a Raw Material
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Min Kyo Oh, Joo Hyun Park, and Tae Sung Kim
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010302 applied physics ,Materials science ,Structural material ,Phosphorus ,Metallurgy ,0211 other engineering and technologies ,Metals and Alloys ,Slag ,chemistry.chemical_element ,02 engineering and technology ,Raw material ,Direct reduced iron ,Condensed Matter Physics ,01 natural sciences ,Volume (thermodynamics) ,chemistry ,Mechanics of Materials ,visual_art ,0103 physical sciences ,Materials Chemistry ,visual_art.visual_art_medium ,021102 mining & metallurgy ,Refining (metallurgy) ,Electric arc furnace - Abstract
The effect of CaF2 addition on dephosphorization reaction between molten steel and electric arc furnace (EAF) slag using direct reduced iron (DRI) at 1823 K (1550 °C) was investigated. Basicity, the thermodynamic parameter affecting the removal capacity of phosphorus (i.e., phosphate capacity), decreased using DRI due to an increased SiO2 concentration in the slag. To minimize slag volume and maximize dephosphorization efficiency, the CaF2 was added to the slag. As CaF2 content increased (0 to 10 mass pct), dephosphorization efficiency also increased. Thermodynamic analysis in conjunction with slag structural studies using Raman spectroscopy were conducted to explain the complicated phenomena. The results exhibited that even 5 to 6 mass pct CaF2 can improve the dephosphorization efficiency when DRI is used as raw material in an EAF process.
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- 2020
25. A physiological model of granulopoiesis to predict clinical drug induced neutropenia from in vitro bone marrow studies: with application to a cell cycle inhibitor
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David Z. D'Argenio, Wenbo Chen, Tae Sung, Diane Wang, Britton Boras, Jenny Zheng, Mary E. Spilker, Wenyue Hu, and Yanke Yu
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Neutropenia ,Filgrastim ,Neutrophils ,Pyridines ,Antineoplastic Agents ,Granulocyte ,Pharmacology ,Palbociclib ,Models, Biological ,030226 pharmacology & pharmacy ,Granulopoiesis ,Article ,Piperazines ,Polyethylene Glycols ,Leukocyte Count ,03 medical and health sciences ,0302 clinical medicine ,Bone Marrow ,Cell Movement ,Granulocyte Colony-Stimulating Factor ,medicine ,Humans ,business.industry ,Stem Cells ,Cell Cycle ,medicine.disease ,Hematopoiesis ,Granulocyte colony-stimulating factor ,medicine.anatomical_structure ,030220 oncology & carcinogenesis ,Absolute neutrophil count ,Bone marrow ,business ,Algorithms ,Granulocytes ,medicine.drug - Abstract
Neutropenia is one of the most common dose-limiting toxocities associated with anticancer drug therapy. The ability to predict the probability and severity of neutropenia based on in vitro studies of drugs in early drug development will aid in advancing safe and efficacious compounds to human testing. Toward this end, a physiological model of granulopoiesis and its regulation is presented that includes the bone marrow progenitor cell cycle, allowing for a mechanistic representation of the action of relevant anticancer drugs based on in vitro studies. Model development used data from previously reported tracer kinetic studies of granulocyte disposition in healthy humans to characterize the dynamics of neutrophil margination in the presence of endogenous granulocyte-colony stimulating factor (G-CSF). In addition, previously published data from healthy volunteers following pegfilgrastim and filgrastim were used to quantify the regulatory effects of support G-CSF therapies on granulopoiesis. The model was evaluated for the cell cycle inhibitor palbociclib, using an in vitro system of human bone marrow mononuclear cells to quantify the action of palbociclib on proliferating progenitor cells, including its inhibitory effect on G1 to S phase transition. The in vitro results were incorporated into the physiological model of granulopoiesis and used to predict the time course of absolute neutrophil count (ANC) and the incidence of neutropenia observed in three previously reported clinical trials of palbociclib. The model was able to predict grade 3 and 4 neutropenia due to palbociclib treatment with 86% accuracy based on in vitro data.
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- 2020
26. Author Correction: Highly efficient, heat dissipating, stretchable organic light-emitting diodes based on a MoO3/Au/MoO3 electrode with encapsulation
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Choi, Dae Keun, primary, Kim, Dong Hyun, additional, Lee, Chang Min, additional, Hafeez, Hassan, additional, Sarker, Subrata, additional, Yang, Jun Su, additional, Chae, Hyung Ju, additional, Jeong, Geon-Woo, additional, Choi, Dong Hyun, additional, Kim, Tae Wook, additional, Yoo, Seunghyup, additional, Song, Jinouk, additional, Ma, Boo Soo, additional, Kim, Taek-Soo, additional, Kim, Chul Hoon, additional, Lee, Hyun Jae, additional, Lee, Jae Woo, additional, Kim, Donghyun, additional, Bae, Tae-Sung, additional, Yu, Seung Min, additional, Kang, Yong-Cheol, additional, Park, Juyun, additional, Kim, Kyoung-Ho, additional, Sujak, Muhammad, additional, Song, Myungkwan, additional, Kim, Chang-Su, additional, and Ryu, Seung Yoon, additional
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- 2021
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27. Effect of LCFeCr Alloy Additions on the Non-metallic Inclusion Characteristics in Ti-Containing Ferritic Stainless Steel
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Wang, Yong, primary, Oh, Min Kyo, additional, Kim, Tae Sung, additional, Karasev, Andrey, additional, Mu, Wangzhong, additional, Park, Joo Hyun, additional, and Jönsson, Pär G., additional
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- 2021
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28. Pharmacokinetics and diuretic effect of furosemide after single intravenous, oral tablet, and newly developed oral disintegrating film administration in healthy beagle dogs
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Koh, Suk-Kyu, primary, Jeong, Jong-Woo, additional, Choi, Seo-In, additional, Kim, Rae Man, additional, Koo, Tae-Sung, additional, Cho, Kwan Hyung, additional, and Seo, Kyoung-Won, additional
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- 2021
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29. ASO Video Abstract: Microsatellite Instability and the Effectiveness of Adjuvant Treatment in pT1N1 Gastric Cancer—A Multi-cohort Study
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Oh, Namkee, primary, Kim, Hyunki, additional, Kim, Kyoung-Mee, additional, Cheong, Jae-Ho, additional, Lee, Jeeyun, additional, Noh, Sung Hoon, additional, Sohn, Tae Sung, additional, Choi, Yoon Young, additional, and An, Ji Yeong, additional
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- 2021
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30. Microsatellite Instability and Effectiveness of Adjuvant Treatment in pT1N1 Gastric Cancer: A Multicohort Study
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Oh, Namkee, primary, Kim, Hyunki, additional, Kim, Kyoung-Mee, additional, Cheong, Jae-Ho, additional, Lee, Jeeyun, additional, Noh, Sung Hoon, additional, Sohn, Tae Sung, additional, Choi, Yoon Young, additional, and An, Ji Yeong, additional
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- 2021
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31. Structural Understanding of MnO–SiO2–Al2O3–Ce2O3 Slag via Raman, 27Al NMR and X-ray Photoelectron Spectroscopies
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Joo Hyun Park, Se Ji Jeong, and Tae Sung Kim
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Materials science ,020502 materials ,Aluminate ,Metals and Alloys ,Analytical chemistry ,chemistry.chemical_element ,02 engineering and technology ,Condensed Matter Physics ,NMR spectra database ,chemistry.chemical_compound ,Cerium ,symbols.namesake ,0205 materials engineering ,chemistry ,Octahedron ,X-ray photoelectron spectroscopy ,Mechanics of Materials ,Oxidation state ,Materials Chemistry ,symbols ,Spectroscopy ,Raman spectroscopy - Abstract
In order to understand sulfur solubility in the MnO–SiO2–Al2O3–Ce2O3 slag or inclusion system (mol MnO/mol SiO2 = M/S = 2.2 or 0.9, Al2O3 = 14.2[± 1.8] mol%, Ce2O3 = 0–5.6 mol%), the effect of Ce3+ ions on the structure of the Mn–aluminosilicate system with different M/S molar ratios has been studied by micro-Raman spectroscopy, solid-state nuclear magnetic resonance (NMR) spectroscopy and X-ray photoelectron spectroscopy (XPS). Because constant oxygen partial pressure was maintained at p(O2) = 2.8 × 10−7 atm, oxidation state of Mn and Ce would be in Mn2+ and Ce3+ in the MnO–SiO2–Al2O3–Ce2O3 system, which were also confirmed by XPS analysis. Although it was difficult to measure the 27Al solid-state NMR spectra of the quenched MnO–SiO2–Al2O3 system due to the paramagnetic effect, 27Al NMR spectra did show structural changes in aluminate when cerium was added to the Mn–aluminosilicate melts. Addition of Ce2O3 in the high M/S(= 2.2) system caused both an explosive enhancement in the intensity of Raman bands at 600 cm−1 and a peak shift in 27Al NMR spectra, indicating the transition from the [AlO4]–:0.5Mn2+ tetrahedron to a [AlO6]3–:Ce3+ octahedron complex due to a strong attraction between aluminate and the cerium ion. XPS spectra show that the transition of the aluminate structure upon introduction of Ce3+ ions consumes free oxygen in Mn–aluminosilicate melts in high M/S(= 2.2) system. However, the same structural changes were not observed when Ce2O3 was added to lower M/S(= 0.9) system, because Ce3+ ions primarily interact with the pre-existing [AlO6]-octahedron in low M/S system.
- Published
- 2019
32. Hyperspectral Image Recovery Using a Color Camera for Detecting Colonies of Foodborne Pathogens on Agar Plate
- Author
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Gerald W. Heitschmidt, Bosoon Park, Tae-Sung Shin, Seung-Chul Yoon, Kurt C. Lawrence, and Gary R. Gamble
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business.industry ,Computer science ,Mechanical Engineering ,Hyperspectral imaging ,Pattern recognition ,Sparse approximation ,Agricultural and Biological Sciences (miscellaneous) ,Computer Science Applications ,Agar plate ,Image recovery ,Bayesian multivariate linear regression ,Test set ,Partial least squares regression ,Hyperspectral image classification ,Artificial intelligence ,business ,Engineering (miscellaneous) - Abstract
Hyperspectral imaging often requires a special camera system to obtain spectral images. The cost for acquisition and process of hyperspectral images is usually much higher than color images. On the contrary, typical consumer-grade digital color cameras are much cheaper to obtain and process spatially high-resolution images than hyperspectral cameras. This paper is concerned with the development of a hyperspectral image recovery technique that can reconstruct hyperspectral images only from color images obtained by a digital color camera. A sparse representation and least squares regression-based classification of foodborne pathogens on agar plates are presented. The target pathogen bacteria were the six representative non-O157 Shiga toxin-producing Escherichia coli (STEC) serogroups (O26, O45, O103, O111, O121, and O145). The wavelength range for the spectral recovery was from 400 to 1000 nm. Unlike many other studies using color charts with known and noise-free spectra for training their spectral recovery models, we directly used the hyperspectral and color images of real scenes for training the spectral recovery models. Both hyperspectral and color images were calibrated to percent reflectance values and then spatially registered. Two spectral recovery models including polynomial multivariate linear regression (MLR) and partial least squares regression (PLSR) were evaluated and compared by cross-validation and independent test. The spectral recovery results showed that the PLSR was more effective than the MLR. The classification accuracy measured with recovered spectra in an independent test set was about 5–10% less than the case of using the true hyperspectral images although the difference in maximum classification accuracy was only about 2%. The results suggested the potential of a cost-effective color imaging system using hyperspectral image classification algorithms for differentiating pathogens in agar plates.
- Published
- 2019
33. Comparison of Postoperative Nutritional Status after Distal Gastrectomy for Gastric Cancer Using Three Reconstructive Methods: a Multicenter Study of over 1300 Patients
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Jun Ho Lee, Jae Moon Bae, Ji Yeong An, Tae Sung Sohn, Sung Kim, Min Gew Choi, You Na Kim, Sung Hoon Noh, and Yoon Young Choi
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medicine.medical_specialty ,Low protein ,medicine.medical_treatment ,Nutritional Status ,Gastroenterology ,03 medical and health sciences ,chemistry.chemical_compound ,Postoperative Complications ,0302 clinical medicine ,Gastrectomy ,Stomach Neoplasms ,Internal medicine ,medicine ,Humans ,Billroth I ,Aged ,Billroth II ,Cholesterol ,business.industry ,Albumin ,Cancer ,Anastomosis, Roux-en-Y ,Perioperative ,medicine.disease ,Treatment Outcome ,chemistry ,030220 oncology & carcinogenesis ,030211 gastroenterology & hepatology ,Surgery ,Gastroenterostomy ,business ,Body mass index - Abstract
Perioperative nutritional status has been reported to be associated with short- and long-term outcomes after surgery in gastric cancer patients. This study compared changes in nutritional status after distal gastrectomy using the Billroth I (BI), Billroth II (BII), and Roux-en-Y (RY) reconstruction techniques in gastric cancer patients.Data from 1305 gastric cancer patients who underwent distal gastrectomy at two tertiary hospitals from January 2011 to December 2016 were reviewed. The patients were divided into three groups according to reconstruction type: BI, BII, and RY. We evaluated changes in nutritional parameters including body mass index (BMI), biochemical data, the prognostic nutritional index (PNI), nutritional risk index (NRI), and geriatric nutritional risk index (GNRI) preoperatively, and 3, 6, and 12 months after surgery.Total protein, albumin, PNI, and NRI were significantly lower in the BII group than in the BI and RY groups during follow-up (P 0.001). In multivariate analysis, reconstruction types were independently related to decreases in BMI ( 10%), low serum protein, albumin, and cholesterol 12 months after surgery. Compared with BI, BII was associated with decreased BMI, low protein, and albumin and RY was associated with decreased BMI and low cholesterol.During the first year after gastric cancer surgery, postoperative nutritional status differed according to the reconstruction type; BI resulted in the least weight and nutritional loss, RY yielded results comparable with BI in the nutritional indexes, and BII resulted in the greatest nutritional loss.
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- 2019
34. Influence of Temperature on Reaction Mechanism of Ilmenite Ore Smelting for Titanium Production
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Joo Hyun Park, Tae Sung Kim, Dong Hyeon Kim, Jung Ho Heo, and Hyun Park
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Pseudobrookite ,Materials science ,0211 other engineering and technologies ,chemistry.chemical_element ,02 engineering and technology ,Activation energy ,engineering.material ,01 natural sciences ,Reaction rate constant ,0103 physical sciences ,Materials Chemistry ,021102 mining & metallurgy ,010302 applied physics ,Precipitation (chemistry) ,Metallurgy ,Metals and Alloys ,Slag ,Condensed Matter Physics ,chemistry ,Mechanics of Materials ,visual_art ,Smelting ,visual_art.visual_art_medium ,engineering ,Ilmenite ,Titanium - Abstract
The carbothermic smelting reduction process of ilmenite ore at high temperature was investigated by thermodynamic calculations in conjunction with smelting experiments. Based on thermodynamic calculations, conducting the smelting process at a higher temperature was recommended to achieve a larger amount of FeO reduction, i.e., higher Ti-enrichment, as less precipitate and thus large amounts of a liquid slag were predicted. However, even though the reduction of FeO in ilmenite ore at the initial stage seemed to be faster as the temperature increased, no significant difference in the TiO2 or FeO concentration was observed after the reaction was complete, regardless of the temperature. This was caused by the precipitation of pseudobrookite due to the local depletion of FeO during reaction at higher temperatures, by which further reduction reaction was prohibited. The apparent rate constant increased with increasing temperature and the activation energy of the reduction process was estimated to be 144 kJ/mol, from which it was concluded that the reduction reaction of FeO in ilmenite slag by carbonaceous reductant was generally controlled through the mass transfer in the slag phase. Additionally, the formation of TiC also occurred in the iron bath. At 1923 K (1650 °C), approx. 20 pct more TiC was generated as compared to TiC formation at 1823 K (1550 °C), which also prevented further reduction of Fe at higher temperatures.
- Published
- 2019
35. Compliance with D2 lymph node dissection in reduced-port totally laparoscopic distal gastrectomy in patients with gastric cancer
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Ji Yeong An, Jae Moon Bae, Jeong Eun Seo, Tae Sung Sohn, Sung Eun Oh, Jun Ho Lee, Min-Gew Choi, and Sung Kim
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Adult ,Male ,Laparoscopic surgery ,medicine.medical_specialty ,Science ,medicine.medical_treatment ,Article ,Young Adult ,Gastrointestinal cancer ,03 medical and health sciences ,0302 clinical medicine ,Port (medical) ,Gastrectomy ,Stomach Neoplasms ,medicine ,Humans ,Lymph node ,Aged ,Aged, 80 and over ,Multidisciplinary ,business.industry ,Cancer ,Postoperative complication ,Middle Aged ,medicine.disease ,Surgery ,Clinical trial ,Dissection ,Treatment Outcome ,medicine.anatomical_structure ,Surgical oncology ,030220 oncology & carcinogenesis ,Medicine ,Lymph Node Excision ,Female ,Laparoscopy ,030211 gastroenterology & hepatology ,Lymph Nodes ,business - Abstract
This phase II clinical trial was performed to determine whether reduced-port laparoscopic surgery with complete D2 lymph node (LN) dissection for gastric cancer is a safe and feasible surgical technique. The prospectively enrolled 65 gastric cancer patients underwent reduced-port surgery (i.e., triple-incision totally laparoscopic distal gastrectomy [Duet TLDG] with D2 lymphadenectomy). Compliance rate was the primary outcome, which was defined as cases in which there was no more than one missing LN station during D2 LN dissection. The secondary outcomes were the numbers of dissected and retrieved LNs in each station and other short-term surgical outcomes and postoperative course. The compliance rate was 58.5%. The total number of retrieved LNs was 41 (range: 14–83 LNs). The most common station missing from LN retrieval was station no. 5 (35/65; 53.8%), followed by station no. 1 (24/65; 36.9%). The overall postoperative complication rate was 20.0% (13/65). One patient underwent surgical treatment for postoperative complications. There was no instances of mortality. Duet TLDG is an oncologically and technically safe surgical method of gastrectomy and D2 lymphadenectomy.
- Published
- 2021
36. A preoperative risk prediction model for high malignancy potential gastrointestinal stromal tumors of the stomach
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Kim, Jun Young, primary, Kim, Tae Jun, additional, Lee, Dong Kyu, additional, Min, Yang Won, additional, Lee, Hyuk, additional, Min, Byung-Hoon, additional, Lee, Jun Haeng, additional, An, Ji Yeong, additional, Choi, Min Gew, additional, Sohn, Tae Sung, additional, Bae, Jae Moon, additional, Kim, Hye Seung, additional, Ahn, Joong Hyun, additional, and Kim, Jae J., additional
- Published
- 2021
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37. Highly efficient, heat dissipating, stretchable organic light-emitting diodes based on a MoO3/Au/MoO3 electrode with encapsulation
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Choi, Dae Keun, primary, Kim, Dong Hyun, additional, Lee, Chang Min, additional, Hafeez, Hassan, additional, Sarker, Subrata, additional, Yang, Jun Su, additional, Chae, Hyung Ju, additional, Jeong, Geon-Woo, additional, Choi, Dong Hyun, additional, Kim, Tae Wook, additional, Yoo, Seunghyup, additional, Song, Jinouk, additional, Ma, Boo Soo, additional, Kim, Taek-Soo, additional, Kim, Chul Hoon, additional, Lee, Hyun Jae, additional, Lee, Jae Woo, additional, Kim, Donghyun, additional, Bae, Tae-Sung, additional, Yu, Seung Min, additional, Kang, Yong-Cheol, additional, Park, Juyun, additional, Kim, Kyoung-Ho, additional, Sujak, Muhammad, additional, Song, Myungkwan, additional, Kim, Chang-Su, additional, and Ryu, Seung Yoon, additional
- Published
- 2021
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- View/download PDF
38. Significant increase in the secretion of extracellular vesicles and antibiotics resistance from methicillin-resistant Staphylococcus aureus induced by ampicillin stress
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Seong Bin Park, Min Woo Ha, Jung Seok Lee, Christopher M. M. Franco, Tae Sung Jung, Ae Rin Lee, Jong Wook Song, Seung-Mann Paek, Wei Zhang, Jong-Su Seo, Jassy Mary S. Lazarte, Jong-Hwan Kim, Myunghwan Jung, Si Won Kim, Jae Wook Jung, Jin Hong Chun, and Jaesung Kim
- Subjects
Methicillin-Resistant Staphylococcus aureus ,0301 basic medicine ,medicine.drug_class ,030106 microbiology ,Antibiotics ,Microbial Sensitivity Tests ,Biology ,beta-Lactams ,Antimicrobial resistance ,medicine.disease_cause ,beta-Lactamases ,Article ,Microbiology ,Extracellular Vesicles ,03 medical and health sciences ,Minimum inhibitory concentration ,Antibiotic resistance ,Bacterial Proteins ,Stress, Physiological ,Ampicillin ,medicine ,Secretion ,Multidisciplinary ,Cell-Free System ,Drug Resistance, Microbial ,biochemical phenomena, metabolism, and nutrition ,biology.organism_classification ,Methicillin-resistant Staphylococcus aureus ,Anti-Bacterial Agents ,030104 developmental biology ,Staphylococcus aureus ,beta-Lactamase Inhibitors ,Bacteria ,medicine.drug - Abstract
Extracellular vesicles (EVs) containing specific cargo molecules from the cell of origin are naturally secreted from bacteria. EVs play significant roles in protecting the bacterium, which can contribute to their survival in the presence of antibiotics. Herein, we isolated EVs from methicillin-resistant Staphylococcus aureus (MRSA) in an environment with or without stressor by adding ampicillin at a lower concentration than the minimum inhibitory concentration (MIC). We investigated whether EVs from MRSA under stress condition or normal condition could defend susceptible bacteria in the presence of several β-lactam antibiotics, and directly degrade the antibiotics. A comparative proteomic approach was carried out in both types of EVs to investigate β-lactam resistant determinants. The secretion of EVs from MRSA under antibiotic stressed conditions was increased by 22.4-fold compared with that of EVs without stress. Proteins related to the degradation of β-lactam antibiotics were abundant in EVs released from the stressed condition. Taken together, the present data reveal that EVs from MRSA play a crucial role in the survival of β-lactam susceptible bacteria by acting as the first line of defense against β-lactam antibiotics, and antibiotic stress leads to release EVs with high defense activity.
- Published
- 2020
39. Mechanical Properties of PP/Glass Fiber/Kenaf/Bamboo Fiber-reinforced Hybrid Composite
- Author
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Lee, Su Kyoung, primary, Park, Eun Young, additional, Park, Tae Sung, additional, and An, Seung Kook, additional
- Published
- 2021
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40. Author Correction: Progerinin, an optimized progerin-lamin A binding inhibitor, ameliorates premature senescence phenotypes of Hutchinson-Gilford progeria syndrome
- Author
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Kang, So-mi, primary, Yoon, Min-Ho, additional, Ahn, Jinsook, additional, Kim, Ji-Eun, additional, Kim, So Young, additional, Kang, Seock Yong, additional, Joo, Jeongmin, additional, Park, Soyoung, additional, Cho, Jung-Hyun, additional, Woo, Tae-Gyun, additional, Oh, Ah-Young, additional, Chung, Kyu Jin, additional, An, So Yon, additional, Hwang, Tae Sung, additional, Lee, Soo Yong, additional, Kim, Jeong-Su, additional, Ha, Nam-Chul, additional, Song, Gyu-Yong, additional, and Park, Bum-Joon, additional
- Published
- 2021
- Full Text
- View/download PDF
41. Compliance with D2 lymph node dissection in reduced-port totally laparoscopic distal gastrectomy in patients with gastric cancer
- Author
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Oh, Sung Eun, primary, Seo, Jeong Eun, additional, An, Ji Yeong, additional, Choi, Min-Gew, additional, Sohn, Tae Sung, additional, Bae, Jae Moon, additional, Kim, Sung, additional, and Lee, Jun Ho, additional
- Published
- 2021
- Full Text
- View/download PDF
42. Satellite radar observation of large surface collapses induced by the 2017 North Korea nuclear test
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Tae Sung Kim, Won-Kyung Baek, and Hyung-Sup Jung
- Subjects
Surface (mathematics) ,Satellite radar ,Solid Earth sciences ,Multidisciplinary ,lcsh:R ,0211 other engineering and technologies ,Compaction ,lcsh:Medicine ,Collapse (topology) ,Geology ,Landslide ,02 engineering and technology ,Deformation (meteorology) ,010502 geochemistry & geophysics ,01 natural sciences ,Article ,Environmental social sciences ,Epicenter ,lcsh:Q ,Nuclear test ,lcsh:Science ,Seismology ,021101 geological & geomatics engineering ,0105 earth and related environmental sciences - Abstract
The artificial earthquake of mb 6.1 related to the North Korea’s sixth nuclear test occured at Mt. Mantap, North Korea on September 3, 2017. It was reported that a large and complex surface deformation was caused by the event. The surface deformation was composed of expansion of explosions, collapse, compaction and landslides. Since the precise vertical deformation measurement is very important to estimate the stability of the nuclear test facility, we retrieved a precise 3D surface deformation field and then decomposed the vertical deformation pattern from the 3D deformation. The measured maximum deformation was about − 491, − 343 and 166 cm with the measurement uncertainty of about 3.3, 4.1 and 2.7 cm in the east, north and up directions, respectively. The maximum horizontal deformation was approximately 515 cm. The horizontal deformation clearly showed a radial pattern because it was mainly caused by the explosions and landslides, while the vertical deformation displayed a rugged pattern because it was affected by the explosions, compaction and collapse. The collapse may seem to occur along the underground tunnels and at the test site’s epicenter as well. Moreover, the severe collapse was observed westside from the epicenter of the sixth nuclear test, and it has a depth of about 68.6 cm on the area of 0.3765 km2. On the basis of our results including the shapes, locations and volume changes of the large collapse, evidently a new vital piece of information was obtained so that it could be used to interprete the sixth nuclear test more accurately.
- Published
- 2020
43. Development and validation of an LC-MS/MS method for monitoring larotrectinib, a tropomyosin-related kinase inhibitor, in mouse and human plasma and application to pharmacokinetic studies
- Author
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Yoon-Jee Chae, Jong Soon Kang, Kyeong-Ryoon Lee, Yoo-Kyung Song, Song-Hee Chae, Tae-Sung Koo, Jae Young Lee, and Min Ju Kim
- Subjects
Formic acid ,lcsh:Analytical chemistry ,General Physics and Astronomy ,01 natural sciences ,General Biochemistry, Genetics and Molecular Biology ,lcsh:Chemistry ,03 medical and health sciences ,chemistry.chemical_compound ,Pharmacokinetics ,Oral administration ,Protein precipitation ,General Materials Science ,Receptor Tyrosine Kinase Gene ,Receptor ,Larotrectinib ,030304 developmental biology ,General Environmental Science ,0303 health sciences ,lcsh:QD71-142 ,Chromatography ,Mass spectrometry ,010401 analytical chemistry ,Selected reaction monitoring ,General Chemistry ,0104 chemical sciences ,lcsh:QD1-999 ,chemistry ,Trk receptor ,TRK inhibitor - Abstract
Larotrectinib is an orally administered drug and the first and only selective pan-tropomyosin receptor kinase (TRK) inhibitor in clinical development to treat cancer patients harboring a neurotrophic receptor tyrosine kinase gene fusion. In this study, an analytical method to quantify the TRK inhibitor in mouse and human plasma was developed and validated using LC-MS/MS following protein precipitation with acetonitrile. Larotrectinib and an internal standard (carbamazepine) were separated from endogenous substances using an Xterra C18 column with acetonitrile containing 0.1% formic acid as the mobile phase. The ions m/z 429.8 → 342.8 for larotrectinib and m/z 237.0 → 194.0 for carbamazepine detected in multiple reaction monitoring mode were used for the quantitation. The detector response of larotrectinib was linear within the concentration range 5–10,000 ng/mL with a correlation coefficient (r2) of not less than 0.999. The intra- and inter-day precision and accuracy were less than 10.48% and within − 8.99%, respectively, in mouse and human plasma. Larotrectinib was stable under various storage and handling conditions, and no significant matrix effect was observed in both mouse and human plasma. Finally, the assay was successfully applied to the pharmacokinetic study of larotrectinib after its intravenous and oral administration to mice.
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- 2020
44. Comprehensive pharmacogenomic characterization of gastric cancer
- Author
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Yong Jae Shin, Harim Koo, Mi-Suk Kim, Sung Kim, Ji Yeong An, Jung Yong Hong, Ho Yeong Lim, Jae Moon Bae, Yun Jee Seo, Joon Oh Park, Ju Sun Kim, Min Gew Choi, In Kyoung Lee, Moon Hee Sim, Hee Jin Cho, Jeeyun Lee, Do Hyun Nam, Mirinae Kim, Tae Sung Sohn, Kyoung-Mee Kim, Se Hoon Park, Joon-Ho Lee, Won Ki Kang, Jason K. Sa, Ja Yeon Kim, Nam Gu Her, Yeri Lee, Seung Tae Kim, and Ha Jung Kim
- Subjects
Drug ,lcsh:QH426-470 ,Pharmacogenomic Variants ,Class I Phosphatidylinositol 3-Kinases ,media_common.quotation_subject ,medicine.medical_treatment ,lcsh:Medicine ,Antineoplastic Agents ,Targeted therapy ,Transcriptome ,Gefitinib ,Stomach Neoplasms ,Cell Line, Tumor ,Tumor Cells, Cultured ,RNF11 ,Genetics ,medicine ,Humans ,Pyrroles ,Protein Kinase Inhibitors ,Wnt Signaling Pathway ,Molecular Biology ,PIK3CA-E542K ,Genetics (clinical) ,media_common ,business.industry ,Research ,lcsh:R ,Wnt signaling pathway ,Cancer ,medicine.disease ,Human genetics ,DNA-Binding Proteins ,ErbB Receptors ,lcsh:Genetics ,Pyrimidines ,Receptors, Vascular Endothelial Growth Factor ,Drug Resistance, Neoplasm ,Pharmacogenomics ,Mutation ,Cancer research ,Molecular Medicine ,Gastric cancer ,business ,medicine.drug - Abstract
BackgroundGastric cancer is among the most lethal human malignancies. Previous studies have identified molecular aberrations that constitute dynamic biological networks and genomic complexities of gastric tumors. However, the clinical translation of molecular-guided targeted therapy is hampered by challenges. Notably, solid tumors often harbor multiple genetic alterations, complicating the development of effective treatments.MethodsTo address such challenges, we established a comprehensive dataset of molecularly annotated patient derivatives coupled with pharmacological profiles for 60 targeted agents to explore dynamic pharmacogenomic interactions in gastric cancers.ResultsWe identified lineage-specific drug sensitivities based on histopathological and molecular subclassification, including substantial sensitivities toward VEGFR and EGFR inhibition therapies in diffuse- and signet ring-type gastric tumors, respectively. We identified potential therapeutic opportunities for WNT pathway inhibitors inALK-mutant tumors, a significant association betweenPIK3CA-E542K mutation and AZD5363 response, and transcriptome expression ofRNF11as a potential predictor of response to gefitinib.ConclusionsCollectively, our results demonstrate the feasibility of drug screening combined with tumor molecular characterization to facilitate personalized therapeutic regimens for gastric tumors.
- Published
- 2020
45. Analysis of complete chloroplast genome sequence of Korean landrace Cymbidium goeringii
- Author
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Soon-Wook Kwon, Joohyun Lee, Su-Hyang Song, Yong-Chul Kim, Mar-Lar San, Tae-Ho Ham, Heng Wang, So-Yeon Park, Tae-Sung Kim, and Dong-Yong Kim
- Subjects
Whole genome sequencing ,Genetics ,biology ,Phylogenetic tree ,Cymbidium ,food and beverages ,Environmental Science (miscellaneous) ,biology.organism_classification ,Agricultural and Biological Sciences (miscellaneous) ,Genome ,Chloroplast DNA ,Original Article ,Indel ,Cymbidium goeringii ,Biotechnology ,NdhF - Abstract
The complete chloroplast genome sequence of Korean Cymbidium goeringii acc. smg222 was analyzed. Based on a comparison with Chinese C. goeringii, losses of nine ndh subunits (ndhA, ndhB, ndhC, ndhD, ndhE, ndhF, ndhH, ndhJ, and ndhK), three protein-coding genes (ycf 1-like, ycf 15, and ycf 68), six transfer RNAs, and one conserved open reading frame (orf 42). In addition, 219 InDels (insertion or deletion) and 171 simple sequence repeats were observed. Twenty-Five of which InDel markers have been evaluated, that useful for distinguishing Korean and Chinese Cymbidium associations based on the polymorphisms of chloroplast genomes between Korean Cymbidium goeringii acc. smg222 and Chinese C. goeringii and evaluation of genetic diversity. Finally, the phylogenetic relationships of the 39 Korean and 22 Chinese species was constructed based on the five InDel markers of them and obtained high support, indicating that our data may be useful in resolving relationships in this genus. The information about chloroplast DNA structure and gene variants of C. goeringii acc. smg222 chloroplast genome will provide sufficient phylogenetic information for resolving evolutionary relationships. The molecular markers developed in here will contribute to further research of Cymbidium species and conservation of endemic Cymbidium species. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s13205-019-2020-1) contains supplementary material, which is available to authorized users.
- Published
- 2020
46. TRIB2 regulates the differentiation of MLL–TET1 transduced myeloid progenitor cells
- Author
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Zae Young Ryoo, Hyeng-Soo Kim, Kwon Moo Park, Ju-Heon Kim, Do-Hyung Kim, Sanggyu Lee, Sang-Un Choi, Jae-Young Kim, Seung Hwan Oh, Wern-Joo Sohn, and Tae Sung Park
- Subjects
0301 basic medicine ,Myeloid ,Mixed Function Oxygenases ,Mice ,03 medical and health sciences ,Myeloid Cell Differentiation ,Downregulation and upregulation ,Proto-Oncogene Proteins ,hemic and lymphatic diseases ,Drug Discovery ,CEBPA ,medicine ,Animals ,Humans ,Myeloid Progenitor Cells ,Genetics (clinical) ,Gene knockdown ,Leukemia ,biology ,Chemistry ,Intracellular Signaling Peptides and Proteins ,Cell Differentiation ,Histone-Lysine N-Methyltransferase ,medicine.disease ,Fusion protein ,Cell biology ,Mice, Inbred C57BL ,HEK293 Cells ,RAW 264.7 Cells ,030104 developmental biology ,medicine.anatomical_structure ,Integrin alpha M ,Calcium-Calmodulin-Dependent Protein Kinases ,biology.protein ,Molecular Medicine ,Myeloid-Lymphoid Leukemia Protein - Abstract
The function and mechanism of action of MLL-TET1 (MT1) fusion protein in hematological cells are unclear and require further investigation. In the present study, we found that the MT1 fusion protein attenuated the expression of Cebpa, Csf1r, and Cd11b and inhibited the differentiation of myeloid progenitor cells. Increased binding of the MT1 fusion protein to the Trib2 promoter upregulated Trib2 mRNA and protein expression and downregulated Cebpa expression. Trib2 knockdown relieved the inhibition of myeloid cell differentiation induced by the MT1 fusion protein. Thus, TRIB2 is important for the survival of leukemia cells during MT1-related leukemogenesis and is important in maintaining differentiation blockade of leukemic cells. KEY MESSAGES: • MLL-TET1 fusion decreases the 5-hmC levels in the myeloid progenitor cells. • MLL-TET1 fusion inhibits myeloid differentiation through decreased expression of Cebpa. • MLL-TET1 fusion blocks the differentiation of the myeloid progenitor cells by overexpressing Trib2. • Knockdown of Trib2 in MLL-TET1 transduced cells induces myeloid differentiation.
- Published
- 2018
47. Methylome analysis and whole-exome sequencing reveal that brain tumors associated with encephalocraniocutaneous lipomatosis are midline pilocytic astrocytomas
- Author
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Rosane G.P. Queiroz, Andrea Wittmann, Elvis Terci Valera, Leonie G. Mikael, Jacek Majewski, A.C. Santos, Luciano Neder, Mi-Sun Yum, Luiz Gonzaga Tone, Raita Fukaya, Gustavo Novelino Simão, Seung-Ki Kim, Leandra Naira Zambelli Ramalho, Hamid Nikbakht, Eric Bareke, Nada Jabado, Melissa K. McConechy, Hye Rim Han, Sung Hye Park, Veridiana Kiill Suazo, Tenzin Gayden, Barbara Rivera, David T.W. Jones, María Sol Brassesco, Tae-Sung Ko, Ji Hoon Phi, Hélio Rubens Machado, Carlos Alberto Scrideli, and Ricardo Santos de Oliveira
- Subjects
Adult ,Male ,0301 basic medicine ,Pathology ,medicine.medical_specialty ,Eye Diseases ,Pilocytic Astrocytomas ,Astrocytoma ,Encephalocraniocutaneous lipomatosis ,Pathology and Forensic Medicine ,03 medical and health sciences ,Cellular and Molecular Neuroscience ,0302 clinical medicine ,Gene Duplication ,Correspondence ,Exome Sequencing ,medicine ,Humans ,Lipomatosis ,Exome ,Receptor, Fibroblast Growth Factor, Type 1 ,Child ,Children ,Exome sequencing ,Brain Neoplasms ,business.industry ,Neurocutaneous Syndromes ,High-Throughput Nucleotide Sequencing ,RASopathies, genetics, brain tumors ,DNA Methylation ,Neoplasm Proteins ,FGFR1 ,Genes, ras ,030104 developmental biology ,Child, Preschool ,Encephalocraniocutaneous Lipomatosis ,DNA methylation ,Female ,Neurology (clinical) ,business ,030217 neurology & neurosurgery - Published
- 2018
48. Difference assessment of composite resins and sound tooth applicable in the resin-imbedded tooth for resin repair using fluorescence, microhardness, DIAGNOdent, and X-ray image
- Author
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Ching-Chang Ko, Jeong-Kil Park, Tae-Sung Jeong, Franklin Garcia-Godoy, and Yong Hoon Kwon
- Subjects
Materials science ,Surface Properties ,Composite number ,In Vitro Techniques ,Composite Resins ,Indentation hardness ,Fluorescence ,03 medical and health sciences ,0302 clinical medicine ,stomatognathic system ,Hardness ,Materials Testing ,Humans ,Bicuspid ,Composite material ,Dental Restoration, Permanent ,General Dentistry ,Sound tooth ,Lasers ,X-Rays ,technology, industry, and agriculture ,030206 dentistry ,Molar ,stomatognathic diseases ,Wavelength ,Tooth cavity ,030220 oncology & carcinogenesis ,X ray image - Abstract
Visual differentiation of resin and tooth in a tooth cavity is not simple due to their highly similar shade. The purpose of the present study was to find any noninvasive method which can effectively differentiate resin from sound tooth in a resin-imbedded tooth for resin repair. For the study, various resin products were imbedded into the cavity of sound tooth. By applying laser of different wavelengths, autofluorescence (AF) of sound tooth and resin products were obtained. Microhardness, X-ray radiograph, and DIAGNOdent were tested for each tooth, resin product, and resin-imbedded tooth. For the AF spectra obtained using the 405-nm wavelength, sound tooth has emission peak at 440–470 nm and near 490 nm. Sound tooth has several times higher microhardness than resin products regardless of position in tooth subsurface. Due to the difference of radiopaque fillers’ composition and concentration, resin products have different brightness in the X-ray radiograph. DIAGNOdent readings for tooth and resin products were inconsistently different, and the difference of obtained values was slightly not to be applicable for the differentiation. Among the tested methods, with noninvasive treatment, AF spectrum by the 405-nm wavelength showed the apparent difference between resin and tooth. For the resin repair in a resin-imbedded tooth cavity, AF spectrum produced by 405-nm wavelength could be a useful method in tracing the resin-tooth boundary if combined with conventional X-ray radiography.
- Published
- 2018
49. Adjuvant Chemotherapy Versus Chemoradiotherapy Versus Surgery Alone for Early Gastric Cancer with One or Two Lymph Node Metastasis
- Author
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Su Mi Kim, Ji Yeong An, Jeeyun Lee, Tae Sung Sohn, and Sung Kim
- Subjects
Male ,medicine.medical_specialty ,Oxaloacetates ,Pyridines ,Adjuvant chemotherapy ,medicine.medical_treatment ,Leucovorin ,Adenocarcinoma ,Deoxycytidine ,Disease-Free Survival ,03 medical and health sciences ,0302 clinical medicine ,Gastrectomy ,Stomach Neoplasms ,Surgical oncology ,Antineoplastic Combined Chemotherapy Protocols ,Humans ,Medicine ,Capecitabine ,Aged ,Neoplasm Staging ,Tegafur ,Chemotherapy ,business.industry ,Cancer ,Radiotherapy Dosage ,Chemoradiotherapy, Adjuvant ,Middle Aged ,medicine.disease ,Early Gastric Cancer ,Surgery ,Oxaliplatin ,Oxonic Acid ,Oncology ,Chemotherapy, Adjuvant ,Lymphatic Metastasis ,030220 oncology & carcinogenesis ,Female ,030211 gastroenterology & hepatology ,Fluorouracil ,Cisplatin ,Neoplasm Recurrence, Local ,business ,Adjuvant ,Chemoradiotherapy - Abstract
Limited studies exist comparing clinical outcomes by adjuvant treatment for pT1N1 gastric cancer. This study compared the disease-free survival (DFS) of patients with pT1N1 gastric cancer according to the type of adjuvant treatment—surgery alone, chemotherapy (CTx), and chemoradiotherapy (CCRTx)—and evaluated risk factors for tumor recurrence. Between 1995 and 2015, 738 patients underwent radical gastrectomy for pT1N1 gastric cancer and were divided into three groups: surgery alone (n = 355), CTx (n = 214), and CCRTx (n = 169). Chronological changes in adjuvant treatment type and chemotherapeutic regimens were evaluated and DFS was compared. Risk factors for tumor recurrence were analyzed. The proportion of patients who underwent surgery alone was more than 50% until 2001, and the proportion of those who had either CTx or CCRTx was more than 50% from 2002 to 2011, after which the proportion who underwent surgery alone increased again. The main chemotherapeutic agent was 5-fluorouracil with leucovorin. The 5-year DFS was 96.5% in the surgery-alone group, 96.0% in the CTx group, and 95.8% in the CCRTx group (no significant difference). The various chemotherapeutic regimens did not show differences in DFS. In univariate and multivariate analyses, adjuvant CTx and CCRTx showed no beneficial effect with regard to tumor recurrence. Because adjuvant CTx and CCRTx did not show any benefit with regard to tumor recurrence, these treatment strategies might be unnecessary for pT1N1 gastric cancer after gastrectomy. Further studies are necessary to reveal pT1N1 gastric cancer patient subgroups who might benefit from adjuvant treatments.
- Published
- 2018
50. Comparison of Open and Laparoscopic Gastrectomy in Elderly Patients
- Author
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Ho Geun Youn, Yoon Young Choi, Sung Kim, Su Mi Kim, Ji Yeong An, Sung Hoon Noh, Seung Jong Oh, and Tae Sung Sohn
- Subjects
Male ,medicine.medical_specialty ,medicine.medical_treatment ,Operative Time ,Blood Loss, Surgical ,Comorbidity ,030230 surgery ,03 medical and health sciences ,Postoperative Complications ,Sex Factors ,0302 clinical medicine ,Quality of life ,Gastrectomy ,Risk Factors ,Stomach Neoplasms ,Diabetes mellitus ,medicine ,Humans ,Postoperative Period ,Laparoscopy ,Retrospective Studies ,Aged, 80 and over ,medicine.diagnostic_test ,business.industry ,Incidence (epidemiology) ,Age Factors ,Gastroenterology ,Cancer ,Postoperative complication ,Recovery of Function ,medicine.disease ,Surgery ,Gastrointestinal Tract ,030220 oncology & carcinogenesis ,Female ,business - Abstract
The purpose of this study was to estimate surgical outcomes of elderly patients older than 80 years who received laparoscopic or open gastrectomy for gastric cancer and to identify risk factors for postoperative complications. Two hundred forty-two elderly patients older than 80 years underwent gastric cancer surgery between January 2010 and December 2016 in three tertiary hospitals. They were divided into two groups: laparoscopic gastrectomy (N = 59) and open gastrectomy (N = 183). The surgical outcomes and risk factors for postoperative complication were evaluated. Among the elderly patients, 24.4% showed an ASA score of 3 or 4, and 20.7% showed a Charlson comorbidity index (CCI) score of 2 or more. 46.3% of patients had hypertension and 15.3% had diabetes. The laparoscopic gastrectomy group showed similar operation time, less intraoperative blood loss, and faster postoperative gastrointestinal recovery compared to the open gastrectomy group. The incidence of postoperative complications was 30.1% in the open group and 22.0% in the laparoscopic group (P = 0.249). One patient died for pulmonary complication in the open gastrectomy group. In multivariate analysis, older age, male, higher CCI score, and open approach were found to be correlated with increased risk for postoperative complications. Although elderly patients over 80 years had a high incidence of comorbidity, gastric cancer surgery can be safely performed. The laparoscopic approach might be feasible for open surgery in improving quality of life in these patients, given a faster postoperative intestinal recovery period, with similar risk for postoperative complications.
- Published
- 2018
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