6 results on '"Hideaki Imai"'
Search Results
2. Comprehensive investigation of RNF213 nonsynonymous variants associated with intracranial artery stenosis
- Author
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Yu Teranishi, Hiroyuki Ishiura, Masahiro Shimizu, Shinichi Yagi, Wei Qu, Hideaki Imai, Jun Yoshimura, Tsuneo Shimizu, Shoji Tsuji, Jun Mitsui, Shinichi Morishita, Koichiro Doi, Hiroki Hongo, Nobuhito Saito, Atsushi Okano, Hirofumi Nakatomi, Satoru Miyawaki, and Hideaki Ono
- Subjects
Adult ,Male ,Nonsynonymous substitution ,medicine.medical_specialty ,dbSNP ,Adolescent ,Genotype ,Ubiquitin-Protein Ligases ,Mutation, Missense ,lcsh:Medicine ,Constriction, Pathologic ,030204 cardiovascular system & hematology ,Polymorphism, Single Nucleotide ,Gastroenterology ,Article ,Young Adult ,03 medical and health sciences ,0302 clinical medicine ,Polymorphism (computer science) ,Internal medicine ,medicine ,Humans ,Missense mutation ,Genetic Predisposition to Disease ,Moyamoya disease ,lcsh:Science ,Alleles ,Genetic Association Studies ,Aged ,Adenosine Triphosphatases ,Aged, 80 and over ,Multidisciplinary ,Molecular medicine ,business.industry ,lcsh:R ,Genetic Variation ,Intracranial Artery ,Sequence Analysis, DNA ,Middle Aged ,medicine.disease ,Stenosis ,Amino Acid Substitution ,Risk factors ,Female ,lcsh:Q ,Intracranial Arterial Diseases ,business ,030217 neurology & neurosurgery - Abstract
Intracranial artery stenosis (ICAS) is the most common cause of ischemic stroke worldwide. RNF213 single nucleotide variant c.14429G > A (p.Arg4810Lys, rs112735431) was recently reported to be associated with ICAS in East Asians. However, the disease susceptibility of other RNF213 variants has not been clarified. This study comprehensively investigated ICAS-associated RNF213 variants in a pool of 168 Japanese ICAS patients and 1,194 control subjects. We found 138 nonsynonymous germline variants by target resequencing of all coding exons in RNF213. Association study between ICAS patients and control subjects revealed that only p.Arg4810Lys had significant association with ICAS (P = 1.5 × 10–28, odds ratio = 29.3, 95% confidence interval 15.31–56.2 [dominant model]). Fourteen of 138 variants were rare variants detected in ICAS patients not harboring p.Arg4810Lys variant. Two of these rare variants (p.Cys118Arg and p.Leu2356Phe) consistent with variants previously reported in moyamoya disease patients characterized by stenosis of intracranial artery and association with RNF213, and three rare variants (p.Ser193Gly, p.Val1817Leu, and p.Asp3329Tyr) were found neither in control subjects and Single Nucleotide Polymorphism Database. The present findings may improve our understanding of the genetic background of intracranial artery stenosis.
- Published
- 2020
3. Correction to: RNF213 p.Arg4810Lys Heterozygosity in Moyamoya Disease Indicates Early Onset and Bilateral Cerebrovascular Events
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Masahiro Shimizu, Yu Teranishi, Hirofumi Nakatomi, Yudai Hirano, Daisuke Shimada, Hiroki Hongo, Nobuhito Saito, Hideaki Imai, Hideaki Ono, Shogo Dofuku, Kenta Ohara, Daiichiro Ishigami, Satoru Miyawaki, Masafumi Segawa, and Satoshi Koizumi
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Loss of heterozygosity ,Pediatrics ,medicine.medical_specialty ,business.industry ,General Neuroscience ,MEDLINE ,Medicine ,Neurology (clinical) ,Moyamoya disease ,Cardiology and Cardiovascular Medicine ,business ,medicine.disease ,Early onset - Published
- 2021
4. [Untitled]
- Author
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Yasuhiro Hashiba, Tsutomu Sasaki, Tatsuya Shimizu, Masahiko Tosaka, Hideaki Imai, and Nobuhito Saito
- Subjects
chemistry.chemical_classification ,Reactive oxygen species ,biology ,Superoxide ,business.industry ,Vasospasm ,Pharmacology ,medicine.disease ,Superoxide dismutase ,chemistry.chemical_compound ,Cerebral vasospasm ,chemistry ,Pyrogallol ,Catalase ,medicine.artery ,Anesthesia ,biology.protein ,Basilar artery ,Medicine ,Surgery ,Neurology (clinical) ,business - Abstract
Background: Cerebral vasospasm is one of the important pathological phenomena which influence morbidity and mortality following subarachnoid haemorrhage. Reactive oxygen species (ROSs) generated by the autoxidation of oxyhemoglobin to methemoglobin may be one of the essential factors in the pathogenesis of cerebral vasospasm. The direct vasocontractile effects of hydrogen peroxide (H2O2), superoxide anion (O2 −), and hydroxyl radical (*OH) on the canine basilar artery and the inhibitory effects of MCI-186 (3-methyl-1-phenyl-2-pyrazolin-5-one), a new *OH scavenger, were investigated. Method: Isometric tension was recorded in basilar artery rings from dogs in vitro. H2O2, pyrogallol (O2 − donor), and vitamin C (VitC)/Fe2+ (*OH-generating system) were used to generate the ROSs. Findings: H2O2 (10 μmol/L), pyrogallol (10 μmol/L), and VitC/Fe2+ (100 μmol/L each) induced fast onset and transient, slow onset and transient, and sustained contraction, respectively, in the canine basilar artery. Contractions induced by H2O2 were almost completely inhibited by pre-incubation with catalase (800 U/mL) and those by pyrogallol with superoxide dismutase (150 U/mL), but neither with MCI-186 (10 μmol/L). The contraction induced by VitC/Fe2+ was clearly inhibited by pre-incubation with MCI-186, but not with catalase or superoxide dismutase. Interpretation: ROSs have direct vasocontractile effects on the canine basilar artery in vitro, but different ROSs have different contractile characteristics. Such contractions might be related to the pathophysiology of cerebral vasospasm. MCI-186 had a clear and selective inhibitory effect against *OH-induced contraction in vitro. Comparison of different radical scavengers may be important in pharmacological assessment, especially targeted on cerebral vasospasm.
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- 2002
5. Management of recurrent pilocytic astrocytoma with leptomeningeal dissemination in childhood
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F. Saitoh, Hideaki Imai, Masaru Tamura, Tomoaki Kano, Akira Zama, Hiroya Fujimaki, and Hideyuki Kurihara
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Male ,medicine.medical_specialty ,medicine.medical_treatment ,Astrocytoma ,Craniospinal Irradiation ,Glioma ,Humans ,Medicine ,Cerebellar Neoplasms ,Child ,Chemotherapy ,Pilocytic astrocytoma ,business.industry ,General Medicine ,medicine.disease ,Combined Modality Therapy ,Magnetic Resonance Imaging ,Surgery ,Radiation therapy ,Tumor progression ,Child, Preschool ,Optic Chiasm ,Pediatrics, Perinatology and Child Health ,Pia Mater ,Female ,Neurology (clinical) ,Neurosurgery ,Arachnoid ,Hypothalamic Neoplasms ,Neoplasm Recurrence, Local ,business - Abstract
Two cases of recurrent pilocytic astrocytoma with leptomeningeal dissemination (LMD) are described. A 6-year-old boy presented with a cerebellar tumor, which was subtotally removed. Tumor recurrence with LMD occurred 4 years later. Reoperation for tumor removal followed by craniospinal irradiation stabilized the LMD over 5 years. A 4-year-old girl presented with a chiasmatic-hypothalamic tumor. Partial removal of the tumor was followed by radiation therapy. Tumor regrowth with LMD occurred 4 years later and was managed by reoperation, chemotherapy and radiotherapy. Tumor recurrence with LMD can be stabilized by multimodal treatment without tumor progression.
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- 1998
6. Clinicohistological study of oligodendroglioma and oligoastrocytoma
- Author
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Tomoaki Kano, Tomoyuki Iwai, Akira Zama, Masaru Tamura, Hideyuki Kurihara, Isao Naito, Shogo Ishiuchi, and Hideaki Imai
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Adult ,Male ,Cancer Research ,medicine.medical_specialty ,Pathology ,Oligoastrocytoma ,Adolescent ,medicine.medical_treatment ,Oligodendroglioma ,Anaplastic oligodendroglioma ,Astrocytoma ,Humans ,Medicine ,In patient ,Anaplastic Oligoastrocytoma ,neoplasms ,Aged ,Chemotherapy ,Brain Neoplasms ,business.industry ,General Medicine ,Middle Aged ,medicine.disease ,nervous system diseases ,Radiation therapy ,Cell Transformation, Neoplastic ,Oncology ,Female ,Neurology (clinical) ,Neurosurgery ,Neoplasm Recurrence, Local ,business - Abstract
The clinical and histological characteristics of oligodendroglioma and oligoastrocytoma were investigated in patients, mainly adults with supratentorial tumors, who were treated with surgery and radiotherapy, and with chemotherapy for recurrent, anaplastic tumors, or both. The median survival time was 13.2 years for oligodendroglioma (four patients), 12.7 years for anaplastic oligodendroglioma (five patients), 13.5 years for oligoastrocytoma (seven patients), and 4.8 years for anaplastic oligoastrocytoma (four patients). Two of three recurrent oligodendrogliomas and two of two recurrent oligoastrocytomas showed malignant transformation. Minigemistocytes were sometimes recognized in recurrent tumors and had a sinister prognosis. Oligodendroglioma and oligoastrocytoma may transform into each other at recurrence.
- Published
- 1997
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