12 results on '"Han-Seok Choi"'
Search Results
2. The effect of metabolic dysfunction-associated fatty liver disease and diabetic kidney disease on the risk of hospitalization of heart failure in type 2 diabetes: a retrospective cohort study
- Author
-
Seung Eun Lee, Juhwan Yoo, Bong-Seong Kim, Han Seok Choi, Kyungdo Han, and Kyoung-Ah Kim
- Subjects
Endocrinology, Diabetes and Metabolism ,Internal Medicine - Abstract
Background Diabetes mellitus is a major risk factor for heart failure. A recent consensus statement recommended annual cardiac biomarker testing (e.g. natriuretic peptide or high-sensitivity cardiac troponin) for all patients with diabetes. We aimed to identify patients at a higher risk of hospitalization for heart failure among patients with type 2 diabetes to prioritize those who would require screening. Methods Overall, 1,189,113 patients who underwent two medical health checkup cycles (2009–2012 and 2011–2014) and had stable diabetic kidney disease (DKD) phenotype in the Korean National Health Insurance Service database were included in this study. After excluding those with concurrent proteinuria (PU) and reduced estimated glomerular filtration rate, three groups (no-DKD, PU+DKD, and PU−DKD) were identified. A fatty liver index of ≥ 60 was defined as metabolic dysfunction–associated fatty liver disease (MAFLD). Patients were followed up until December 2018 or until outcomes developed. The Cox proportional hazard model was used to compare the risk of hospitalization for heart failure across groups. Results During an average of 6.6 years of follow-up, 5781 patients developed hospitalization for heart failure. After adjusting for covariates, the risk of hospitalization for heart failure was highest in the PU+DKD group [HR 3.12, 95% CI (2.75–3.55)], followed by the PU−DKD group [HR 1.85, 95% CI (1.73–1.99)] using the no-DKD group as the reference category. The risk of hospitalization for heart failure was comparable regardless of MAFLD status in patients who already had DKD. However, in the no-DKD group, the risk of hospitalization for heart failure was 1.4 times higher in patients with MAFLD than in those without [HR 1.41, 95% CI (1.31–1.52)]. Conclusions In lines with the international consensus statement, we suggest that annual cardiac biomarker testing should be conducted at least in patients with DKD and/or MAFLD.
- Published
- 2023
3. Association Between Sarcopenic Obesity and Pulmonary Function in Korean Elderly: Results from the Korean National Health and Nutrition Examination Survey
- Author
-
Seung Eun Lee, Yun-Seong Kang, Kyoung-Ah Kim, Ju-Hyun Park, and Han Seok Choi
- Subjects
Male ,0301 basic medicine ,Aging ,Sarcopenia ,medicine.medical_specialty ,National Health and Nutrition Examination Survey ,Endocrinology, Diabetes and Metabolism ,030209 endocrinology & metabolism ,Body Mass Index ,Pulmonary function testing ,03 medical and health sciences ,FEV1/FVC ratio ,0302 clinical medicine ,Endocrinology ,Internal medicine ,Republic of Korea ,Prevalence ,medicine ,Humans ,Orthopedics and Sports Medicine ,Sarcopenic obesity ,Restrictive lung disease ,Obesity ,Muscle, Skeletal ,Lung ,Aged ,Aged, 80 and over ,Hand Strength ,business.industry ,Odds ratio ,Middle Aged ,respiratory system ,Nutrition Surveys ,medicine.disease ,Obstructive lung disease ,Respiratory Function Tests ,respiratory tract diseases ,Female ,030101 anatomy & morphology ,business ,Body mass index - Abstract
Although body composition is related to lung function, few studies have reported the effects of sarcopenic obesity on lung function. Thus, the aim of this study was to investigate the associations between lung function and sarcopenia in the presence and in the absence of obesity. We analyzed nationally representative data of 3044 adults aged > 60 years as collated by the ‘Korean National Health and Nutrition Examination Survey 2014–2016. Subjects were classified into four groups: non-sarcopenic non-obese (S−O−), non-sarcopenic obese (S−O+), sarcopenic non-obese (S+O−), and sarcopenic obese (S+O+) according to handgrip strength (GS) and body mass index (BMI). GS was found to be positively associated with forced volume vital capacity (FVC). The S+O+ group had significantly lower FVC values than the S−O− group. Subjects in the S+O+ group were more likely to have restrictive lung disease than those in the S−O− group (odds ratios [ORs] 2.81, 95% confidence interval [CI] 1.72–4.59), and the ORs of restrictive lung disease in S+O+ group were higher than in the S−O+ or S+O− groups. These results were consistent after stratifying by sex and age (61–70 and 71–80). FEV1/FVC ratios (a marker for obstructive lung disease) were not significantly different between S+O+ and S−O− groups. Sarcopenic obesity is associated with a higher risk of restrictive lung disease in Korean elderly.
- Published
- 2019
4. Effect of heat-treated Nuruk on the quality characteristics of aged Yakju
- Author
-
Seok-Tae Jeong, Chan-Woo Kim, Yong-Suk Kim, Soo-Hwan Yeo, Han Seok Choi, and Ji-Eun Kang
- Subjects
0106 biological sciences ,0301 basic medicine ,Taste ,030109 nutrition & dietetics ,biology ,Chemistry ,food and beverages ,biology.organism_classification ,01 natural sciences ,Applied Microbiology and Biotechnology ,03 medical and health sciences ,Odor ,010608 biotechnology ,Browning ,Heat treated ,Fermentation ,Food science ,Quality characteristics ,Aroma ,Flavor ,Food Science ,Biotechnology - Abstract
Long-term aging of Yakju, a traditional Korean liquor made of rice and Nuruk (a fermentation agent), causes browning and odor and flavor development. This study investigated the effects of heat-treated Nuruk (50–80 °C, 30 min) on Yakju quality. The saccharogenic powers and glucoamylase, α-amylase, and carboxypeptidase activities were similar in non-heat-treated Nuruk and that treated at 50 °C. However, acidic protease and alcohol dehydrogenase decreased above 50 °C. The content of nitrogen-containing compounds was inversely proportional to the heat-treatment temperature. Compounds that cause off-flavors decreased at 50–60 °C, but increased at 70–80 °C, whereas compounds that provide fragrance increased at 50–60 °C. Sensory evaluation indicated that bad taste attributes were higher in Yakju produced using non-heat-treated Nuruk. Therefore, heat treatment of Nuruk at 50 °C can be adopted as a method for improving Yakju quality, as enzymatic activities that affect color, aroma, and taste are regulated.
- Published
- 2018
5. The prevention of 2,4-dinitrochlorobenzene-induced inflammation in atopic dermatitis-like skin lesions in BALB/c mice by Jawoongo
- Author
-
Yong Cheol Shin, Tai Young Kim, Soon Re Kim, Hye Sook Seo, Se Hyang Hong, Chunhoo Cheon, Han-Seok Choi, Dong Uk Kim, So Mi Oh, Hyo In Kim, Seong-Gyu Ko, and Jin Mo Ku
- Subjects
Male ,medicine.medical_treatment ,Anti-Inflammatory Agents ,Inflammation ,Immunoglobulin E ,Dermatitis, Atopic ,2,4-dinitrochlorobenzene ,BALB/c ,Mice ,03 medical and health sciences ,0302 clinical medicine ,Dinitrochlorobenzene ,medicine ,Animals ,Humans ,Jawoongo ,Viability assay ,Cytokine ,Angelica ,Atopic dermatitis ,Mice, Inbred BALB C ,Interleukin-13 ,biology ,Interleukin-6 ,Plant Extracts ,Tumor Necrosis Factor-alpha ,business.industry ,Lithospermum ,Macrophages ,lcsh:Other systems of medicine ,General Medicine ,lcsh:RZ201-999 ,biology.organism_classification ,medicine.disease ,Interleukin 10 ,RAW 264.7 Cells ,Complementary and alternative medicine ,030220 oncology & carcinogenesis ,Immunology ,biology.protein ,Interleukin 12 ,medicine.symptom ,business ,Research Article ,030215 immunology - Abstract
Background Jawoongo is an herbal mixture used in traditional medicine to treat skin diseases. This study aimed to investigate whether Jawoongo ameliorates Atopic dermatitis (AD)-like pathology in mice and to understand its underlying cellular mechanisms. Methods AD was induced by 2, 4-Dinitrocholrlbenzene (DNCB) in BALB/c mice. Treatment with Jawoongo was assessed to study the effect of Jawoongo on AD in mice. Histological Analysis, blood analysis, RT-PCR, western blot analysis, ELISA assay and cell viability assay were performed to verify the inhibitory effect of Jawoongo on AD in mice. Results We found that application of Jawoongo in an ointment form on AD-like skin lesions on DNCB-exposed BALB/c mice reduced skin thickness and ameliorated skin infiltration with inflammatory cells, mast cells and CD4+ cells. The ointment also reduced the mRNA levels of IL-2, IL-4, IL-13 and TNF-α in the sensitized skin. Leukocyte counts and the levels of IgE, IL-6, IL-10 and IL-12 were decreased in the blood of the DNCB-treated mice. Furthermore, studies on cultured cells demonstrated that Jawoongo exhibits anti-inflammatory activities, including the suppression of proinflammatory cytokine expression, nitric oxide (NO) production, and inflammation-associated molecule levels in numerous types of agonist-stimulated innate immune cell, including human mast cells (HMC-1), murine macrophage RAW264.7 cells, and splenocytes isolated from mice. Conclusion These findings indicate that Jawoongo alleviates DNCB-induced AD-like symptoms via the modulation of several inflammatory responses, indicating that Jawoongo might be a useful drug for the treatment of AD. Electronic supplementary material The online version of this article (10.1186/s12906-018-2280-z) contains supplementary material, which is available to authorized users.
- Published
- 2018
6. Pseudoxanthomonas humi sp. nov., a bacterium isolated from rhizospheric soil of Fraxinus chinensis in Gyeonggi Province, South Korea
- Author
-
Juan Du, Myung-Kon Kim, KyungHwa Won, Shahina Akter, Hongshan Yu, Tae-Hoo Yi, Chang Shik Yin, MooChang Kook, Han Seok Choi, and Hae Jo
- Subjects
DNA, Bacterial ,Xanthomonadaceae ,Biology ,Fraxinus ,Plant Roots ,Biochemistry ,Microbiology ,RNA, Ribosomal, 16S ,Republic of Korea ,Botany ,Genetics ,Molecular Biology ,Phospholipids ,Phylogeny ,Soil Microbiology ,Base Composition ,Rhizosphere ,Strain (chemistry) ,Fatty Acids ,Nucleic Acid Hybridization ,Sequence Analysis, DNA ,General Medicine ,biology.organism_classification ,16S ribosomal RNA ,Bacterial Typing Techniques ,Fraxinus chinensis ,Soil microbiology ,Bacteria - Abstract
A novel bacterial strain THG-MM13(T) was isolated from rhizospheric soil sample and was characterized by using a polyphasic approach. Cells were Gram-reaction-negative, non-motile and rod-shaped. The strain was aerobic, catalase and oxidase positive, and optimum growth temperature and pH were 28 °C and 7.0, respectively. On the basis of 16S rRNA gene sequence analysis, strain THG-MM13(T) (KM598260) belongs to the genus Pseudoxanthomonas and is most closely related to Pseudoxanthomonas wuyuanensis KCTC 23877(T) (97.4 %) (JN247803), followed by Pseudoxanthomonas koreensis KCTC 12208(T) (96.7 %) (AY550263) and Pseudoxanthomonas yeongjuensis KACC 11580(T) (96.7 %) (DQ438977). The DNA G + C content was 63.7 mol%, and the predominant respiratory quinone was ubiquinone-8. The major polar lipids were diphosphatidylglycerol and phosphatidylethanolamine. The major fatty acids were iso-C15:0 (31.3 %) and iso-C16:0 (19.3 %). The DNA-DNA relatedness value between strain THG-MM13(T) and P. wuyuanensis KCTC 23877(T) was below 50 %. The DNA-DNA hybridization result and results of the genotypic analysis in combination with chemotaxonomic and physiological data demonstrated that strain THG-MM13(T) represented a novel species within the genus Pseudoxanthomonas, for which the name Pseudoxanthomonas humi is proposed. The type strain is THG-MM13(T) (=KACC 18280(T) = CCTCC AB 2015122(T)).
- Published
- 2015
7. Cucurbitacin D induces cell cycle arrest and apoptosis by inhibiting STAT3 and NF-κB signaling in doxorubicin-resistant human breast carcinoma (MCF7/ADR) cells
- Author
-
Jin Mo Ku, Soon Re Kim, Han-Seok Choi, Hye Sook Seo, Seong-Gyu Ko, Yong Cheol Shin, and Se Hyang Hong
- Subjects
STAT3 Transcription Factor ,Programmed cell death ,Cell Survival ,MCF7 cell ,Clinical Biochemistry ,Apoptosis ,Breast Neoplasms ,Multidrug resistance ,MCF7/ADR cell ,Biology ,Article ,chemistry.chemical_compound ,Breast cancer ,NF-KappaB Inhibitor alpha ,Cell Line, Tumor ,medicine ,Humans ,Doxorubicin ,Propidium iodide ,Viability assay ,Cucurbitacin D ,Molecular Biology ,Cell Proliferation ,Cell growth ,NF-kappa B ,Cancer ,Cell Biology ,General Medicine ,medicine.disease ,Drug Resistance, Multiple ,Triterpenes ,G2 Phase Cell Cycle Checkpoints ,Gene Expression Regulation, Neoplastic ,chemistry ,Drug Resistance, Neoplasm ,Caspases ,MCF-7 Cells ,Cancer research ,Female ,I-kappa B Proteins ,Signal Transduction ,medicine.drug - Abstract
Breast cancer is the most common cancer for women and is a major cause of mortality in women. Doxorubicin is a generally used chemotherapy drug for breast cancer. However, multidrug resistance of breast cancer interferes with the chemotherapy. We examined whether cucurbitacin D affects doxorubicin resistance of MCF7/ADR breast cancer cells. Cell viability was measured by MTT assay. Levels of p-STAT3, p-NF-κB, IκB, and caspases were measured by Western blot analysis. Nuclear staining of Stat3 and NF-κB was measured by immunocytochemistry. STAT3 and NF-κB transcriptional activity was detected by STAT3 and NF-κB luciferase reporter gene assays. Analysis of cell cycle arrest was performed by flow cytometry. Induction of apoptosis by cucurbitacin D was measured by Annexin V-FITC/propidium iodide assay. More than 90 % of MCF7/ADR cells lived upon treatment with doxorubicin for 24 h. However, upon treatment with cucurbitacin D, cell death was more than 60 %. Co-administration of cucurbitacin D and doxorubicin induced apoptosis, and G2/M cell cycle arrest, and inhibited upregulated Stat3 by doxorubicin on MCF7/ADR cells. Additionally, cucurbitacin D led to an increase in the IκBα level in the cytosol and a decrease in the p-NF-κB level in the nucleus. Finally, cucurbitacin D inhibited translocation of Stat3 and NF-κB and decreased transcriptional activity in the nucleus. Cucurbitacin D decreases cell proliferation and induces apoptosis by inhibiting Stat3 and NF-κB signaling in doxorubicin-resistant breast cancer cells. Cucurbitacin D could be used as a useful compound to treat adriamycin-resistant patients.
- Published
- 2015
8. Anti-inflammatory and anti-proliferative effect of Angelica gigas Nakai (AGN) in RAW264.7 cells
- Author
-
Ilhwan Kim, Hye Sook Seo, Seong-Gyu Ko, Soon Re Kim, Youn Kyung Choi, Yong Cheol Shin, Han-Seok Choi, Hansol Hur, and Changhyeok Na
- Subjects
Lipopolysaccharide ,Cell growth ,Inflammation ,Biology ,biology.organism_classification ,Molecular biology ,chemistry.chemical_compound ,Angelica gigas ,Complementary and alternative medicine ,chemistry ,Biochemistry ,Apoptosis ,medicine ,lipids (amino acids, peptides, and proteins) ,Trypan blue ,medicine.symptom ,G1 phase ,Protein kinase B - Abstract
In the present study, we analyzed the effect of Angelica gigas Nakai (AGN) on LPS-induced inflammatory responses in RAW264.7 mouse macrophage cells. For this purpose, we treated RAW264.7 cells with various concentrations of AGN and LPS for indicated times. Then, we performed WST assay, trypan blue assay, counting of activated cells, FACS analysis and western blot. We found that AGN inhibited cell proliferation in a dose-dependent manner. AGN caused G1 cell cycle arrest, and prevented the phosphorylation of AKT, ERK, p38 and NF-κB induced by LPS. AGN also reduced iNOS and Cox-2 mRNA expression level induced by LPS. It also diminished intracellular ROS level induced by LPS. Moreover, AGN decreased mitochondrial membrane potential and induced PARP and caspase-3 cleavage suggesting that AGN causes apoptosis. Our study clearly showed that AGN may be beneficial to prevent/treat inflammatory diseases and cancer.
- Published
- 2014
9. Induction of apoptotic cell death by ursolic acid through mitochondrial death pathway and extrinsic death receptor pathway in MDA-MB-231 cells
- Author
-
Kyung Hun Kim, In-Hwa Choi, Seong-Gyu Ko, Han-Seok Choi, Hye Sook Seo, and Yong Cheol Shin
- Subjects
Cell Survival ,Drug Evaluation, Preclinical ,Down-Regulation ,Apoptosis ,Breast Neoplasms ,Cysteine Proteinase Inhibitors ,Mitochondrion ,Amino Acid Chloromethyl Ketones ,chemistry.chemical_compound ,Ursolic acid ,Cell Line, Tumor ,Drug Discovery ,Humans ,Caspase ,Cell Proliferation ,bcl-2-Associated X Protein ,Membrane Potential, Mitochondrial ,biology ,Cytochrome c ,Cell Cycle ,Organic Chemistry ,Intrinsic apoptosis ,Cytochromes c ,Receptors, Death Domain ,Fas receptor ,Antineoplastic Agents, Phytogenic ,Triterpenes ,Mitochondria ,Up-Regulation ,Cell biology ,chemistry ,Caspases ,biology.protein ,Molecular Medicine ,Female ,Tumor promotion ,Drug Screening Assays, Antitumor ,Poly(ADP-ribose) Polymerases ,Signal Transduction - Abstract
Ursolic acid (3-hydroxy-urs-12-en-28-oic acid) is a pentacyclic triterpenoid derived from leaves, berries, fruits, and flowers of medicinal plants, such as Rosemarinus officinalis. Ursolic acid has been shown to inhibit tumorigenesis, tumor promotion, and suppress angiogenesis. In our present study, we found that ursolic acid decreased cell proliferation rate and induce apoptosis in human breast cancer cell line, MDA-MB-231. When we checked the expression levels of proteins associated with apoptosis signal by using immunoblotting, we found that ursolic acid induces various apoptotic molecules related to either extrinsic or intrinsic apoptosis signal pathway in MDA-MB-231 cells. In our study, we found that ursolic acid induced the appearance of Fas receptor and cleavage of caspase-8, -3 and PARP. We also found that ursolic acid induced Bax up-regulation and Bcl-2 down-regulation and release of cytochrome C to the cytosol from mitochondria. Moreover, ursolic acid cleaved caspase-9 and decreased mitochondrial membrane potential (ΔΨm) as shown with JC-1 staining. These data indicate that ursolic acid induce apoptosis through both mitochondrial death pathway and extrinsic death receptor dependent pathway in MDA-MB-231 cells. Our data clearly indicate that ursolic acid could be used as a potential anticancer drug for breast cancer.
- Published
- 2011
10. Differences in femoral neck geometry associated with age and ethnicity
- Author
-
Kwang Joon Kim, H. N. Kim, Yumie Rhee, Han Seok Choi, J. K. Brown, Sung Kil Lim, and Kyoung Min Kim
- Subjects
Aging ,medicine.medical_specialty ,Endocrinology, Diabetes and Metabolism ,Osteoporosis ,Dentistry ,Absorptiometry, Photon ,Bone Density ,medicine ,Humans ,Femur ,Quantitative computed tomography ,Aged ,Femoral neck ,Aged, 80 and over ,Bone mineral ,Hip fracture ,Korea ,medicine.diagnostic_test ,Femur Neck ,business.industry ,Middle Aged ,medicine.disease ,Postmenopause ,Cross-Sectional Studies ,medicine.anatomical_structure ,Orthopedic surgery ,Spinal Fractures ,Female ,Cortical bone ,Tomography, X-Ray Computed ,business - Abstract
We studied femoral geometry in relation to age and ethnicity in a cross-sectional study. Age-associated cortical thinning showed the most pronounced effect, and Koreans studied here had thicker cortices and lower buckling ratios than those reported for other races. Cortical thickness may thus be a major determinant of hip fracture risk. The rate of hip fracture varies by age and ethnicity. The geometric properties of the femur influence femoral strength and fragility, but differences in femoral geometry according to age and ethnicity are poorly understood. To explain the high prevalence of hip fractures in the elderly and the relatively low hip fracture rate in Asian populations, we studied age-related changes and ethnic differences in femoral geometry. We recruited 214 peri- or postmenopausal women aged 46 to 85 years (mean age, 60.6 years). Their proximal femoral bone mineral densities (BMD) were measured by quantitative computed tomography and further analyzed geometric properties. We observed large declines in trabecular volumetric bone mineral density associated with aging (33.03% less than the reference value in the oldest group, respectively). Cortical thickness decreased remarkably with age as well, and only 53.94% of the baseline value remained in the oldest group. As a result, the cortical buckling ratio increased geometrically and reached 239.14% of the reference value in the oldest group. In comparisons with other ethnic groups, Korean subjects had thicker cortices than their American, European, and African counterparts. In this cross-sectional study, cortical thickness showed a pronounced age-associated decrease, and the cortical buckling ratio showed a strong age-associated increase. This may in part explain the higher rates of hip fractures in the elderly. When compared with other races, Asians had thicker cortical bone and lower buckling ratios, which may partially explain the lower prevalence of hip fractures in Asians.
- Published
- 2010
11. Relationship Between Visceral Adiposity and Bone Mineral Density in Korean Adults
- Author
-
Nam Wook Hur, Yumie Rhee, Kyoung Min Kim, Kwang Joon Kim, Han Seok Choi, Sung Kil Lim, Eun Jig Lee, and Dae Suk Han
- Subjects
Adult ,Male ,musculoskeletal diseases ,medicine.medical_specialty ,Bone density ,Endocrinology, Diabetes and Metabolism ,Subcutaneous Fat ,Adipose tissue ,chemistry.chemical_compound ,Endocrinology ,High-density lipoprotein ,Bone Density ,Internal medicine ,Republic of Korea ,medicine ,Humans ,Orthopedics and Sports Medicine ,Adiposity ,Aged ,Femoral neck ,Aged, 80 and over ,Bone mineral ,business.industry ,Cholesterol ,Cholesterol, HDL ,Confounding ,Cholesterol, LDL ,Middle Aged ,musculoskeletal system ,medicine.disease ,Obesity ,Radiography ,Viscera ,Cross-Sectional Studies ,medicine.anatomical_structure ,chemistry ,Body Composition ,Female ,business - Abstract
The objective of the study was to investigate the relationship between visceral and subcutaneous adiposity measured by computed tomography and bone mineral density (BMD) and to identify the metabolic factors associated with BMD. We studied 461 subjects recruited from the health-care center at Severance Hospital, Yonsei University College of Medicine. Multivariate regression analyses were conducted to examine the cross-sectional associations between body composition-related or metabolic parameters and BMD. After adjusting for body weight and other confounders, visceral fat area had an inverse association with BMD in men (beta = -0.133, P = 0.049 for lumbar spine; beta = -0.135, P = 0.037 for femoral neck; beta = -0.179, P = 0.005 for total hip) and women (beta = -0.424, P0.001 for lumbar spine; beta = -0.302, P = 0.005 for femoral neck; beta = -0.274, P = 0.014 for total hip). However, the subcutaneous fat area showed no statistically significant relationship with BMD at most sites. Among the metabolic parameters, HDL cholesterol was positively associated with BMD, while LDL cholesterol was negatively associated with BMD in men. In women, total and LDL cholesterol were negatively associated with BMD at the lumbar spine. We conclude that visceral adiposity is inversely associated with BMD after adjusting for confounders and that metabolic factors may partly contribute to this inverse relation.
- Published
- 2010
12. Erratum to: Apigenin induces apoptosis via extrinsic pathway, inducing p53 and inhibiting STAT3 and NFκB signaling in HER2-overexpressing breast cancer cells
- Author
-
Hye-Sook Seo, Han-Seok Choi, Soon-Re Kim, Youn Kyung Choi, Sang-Mi Woo, Incheol Shin, Jong-Kyu Woo, Sang-Yoon Park, Yong Cheol Shin, and Seong-Gyu Ko
- Subjects
Clinical Biochemistry ,Cell Biology ,General Medicine ,Molecular Biology - Published
- 2012
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.