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This study explores the effects of various heat treatments on the structure and mechanical properties of Ti-25Nb-8Sn alloy (wt.%). After a β solution treatment at 1100 °C for 10 min, the samples were subjected to water quenching, furnace cooling, or air cooling. Additionally, aging treatment was performed on the specimens in a vacuum furnace at 400, 500, and 600 °C for 45 min. The experimental results showed that the microstructure and mechanical properties of these alloys have changed under different heat treatment conditions. The as-cast Ti-25Nb-8Sn alloy was comprised entirely of the β phase, whereas the β+α phases were found in the furnace-cooled specimen. The air-cooled sample mainly consisted of the β phase and a small amount of the α″ phase. The water-quenched sample exhibited the β phase after it was cooled from 1100 °C. In addition, after aging at 400 °C, only the β phase was found. After aging at 500 or 600 °C, the β phase still existed, while a small amount of the α phase also appeared. Moreover, as the aging temperature increased, the intensity of the α peaks was increased. It is worth noting that the Ti-25Nb-8Sn alloy age-treated at 400 and 500 °C exhibited much higher bending strength/modulus ratios, some of which were as great as 23.14 and 24.86, respectively, than that of c.p. Ti (8.5) and Ti-6Al-4V (17.4). Thus, from the perspective of low modulus and high strength/modulus ratio, the Ti-25Nb-8Sn alloys age-treated at 400 and 500 °C are both suitable candidates for biomedical applications.

Monitoring precursory decline in groundwater radon at the Antung hot spring is a useful means of forecasting the magnitude and precursor time of local disastrous earthquakes. With the help of a case study in southeastern Taiwan, this paper demonstrates the effect of tectonic setting in the subduction zone on the correlation between radon decline, precursory time and earthquake magnitude. Given a radon-monitoring site located near the plate boundary in the tectonic setting of advanced arc-continental collision, the observed radon decline and precursory time prior to the earthquakes in the tectonic setting of initial arc-continental collision are smaller than those observed prior to the earthquakes occurring on the plate boundary in the tectonic setting of advanced arc-continental collision. In the advanced arc-continental collision state, the coupling between the plates is strong and the stress transfer is efficient, whereas in the incipient collision state, the coupling and stress transfer are not as good. It also takes additional time lag and attenuation for the stress transfer from one tectonic setting to the other. This paper presents the difference in the precursory behavior of groundwater radon between earthquakes which occurred in two different tectonic settings: advanced and initial arc-continental collision.

The neurodegenerative Alzheimer’s disease (AD) affects more than 30 million people worldwide. There is thus far no cure or prevention for AD. Aggregation of hyperphosphorylated tau in the brain correlates with the cognitive decline of patients of AD and other neurodegenerative tauopathies. Intracerebral injection of tau aggregates isolated from tauopathy brains causes similar pathology in the recipient mice, demonstrating the pathogenic role of abnormally phosphorylated tau. Compounds controlling the aggregation of hyperphosphorylated tau therefore are probable modulators for the disease. Here we report the use of recombinant hyperphosphorylated tau (p-tau) to identify potential tauopathy therapeutics and risk factors. Hyperphosphorylation renders tau prone to aggregate and to impair cell viability. Taking advantage of these two characters of p-tau, we performed a screen of a 1280-compound library, and tested a selective group of prescription drugs in p-tau aggregation and cytotoxicity assays. R-(−)-apomorphine and raloxifene were found to be p-tau aggregation inhibitors that protected p-tau-treated cells. In contrast, a subset of benzodiazepines exacerbated p-tau cytotoxicity apparently via enhancing p-tau aggregation. R-(−)apomorphine and raloxifene have been shown to improve cognition in animals or in humans, whereas benzodiazepines were linked to increased risks of dementia. Our results demonstrate the feasibility and potential of using hyperphosphorylated tau-based assays for AD drug discovery and risk factor identification.

A deadly Mw 6.4 earthquake occurred in the Hualien area of eastern Taiwan on 6 February 2018. It caused severe damage to infrastructure and creating surface ruptures in several areas mostly near the Milun Fault in Hualien City. In this study, we investigated the distribution of co-seismic surface ruptures by measuring the orientations of the ruptures, classifying the fracture patterns, and measuring the fracture geometries to calculate the principal displacement zone (PDZ) and the regional stress directions. As a result, local PDZ is observed to rotate anti-clockwise along the Milun Fault from north to south. Considering the deformation behaviors of the fractures and their relative positions along the Milun Fault, the shear zone in Qixingtan area is a horsetail structure derived from the right side of the end of the left-lateral strike-slip fault. In addition, the 170° trending fault splay in the middle segment and the fault branch corresponding to the Beipu Fault are elements of the Riedel shear structure associated with the left-lateral moving Milun Fault. Our results show that Riedel shear structures are common within co-seismic surface rupture zones in this area, and the variations in the orientations of Riedel structures reflect the influence of the pre-existing Milun Fault. We can also determine the most recent geometry, kinematics, and displacement characteristics of the Milun Fault through co-seismic surface ruptures and macro-scale Riedel shear structure analysis. This study provides a good example of understanding the relationship between the outcrop scale and the macroscale of the Riedel shear model.

Mw 6.4 Meinong earthquake occurred on 6 February 2016 in southern Taiwan, resulting in more than one hundred casualties and several collapsed buildings. The aftershocks occurred mostly at mid-to-lower crustal depths (10 - 30 km), related to a blind fault system. However, several centimeters of cosesimic surface uplift within the Liushuang, Erhchungli, and GutingKeng Formations, composed mainly of mudstone, was recorded from the InSAR results. The uplifted pattern is similar to that of GPS and leveling data from 2000 - 2010, which indicates the deformation is accomplished by creeping due to the shallow mudstone structure related to mud diapir. Previous studies have shown limited information about the shallow structure in this region due to few deployed seismic stations. We deployed 36 temporary seismic stations (~5 km spacing) in this study around one month after the main shock to obtain a 3-D shear wave shallow crustal velocity structure using ambient noise tomography. The reliable periods of group and phase velocities from Rayleigh waves were 0.6 - 5 s, corresponding to around 0 - 5 km at depths. As a result, the low S-wave pattern speeds at 0 - 4 km depths correspond to the uplift region from both InSAR data for the coseismic period and GPS and leveling data for the interseismic period. The results from this study are compatible with the reflected seismic profile. The results show that with dense seismic array deployment we can obtain high subsurface image resolution to link the relationship between the surface observations to the subsurface structures.

Recurrent groundwater radon anomalous declines were observed from well measurements in the Antung hot spring area (eastern Taiwan) prior to five of six earthquakes that occurred between 2003 and 2011 (M w range 5.0–6.8). The relationship between the detectability of radon anomalies and the first motions of P-waves was investigated. Based on the first motions of P-waves recorded near the investigated well, a precursory decrease in groundwater radon can be detected only when the first motion is compression. No precursory change in groundwater radon concentration was observed for the downward first motion of P-waves.

In a modern society that is increasingly older and "heavier," it is understandable that the majority favors a slimmer body that helps to sail smoothly into the dusk of life. Given the association between obesity and many metabolic and cardiovascular disorders, there are stern criticisms over such a thought of "good fat". Ironically, a phenomenon called "obesity paradox", that is, the overweight population purportedly enjoys the lowest all-cause mortality, and baffles open-minded clinicians and scientists. Lipids are essential to all life forms. Fat, in particular, triacylglycerol, also exists in different forms and in different locations in the human body, making any simple statement that vilifies all fat invalid. Whether the phenomenon of obesity paradox, indeed, has its root in a hitherto unrealized pro-survival function of fat deserves a serious look. Indeed, a recent publication using yeast as the model showed that elevation in the cellular storage of triacylglycerol extends lifespan in an energy expenditure independent fashion. In stark contrast, lean cells devoid of triacylglycerol biosynthetic capability die upon entering the senescence phase. Together, a new cytoprotective function of fat emerges. This mini-review aims to discuss potential mechanisms for the observed lifespan preservation function of triacylglycerol.

We report the demonstration of high-photoresponsivity Ge-dot photoMOSFETs in a standard MOS configuration for the detection of 850–1550 nm illumination. Each device has a self-organized, gate-stacking heterostructure of SiO2/Ge-dot/SiO2/SiGe-channel which is simultaneously fabricated in a single oxidation step. Superior control of the geometrical size and chemical composition for our Ge nanodots/SiO2/Si1-xGex-shell MOS structure enables the practically-achievable, gate-stacking design for our Ge-dot photoMOSFETs. Both the gate oxide thickness and the diameter of the Ge dots are controllable. Large photocurrent enhancement was achieved for our Ge-dot photoMOSFETs when electrically-biased at ON- and OFF-states based on the Ge dot mediating photovoltaic and photoconductive effects, respectively. Both photoelectric conversion efficiency and response speed are significantly improved by reducing the gate-oxide thickness from 38.5 nm to 3.5 nm, and by decreasing Ge-dot size from 90 nm to 50 nm for a given areal density of Ge dots. Photoresponsivity ("Equation missing") values as high as 1.2 × 104 A/W and 300 A/W are measured for 10 nW illumination at 850 nm and 1550 nm, respectively. A response time of 0.48 ns and a 3 dB-frequency of 2 GHz were achieved for 50 nm-Ge-dot photoMOSFETs with channel lengths of 3 μm under pulsed 850 nm illumination.

Advanced first-order second-moment (AFOSM) is commonly used to obtain an upper-bound estimate for a probabilistic analysis. This study presents a new AFOSM application to engineering seismology, estimating major earthquake probabilities based on fault length and slip rate, along with an earthquake empirical model subject to a model error of 0.26 M w. The AFOSM analysis shows that the probability could be as high as 64 % for a major earthquake in northern Taiwan to exceed M w 7.0, considering the length and slip rate of the Sanchiao fault are equal to 36 km and 2 ± 1 mm per year. By contrast, the other case study shows that for the Meishan fault in central Taiwan, the probability is “only” 4 % for earthquake magnitude to exceed M w 7.0, given a shorter fault length of 14 km and a larger slip rate of 6 ± 3 mm per year.

In this paper, we focus on ways to optimize the manufacturing of products whereby the final product performance is measured by the aggregated performances of its components. Specifically for hard disk drives, the final recording capacity is the aggregate of the components’ achievable capacities. As is the case for hard disk drive, a drive normally has a targeted capacity such that if it falls below its target, it will be rejected or downgraded. Similarly, products achieving well above the target will still be sold at the target capacity. At both extremes, it results in loss of profits. Hence, the aim of this paper is to propose a novel selective assembly strategy which can improve profitability by reducing the variation of components in the final product assemblies and achieving the target performance. As our case study, the assembly of hard disk drive (HDD) is used to demonstrate its feasibility in real manufacturing settings. Two theorems, (1) discarding theorem and (2) binning theorem, are formulated to guide the selective assembly strategy. They provide the rules for discarding inferior components before assembly to ensure the quality of the starting population and the rules for selecting matching pairs of components to prevent producing over qualified product. The improvement in component utilization rate over random binning is guaranteed by the two theorems.

New findings in deposition of the phosphorus (P)-doped n+ a-Si (amorphous silicon) thin layer as source/drain regions for a scaled thin-film transistor were studied systematically. The sheet resistance of the n+ a-Si layer decreases with decreasing PH3 gas flow rate. As a result, both on-current and on/off current ratio enhance with decreasing PH3 flow rate up to 370 and 1,515 %, respectively. These observations are contrary to the conventional plasma-enhanced CVD doping process, i.e., lower doping will result in a low sheet resistance. Based on the SEM, AFM, FTIR, XRD and Raman analyses, we attribute the new observations to the change of film structure, i.e., from amorphous Si to nano-Si or micro-Si. Also, the origins of the structure shift are discussed in details.

Significant progress has been made recently in demonstrating that silicon photonics is a promising technology for low-cost optical detectors, modulators and light sources1,2,3,4,5,6,7,8,9,10,11,12. It has often been assumed, however, that their performance is inferior to InP-based devices. Although this is true in most cases, one of the exceptions is the area of avalanche photodetectors, where silicon's material properties allow for high gain with less excess noise than InP-based avalanche photodetectors and a theoretical sensitivity improvement of 3 dB or more. Here, we report a monolithically grown germanium/silicon avalanche photodetector with a gain–bandwidth product of 340 GHz, a keff of 0.09 and a sensitivity of −28 dB m at 10 Gb s−1. This is the highest reported gain–bandwidth product for any avalanche photodetector operating at 1,300 nm and a sensitivity that is equivalent to mature, commercially available III–V compound avalanche photodetectors. This work paves the way for the future development of low-cost, CMOS-based germanium/silicon avalanche photodetectors operating at data rates of 40 Gb s−1 or higher. A monolithically grown Ge/Si avalanche photodetectors (APD) with a gain–bandwidth product of 340 GHz, the highest value for any APDs operating at 1,300 nm, and a sensitivity equivalent to commercially available III-V compound APDs is reported. The excellent performance paves the way to achieving low-cost, CMOS-based, Ge/Si APDs operating at data rates of 40 Gb s−1 or higher, where the performance of III-V APDs is severely limited.

We report the first demonstration of a low-threshold continuous-wave (c.w.) Raman silicon laser based on a ring-resonator-cavity configuration. We achieved a lasing threshold of 20 mW, slope efficiency of 28% and an output power of 50 mW, with a 25 V reverse bias applied to the p-i-n silicon waveguides. This represents nearly a tenfold improvement in the lasing threshold and more than a fivefold improvement in both slope efficiency and output power over previous results. In addition, we demonstrate for the first time c.w. lasing with zero bias voltage. In this arrangement, the laser does not require an external electrical power supply, and we obtained a lasing threshold of 26 mW and laser output power exceeding 10 mW. The realization of low-threshold lasing and lasing with no external bias is a major advance towards producing practical silicon lasers based on stimulated Raman scattering, for applications ranging from telecommunications and interconnects to optical sensing and biomedical applications.

Multi-wall carbon nanotubes (MWCNTs) were grown by thermal chemical vapor deposition (thermal CVD) of CH4 by using Ni-MCM-41 as the catalyst. Methane pyrolysis has been performed in a quartz tube reactor over the catalyst surface to form carbon atoms via dehydrogenation process. The migration and rearrangement of the surface carbon atoms result in the formation of MWCNTs. Transmission electron microscope (TEM) and scanning electron microscope (SEM) were used to determine the morphologies and structures of CNTs, and Raman spectroscopy was exploited to analyze their purity with the relative intensity between the D-band (Disorder band) in the vicinity of 1,350 cm−1 which is characteristic of the sp3 structure and G-band (Graphitic band) in vicinity of 1,580 cm−1 which is characteristic of the sp2 structure. In addition, the controlling factors of methane pyrolysis such as the catalyst composition; the reaction temperature, and the methane flow rate on the formation of MWCNTs were investigated to optimize the structure and yield of MWCNTs. SEM/TEM results indicate that the yield of the CNTs increases with increasing Ni concentration in the catalyst. The optimized reaction temperature to grow CNT is located between 640 and 670 °C. The uniform and narrow diameter MWCNTs form at lower flow rate of methane (∼30 sccm), and non-uniform in diameter and disorder structure of MWCNTs are observed at higher flow rate of methane. This is consistent with Raman analysis that the relative intensity of I D/I G increases with increasing methane flow rate. The formation mechanisms of the MWCNTs on the Ni-MCM-41 catalyst have been determined to be a Tip-Growth mode with a nanoscale catalyst particle capsulated in the tip of the CNT.

Mesoporous oxides attract a great deal of interest in many fields, including energy, catalysis and separation, because of their tunable structural properties such as surface area, pore volume and size, and nanocrystalline walls. Here we report thermally stable, crystalline, thermally controlled monomodal pore size mesoporous materials. Generation of such materials involves the use of inverse micelles, elimination of solvent effects, minimizing the effect of water content and controlling the condensation of inorganic frameworks by NO(x) decomposition. Nanosize particles are formed in inverse micelles and are randomly packed to a mesoporous structure. The mesopores are created by interconnected intraparticle voids and can be tuned from 1.2 to 25 nm by controlling the nanoparticle size. Such phenomena allow the preparation of multiple phases of the same metal oxide and syntheses of materials having compositions throughout much of the periodic table, with different structures and thermal stabilities as high as 800 °C.

The yeast transcriptional adaptor, Gcn5p, is a catalytic subunit of a nuclear (type A) histone acetyltransferase linking histone acetylation to gene activation. Here we report that Gcn5p acetylates histones H3 and H4 non-randomly at specific lysines in the amino-terminal domains. Lysine 14 of H3 and lysines 8 and 16 of H4 are highly preferred acetylation sites for Gcn5p. We also demonstrate that lysine 9 is the preferred position of acetylation in newly synthesized yeast H3 in vivo. This finding, along with the fact that lysines 5 and 12 in H4 are predominant acetylation sites during chromatin assembly of many organisms, indicates that Gcn5p acetylates a distinct set of lysines that do not overlap with those sites characteristically used by type B histone acetyltransferases for histone deposition and chromatin assembly.

The expansion of 802.11 AP deployment provides opportunistic Wi-Fi access in underground mass rapid transit (MRT) system. However, such vehicular network faces the challenge of limited time for the MS on the train to connect the base station at the station. Therefore, to maximize the throughput within these several tens of seconds becomes crucial to the network. To achieve this goal, we propose accelerometer-assisted rate adaptation (AARA), a mechanism utilizes the out-of-band information of a train’s acceleration to improve the conventional rate adaptation scheme. AARA consists of two parts: First, AARA divides a train’s movement into four phases and performs real-time estimation on the train’s current movement phase. Second, AARA employs the estimation results to enhance the bit-rate selection during each phase. We conduct experiments on two different Taipei MRT systems: high-capacity MRT and medium-capacity MRT. The experimental results show that the average throughput of AARA outperforms that of the conventional scheme in different scenarios. In addition, we also design a mechanism of power saving with the aid of the movement estimation.

Signals from ten explosions were used to examine earthquake location uncertainty in Taiwan. Location errors for explosion sites determined using a relocation process were expressed in terms of statistical measurements for standard errors in the depth (ERZ), the epicenter (ERH), the root-mean-square of the travel time residuals (RMS), and the station coverage gap (GAP). In general, for this study, major factors in location errors resulted from the poor coverage of seismic stations (e.g., a large value of GAP). Using the relationship between location errors and parameters from the explosion location assessment, uncertainties for earthquake locations in the Taiwan region for a total of 384064 events from 1991 to 2011 were evaluated. Offshore regions in southwestern and northeastern Taiwan had larger location errors. For the inland locales, location errors in longitude, latitude, and depth were approximately 3.1 ± 2.7, 1.3 ± 1.6, and 4.6 ± 3.9 km, respectively. The uncertainties estimated from this study could offer a good reference for other related studies.