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Your search keyword '"Hauser, Blake M"' showing total 11 results
Start Over Author "Hauser, Blake M" Publisher springer science and business media llc
11 results on '"Hauser, Blake M"'

1. Structure-based network analysis predicts pathogenic variants in human proteins associated with inherited retinal disease

Author

Hauser, Blake M., primary, Luo, Yuyang, additional, Nathan, Anusha, additional, Al-Moujahed, Ahmad, additional, Vavvas, Demetrios G., additional, Comander, Jason, additional, Pierce, Eric A., additional, Place, Emily M., additional, Bujakowska, Kinga M., additional, Gaiha, Gaurav D., additional, and Rossin, Elizabeth J., additional

Published
2024
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2. Enhancing antibody responses by multivalent antigen display on thymus-independent DNA origami scaffolds

Author

Wamhoff, Eike-Christian, Ronsard, Larance, Feldman, Jared, Knappe, Grant A., Hauser, Blake M., Romanov, Anna, Case, James Brett, Sanapala, Shilpa, Lam, Evan C., Denis, Kerri J. St., Boucau, Julie, Barczak, Amy K., Balazs, Alejandro B., Diamond, Michael S., Schmidt, Aaron G., Lingwood, Daniel, Bathe, Mark, Wamhoff, Eike-Christian, Ronsard, Larance, Feldman, Jared, Knappe, Grant A., Hauser, Blake M., Romanov, Anna, Case, James Brett, Sanapala, Shilpa, Lam, Evan C., Denis, Kerri J. St., Boucau, Julie, Barczak, Amy K., Balazs, Alejandro B., Diamond, Michael S., Schmidt, Aaron G., Lingwood, Daniel, and Bathe, Mark

Abstract

Protein-based virus-like particles (P-VLPs) are commonly used to spatially organize antigens and enhance humoral immunity through multivalent antigen display. However, P-VLPs are thymus-dependent antigens that are themselves immunogenic and can induce B cell responses that may neutralize the platform. Here, we investigate thymus-independent DNA origami as an alternative material for multivalent antigen display using the receptor binding domain (RBD) of the SARS-CoV-2 spike protein, the primary target of neutralizing antibody responses. Sequential immunization of mice with DNA-based VLPs (DNA-VLPs) elicits protective neutralizing antibodies to SARS-CoV-2 in a manner that depends on the valency of the antigen displayed and on T cell help. Importantly, the immune sera do not contain boosted, class-switched antibodies against the DNA scaffold, in contrast to P-VLPs that elicit strong B cell memory against both the target antigen and the scaffold. Thus, DNA-VLPs enhance target antigen immunogenicity without generating scaffold-directed immunity and thereby offer an important alternative material for particulate vaccine design.

Published
2024

3. Publisher Correction: Carbohydrate fatty acid monosulphate: oil-in-water adjuvant enhances SARS-CoV-2 RBD nanoparticle-induced immunogenicity and protection in mice

Author

Nanishi, Etsuro, primary, Borriello, Francesco, additional, Seo, Hyuk-Soo, additional, O’Meara, Timothy R., additional, McGrath, Marisa E., additional, Saito, Yoshine, additional, Chen, Jing, additional, Diray-Arce, Joann, additional, Song, Kijun, additional, Xu, Andrew Z., additional, Barman, Soumik, additional, Menon, Manisha, additional, Dong, Danica, additional, Caradonna, Timothy M., additional, Feldman, Jared, additional, Hauser, Blake M., additional, Schmidt, Aaron G., additional, Baden, Lindsey R., additional, Ernst, Robert K., additional, Dillen, Carly, additional, Yu, Jingyou, additional, Chang, Aiquan, additional, Hilgers, Luuk, additional, Platenburg, Peter Paul, additional, Dhe-Paganon, Sirano, additional, Barouch, Dan H., additional, Ozonoff, Al, additional, Zanoni, Ivan, additional, Frieman, Matthew B., additional, Dowling, David J., additional, and Levy, Ofer, additional

Published
2023
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4. Carbohydrate fatty acid monosulphate: oil-in-water adjuvant enhances SARS-CoV-2 RBD nanoparticle-induced immunogenicity and protection in mice

Author

Nanishi, Etsuro, primary, Borriello, Francesco, additional, Seo, Hyuk-Soo, additional, O’Meara, Timothy R., additional, McGrath, Marisa E., additional, Saito, Yoshine, additional, Chen, Jing, additional, Diray-Arce, Joann, additional, Song, Kijun, additional, Xu, Andrew Z., additional, Barman, Soumik, additional, Menon, Manisha, additional, Dong, Danica, additional, Caradonna, Timothy M., additional, Feldman, Jared, additional, Hauser, Blake M., additional, Schmidt, Aaron G., additional, Baden, Lindsey R., additional, Ernst, Robert K., additional, Dillen, Carly, additional, Yu, Jingyou, additional, Chang, Aiquan, additional, Hilgers, Luuk, additional, Platenburg, Peter Paul, additional, Dhe-Paganon, Sirano, additional, Barouch, Dan H., additional, Ozonoff, Al, additional, Zanoni, Ivan, additional, Frieman, Matthew B., additional, Dowling, David J., additional, and Levy, Ofer, additional

Published
2023
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5. Rebound HIV-1 in cerebrospinal fluid after antiviral therapy interruption is mainly clonally amplified R5 T cell-tropic virus

Author

Kincer, Laura P., primary, Joseph, Sarah Beth, additional, Gilleece, Maria M., additional, Hauser, Blake M., additional, Sizemore, Sabrina, additional, Zhou, Shuntai, additional, Di Germanio, Clara, additional, Zetterberg, Henrik, additional, Fuchs, Dietmar, additional, Deeks, Steven G., additional, Spudich, Serena, additional, Gisslen, Magnus, additional, Price, Richard W., additional, and Swanstrom, Ronald, additional

Published
2023
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6. Rapid generation of potent antibodies by autonomous hypermutation in yeast

Author

Wellner, Alon, primary, McMahon, Conor, additional, Gilman, Morgan S. A., additional, Clements, Jonathan R., additional, Clark, Sarah, additional, Nguyen, Kianna M., additional, Ho, Ming H., additional, Hu, Vincent J., additional, Shin, Jung-Eun, additional, Feldman, Jared, additional, Hauser, Blake M., additional, Caradonna, Timothy M., additional, Wingler, Laura M., additional, Schmidt, Aaron G., additional, Marks, Debora S., additional, Abraham, Jonathan, additional, Kruse, Andrew C., additional, and Liu, Chang C., additional

Published
2021
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7. Publisher Correction: Single-shot Ad26 vaccine protects against SARS-CoV-2 in rhesus macaques

Author

Mercado, Noe B., primary, Zahn, Roland, additional, Wegmann, Frank, additional, Loos, Carolin, additional, Chandrashekar, Abishek, additional, Yu, Jingyou, additional, Liu, Jinyan, additional, Peter, Lauren, additional, McMahan, Katherine, additional, Tostanoski, Lisa H., additional, He, Xuan, additional, Martinez, David R., additional, Rutten, Lucy, additional, Bos, Rinke, additional, van Manen, Danielle, additional, Vellinga, Jort, additional, Custers, Jerome, additional, Langedijk, Johannes P., additional, Kwaks, Ted, additional, Bakkers, Mark J. G., additional, Zuijdgeest, David, additional, Huber, Sietske K. Rosendahl, additional, Atyeo, Caroline, additional, Fischinger, Stephanie, additional, Burke, John S., additional, Feldman, Jared, additional, Hauser, Blake M., additional, Caradonna, Timothy M., additional, Bondzie, Esther A., additional, Dagotto, Gabriel, additional, Gebre, Makda S., additional, Hoffman, Emily, additional, Jacob-Dolan, Catherine, additional, Kirilova, Marinela, additional, Li, Zhenfeng, additional, Lin, Zijin, additional, Mahrokhian, Shant H., additional, Maxfield, Lori F., additional, Nampanya, Felix, additional, Nityanandam, Ramya, additional, Nkolola, Joseph P., additional, Patel, Shivani, additional, Ventura, John D., additional, Verrington, Kaylee, additional, Wan, Huahua, additional, Pessaint, Laurent, additional, Van Ry, Alex, additional, Blade, Kelvin, additional, Strasbaugh, Amanda, additional, Cabus, Mehtap, additional, Brown, Renita, additional, Cook, Anthony, additional, Zouantchangadou, Serge, additional, Teow, Elyse, additional, Andersen, Hanne, additional, Lewis, Mark G., additional, Cai, Yongfei, additional, Chen, Bing, additional, Schmidt, Aaron G., additional, Reeves, R. Keith, additional, Baric, Ralph S., additional, Lauffenburger, Douglas A., additional, Alter, Galit, additional, Stoffels, Paul, additional, Mammen, Mathai, additional, Van Hoof, Johan, additional, Schuitemaker, Hanneke, additional, and Barouch, Dan H., additional

Published
2021
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8. Ultrasensitive high-resolution profiling of early seroconversion in patients with COVID-19

Author

Norman, Maia, primary, Gilboa, Tal, additional, Ogata, Alana F., additional, Maley, Adam M., additional, Cohen, Limor, additional, Busch, Evan L., additional, Lazarovits, Roey, additional, Mao, Chih-Ping, additional, Cai, Yongfei, additional, Zhang, Jun, additional, Feldman, Jared E., additional, Hauser, Blake M., additional, Caradonna, Timothy M., additional, Chen, Bing, additional, Schmidt, Aaron G., additional, Alter, Galit, additional, Charles, Richelle C., additional, Ryan, Edward T., additional, and Walt, David R., additional

Published
2020
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9. Ad26 vaccine protects against SARS-CoV-2 severe clinical disease in hamsters

Author

Tostanoski, Lisa H., primary, Wegmann, Frank, additional, Martinot, Amanda J., additional, Loos, Carolin, additional, McMahan, Katherine, additional, Mercado, Noe B., additional, Yu, Jingyou, additional, Chan, Chi N., additional, Bondoc, Stephen, additional, Starke, Carly E., additional, Nekorchuk, Michael, additional, Busman-Sahay, Kathleen, additional, Piedra-Mora, Cesar, additional, Wrijil, Linda M., additional, Ducat, Sarah, additional, Custers, Jerome, additional, Atyeo, Caroline, additional, Fischinger, Stephanie, additional, Burke, John S., additional, Feldman, Jared, additional, Hauser, Blake M., additional, Caradonna, Timothy M., additional, Bondzie, Esther A., additional, Dagotto, Gabriel, additional, Gebre, Makda S., additional, Jacob-Dolan, Catherine, additional, Lin, Zijin, additional, Mahrokhian, Shant H., additional, Nampanya, Felix, additional, Nityanandam, Ramya, additional, Pessaint, Laurent, additional, Porto, Maciel, additional, Ali, Vaneesha, additional, Benetiene, Dalia, additional, Tevi, Komlan, additional, Andersen, Hanne, additional, Lewis, Mark G., additional, Schmidt, Aaron G., additional, Lauffenburger, Douglas A., additional, Alter, Galit, additional, Estes, Jacob D., additional, Schuitemaker, Hanneke, additional, Zahn, Roland, additional, and Barouch, Dan H., additional

Published
2020
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10. Single-shot Ad26 vaccine protects against SARS-CoV-2 in rhesus macaques

Author

Mercado, Noe B., primary, Zahn, Roland, additional, Wegmann, Frank, additional, Loos, Carolin, additional, Chandrashekar, Abishek, additional, Yu, Jingyou, additional, Liu, Jinyan, additional, Peter, Lauren, additional, McMahan, Katherine, additional, Tostanoski, Lisa H., additional, He, Xuan, additional, Martinez, David R., additional, Rutten, Lucy, additional, Bos, Rinke, additional, van Manen, Danielle, additional, Vellinga, Jort, additional, Custers, Jerome, additional, Langedijk, Johannes P., additional, Kwaks, Ted, additional, Bakkers, Mark J. G., additional, Zuijdgeest, David, additional, Rosendahl Huber, Sietske K., additional, Atyeo, Caroline, additional, Fischinger, Stephanie, additional, Burke, John S., additional, Feldman, Jared, additional, Hauser, Blake M., additional, Caradonna, Timothy M., additional, Bondzie, Esther A., additional, Dagotto, Gabriel, additional, Gebre, Makda S., additional, Hoffman, Emily, additional, Jacob-Dolan, Catherine, additional, Kirilova, Marinela, additional, Li, Zhenfeng, additional, Lin, Zijin, additional, Mahrokhian, Shant H., additional, Maxfield, Lori F., additional, Nampanya, Felix, additional, Nityanandam, Ramya, additional, Nkolola, Joseph P., additional, Patel, Shivani, additional, Ventura, John D., additional, Verrington, Kaylee, additional, Wan, Huahua, additional, Pessaint, Laurent, additional, Van Ry, Alex, additional, Blade, Kelvin, additional, Strasbaugh, Amanda, additional, Cabus, Mehtap, additional, Brown, Renita, additional, Cook, Anthony, additional, Zouantchangadou, Serge, additional, Teow, Elyse, additional, Andersen, Hanne, additional, Lewis, Mark G., additional, Cai, Yongfei, additional, Chen, Bing, additional, Schmidt, Aaron G., additional, Reeves, R. Keith, additional, Baric, Ralph S., additional, Lauffenburger, Douglas A., additional, Alter, Galit, additional, Stoffels, Paul, additional, Mammen, Mathai, additional, Van Hoof, Johan, additional, Schuitemaker, Hanneke, additional, and Barouch, Dan H., additional

Published
2020
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