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235 results on '"Hansen, Torben"'

1. Analysis of admixed Greenlandic siblings shows that the mean genotypic values for metabolic phenotypes differ between Inuit and Europeans

Author

Lin, Long, primary, Andersen, Mette K., additional, Stæger, Frederik Filip, additional, Li, Zilong, additional, Hanghøj, Kristian, additional, Linneberg, Allan, additional, Grarup, Niels, additional, Jørgensen, Marit Eika, additional, Hansen, Torben, additional, Moltke, Ida, additional, and Albrechtsen, Anders, additional

Published
2024
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2. Low birthweight in patients with type 2 diabetes is associated with elevated risk of cardiovascular events and mortality

Author

Hansen, Aleksander L., primary, Brøns, Charlotte, additional, Engelhard, Leonie M., additional, Andersen, Mette K., additional, Hansen, Torben, additional, Nielsen, Jens S., additional, Vestergaard, Peter, additional, Højlund, Kurt, additional, Jessen, Niels, additional, Olsen, Michael H., additional, Sørensen, Henrik T., additional, Thomsen, Reimar W., additional, and Vaag, Allan, additional

Published
2024
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4. Characterization of the gut bacterial and viral microbiota in latent autoimmune diabetes in adults

Author

Poulsen, Casper S., primary, Hesse, Dan, additional, Fernandes, Gabriel R., additional, Hansen, Tue H., additional, Kern, Timo, additional, Linneberg, Allan, additional, Van Espen, Lore, additional, Jørgensen, Torben, additional, Nielsen, Trine, additional, Alibegovic, Amra C., additional, Matthijnssens, Jelle, additional, Pedersen, Oluf, additional, Vestergaard, Henrik, additional, Hansen, Torben, additional, and Andersen, Mette K., additional

Published
2024
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5. Lifestyle and demographic associations with 47 inflammatory and vascular stress biomarkers in 9876 blood donors

Author

Kjerulff, Bertram, primary, Dowsett, Joseph, additional, Jacobsen, Rikke Louise, additional, Gladov, Josephine, additional, Larsen, Margit Hørup, additional, Lundgaard, Agnete Troen, additional, Banasik, Karina, additional, Westergaard, David, additional, Mikkelsen, Susan, additional, Dinh, Khoa Manh, additional, Hindhede, Lotte, additional, Kaspersen, Kathrine Agergård, additional, Schwinn, Michael, additional, Juul, Anders, additional, Poulsen, Betina, additional, Lindegaard, Birgitte, additional, Pedersen, Carsten Bøcker, additional, Sabel, Clive Eric, additional, Bundgaard, Henning, additional, Nielsen, Henriette Svarre, additional, Møller, Janne Amstrup, additional, Boldsen, Jens Kjærgaard, additional, Burgdorf, Kristoffer Sølvsten, additional, Kessing, Lars Vedel, additional, Handgaard, Linda Jenny, additional, Thørner, Lise Wegner, additional, Didriksen, Maria, additional, Nyegaard, Mette, additional, Grarup, Niels, additional, Ødum, Niels, additional, Johansson, Pär I., additional, Jennum, Poul, additional, Frikke-Schmidt, Ruth, additional, Berger, Sanne Schou, additional, Brunak, Søren, additional, Jacobsen, Søren, additional, Hansen, Thomas Folkmann, additional, Lundquist, Tine Kirkeskov, additional, Hansen, Torben, additional, Sørensen, Torben Lykke, additional, Sigsgaard, Torben, additional, Nielsen, Kaspar René, additional, Bruun, Mie Topholm, additional, Hjalgrim, Henrik, additional, Ullum, Henrik, additional, Rostgaard, Klaus, additional, Sørensen, Erik, additional, Pedersen, Ole Birger, additional, Ostrowski, Sisse Rye, additional, and Erikstrup, Christian, additional

Published
2024
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6. Description of an activity-based enzyme biosensor for lung cancer detection

Author

Dempsey, Paul W., primary, Sandu, Cristina-Mihaela, additional, Gonzalezirias, Ricardo, additional, Hantula, Spencer, additional, Covarrubias-Zambrano, Obdulia, additional, Bossmann, Stefan H., additional, Nagji, Alykhan S., additional, Veeramachaneni, Nirmal K., additional, Ermerak, Nezih O., additional, Kocakaya, Derya, additional, Lacin, Tunc, additional, Yildizeli, Bedrittin, additional, Lilley, Patrick, additional, Wen, Sara W. C., additional, Nederby, Line, additional, Hansen, Torben F., additional, and Hilberg, Ole, additional

Published
2024
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7. Study protocol: fish oil supplement in prevention of oxaliplatin-induced peripheral neuropathy in adjuvant colorectal cancer patients – a randomized controlled trial. (OxaNeuro)

Author

Gehr, Nina Lykkegaard, primary, Karlsson, Páll, additional, Timm, Signe, additional, Christensen, Signe, additional, Hvid, Christian Andreas, additional, Peric, Jana, additional, Hansen, Torben Frøstrup, additional, Lauritzen, Lotte, additional, Finnerup, Nanna Brix, additional, and Ventzel, Lise, additional

Published
2024
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8. Markers of inflammation predict survival in newly diagnosed cirrhosis: a prospective registry study

Author

Mynster Kronborg, Thit, primary, Webel, Henry, additional, O’Connell, Malene Barfod, additional, Danielsen, Karen Vagner, additional, Hobolth, Lise, additional, Møller, Søren, additional, Jensen, Rasmus Tanderup, additional, Bendtsen, Flemming, additional, Hansen, Torben, additional, Rasmussen, Simon, additional, Juel, Helene Bæk, additional, and Kimer, Nina, additional

Published
2023
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10. GWAS of lipids in Greenlanders finds association signals shared with Europeans and reveals an independent PCSK9 association signal

Author

Senftleber, Ninna Karsbæk, primary, Andersen, Mette K., additional, Jørsboe, Emil, additional, Stæger, Frederik Filip, additional, Nøhr, Anne Krogh, additional, Garcia-Erill, Genis, additional, Meisner, Jonas, additional, Santander, Cindy G., additional, Balboa, Renzo F., additional, Gilly, Arthur, additional, Bjerregaard, Peter, additional, Larsen, Christina Viskum Lytken, additional, Grarup, Niels, additional, Jørgensen, Marit Eika, additional, Zeggini, Eleftheria, additional, Moltke, Ida, additional, Hansen, Torben, additional, and Albrechtsen, Anders, additional

Published
2023
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11. Second international consensus report on gaps and opportunities for the clinical translation of precision diabetes medicine

Author

Tobias, Deirdre K., primary, Merino, Jordi, additional, Ahmad, Abrar, additional, Aiken, Catherine, additional, Benham, Jamie L., additional, Bodhini, Dhanasekaran, additional, Clark, Amy L., additional, Colclough, Kevin, additional, Corcoy, Rosa, additional, Cromer, Sara J., additional, Duan, Daisy, additional, Felton, Jamie L., additional, Francis, Ellen C., additional, Gillard, Pieter, additional, Gingras, Véronique, additional, Gaillard, Romy, additional, Haider, Eram, additional, Hughes, Alice, additional, Ikle, Jennifer M., additional, Jacobsen, Laura M., additional, Kahkoska, Anna R., additional, Kettunen, Jarno L. T., additional, Kreienkamp, Raymond J., additional, Lim, Lee-Ling, additional, Männistö, Jonna M. E., additional, Massey, Robert, additional, Mclennan, Niamh-Maire, additional, Miller, Rachel G., additional, Morieri, Mario Luca, additional, Most, Jasper, additional, Naylor, Rochelle N., additional, Ozkan, Bige, additional, Patel, Kashyap Amratlal, additional, Pilla, Scott J., additional, Prystupa, Katsiaryna, additional, Raghavan, Sridharan, additional, Rooney, Mary R., additional, Schön, Martin, additional, Semnani-Azad, Zhila, additional, Sevilla-Gonzalez, Magdalena, additional, Svalastoga, Pernille, additional, Takele, Wubet Worku, additional, Tam, Claudia Ha-ting, additional, Thuesen, Anne Cathrine B., additional, Tosur, Mustafa, additional, Wallace, Amelia S., additional, Wang, Caroline C., additional, Wong, Jessie J., additional, Yamamoto, Jennifer M., additional, Young, Katherine, additional, Amouyal, Chloé, additional, Andersen, Mette K., additional, Bonham, Maxine P., additional, Chen, Mingling, additional, Cheng, Feifei, additional, Chikowore, Tinashe, additional, Chivers, Sian C., additional, Clemmensen, Christoffer, additional, Dabelea, Dana, additional, Dawed, Adem Y., additional, Deutsch, Aaron J., additional, Dickens, Laura T., additional, DiMeglio, Linda A., additional, Dudenhöffer-Pfeifer, Monika, additional, Evans-Molina, Carmella, additional, Fernández-Balsells, María Mercè, additional, Fitipaldi, Hugo, additional, Fitzpatrick, Stephanie L., additional, Gitelman, Stephen E., additional, Goodarzi, Mark O., additional, Grieger, Jessica A., additional, Guasch-Ferré, Marta, additional, Habibi, Nahal, additional, Hansen, Torben, additional, Huang, Chuiguo, additional, Harris-Kawano, Arianna, additional, Ismail, Heba M., additional, Hoag, Benjamin, additional, Johnson, Randi K., additional, Jones, Angus G., additional, Koivula, Robert W., additional, Leong, Aaron, additional, Leung, Gloria K. W., additional, Libman, Ingrid M., additional, Liu, Kai, additional, Long, S. Alice, additional, Lowe, William L., additional, Morton, Robert W., additional, Motala, Ayesha A., additional, Onengut-Gumuscu, Suna, additional, Pankow, James S., additional, Pathirana, Maleesa, additional, Pazmino, Sofia, additional, Perez, Dianna, additional, Petrie, John R., additional, Powe, Camille E., additional, Quinteros, Alejandra, additional, Jain, Rashmi, additional, Ray, Debashree, additional, Ried-Larsen, Mathias, additional, Saeed, Zeb, additional, Santhakumar, Vanessa, additional, Kanbour, Sarah, additional, Sarkar, Sudipa, additional, Monaco, Gabriela S. F., additional, Scholtens, Denise M., additional, Selvin, Elizabeth, additional, Sheu, Wayne Huey-Herng, additional, Speake, Cate, additional, Stanislawski, Maggie A., additional, Steenackers, Nele, additional, Steck, Andrea K., additional, Stefan, Norbert, additional, Støy, Julie, additional, Taylor, Rachael, additional, Tye, Sok Cin, additional, Ukke, Gebresilasea Gendisha, additional, Urazbayeva, Marzhan, additional, Van der Schueren, Bart, additional, Vatier, Camille, additional, Wentworth, John M., additional, Hannah, Wesley, additional, White, Sara L., additional, Yu, Gechang, additional, Zhang, Yingchai, additional, Zhou, Shao J., additional, Beltrand, Jacques, additional, Polak, Michel, additional, Aukrust, Ingvild, additional, de Franco, Elisa, additional, Flanagan, Sarah E., additional, Maloney, Kristin A., additional, McGovern, Andrew, additional, Molnes, Janne, additional, Nakabuye, Mariam, additional, Njølstad, Pål Rasmus, additional, Pomares-Millan, Hugo, additional, Provenzano, Michele, additional, Saint-Martin, Cécile, additional, Zhang, Cuilin, additional, Zhu, Yeyi, additional, Auh, Sungyoung, additional, de Souza, Russell, additional, Fawcett, Andrea J., additional, Gruber, Chandra, additional, Mekonnen, Eskedar Getie, additional, Mixter, Emily, additional, Sherifali, Diana, additional, Eckel, Robert H., additional, Nolan, John J., additional, Philipson, Louis H., additional, Brown, Rebecca J., additional, Billings, Liana K., additional, Boyle, Kristen, additional, Costacou, Tina, additional, Dennis, John M., additional, Florez, Jose C., additional, Gloyn, Anna L., additional, Gomez, Maria F., additional, Gottlieb, Peter A., additional, Greeley, Siri Atma W., additional, Griffin, Kurt, additional, Hattersley, Andrew T., additional, Hirsch, Irl B., additional, Hivert, Marie-France, additional, Hood, Korey K., additional, Josefson, Jami L., additional, Kwak, Soo Heon, additional, Laffel, Lori M., additional, Lim, Siew S., additional, Loos, Ruth J. F., additional, Ma, Ronald C. W., additional, Mathieu, Chantal, additional, Mathioudakis, Nestoras, additional, Meigs, James B., additional, Misra, Shivani, additional, Mohan, Viswanathan, additional, Murphy, Rinki, additional, Oram, Richard, additional, Owen, Katharine R., additional, Ozanne, Susan E., additional, Pearson, Ewan R., additional, Perng, Wei, additional, Pollin, Toni I., additional, Pop-Busui, Rodica, additional, Pratley, Richard E., additional, Redman, Leanne M., additional, Redondo, Maria J., additional, Reynolds, Rebecca M., additional, Semple, Robert K., additional, Sherr, Jennifer L., additional, Sims, Emily K., additional, Sweeting, Arianne, additional, Tuomi, Tiinamaija, additional, Udler, Miriam S., additional, Vesco, Kimberly K., additional, Vilsbøll, Tina, additional, Wagner, Robert, additional, Rich, Stephen S., additional, and Franks, Paul W., additional

Published
2023
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14. Discovery of drug-omics associations in type 2 diabetes with generative deep-learning models

Author

Allesøe, Rosa Lundbye, Lundgaard, Agnete Troen, Hernández Medina, Ricardo, Aguayo-Orozco, Alejandro, Johansen, Joachim, Nissen, Jakob Nybo, Brorsson, Caroline, Mazzoni, Gianluca, Niu, Lili, Biel, Jorge Hernansanz, Leal Rodríguez, Cristina, Brasas, Valentas, Webel, Henry, Benros, Michael Eriksen, Pedersen, Anders Gorm, Chmura, Piotr Jaroslaw, Jacobsen, Ulrik Plesner, Mari, Andrea, Koivula, Robert, Mahajan, Anubha, Vinuela, Ana, Tajes, Juan Fernandez, Sharma, Sapna, Haid, Mark, Hong, Mun-Gwan, Musholt, Petra B, De Masi, Federico, Vogt, Josef, Pedersen, Helle Krogh, Gudmundsdottir, Valborg, Jones, Angus, Kennedy, Gwen, Bell, Jimmy, Thomas, E Louise, Frost, Gary, Thomsen, Henrik, Hansen, Elizaveta, Hansen, Tue Haldor, Vestergaard, Henrik, Muilwijk, Mirthe, Blom, Marieke T, 't Hart, Leen M, Pattou, Francois, Raverdy, Violeta, Brage, Soren, Kokkola, Tarja, Heggie, Alison, McEvoy, Donna, Mourby, Miranda, Kaye, Jane, Hattersley, Andrew, McDonald, Timothy, Ridderstråle, Martin, Walker, Mark, Forgie, Ian, Giordano, Giuseppe N, Pavo, Imre, Ruetten, Hartmut, Pedersen, Oluf, Hansen, Torben, Dermitzakis, Emmanouil, Franks, Paul W, Schwenk, Jochen M, Adamski, Jerzy, McCarthy, Mark I, Pearson, Ewan, Banasik, Karina, Rasmussen, Simon, Brunak, Søren, IMI DIRECT Consortium, Lundgaard, Agnete Troen [0000-0001-7447-6560], Hernández Medina, Ricardo [0000-0001-6373-2362], Johansen, Joachim [0000-0001-7052-1870], Niu, Lili [0000-0003-4571-4368], Biel, Jorge Hernansanz [0000-0002-3125-2951], Leal Rodríguez, Cristina [0000-0002-3133-0630], Benros, Michael Eriksen [0000-0003-4939-9465], Pedersen, Anders Gorm [0000-0001-9650-8965], Jacobsen, Ulrik Plesner [0000-0001-9181-6854], Koivula, Robert [0000-0002-1646-4163], Vinuela, Ana [0000-0003-3771-8537], Haid, Mark [0000-0001-6118-1333], Hong, Mun-Gwan [0000-0001-8603-8293], Kennedy, Gwen [0000-0002-9856-3236], Thomas, E Louise [0000-0003-4235-4694], Frost, Gary [0000-0003-0529-6325], Hansen, Tue Haldor [0000-0001-5948-8993], Kaye, Jane [0000-0002-7311-4725], Hattersley, Andrew [0000-0001-5620-473X], Ridderstråle, Martin [0000-0002-3270-9167], Pedersen, Oluf [0000-0002-3321-3972], Hansen, Torben [0000-0001-8748-3831], Schwenk, Jochen M [0000-0001-8141-8449], Rasmussen, Simon [0000-0001-6323-9041], Brunak, Søren [0000-0003-0316-5866], and Apollo - University of Cambridge Repository

Subjects
Deep Learning, Diabetes Mellitus, Type 2, Humans, Algorithms
Abstract

The application of multiple omics technologies in biomedical cohorts has the potential to reveal patient-level disease characteristics and individualized response to treatment. However, the scale and heterogeneous nature of multi-modal data makes integration and inference a non-trivial task. We developed a deep-learning-based framework, multi-omics variational autoencoders (MOVE), to integrate such data and applied it to a cohort of 789 people with newly diagnosed type 2 diabetes with deep multi-omics phenotyping from the DIRECT consortium. Using in silico perturbations, we identified drug-omics associations across the multi-modal datasets for the 20 most prevalent drugs given to people with type 2 diabetes with substantially higher sensitivity than univariate statistical tests. From these, we among others, identified novel associations between metformin and the gut microbiota as well as opposite molecular responses for the two statins, simvastatin and atorvastatin. We used the associations to quantify drug-drug similarities, assess the degree of polypharmacy and conclude that drug effects are distributed across the multi-omics modalities.

Published
2023

15. Primary weight loss failure after Roux-en-Y gastric bypass is characterized by impaired gut-hormone mediated regulation of food intake

Author

Bojsen-Møller, Kirstine Nyvold, primary, Svane, Maria Saur, additional, Martinussen, Christoffer, additional, Dirksen, Carsten, additional, Jørgensen, Nils Bruun, additional, Jensen, Jens-Erik Beck, additional, Jensen, Christian Zinck, additional, Torekov, Signe Sørensen, additional, Kristiansen, Viggo Bjerregaard, additional, Rehfeld, Jens Frederik, additional, Bork-Jensen, Jette, additional, Grarup, Niels, additional, Hansen, Torben, additional, Hartmann, Bolette, additional, Holst, Jens Juul, additional, and Madsbad, Sten, additional

Published
2023
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17. Low birthweight is associated with a higher incidence of type 2 diabetes over two decades independent of adult BMI and genetic predisposition

Author

Wibaek, Rasmus, primary, Andersen, Gregers S., additional, Linneberg, Allan, additional, Hansen, Torben, additional, Grarup, Niels, additional, Thuesen, Anne Cathrine B., additional, Jensen, Rasmus T., additional, Wells, Jonathan C. K., additional, Pilgaard, Kasper A., additional, Brøns, Charlotte, additional, Vistisen, Dorte, additional, and Vaag, Allan A., additional

Published
2023
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18. Birthweight is associated with clinical characteristics in people with recently diagnosed type 2 diabetes

Author

Hansen, Aleksander L., primary, Thomsen, Reimar W., additional, Brøns, Charlotte, additional, Svane, Helene M. L., additional, Jensen, Rasmus T., additional, Andersen, Mette K., additional, Hansen, Torben, additional, Nielsen, Jens S., additional, Vestergaard, Peter, additional, Højlund, Kurt, additional, Jessen, Niels, additional, Olsen, Michael H., additional, Sørensen, Henrik T., additional, and Vaag, Allan A., additional

Published
2023
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19. Precision medicine applied to metastatic colorectal cancer using tumor-derived organoids and in-vitro sensitivity testing: a phase 2, single-center, open-label, and non-comparative study

Author

Jensen, Lars Henrik, primary, Rogatto, Silvia Regina, additional, Lindebjerg, Jan, additional, Havelund, Birgitte, additional, Abildgaard, Cecilie, additional, do Canto, Luisa Matos, additional, Vagn-Hansen, Chris, additional, Dam, Claus, additional, Rafaelsen, Søren, additional, and Hansen, Torben Frøstrup, additional

Published
2023
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20. A comprehensive map of human glucokinase variant activity

Author

Gersing, Sarah, primary, Cagiada, Matteo, additional, Gebbia, Marinella, additional, Gjesing, Anette P., additional, Coté, Atina G., additional, Seesankar, Gireesh, additional, Li, Roujia, additional, Tabet, Daniel, additional, Weile, Jochen, additional, Stein, Amelie, additional, Gloyn, Anna L., additional, Hansen, Torben, additional, Roth, Frederick P., additional, Lindorff-Larsen, Kresten, additional, and Hartmann-Petersen, Rasmus, additional

Published
2023
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21. Genetic architecture of spatial electrical biomarkers for cardiac arrhythmia and relationship with cardiovascular disease

Author

Young, William J., primary, Haessler, Jeffrey, additional, Benjamins, Jan-Walter, additional, Repetto, Linda, additional, Yao, Jie, additional, Isaacs, Aaron, additional, Harper, Andrew R., additional, Ramirez, Julia, additional, Garnier, Sophie, additional, van Duijvenboden, Stefan, additional, Baldassari, Antoine R., additional, Concas, Maria Pina, additional, Duong, ThuyVy, additional, Foco, Luisa, additional, Isaksen, Jonas L., additional, Mei, Hao, additional, Noordam, Raymond, additional, Nursyifa, Casia, additional, Richmond, Anne, additional, Santolalla, Meddly L., additional, Sitlani, Colleen M., additional, Soroush, Negin, additional, Thériault, Sébastien, additional, Trompet, Stella, additional, Aeschbacher, Stefanie, additional, Ahmadizar, Fariba, additional, Alonso, Alvaro, additional, Brody, Jennifer A., additional, Campbell, Archie, additional, Correa, Adolfo, additional, Darbar, Dawood, additional, De Luca, Antonio, additional, Deleuze, Jean-François, additional, Ellervik, Christina, additional, Fuchsberger, Christian, additional, Goel, Anuj, additional, Grace, Christopher, additional, Guo, Xiuqing, additional, Hansen, Torben, additional, Heckbert, Susan R., additional, Jackson, Rebecca D., additional, Kors, Jan A., additional, Lima-Costa, Maria Fernanda, additional, Linneberg, Allan, additional, Macfarlane, Peter W., additional, Morrison, Alanna C., additional, Navarro, Pau, additional, Porteous, David J., additional, Pramstaller, Peter P., additional, Reiner, Alexander P., additional, Risch, Lorenz, additional, Schotten, Ulrich, additional, Shen, Xia, additional, Sinagra, Gianfranco, additional, Soliman, Elsayed Z., additional, Stoll, Monika, additional, Tarazona-Santos, Eduardo, additional, Tinker, Andrew, additional, Trajanoska, Katerina, additional, Villard, Eric, additional, Warren, Helen R., additional, Whitsel, Eric A., additional, Wiggins, Kerri L., additional, Arking, Dan E., additional, Avery, Christy L., additional, Conen, David, additional, Girotto, Giorgia, additional, Grarup, Niels, additional, Hayward, Caroline, additional, Jukema, J.Wouter, additional, Mook-Kanamori, Dennis O., additional, Olesen, Morten Salling, additional, Padmanabhan, Sandosh, additional, Psaty, Bruce M., additional, Pattaro, Cristian, additional, Ribeiro, Antonio Luiz P., additional, Rotter, Jerome I., additional, Stricker, Bruno H., additional, van der Harst, Pim, additional, van Duijn, Cornelia M., additional, Verweij, Niek, additional, Wilson, James G., additional, Orini, Michele, additional, Charron, Philippe, additional, Watkins, Hugh, additional, Kooperberg, Charles, additional, Lin, Henry J., additional, Wilson, James F., additional, Kanters, Jørgen K., additional, Sotoodehnia, Nona, additional, Mifsud, Borbala, additional, Lambiase, Pier D., additional, Tereshchenko, Larisa G., additional, and Munroe, Patricia B., additional

Published
2023
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22. Genome-wide association analyses of physical activity and sedentary behavior provide insights into underlying mechanisms and roles in disease prevention

Author

Wang, Zhe, Emmerich, Andrew, Pillon, Nicolas J., Moore, Tim, Hemerich, Daiane, Cornelis, Marilyn C., Mazzaferro, Eugenia, Broos, Siacia, Ahluwalia, Tarunveer S., Bartz, Traci M., Bentley, Amy R., Bielak, Lawrence F., Chong, Mike, Chu, Audrey Y., Berry, Diane, Dorajoo, Rajkumar, Dueker, Nicole D., Kasbohm, Elisa, Feenstra, Bjarke, Feitosa, Mary F., Gieger, Christian, Graff, Mariaelisa, Hall, Leanne M., Haller, Toomas, Hartwig, Fernando P., Hillis, David A., Huikari, Ville, Heard-Costa, Nancy, Holzapfel, Christina, Jackson, Anne U., Johansson, Åsa, Jørgensen, Anja Moltke, Kaakinen, Marika A., Karlsson, Robert, Kerr, Kathleen F., Kim, Boram, Koolhaas, Chantal M., Kutalik, Zoltan, Lagou, Vasiliki, Lind, Penelope A., Lorentzon, Mattias, Lyytikäinen, Leo-Pekka, Mangino, Massimo, Metzendorf, Christoph, Monroe, Kristine R., Pacolet, Alexander, Pérusse, Louis, Pool, Rene, Richmond, Rebecca C., Rivera, Natalia V., Robiou-du-Pont, Sebastien, Schraut, Katharina E., Schulz, Christina-Alexandra, Stringham, Heather M., Tanaka, Toshiko, Teumer, Alexander, Turman, Constance, van der Most, Peter J., Vanmunster, Mathias, van Rooij, Frank J. A., van Vliet-Ostaptchouk, Jana V., Zhang, Xiaoshuai, Zhao, Jing-Hua, Zhao, Wei, Balkhiyarova, Zhanna, Balslev-Harder, Marie N., Baumeister, Sebastian E., Beilby, John, Blangero, John, Boomsma, Dorret I., Brage, Søren Karl, Braund, Peter S., Brody, Jennifer A., Bruinenberg, Marcel, Ekelund, Ulf, Liu, Ching-Ti, Cole, John W., Collins, Francis S., Cupples, L. Adrienne, Esko, Tõnu, Enroth, Stefan, Faul, Jessica D., Fernandez-Rhodes, Lindsay, Fohner, Alison E., Franco, Oscar H., Galesloot, Tessel E., Gordon, Scott D., Grarup, Niels, Hartman, Catharina A., Heiss, Gerardo, Hui, Jennie, Illig, Thomas, Jago, Russell, James, Alan, Joshi, Peter K., Jung, Taeyeong, Kähönen, Mika, Kilpeläinen, Tuomas O., Koh, Woon-Puay, Kolcic, Ivana, Kraft, Peter P., Kuusisto, Johanna, Launer, Lenore J., Li, Aihua, Linneberg, Allan, Luan, Jian’an, Vidal, Pedro Marques, Medland, Sarah E., Milaneschi, Yuri, Moscati, Arden, Musk, Bill, Nelson, Christopher P., Nolte, Ilja M., Pedersen, Nancy L., Peters, Annette, Peyser, Patricia A., Power, Christine, Raitakari, Olli T., Reedik, Mägi, Reiner, Alex P., Ridker, Paul M., Rudan, Igor, Ryan, Kathy, Sarzynski, Mark A., Scott, Laura J., Scott, Robert A., Sidney, Stephen, Siggeirsdottir, Kristin, Smith, Albert V., Smith, Jennifer A., Sonestedt, Emily, Strøm, Marin, Tai, E. Shyong, Teo, Koon K., Thorand, Barbara, Tönjes, Anke, Tremblay, Angelo, Uitterlinden, Andre G., Vangipurapu, Jagadish, van Schoor, Natasja, Völker, Uwe, Willemsen, Gonneke, Williams, Kayleen, Wong, Quenna, Xu, Huichun, Young, Kristin L., Yuan, Jian Min, Zillikens, M. Carola, Zonderman, Alan B., Ameur, Adam, Bandinelli, Stefania, Bis, Joshua C., Boehnke, Michael, Bouchard, Claude, Chasman, Daniel I., Smith, George Davey, de Geus, Eco J. C., Deldicque, Louise, Dörr, Marcus, Evans, Michele K., Ferrucci, Luigi, Fornage, Myriam, Fox, Caroline, Garland, Theodore, Gudnason, Vilmundur, Gyllensten, Ulf, Hansen, Torben, Hayward, Caroline, Horta, Bernardo L., Hyppönen, Elina, Jarvelin, Marjo-Riitta, Johnson, W. Craig, Kardia, Sharon L. R., Kiemeney, Lambertus A., Laakso, Markku, Langenberg, Claudia, Lehtimäki, Terho, Marchand, Loic Le, Alizadeh, Behrooz Z., Boezen, H. Marike, Franke, Lude, Swertz, Morris, Wijmenga, Tjitske Nienke, van der Harst, Pim, Navis, Gerjan, Rots, Marianne, Wolffenbuttel, Bruce H. R., Magnusson, Patrik K. E., Martin, Nicholas G., Melbye, Mads, Metspalu, Andres, Meyre, David, North, Kari E., Ohlsson, Claes, Oldehinkel, Albertine J., Orho-Melander, Marju, Pare, Guillaume, Park, Taesung, Pedersen, Oluf, Penninx, Brenda W. J. H., Pers, Tune H., Polasek, Ozren, Prokopenko, Inga, Rotimi, Charles N., Samani, Nilesh J., Sim, Xueling, Snieder, Harold, Sørensen, Thorkild I. A., Spector, Tim D., Timpson, Nicholas J., van Dam, Rob M., van der Velde, Nathalie, van Duijn, Cornelia M., Vollenweider, Peter, Völzke, Henry, Voortman, Trudy, Waeber, Gérard, Wareham, Nicholas J., Weir, David R., Wichmann, Heinz-Erich, Wilson, James F., Hevener, Andrea L., Krook, Anna, Zierath, Juleen R., Thomis, Martine A. I., Loos, Ruth J. F., Hoed, Marcel den, Epidemiology, Internal Medicine, Tampere University, Department of Clinical Chemistry, Clinical Medicine, Department of Clinical Physiology and Nuclear Medicine, Wang, Zhe, Emmerich, Andrew, Pillon, Nicolas J, Moore, Tim, Hyppönen, Elina, den Hoed, Marcel, Lifelines Cohort Study, Alizadeh, B.Z., Boezen, H.M., Franke, L., Swertz, M., Wijmenga, C., van der Harst, P., Navis, G., Rots, M., Wolffenbuttel, BHR, Wang, Zhe [0000-0002-8046-4969], Emmerich, Andrew [0000-0002-0908-9924], Pillon, Nicolas J [0000-0003-1107-9490], Moore, Tim [0000-0003-4250-3370], Ameur, Adam [0000-0001-6085-6749], Bis, Joshua C [0000-0002-3409-1110], Boehnke, Michael [0000-0002-6442-7754], Bouchard, Claude [0000-0002-0048-491X], Chasman, Daniel I [0000-0003-3357-0862], Smith, George Davey [0000-0002-1407-8314], de Geus, Eco JC [0000-0001-6022-2666], Dörr, Marcus [0000-0001-7471-475X], Ferrucci, Luigi [0000-0002-6273-1613], Fornage, Myriam [0000-0003-0677-8158], Garland, Theodore [0000-0002-7916-3552], Gyllensten, Ulf [0000-0002-6316-3355], Hansen, Torben [0000-0001-8748-3831], Horta, Bernardo L [0000-0001-9843-412X], Hyppönen, Elina [0000-0003-3670-9399], Johnson, W Craig [0000-0002-3161-3753], Kiemeney, Lambertus A [0000-0002-2368-1326], Laakso, Markku [0000-0002-3394-7749], Langenberg, Claudia [0000-0002-5017-7344], Lehtimäki, Terho [0000-0002-2555-4427], Magnusson, Patrik KE [0000-0002-7315-7899], Martin, Nicholas G [0000-0003-4069-8020], Melbye, Mads [0000-0001-8264-6785], Metspalu, Andres [0000-0002-3718-796X], Meyre, David [0000-0003-4850-7444], North, Kari E [0000-0002-8903-0366], Ohlsson, Claes [0000-0002-9633-2805], Oldehinkel, Albertine J [0000-0003-3925-3913], Orho-Melander, Marju [0000-0002-3578-2503], Pare, Guillaume [0000-0002-6795-4760], Park, Taesung [0000-0002-8294-590X], Pedersen, Oluf [0000-0002-3321-3972], Pers, Tune H [0000-0003-0207-4831], Polasek, Ozren [0000-0002-5765-1862], Prokopenko, Inga [0000-0003-1624-7457], Rotimi, Charles N [0000-0001-5759-053X], Sim, Xueling [0000-0002-1233-7642], Snieder, Harold [0000-0003-1949-2298], Sørensen, Thorkild IA [0000-0003-4821-430X], Spector, Tim D [0000-0002-9795-0365], Timpson, Nicholas J [0000-0002-7141-9189], Voortman, Trudy [0000-0003-2830-6813], Waeber, Gérard [0000-0003-4193-788X], Wareham, Nicholas J [0000-0003-1422-2993], Weir, David R [0000-0002-1661-2402], Wilson, James F [0000-0001-5751-9178], Krook, Anna [0000-0002-0891-0258], Zierath, Juleen R [0000-0001-6891-7497], Thomis, Martine AI [0000-0001-9093-2191], Loos, Ruth JF [0000-0002-8532-5087], Hoed, Marcel den [0000-0001-8081-428X], Apollo - University of Cambridge Repository, Center for Liver, Digestive and Metabolic Diseases (CLDM), Interdisciplinary Centre Psychopathology and Emotion regulation (ICPE), Life Course Epidemiology (LCE), Geriatrics, AMS - Ageing & Vitality, APH - Aging & Later Life, Biological Psychology, APH - Health Behaviors & Chronic Diseases, APH - Personalized Medicine, APH - Mental Health, APH - Methodology, and AMS - Sports

Subjects
Vascular damage Radboud Institute for Health Sciences [Radboudumc 16], 631/208/205/2138, 610 Medicine & health, heritability, Actinin/genetics, Cross-Sectional Studies, Exercise/physiology, Genome-Wide Association Study, Humans, Leisure Activities, Sedentary Behavior, apolipoprotein-e genotype, Lifelines Cohort Study, 360 Social problems & social services, 692/308/575, Genetics, Actinin, Exercise, Medicinsk genetik, exercise, APOLIPOPROTEIN-E GENOTYPE, LD SCORE REGRESSION, GENE-EXPRESSION, EXERCISE, COMPLEX, PERFORMANCE, GWAS, HERITABILITY, MORTALITY, FITNESS, 360 Soziale Probleme, Sozialdienste, 692/308/2056, article, gwas, gene-expression, mortality, 3142 Public health care science, environmental and occupational health, fitness, Urological cancers Radboud Institute for Health Sciences [Radboudumc 15], LD score regression, 3111 Biomedicine, 610 Medizin und Gesundheit, Medical Genetics, complex, performance
Abstract

Funder: Kjell och Märta Beijers Stiftelse (Kjell and Marta Beijer Foundation); doi: https://doi.org/10.13039/501100006353, Although physical activity and sedentary behavior are moderately heritable, little is known about the mechanisms that influence these traits. Combining data for up to 703,901 individuals from 51 studies in a multi-ancestry meta-analysis of genome-wide association studies yields 99 loci that associate with self-reported moderate-to-vigorous intensity physical activity during leisure time (MVPA), leisure screen time (LST) and/or sedentary behavior at work. Loci associated with LST are enriched for genes whose expression in skeletal muscle is altered by resistance training. A missense variant in ACTN3 makes the alpha-actinin-3 filaments more flexible, resulting in lower maximal force in isolated type IIA muscle fibers, and possibly protection from exercise-induced muscle damage. Finally, Mendelian randomization analyses show that beneficial effects of lower LST and higher MVPA on several risk factors and diseases are mediated or confounded by body mass index (BMI). Our results provide insights into physical activity mechanisms and its role in disease prevention.

Published
2022
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23. How to define CSF overdrainage: a systematic literature review

Author

Pedersen, Sarah Hornshoej, primary, Prein, Tobias Hannibal, additional, Ammar, Ahmed, additional, Grotenhuis, André, additional, Hamilton, Mark G., additional, Hansen, Torben Skovbo, additional, Kehler, Uwe, additional, Rekate, Harold, additional, Thomale, Ulrich-Wilhelm, additional, and Juhler, Marianne, additional

Published
2023
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24. The gut microbiota in multiple sclerosis varies with disease activity

Author

Thirion, Florence, primary, Sellebjerg, Finn, additional, Fan, Yong, additional, Lyu, Liwei, additional, Hansen, Tue H., additional, Pons, Nicolas, additional, Levenez, Florence, additional, Quinquis, Benoit, additional, Stankevic, Evelina, additional, Søndergaard, Helle B., additional, Dantoft, Thomas M., additional, Poulsen, Casper S., additional, Forslund, Sofia K., additional, Vestergaard, Henrik, additional, Hansen, Torben, additional, Brix, Susanne, additional, Oturai, Annette, additional, Sørensen, Per Soelberg, additional, Ehrlich, Stanislav D., additional, and Pedersen, Oluf, additional

Published
2023
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25. Implicating genes, pleiotropy, and sexual dimorphism at blood lipid loci through multi-ancestry meta-analysis

Author

Kanoni, Stavroula, primary, Graham, Sarah E., additional, Wang, Yuxuan, additional, Surakka, Ida, additional, Ramdas, Shweta, additional, Zhu, Xiang, additional, Clarke, Shoa L., additional, Bhatti, Konain Fatima, additional, Vedantam, Sailaja, additional, Winkler, Thomas W., additional, Locke, Adam E., additional, Marouli, Eirini, additional, Zajac, Greg J. M., additional, Wu, Kuan-Han H., additional, Ntalla, Ioanna, additional, Hui, Qin, additional, Klarin, Derek, additional, Hilliard, Austin T., additional, Wang, Zeyuan, additional, Xue, Chao, additional, Thorleifsson, Gudmar, additional, Helgadottir, Anna, additional, Gudbjartsson, Daniel F., additional, Holm, Hilma, additional, Olafsson, Isleifur, additional, Hwang, Mi Yeong, additional, Han, Sohee, additional, Akiyama, Masato, additional, Sakaue, Saori, additional, Terao, Chikashi, additional, Kanai, Masahiro, additional, Zhou, Wei, additional, Brumpton, Ben M., additional, Rasheed, Humaira, additional, Havulinna, Aki S., additional, Veturi, Yogasudha, additional, Pacheco, Jennifer Allen, additional, Rosenthal, Elisabeth A., additional, Lingren, Todd, additional, Feng, QiPing, additional, Kullo, Iftikhar J., additional, Narita, Akira, additional, Takayama, Jun, additional, Martin, Hilary C., additional, Hunt, Karen A., additional, Trivedi, Bhavi, additional, Haessler, Jeffrey, additional, Giulianini, Franco, additional, Bradford, Yuki, additional, Miller, Jason E., additional, Campbell, Archie, additional, Lin, Kuang, additional, Millwood, Iona Y., additional, Rasheed, Asif, additional, Hindy, George, additional, Faul, Jessica D., additional, Zhao, Wei, additional, Weir, David R., additional, Turman, Constance, additional, Huang, Hongyan, additional, Graff, Mariaelisa, additional, Choudhury, Ananyo, additional, Sengupta, Dhriti, additional, Mahajan, Anubha, additional, Brown, Michael R., additional, Zhang, Weihua, additional, Yu, Ketian, additional, Schmidt, Ellen M., additional, Pandit, Anita, additional, Gustafsson, Stefan, additional, Yin, Xianyong, additional, Luan, Jian’an, additional, Zhao, Jing-Hua, additional, Matsuda, Fumihiko, additional, Jang, Hye-Mi, additional, Yoon, Kyungheon, additional, Medina-Gomez, Carolina, additional, Pitsillides, Achilleas, additional, Hottenga, Jouke Jan, additional, Wood, Andrew R., additional, Ji, Yingji, additional, Gao, Zishan, additional, Haworth, Simon, additional, Yousri, Noha A., additional, Mitchell, Ruth E., additional, Chai, Jin Fang, additional, Aadahl, Mette, additional, Bjerregaard, Anne A., additional, Yao, Jie, additional, Manichaikul, Ani, additional, Hwu, Chii-Min, additional, Hung, Yi-Jen, additional, Warren, Helen R., additional, Ramirez, Julia, additional, Bork-Jensen, Jette, additional, Kårhus, Line L., additional, Goel, Anuj, additional, Sabater-Lleal, Maria, additional, Noordam, Raymond, additional, Mauro, Pala, additional, Matteo, Floris, additional, McDaid, Aaron F., additional, Marques-Vidal, Pedro, additional, Wielscher, Matthias, additional, Trompet, Stella, additional, Sattar, Naveed, additional, Møllehave, Line T., additional, Munz, Matthias, additional, Zeng, Lingyao, additional, Huang, Jianfeng, additional, Yang, Bin, additional, Poveda, Alaitz, additional, Kurbasic, Azra, additional, Lamina, Claudia, additional, Forer, Lukas, additional, Scholz, Markus, additional, Galesloot, Tessel E., additional, Bradfield, Jonathan P., additional, Ruotsalainen, Sanni E., additional, Daw, EWarwick, additional, Zmuda, Joseph M., additional, Mitchell, Jonathan S., additional, Fuchsberger, Christian, additional, Christensen, Henry, additional, Brody, Jennifer A., additional, Vazquez-Moreno, Miguel, additional, Feitosa, Mary F., additional, Wojczynski, Mary K., additional, Wang, Zhe, additional, Preuss, Michael H., additional, Mangino, Massimo, additional, Christofidou, Paraskevi, additional, Verweij, Niek, additional, Benjamins, Jan W., additional, Engmann, Jorgen, additional, Tsao, Noah L., additional, Verma, Anurag, additional, Slieker, Roderick C., additional, Lo, Ken Sin, additional, Zilhao, Nuno R., additional, Le, Phuong, additional, Kleber, Marcus E., additional, Delgado, Graciela E., additional, Huo, Shaofeng, additional, Ikeda, Daisuke D., additional, Iha, Hiroyuki, additional, Yang, Jian, additional, Liu, Jun, additional, Demirkan, Ayşe, additional, Leonard, Hampton L., additional, Marten, Jonathan, additional, Frank, Mirjam, additional, Schmidt, Börge, additional, Smyth, Laura J., additional, Cañadas-Garre, Marisa, additional, Wang, Chaolong, additional, Nakatochi, Masahiro, additional, Wong, Andrew, additional, Hutri-Kähönen, Nina, additional, Sim, Xueling, additional, Xia, Rui, additional, Huerta-Chagoya, Alicia, additional, Fernandez-Lopez, Juan Carlos, additional, Lyssenko, Valeriya, additional, Nongmaithem, Suraj S., additional, Bayyana, Swati, additional, Stringham, Heather M., additional, Irvin, Marguerite R., additional, Oldmeadow, Christopher, additional, Kim, Han-Na, additional, Ryu, Seungho, additional, Timmers, Paul R. H. J., additional, Arbeeva, Liubov, additional, Dorajoo, Rajkumar, additional, Lange, Leslie A., additional, Prasad, Gauri, additional, Lorés-Motta, Laura, additional, Pauper, Marc, additional, Long, Jirong, additional, Li, Xiaohui, additional, Theusch, Elizabeth, additional, Takeuchi, Fumihiko, additional, Spracklen, Cassandra N., additional, Loukola, Anu, additional, Bollepalli, Sailalitha, additional, Warner, Sophie C., additional, Wang, Ya Xing, additional, Wei, Wen B., additional, Nutile, Teresa, additional, Ruggiero, Daniela, additional, Sung, Yun Ju, additional, Chen, Shufeng, additional, Liu, Fangchao, additional, Yang, Jingyun, additional, Kentistou, Katherine A., additional, Banas, Bernhard, additional, Nardone, Giuseppe Giovanni, additional, Meidtner, Karina, additional, Bielak, Lawrence F., additional, Smith, Jennifer A., additional, Hebbar, Prashantha, additional, Farmaki, Aliki-Eleni, additional, Hofer, Edith, additional, Lin, Maoxuan, additional, Concas, Maria Pina, additional, Vaccargiu, Simona, additional, van der Most, Peter J., additional, Pitkänen, Niina, additional, Cade, Brian E., additional, van der Laan, Sander W., additional, Chitrala, Kumaraswamy Naidu, additional, Weiss, Stefan, additional, Bentley, Amy R., additional, Doumatey, Ayo P., additional, Adeyemo, Adebowale A., additional, Lee, Jong Young, additional, Petersen, Eva R. B., additional, Nielsen, Aneta A., additional, Choi, Hyeok Sun, additional, Nethander, Maria, additional, Freitag-Wolf, Sandra, additional, Southam, Lorraine, additional, Rayner, Nigel W., additional, Wang, Carol A., additional, Lin, Shih-Yi, additional, Wang, Jun-Sing, additional, Couture, Christian, additional, Lyytikäinen, Leo-Pekka, additional, Nikus, Kjell, additional, Cuellar-Partida, Gabriel, additional, Vestergaard, Henrik, additional, Hidalgo, Bertha, additional, Giannakopoulou, Olga, additional, Cai, Qiuyin, additional, Obura, Morgan O., additional, van Setten, Jessica, additional, Li, Xiaoyin, additional, Liang, Jingjing, additional, Tang, Hua, additional, Terzikhan, Natalie, additional, Shin, Jae Hun, additional, Jackson, Rebecca D., additional, Reiner, Alexander P., additional, Martin, Lisa Warsinger, additional, Chen, Zhengming, additional, Li, Liming, additional, Kawaguchi, Takahisa, additional, Thiery, Joachim, additional, Bis, Joshua C., additional, Launer, Lenore J., additional, Li, Huaixing, additional, Nalls, Mike A., additional, Raitakari, Olli T., additional, Ichihara, Sahoko, additional, Wild, Sarah H., additional, Nelson, Christopher P., additional, Campbell, Harry, additional, Jäger, Susanne, additional, Nabika, Toru, additional, Al-Mulla, Fahd, additional, Niinikoski, Harri, additional, Braund, Peter S., additional, Kolcic, Ivana, additional, Kovacs, Peter, additional, Giardoglou, Tota, additional, Katsuya, Tomohiro, additional, de Kleijn, Dominique, additional, de Borst, Gert J., additional, Kim, Eung Kweon, additional, Adams, Hieab H. H., additional, Ikram, M. Arfan, additional, Zhu, Xiaofeng, additional, Asselbergs, Folkert W., additional, Kraaijeveld, Adriaan O., additional, Beulens, Joline W. J., additional, Shu, Xiao-Ou, additional, Rallidis, Loukianos S., additional, Pedersen, Oluf, additional, Hansen, Torben, additional, Mitchell, Paul, additional, Hewitt, Alex W., additional, Kähönen, Mika, additional, Pérusse, Louis, additional, Bouchard, Claude, additional, Tönjes, Anke, additional, Chen, Yii-Der Ida, additional, Pennell, Craig E., additional, Mori, Trevor A., additional, Lieb, Wolfgang, additional, Franke, Andre, additional, Ohlsson, Claes, additional, Mellström, Dan, additional, Cho, Yoon Shin, additional, Lee, Hyejin, additional, Yuan, Jian-Min, additional, Koh, Woon-Puay, additional, Rhee, Sang Youl, additional, Woo, Jeong-Taek, additional, Heid, Iris M., additional, Stark, Klaus J., additional, Zimmermann, Martina E., additional, Völzke, Henry, additional, Homuth, Georg, additional, Evans, Michele K., additional, Zonderman, Alan B., additional, Polasek, Ozren, additional, Pasterkamp, Gerard, additional, Hoefer, Imo E., additional, Redline, Susan, additional, Pahkala, Katja, additional, Oldehinkel, Albertine J., additional, Snieder, Harold, additional, Biino, Ginevra, additional, Schmidt, Reinhold, additional, Schmidt, Helena, additional, Bandinelli, Stefania, additional, Dedoussis, George, additional, Thanaraj, Thangavel Alphonse, additional, Kardia, Sharon L. R., additional, Peyser, Patricia A., additional, Kato, Norihiro, additional, Schulze, Matthias B., additional, Girotto, Giorgia, additional, Böger, Carsten A., additional, Jung, Bettina, additional, Joshi, Peter K., additional, Bennett, David A., additional, De Jager, Philip L., additional, Lu, Xiangfeng, additional, Mamakou, Vasiliki, additional, Brown, Morris, additional, Caulfield, Mark J., additional, Munroe, Patricia B., additional, Guo, Xiuqing, additional, Ciullo, Marina, additional, Jonas, Jost B., additional, Samani, Nilesh J., additional, Kaprio, Jaakko, additional, Pajukanta, Päivi, additional, Tusié-Luna, Teresa, additional, Aguilar-Salinas, Carlos A., additional, Adair, Linda S., additional, Bechayda, Sonny Augustin, additional, de Silva, H. Janaka, additional, Wickremasinghe, Ananda R., additional, Krauss, Ronald M., additional, Wu, Jer-Yuarn, additional, Zheng, Wei, additional, Hollander, Anneke Iden, additional, Bharadwaj, Dwaipayan, additional, Correa, Adolfo, additional, Wilson, James G., additional, Lind, Lars, additional, Heng, Chew-Kiat, additional, Nelson, Amanda E., additional, Golightly, Yvonne M., additional, Wilson, James F., additional, Penninx, Brenda, additional, Kim, Hyung-Lae, additional, Attia, John, additional, Scott, Rodney J., additional, Rao, D. C., additional, Arnett, Donna K., additional, Hunt, Steven C., additional, Walker, Mark, additional, Koistinen, Heikki A., additional, Chandak, Giriraj R., additional, Mercader, Josep M., additional, Costanzo, Maria C., additional, Jang, Dongkeun, additional, Burtt, Noël P., additional, Villalpando, Clicerio Gonzalez, additional, Orozco, Lorena, additional, Fornage, Myriam, additional, Tai, EShyong, additional, van Dam, Rob M., additional, Lehtimäki, Terho, additional, Chaturvedi, Nish, additional, Yokota, Mitsuhiro, additional, Liu, Jianjun, additional, Reilly, Dermot F., additional, McKnight, Amy Jayne, additional, Kee, Frank, additional, Jöckel, Karl-Heinz, additional, McCarthy, Mark I., additional, Palmer, Colin N. A., additional, Vitart, Veronique, additional, Hayward, Caroline, additional, Simonsick, Eleanor, additional, van Duijn, Cornelia M., additional, Jin, Zi-Bing, additional, Qu, Jia, additional, Hishigaki, Haretsugu, additional, Lin, Xu, additional, März, Winfried, additional, Gudnason, Vilmundur, additional, Tardif, Jean-Claude, additional, Lettre, Guillaume, additional, Hart, Leen M.‘t, additional, Elders, Petra J. M., additional, Damrauer, Scott M., additional, Kumari, Meena, additional, Kivimaki, Mika, additional, van der Harst, Pim, additional, Spector, Tim D., additional, Loos, Ruth J. F., additional, Province, Michael A., additional, Parra, Esteban J., additional, Cruz, Miguel, additional, Psaty, Bruce M., additional, Brandslund, Ivan, additional, Pramstaller, Peter P., additional, Rotimi, Charles N., additional, Christensen, Kaare, additional, Ripatti, Samuli, additional, Widén, Elisabeth, additional, Hakonarson, Hakon, additional, Grant, Struan F. A., additional, Kiemeney, Lambertus A. L. M., additional, de Graaf, Jacqueline, additional, Loeffler, Markus, additional, Kronenberg, Florian, additional, Gu, Dongfeng, additional, Erdmann, Jeanette, additional, Schunkert, Heribert, additional, Franks, Paul W., additional, Linneberg, Allan, additional, Jukema, J. Wouter, additional, Khera, Amit V., additional, Männikkö, Minna, additional, Jarvelin, Marjo-Riitta, additional, Kutalik, Zoltan, additional, Francesco, Cucca, additional, Mook-Kanamori, Dennis O., additional, van Dijk, Ko Willems, additional, Watkins, Hugh, additional, Strachan, David P., additional, Grarup, Niels, additional, Sever, Peter, additional, Poulter, Neil, additional, Chuang, Lee-Ming, additional, Rotter, Jerome I., additional, Dantoft, Thomas M., additional, Karpe, Fredrik, additional, Neville, Matt J., additional, Timpson, Nicholas J., additional, Cheng, Ching-Yu, additional, Wong, Tien-Yin, additional, Khor, Chiea Chuen, additional, Li, Hengtong, additional, Sabanayagam, Charumathi, additional, Peters, Annette, additional, Gieger, Christian, additional, Hattersley, Andrew T., additional, Pedersen, Nancy L., additional, Magnusson, Patrik K. E., additional, Boomsma, Dorret I., additional, Willemsen, Allegonda H. M., additional, Cupples, LAdrienne, additional, van Meurs, Joyce B. J., additional, Ghanbari, Mohsen, additional, Gordon-Larsen, Penny, additional, Huang, Wei, additional, Kim, Young Jin, additional, Tabara, Yasuharu, additional, Wareham, Nicholas J., additional, Langenberg, Claudia, additional, Zeggini, Eleftheria, additional, Kuusisto, Johanna, additional, Laakso, Markku, additional, Ingelsson, Erik, additional, Abecasis, Goncalo, additional, Chambers, John C., additional, Kooner, Jaspal S., additional, de Vries, Paul S., additional, Morrison, Alanna C., additional, Hazelhurst, Scott, additional, Ramsay, Michèle, additional, North, Kari E., additional, Daviglus, Martha, additional, Kraft, Peter, additional, Martin, Nicholas G., additional, Whitfield, John B., additional, Abbas, Shahid, additional, Saleheen, Danish, additional, Walters, Robin G., additional, Holmes, Michael V., additional, Black, Corri, additional, Smith, Blair H., additional, Baras, Aris, additional, Justice, Anne E., additional, Buring, Julie E., additional, Ridker, Paul M., additional, Chasman, Daniel I., additional, Kooperberg, Charles, additional, Tamiya, Gen, additional, Yamamoto, Masayuki, additional, van Heel, David A., additional, Trembath, Richard C., additional, Wei, Wei-Qi, additional, Jarvik, Gail P., additional, Namjou, Bahram, additional, Hayes, M. Geoffrey, additional, Ritchie, Marylyn D., additional, Jousilahti, Pekka, additional, Salomaa, Veikko, additional, Hveem, Kristian, additional, Åsvold, Bjørn Olav, additional, Kubo, Michiaki, additional, Kamatani, Yoichiro, additional, Okada, Yukinori, additional, Murakami, Yoshinori, additional, Kim, Bong-Jo, additional, Thorsteinsdottir, Unnur, additional, Stefansson, Kari, additional, Zhang, Jifeng, additional, Chen, YEugene, additional, Ho, Yuk-Lam, additional, Lynch, Julie A., additional, Rader, Daniel J., additional, Tsao, Philip S., additional, Chang, Kyong-Mi, additional, Cho, Kelly, additional, O’Donnell, Christopher J., additional, Gaziano, John M., additional, Wilson, Peter W. F., additional, Frayling, Timothy M., additional, Hirschhorn, Joel N., additional, Kathiresan, Sekar, additional, Mohlke, Karen L., additional, Sun, Yan V., additional, Morris, Andrew P., additional, Boehnke, Michael, additional, Brown, Christopher D., additional, Natarajan, Pradeep, additional, Deloukas, Panos, additional, Willer, Cristen J., additional, Assimes, Themistocles L., additional, and Peloso, Gina M., additional

Published
2022
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27. Genetic analyses of the electrocardiographic QT interval and its components identify additional loci and pathways

Author

Young, William J., primary, Lahrouchi, Najim, additional, Isaacs, Aaron, additional, Duong, ThuyVy, additional, Foco, Luisa, additional, Ahmed, Farah, additional, Brody, Jennifer A., additional, Salman, Reem, additional, Noordam, Raymond, additional, Benjamins, Jan-Walter, additional, Haessler, Jeffrey, additional, Lyytikäinen, Leo-Pekka, additional, Repetto, Linda, additional, Concas, Maria Pina, additional, van den Berg, Marten E., additional, Weiss, Stefan, additional, Baldassari, Antoine R., additional, Bartz, Traci M., additional, Cook, James P., additional, Evans, Daniel S., additional, Freudling, Rebecca, additional, Hines, Oliver, additional, Isaksen, Jonas L., additional, Lin, Honghuang, additional, Mei, Hao, additional, Moscati, Arden, additional, Müller-Nurasyid, Martina, additional, Nursyifa, Casia, additional, Qian, Yong, additional, Richmond, Anne, additional, Roselli, Carolina, additional, Ryan, Kathleen A., additional, Tarazona-Santos, Eduardo, additional, Thériault, Sébastien, additional, van Duijvenboden, Stefan, additional, Warren, Helen R., additional, Yao, Jie, additional, Raza, Dania, additional, Aeschbacher, Stefanie, additional, Ahlberg, Gustav, additional, Alonso, Alvaro, additional, Andreasen, Laura, additional, Bis, Joshua C., additional, Boerwinkle, Eric, additional, Campbell, Archie, additional, Catamo, Eulalia, additional, Cocca, Massimiliano, additional, Cutler, Michael J., additional, Darbar, Dawood, additional, De Grandi, Alessandro, additional, De Luca, Antonio, additional, Ding, Jun, additional, Ellervik, Christina, additional, Ellinor, Patrick T., additional, Felix, Stephan B., additional, Froguel, Philippe, additional, Fuchsberger, Christian, additional, Gögele, Martin, additional, Graff, Claus, additional, Graff, Mariaelisa, additional, Guo, Xiuqing, additional, Hansen, Torben, additional, Heckbert, Susan R., additional, Huang, Paul L., additional, Huikuri, Heikki V., additional, Hutri-Kähönen, Nina, additional, Ikram, M. Arfan, additional, Jackson, Rebecca D., additional, Junttila, Juhani, additional, Kavousi, Maryam, additional, Kors, Jan A., additional, Leal, Thiago P., additional, Lemaitre, Rozenn N., additional, Lin, Henry J., additional, Lind, Lars, additional, Linneberg, Allan, additional, Liu, Simin, additional, MacFarlane, Peter W., additional, Mangino, Massimo, additional, Meitinger, Thomas, additional, Mezzavilla, Massimo, additional, Mishra, Pashupati P., additional, Mitchell, Rebecca N., additional, Mononen, Nina, additional, Montasser, May E., additional, Morrison, Alanna C., additional, Nauck, Matthias, additional, Nauffal, Victor, additional, Navarro, Pau, additional, Nikus, Kjell, additional, Pare, Guillaume, additional, Patton, Kristen K., additional, Pelliccione, Giulia, additional, Pittman, Alan, additional, Porteous, David J., additional, Pramstaller, Peter P., additional, Preuss, Michael H., additional, Raitakari, Olli T., additional, Reiner, Alexander P., additional, Ribeiro, Antonio Luiz P., additional, Rice, Kenneth M., additional, Risch, Lorenz, additional, Schlessinger, David, additional, Schotten, Ulrich, additional, Schurmann, Claudia, additional, Shen, Xia, additional, Shoemaker, M. Benjamin, additional, Sinagra, Gianfranco, additional, Sinner, Moritz F., additional, Soliman, Elsayed Z., additional, Stoll, Monika, additional, Strauch, Konstantin, additional, Tarasov, Kirill, additional, Taylor, Kent D., additional, Tinker, Andrew, additional, Trompet, Stella, additional, Uitterlinden, André, additional, Völker, Uwe, additional, Völzke, Henry, additional, Waldenberger, Melanie, additional, Weng, Lu-Chen, additional, Whitsel, Eric A., additional, Wilson, James G., additional, Avery, Christy L., additional, Conen, David, additional, Correa, Adolfo, additional, Cucca, Francesco, additional, Dörr, Marcus, additional, Gharib, Sina A., additional, Girotto, Giorgia, additional, Grarup, Niels, additional, Hayward, Caroline, additional, Jamshidi, Yalda, additional, Järvelin, Marjo-Riitta, additional, Jukema, J. Wouter, additional, Kääb, Stefan, additional, Kähönen, Mika, additional, Kanters, Jørgen K., additional, Kooperberg, Charles, additional, Lehtimäki, Terho, additional, Lima-Costa, Maria Fernanda, additional, Liu, Yongmei, additional, Loos, Ruth J. F., additional, Lubitz, Steven A., additional, Mook-Kanamori, Dennis O., additional, Morris, Andrew P., additional, O’Connell, Jeffrey R., additional, Olesen, Morten Salling, additional, Orini, Michele, additional, Padmanabhan, Sandosh, additional, Pattaro, Cristian, additional, Peters, Annette, additional, Psaty, Bruce M., additional, Rotter, Jerome I., additional, Stricker, Bruno, additional, van der Harst, Pim, additional, van Duijn, Cornelia M., additional, Verweij, Niek, additional, Wilson, James F., additional, Arking, Dan E., additional, Ramirez, Julia, additional, Lambiase, Pier D., additional, Sotoodehnia, Nona, additional, Mifsud, Borbala, additional, Newton-Cheh, Christopher, additional, and Munroe, Patricia B., additional

Published
2022
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28. Single-cell transcriptome and cell type-specific molecular pathways of human non-alcoholic steatohepatitis

Author

Fred, Rikard G., primary, Steen Pedersen, Julie, additional, Thompson, Jonatan J., additional, Lee, Julie, additional, Timshel, Pascal N., additional, Stender, Stefan, additional, Opseth Rygg, Marte, additional, Gluud, Lise Lotte, additional, Bjerregaard Kristiansen, Viggo, additional, Bendtsen, Flemming, additional, Hansen, Torben, additional, and Pers, Tune H., additional

Published
2022
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30. Medial congruent polyethylene design show different tibiofemoral kinematics and enhanced congruency compared to a standard symmetrical cruciate retaining design for total knee arthroplasty—an in vivo randomized controlled study of gait using dynamic radiostereometry

Author

Petersen, Emil Toft, primary, Rytter, Søren, additional, Koppens, Daan, additional, Dalsgaard, Jesper, additional, Hansen, Torben Bæk, additional, Andersen, Michael Skipper, additional, and Stilling, Maiken, additional

Published
2022
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31. Noninvasive proteomic biomarkers for alcohol-related liver disease

Author

Niu, Lili, primary, Thiele, Maja, additional, Geyer, Philipp E., additional, Rasmussen, Ditlev Nytoft, additional, Webel, Henry Emanuel, additional, Santos, Alberto, additional, Gupta, Rajat, additional, Meier, Florian, additional, Strauss, Maximilian, additional, Kjaergaard, Maria, additional, Lindvig, Katrine, additional, Jacobsen, Suganya, additional, Rasmussen, Simon, additional, Hansen, Torben, additional, Krag, Aleksander, additional, and Mann, Matthias, additional

Published
2022
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32. Influence of NAFLD and bariatric surgery on hepatic and adipose tissue mitochondrial biogenesis and respiration

Author

Pedersen, Julie S., primary, Rygg, Marte O., additional, Chrøis, Karoline, additional, Sustarsic, Elahu G., additional, Gerhart-Hines, Zach, additional, Wever Albrechtsen, Nicolai J., additional, Serizawa, Reza R., additional, Kristiansen, Viggo B., additional, Basse, Astrid L., additional, Boilesen, Astrid E. B., additional, Olsen, Beth H., additional, Hansen, Torben, additional, Gluud, Lise Lotte, additional, Madsbad, Sten, additional, Larsen, Steen, additional, Bendtsen, Flemming, additional, and Dela, Flemming, additional

Published
2022
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35. Microbiome and metabolome features of the cardiometabolic disease spectrum

Author

Fromentin, Sebastien, primary, Forslund, Sofia K., additional, Chechi, Kanta, additional, Aron-Wisnewsky, Judith, additional, Chakaroun, Rima, additional, Nielsen, Trine, additional, Tremaroli, Valentina, additional, Ji, Boyang, additional, Prifti, Edi, additional, Myridakis, Antonis, additional, Chilloux, Julien, additional, Andrikopoulos, Petros, additional, Fan, Yong, additional, Olanipekun, Michael T., additional, Alves, Renato, additional, Adiouch, Solia, additional, Bar, Noam, additional, Talmor-Barkan, Yeela, additional, Belda, Eugeni, additional, Caesar, Robert, additional, Coelho, Luis Pedro, additional, Falony, Gwen, additional, Fellahi, Soraya, additional, Galan, Pilar, additional, Galleron, Nathalie, additional, Helft, Gerard, additional, Hoyles, Lesley, additional, Isnard, Richard, additional, Le Chatelier, Emmanuelle, additional, Julienne, Hanna, additional, Olsson, Lisa, additional, Pedersen, Helle Krogh, additional, Pons, Nicolas, additional, Quinquis, Benoit, additional, Rouault, Christine, additional, Roume, Hugo, additional, Salem, Joe-Elie, additional, Schmidt, Thomas S. B., additional, Vieira-Silva, Sara, additional, Li, Peishun, additional, Zimmermann-Kogadeeva, Maria, additional, Lewinter, Christian, additional, Søndertoft, Nadja B., additional, Hansen, Tue H., additional, Gauguier, Dominique, additional, Gøtze, Jens Peter, additional, Køber, Lars, additional, Kornowski, Ran, additional, Vestergaard, Henrik, additional, Hansen, Torben, additional, Zucker, Jean-Daniel, additional, Hercberg, Serge, additional, Letunic, Ivica, additional, Bäckhed, Fredrik, additional, Oppert, Jean-Michel, additional, Nielsen, Jens, additional, Raes, Jeroen, additional, Bork, Peer, additional, Stumvoll, Michael, additional, Segal, Eran, additional, Clément, Karine, additional, Dumas, Marc-Emmanuel, additional, Ehrlich, S. Dusko, additional, and Pedersen, Oluf, additional

Published
2022
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36. Association of milk intake with hay fever, asthma, and lung function: a Mendelian randomization analysis

Author

Skaaby, Tea, primary, Kilpeläinen, Tuomas O., additional, Mahendran, Yuvaraj, additional, Huang, Lam Opal, additional, Sallis, Hannah, additional, Thuesen, Betina H., additional, Kårhus, Line Lund, additional, Leth-Møller, Katja Biering, additional, Grarup, Niels, additional, Hansen, Torben, additional, Pedersen, Oluf, additional, Burgess, Stephen, additional, Munafò, Marcus R., additional, and Linneberg, Allan, additional

Published
2022
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38. DeepFake electrocardiograms using generative adversarial networks are the beginning of the end for privacy issues in medicine

Author

Thambawita, Vajira, primary, Isaksen, Jonas L., additional, Hicks, Steven A., additional, Ghouse, Jonas, additional, Ahlberg, Gustav, additional, Linneberg, Allan, additional, Grarup, Niels, additional, Ellervik, Christina, additional, Olesen, Morten Salling, additional, Hansen, Torben, additional, Graff, Claus, additional, Holstein-Rathlou, Niels-Henrik, additional, Strümke, Inga, additional, Hammer, Hugo L., additional, Maleckar, Mary M., additional, Halvorsen, Pål, additional, Riegler, Michael A., additional, and Kanters, Jørgen K., additional

Published
2021
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39. Conjugated C-6 hydroxylated bile acids in serum relate to human metabolic health and gut Clostridia species

Author

Petersen, Anders Ø, primary, Julienne, Hanna, additional, Hyötyläinen, Tuulia, additional, Sen, Partho, additional, Fan, Yong, additional, Pedersen, Helle Krogh, additional, Jäntti, Sirkku, additional, Hansen, Tue H., additional, Nielsen, Trine, additional, Jørgensen, Torben, additional, Hansen, Torben, additional, Myers, Pernille Neve, additional, Nielsen, H. Bjørn, additional, Ehrlich, S. Dusko, additional, Orešič, Matej, additional, and Pedersen, Oluf, additional

Published
2021
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41. Explaining deep neural networks for knowledge discovery in electrocardiogram analysis

Author

Hicks, Steven A., primary, Isaksen, Jonas L., additional, Thambawita, Vajira, additional, Ghouse, Jonas, additional, Ahlberg, Gustav, additional, Linneberg, Allan, additional, Grarup, Niels, additional, Strümke, Inga, additional, Ellervik, Christina, additional, Olesen, Morten Salling, additional, Hansen, Torben, additional, Graff, Claus, additional, Holstein-Rathlou, Niels-Henrik, additional, Halvorsen, Pål, additional, Maleckar, Mary M., additional, Riegler, Michael A., additional, and Kanters, Jørgen K., additional

Published
2021
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42. Physical activity attenuates postprandial hyperglycaemia in homozygous TBC1D4 loss-of-function mutation carriers

Author

Schnurr, Theresia M., primary, Jørsboe, Emil, additional, Chadt, Alexandra, additional, Dahl-Petersen, Inger K., additional, Kristensen, Jonas M., additional, Wojtaszewski, Jørgen F. P., additional, Springer, Christian, additional, Bjerregaard, Peter, additional, Brage, Søren, additional, Pedersen, Oluf, additional, Moltke, Ida, additional, Grarup, Niels, additional, Al-Hasani, Hadi, additional, Albrechtsen, Anders, additional, Jørgensen, Marit E., additional, and Hansen, Torben, additional

Published
2021
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43. Trans-ethnic gut microbial signatures of prediabetic subjects from India and Denmark

Author

Pinna, Nishal Kumar, primary, Anjana, Ranjit Mohan, additional, Saxena, Shruti, additional, Dutta, Anirban, additional, Gnanaprakash, Visvanathan, additional, Rameshkumar, Gnanavadivel, additional, Aswath, Sukumaran, additional, Raghavan, Srividhya, additional, Rani, Coimbatore Subramanian Shanthi, additional, Radha, Venkatesan, additional, Balasubramanyam, Muthuswamy, additional, Pant, Archana, additional, Nielsen, Trine, additional, Jørgensen, Torben, additional, Færch, Kristine, additional, Kashani, Alireza, additional, Silva, Maria Camila Alvarez, additional, Vestergaard, Henrik, additional, Hansen, Tue Haldor, additional, Hansen, Torben, additional, Arumugam, Manimozhiyan, additional, Nair, Gopinath Balakrish, additional, Das, Bhabatosh, additional, Pedersen, Oluf, additional, Mohan, Viswanathan, additional, and Mande, Sharmila Shekhar, additional

Published
2021
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44. Trans-ethnic gut microbiota signatures of type 2 diabetes in Denmark and India

Author

Alvarez-Silva, Camila, primary, Kashani, Alireza, additional, Hansen, Tue Haldor, additional, Pinna, Nishal Kumar, additional, Anjana, Ranjit Mohan, additional, Dutta, Anirban, additional, Saxena, Shruti, additional, Støy, Julie, additional, Kampmann, Ulla, additional, Nielsen, Trine, additional, Jørgensen, Torben, additional, Gnanaprakash, Visvanathan, additional, Gnanavadivel, Rameshkumar, additional, Sukumaran, Aswath, additional, Rani, Coimbatore Subramanian Shanthi, additional, Færch, Kristine, additional, Radha, Venkatesan, additional, Balasubramanyam, Muthuswamy, additional, Nair, Gopinath Balakrish, additional, Das, Bhabatosh, additional, Vestergaard, Henrik, additional, Hansen, Torben, additional, Mande, Sharmila Shekhar, additional, Mohan, Viswanathan, additional, Arumugam, Manimozhiyan, additional, and Pedersen, Oluf, additional

Published
2021
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45. The role of physical activity in metabolic homeostasis before and after the onset of type 2 diabetes: an IMI DIRECT study

Author

Koivula, Robert W, Atabaki-Pasdar, Naeimeh, Giordano, Giuseppe N, White, Tom, Adamski, Jerzy, Bell, Jimmy D, Beulens, Joline, Brage, Søren, Brunak, Søren, De Masi, Federico, Dermitzakis, Emmanouil T, Forgie, Ian M, Frost, Gary, Hansen, Torben, Hansen, Tue H, Hattersley, Andrew, Kokkola, Tarja, Kurbasic, Azra, Laakso, Markku, Mari, Andrea, McDonald, Timothy J, Pedersen, Oluf, Rutters, Femke, Schwenk, Jochen M, Teare, Harriet JA, Thomas, E Louise, Vinuela, Ana, Mahajan, Anubha, McCarthy, Mark I, Ruetten, Hartmut, Walker, Mark, Pearson, Ewan, Pavo, Imre, Franks, Paul W, IMI DIRECT Consortium, Koivula, Robert W [0000-0002-1646-4163], and Apollo - University of Cambridge Repository

Subjects
Blood Glucose, Male, Denmark, Glycemic Control, Ectopic fat, Cohort Studies, Glycaemic control, Homeostasis, Humans, Exercise, Finland, Aged, Netherlands, Sweden, Physical activity, Beta cell function, Type 2 diabetes, Glucose Tolerance Test, Middle Aged, Insulin sensitivity, Cross-Sectional Studies, Diabetes Mellitus, Type 2, Structural equation modelling, Female, Insulin Resistance, Energy Metabolism, Prediabetes
Abstract

AIMS/HYPOTHESIS: It is well established that physical activity, abdominal ectopic fat and glycaemic regulation are related but the underlying structure of these relationships is unclear. The previously proposed twin-cycle hypothesis (TC) provides a mechanistic basis for impairment in glycaemic control through the interactions of substrate availability, substrate metabolism and abdominal ectopic fat accumulation. Here, we hypothesise that the effect of physical activity in glucose regulation is mediated by the twin-cycle. We aimed to examine this notion in the Innovative Medicines Initiative Diabetes Research on Patient Stratification (IMI DIRECT) Consortium cohorts comprised of participants with normal or impaired glucose regulation (cohort 1: N ≤ 920) or with recently diagnosed type 2 diabetes (cohort 2: N ≤ 435). METHODS: We defined a structural equation model that describes the TC and fitted this within the IMI DIRECT dataset. A second model, twin-cycle plus physical activity (TC-PA), to assess the extent to which the effects of physical activity in glycaemic regulation are mediated by components in the twin-cycle, was also fitted. Beta cell function, insulin sensitivity and glycaemic control were modelled from frequently sampled 75 g OGTTs (fsOGTTs) and mixed-meal tolerance tests (MMTTs) in participants without and with diabetes, respectively. Abdominal fat distribution was assessed using MRI, and physical activity through wrist-worn triaxial accelerometry. Results are presented as standardised beta coefficients, SE and p values, respectively. RESULTS: The TC and TC-PA models showed better fit than null models (TC: χ2 = 242, p = 0.004 and χ2 = 63, p = 0.001 in cohort 1 and 2, respectively; TC-PA: χ2 = 180, p = 0.041 and χ2 = 60, p = 0.008 in cohort 1 and 2, respectively). The association of physical activity with glycaemic control was primarily mediated by variables in the liver fat cycle. CONCLUSIONS/INTERPRETATION: These analyses partially support the mechanisms proposed in the twin-cycle model and highlight mechanistic pathways through which insulin sensitivity and liver fat mediate the association between physical activity and glycaemic control.

Published
2020

47. Large-scale association analyses identify host factors influencing human gut microbiome composition

Author

Kurilshikov, Alexander, primary, Medina-Gomez, Carolina, additional, Bacigalupe, Rodrigo, additional, Radjabzadeh, Djawad, additional, Wang, Jun, additional, Demirkan, Ayse, additional, Le Roy, Caroline I., additional, Raygoza Garay, Juan Antonio, additional, Finnicum, Casey T., additional, Liu, Xingrong, additional, Zhernakova, Daria V., additional, Bonder, Marc Jan, additional, Hansen, Tue H., additional, Frost, Fabian, additional, Rühlemann, Malte C., additional, Turpin, Williams, additional, Moon, Jee-Young, additional, Kim, Han-Na, additional, Lüll, Kreete, additional, Barkan, Elad, additional, Shah, Shiraz A., additional, Fornage, Myriam, additional, Szopinska-Tokov, Joanna, additional, Wallen, Zachary D., additional, Borisevich, Dmitrii, additional, Agreus, Lars, additional, Andreasson, Anna, additional, Bang, Corinna, additional, Bedrani, Larbi, additional, Bell, Jordana T., additional, Bisgaard, Hans, additional, Boehnke, Michael, additional, Boomsma, Dorret I., additional, Burk, Robert D., additional, Claringbould, Annique, additional, Croitoru, Kenneth, additional, Davies, Gareth E., additional, van Duijn, Cornelia M., additional, Duijts, Liesbeth, additional, Falony, Gwen, additional, Fu, Jingyuan, additional, van der Graaf, Adriaan, additional, Hansen, Torben, additional, Homuth, Georg, additional, Hughes, David A., additional, Ijzerman, Richard G., additional, Jackson, Matthew A., additional, Jaddoe, Vincent W. V., additional, Joossens, Marie, additional, Jørgensen, Torben, additional, Keszthelyi, Daniel, additional, Knight, Rob, additional, Laakso, Markku, additional, Laudes, Matthias, additional, Launer, Lenore J., additional, Lieb, Wolfgang, additional, Lusis, Aldons J., additional, Masclee, Ad A. M., additional, Moll, Henriette A., additional, Mujagic, Zlatan, additional, Qibin, Qi, additional, Rothschild, Daphna, additional, Shin, Hocheol, additional, Sørensen, Søren J., additional, Steves, Claire J., additional, Thorsen, Jonathan, additional, Timpson, Nicholas J., additional, Tito, Raul Y., additional, Vieira-Silva, Sara, additional, Völker, Uwe, additional, Völzke, Henry, additional, Võsa, Urmo, additional, Wade, Kaitlin H., additional, Walter, Susanna, additional, Watanabe, Kyoko, additional, Weiss, Stefan, additional, Weiss, Frank U., additional, Weissbrod, Omer, additional, Westra, Harm-Jan, additional, Willemsen, Gonneke, additional, Payami, Haydeh, additional, Jonkers, Daisy M. A. E., additional, Arias Vasquez, Alejandro, additional, de Geus, Eco J. C., additional, Meyer, Katie A., additional, Stokholm, Jakob, additional, Segal, Eran, additional, Org, Elin, additional, Wijmenga, Cisca, additional, Kim, Hyung-Lae, additional, Kaplan, Robert C., additional, Spector, Tim D., additional, Uitterlinden, Andre G., additional, Rivadeneira, Fernando, additional, Franke, Andre, additional, Lerch, Markus M., additional, Franke, Lude, additional, Sanna, Serena, additional, D’Amato, Mauro, additional, Pedersen, Oluf, additional, Paterson, Andrew D., additional, Kraaij, Robert, additional, Raes, Jeroen, additional, and Zhernakova, Alexandra, additional

Published
2021
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48. Genome-wide association study of circulating levels of glucagon during an oral glucose tolerance test

Author

Jonsson, Anna, primary, Stinson, Sara E., additional, Torekov, Signe S., additional, Clausen, Tine D., additional, Færch, Kristine, additional, Kelstrup, Louise, additional, Grarup, Niels, additional, Mathiesen, Elisabeth R., additional, Damm, Peter, additional, Witte, Daniel R., additional, Jørgensen, Marit E., additional, Pedersen, Oluf, additional, Holst, Jens Juul, additional, and Hansen, Torben, additional

Published
2021
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50. FUT2–ABO epistasis increases the risk of early childhood asthma and Streptococcus pneumoniae respiratory illnesses

Author

Ahluwalia, Tarunveer S., primary, Eliasen, Anders U., additional, Sevelsted, Astrid, additional, Pedersen, Casper-Emil T., additional, Stokholm, Jakob, additional, Chawes, Bo, additional, Bork-Jensen, Jette, additional, Grarup, Niels, additional, Pedersen, Oluf, additional, Hansen, Torben, additional, Linneberg, Allan, additional, Sharma, Amitabh, additional, Weiss, Scott T., additional, Evans, Michael D., additional, Jackson, Daniel J., additional, Morin, Andreanne, additional, Krogfelt, Karen A., additional, Schjørring, Susanne, additional, Mortensen, Preben B., additional, Hougaard, David M., additional, Bybjerg-Grauholm, Jonas, additional, Bækvad-Hansen, Marie, additional, Mors, Ole, additional, Nordentoft, Merete, additional, Børglum, Anders D., additional, Werge, Thomas, additional, Agerbo, Esben, additional, Gern, James E., additional, Lemanske, Robert F., additional, Ober, Carole, additional, Pedersen, Anders G., additional, Bisgaard, Hans, additional, and Bønnelykke, Klaus, additional

Published
2020
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