1. Supplementation with selenium and human immune cell functions: I. Effect on lymphocyte proliferation and interleukin 2 receptor expression
- Author
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H. I. Wishe, M. W. Cohen, Martin Roy, L. Kiremidjian-Schumacher, and G. Stotzky
- Subjects
Adult ,Male ,Interleukin 2 ,medicine.medical_specialty ,Receptor expression ,Endocrinology, Diabetes and Metabolism ,Clinical Biochemistry ,chemical and pharmacologic phenomena ,Lymphocyte proliferation ,Lymphocyte Activation ,Biochemistry ,Inorganic Chemistry ,Selenium ,Immune system ,Internal medicine ,medicine ,Humans ,Cytotoxic T cell ,Receptor ,Chemistry ,Biochemistry (medical) ,High Affinity Interleukin-2 Receptor ,Receptors, Interleukin-2 ,General Medicine ,Mixed lymphocyte reaction ,Endocrinology ,Immunology ,Female ,Lymphocyte Culture Test, Mixed ,medicine.drug - Abstract
Selenium (Se) is an essential nutritional factor that was shown by us to alter the expression of the high affinity interleukin 2 receptor (Il2-R) and its subunits, cell proliferation, and clonal expansion of cytotoxic T-lymphocytes in mice. This study shows that dietary supplementation of Se-replete humans with 200 micrograms/d of sodium selenite for 8 wk, or in vitro supplementation with 1 x 10(-7) M Se (as sodium selenite), result in a significant augmentation of the ability of peripheral blood lymphocytes to respond to stimulation with 1 microgram/mL of phytohemagglutinin or alloantigen (mixed lymphocyte reaction) and to express high affinity Il2-R on their surface. There was a clear correlation between supplementation with Se and enhanced 3H-thymidine incorporation into nuclear DNA, preceded by enhanced expression of high affinity Il2-R. Supplementation with Se can apparently modulate T-lymphocyte mediated immune responses in humans that depend on signals generated by the interaction of interleukin 2 with Il2-R.
- Published
- 1994
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