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Your search keyword '"Hammarstedt, Ann"' showing total 12 results
Start Over Author "Hammarstedt, Ann" Publisher springer science and business media llc
12 results on '"Hammarstedt, Ann"'

1. Effects of dapagliflozin and dapagliflozin-saxagliptin on erythropoiesis, iron and inflammation markers in patients with type 2 diabetes and chronic kidney disease: data from the DELIGHT trial

Author

Koshino, Akihiko, primary, Neuen, Brendon L., additional, Jongs, Niels, additional, Pollock, Carol, additional, Greasley, Peter J., additional, Andersson, Eva-Marie, additional, Hammarstedt, Ann, additional, Karlsson, Cecilia, additional, Langkilde, Anna Maria, additional, Wada, Takashi, additional, and Heerspink, Hiddo J.L., additional

Published
2023
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2. Adipose tissue morphology, imaging and metabolomics predicting cardiometabolic risk and family history of type 2 diabetes in non-obese men

Author

Rawshani, Aidin, primary, Eliasson, Björn, additional, Rawshani, Araz, additional, Henninger, Josefin, additional, Mardinoglu, Adil, additional, Carlsson, Åsa, additional, Sohlin, Maja, additional, Ljungberg, Maria, additional, Hammarstedt, Ann, additional, Rosengren, Annika, additional, and Smith, Ulf, additional

Published
2020
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4. TP53INP2 regulates adiposity by activating β-catenin through autophagy-dependent sequestration of GSK3β

Author

Romero, Montserrat, primary, Sabaté-Pérez, Alba, additional, Francis, Víctor A., additional, Castrillón-Rodriguez, Ignacio, additional, Díaz-Ramos, Ángels, additional, Sánchez-Feutrie, Manuela, additional, Durán, Xavier, additional, Palacín, Manuel, additional, Moreno-Navarrete, José María, additional, Gustafson, Birgit, additional, Hammarstedt, Ann, additional, Fernández-Real, José Manuel, additional, Vendrell, Joan, additional, Smith, Ulf, additional, and Zorzano, Antonio, additional

Published
2018
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5. CCN5/WISP2 and metabolic diseases

Author

Grünberg, John R, primary, Elvin, Johannes, additional, Paul, Alexandra, additional, Hedjazifar, Shahram, additional, Hammarstedt, Ann, additional, and Smith, Ulf, additional

Published
2017
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6. Epigenetic modifications of the Zfp/ZNF423 gene control murine adipogenic commitment and are dysregulated in human hypertrophic obesity

Author

Longo, Michele, primary, Raciti, Gregory A., additional, Zatterale, Federica, additional, Parrillo, Luca, additional, Desiderio, Antonella, additional, Spinelli, Rosa, additional, Hammarstedt, Ann, additional, Hedjazifar, Shahram, additional, Hoffmann, Jenny M., additional, Nigro, Cecilia, additional, Mirra, Paola, additional, Fiory, Francesca, additional, Formisano, Pietro, additional, Miele, Claudia, additional, Smith, Ulf, additional, and Beguinot, Francesco, additional

Published
2017
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8. Overexpressing the novel autocrine/endocrine adipokine WISP2 induces hyperplasia of the heart, white and brown adipose tissues and prevents insulin resistance

Author

Grünberg, John R., primary, Hoffmann, Jenny M., additional, Hedjazifar, Shahram, additional, Nerstedt, Annika, additional, Jenndahl, Lachmi, additional, Elvin, Johannes, additional, Castellot, John, additional, Wei, Lan, additional, Movérare-Skrtic, Sofia, additional, Ohlsson, Claes, additional, Holm, Louise Mannerås, additional, Bäckhed, Fredrik, additional, Syed, Ismail, additional, Bosch, Fatima, additional, Saghatelian, Alan, additional, Kahn, Barbara B., additional, Hammarstedt, Ann, additional, and Smith, Ulf, additional

Published
2017
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10. Osteoblast-derived WNT16 represses osteoclastogenesis and prevents cortical bone fragility fractures

Author

Movérare-Skrtic, Sofia, primary, Henning, Petra, additional, Liu, Xianwen, additional, Nagano, Kenichi, additional, Saito, Hiroaki, additional, Börjesson, Anna E, additional, Sjögren, Klara, additional, Windahl, Sara H, additional, Farman, Helen, additional, Kindlund, Bert, additional, Engdahl, Cecilia, additional, Koskela, Antti, additional, Zhang, Fu-Ping, additional, Eriksson, Emma E, additional, Zaman, Farasat, additional, Hammarstedt, Ann, additional, Isaksson, Hanna, additional, Bally, Marta, additional, Kassem, Ali, additional, Lindholm, Catharina, additional, Sandberg, Olof, additional, Aspenberg, Per, additional, Sävendahl, Lars, additional, Feng, Jian Q, additional, Tuckermann, Jan, additional, Tuukkanen, Juha, additional, Poutanen, Matti, additional, Baron, Roland, additional, Lerner, Ulf H, additional, Gori, Francesca, additional, and Ohlsson, Claes, additional

Published
2014
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12. CCN5/WISP2 and metabolic diseases

Author

Grünberg, John R, Elvin, Johannes, Paul, Alexandra, Hedjazifar, Shahram, Hammarstedt, Ann, and Smith, Ulf

Subjects
Metabolism, WNT-signaling, Adipose tissue, Mesenchymal stem cells, Insulin resistance, Fibrosis, 3. Good health
Abstract

This is the final version of the article. It first appeared from Springer via https://doi.org/10.1007/s12079-017-0437-z, Obesity and type 2 diabetes increase worldwide at an epidemic rate. It is expected that by the year 2030 around 500 million people will have diabetes; predominantly type 2 diabetes. The CCN family of proteins has become of interest in both metabolic and other common human diseases because of their effects on mesenchymal stem cell (MSCs) proliferation and differentiation as well as being important regulators of fibrosis. We here review current knowledge of the WNT1 inducible signaling pathway protein 2 (CCN5/WISP2). It has been shown to be an important regulator of both these processes through effects on both the canonical WNT and the TGFβ pathways. It is also under normal regulation by the adipogenic commitment factor BMP4, in contrast to conventional canonical WNT ligands, and allows MSCs to undergo normal adipose cell differentiation. CCN5/WISP2 is highly expressed in, and secreted by, MSCs and is an important regulator of MSCs growth. In a transgenic mouse model overexpressing CCN5/WISP2 in the adipose tissue, we have shown that it is secreted and circulating in the blood, the mice develop hypercellular white and brown adipose tissue, have increased lean body mass and enlarged hypercellular hearts. Obese transgenic mice had improved insulin sensitivity. Interestingly, the anti-fibrotic effect of CCN5/WISP2 is protective against heart failure by inhibition of the TGFβ pathway. Understanding how CCN5/WISP2 is regulated and signals is important and may be useful for developing new treatment strategies in obesity and metabolic diseases and it can also be a target in regenerative medicine.

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