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81 results on '"Herms, Jochen"'

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1. Transcriptomic and epigenetic dissection of spinal ependymoma (SP-EPN) identifies clinically relevant subtypes enriched for tumors with and without NF2 mutation

4. Translocator protein (18kDA) (TSPO) marks mesenchymal glioblastoma cell populations characterized by elevated numbers of tumor-associated macrophages

5. Targeting the glycine-rich domain of TDP-43 with antibodies prevents its aggregation in vitro and reduces neurofilament levels in vivo

6. Treatment benefit in patients aged 80 years or older with biopsy-proven and non-resected glioblastoma is dependent on MGMT promoter methylation status

8. Long-term diazepam treatment enhances microglial spine engulfment and impairs cognitive performance via the mitochondrial 18 kDa translocator protein (TSPO)

9. [18F]F-DED PET imaging of reactive astrogliosis in neurodegenerative diseases: preclinical proof of concept and first-in-human data

11. A deep learning-based histopathology classifier for Focal Cortical Dysplasia

12. Depletion and activation of microglia impact metabolic connectivity of the mouse brain

13. Toxicity of extracellular alpha-synuclein is independent of intracellular alpha-synuclein

14. TSPO PET signal using [18F]GE180 is associated with survival in recurrent gliomas

15. Combination of pre-treatment dynamic [18F]FET PET radiomics and conventional clinical parameters for the survival stratification in patients with IDH-wildtype glioblastoma

16. TP53 mutations in functional corticotroph tumors are linked to invasion and worse clinical outcome

17. Single-nucleus chromatin accessibility profiling highlights distinct astrocyte signatures in progressive supranuclear palsy and corticobasal degeneration

18. Multiple tumorous lesions of the pituitary gland

20. Adrenal tropism of SARS-CoV-2 and adrenal findings in a post-mortem case series of patients with severe fatal COVID-19

21. Tau deposition patterns are associated with functional connectivity in primary tauopathies

22. L-type amino acid transporter (LAT) 1 expression in 18F-FET-negative gliomas

24. TREM2 modulates differential deposition of modified and non-modified Aβ species in extracellular plaques and intraneuronal deposits

26. Prediction of TERTp-mutation status in IDH-wildtype high-grade gliomas using pre-treatment dynamic [18F]FET PET radiomics

28. Phenotypic diversity of genetic Creutzfeldt–Jakob disease: a histo-molecular-based classification

32. Glial activation is moderated by sex in response to amyloidosis but not to tau pathology in mouse models of neurodegenerative diseases

34. Longitudinal TSPO expression in tau transgenic P301S mice predicts increased tau accumulation and deteriorated spatial learning

35. Early-phase [18F]PI-2620 tau-PET imaging as a surrogate marker of neuronal injury

36. Loss of fragile X mental retardation protein precedes Lewy pathology in Parkinson’s disease

37. Early defects in translation elongation factor 1α levels at excitatory synapses in α-synucleinopathy

38. Non-invasive prediction of IDH-wildtype genotype in gliomas using dynamic 18F-FET PET

39. Late-stage Anle138b treatment ameliorates tau pathology and metabolic decline in a mouse model of human Alzheimer’s disease tau

40. The neuropathology of fatal encephalomyelitis in human Borna virus infection

43. Genome-wide analyses as part of the international FTLD-TDP whole-genome sequencing consortium reveals novel disease risk factors and increases support for immune dysfunction in FTLD

44. Publisher Correction: ApoE attenuates unresolvable inflammation by complex formation with activated C1q

45. ApoE attenuates unresolvable inflammation by complex formation with activated C1q

46. Loss of TREM2 function increases amyloid seeding but reduces plaque-associated ApoE

47. Microglial response to increasing amyloid load saturates with aging: a longitudinal dual tracer in vivo μPET-study

48. The Trem2 R47H Alzheimer’s risk variant impairs splicing and reduces Trem2 mRNA and protein in mice but not in humans

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