6 results on '"Hövelmeyer N"'
Search Results
2. Aberrant splicing of the tumor suppressor CYLD promotes the development of chronic lymphocytic leukemia via sustained NF-κB signaling
- Author
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Hahn, M, primary, Bürckert, J-P, additional, Luttenberger, C A, additional, Klebow, S, additional, Hess, M, additional, Al-Maarri, M, additional, Vogt, M, additional, Reißig, S, additional, Hallek, M, additional, Wienecke-Baldacchino, A, additional, Buch, T, additional, Muller, C P, additional, Pallasch, C P, additional, Wunderlich, F T, additional, Waisman, A, additional, and Hövelmeyer, N, additional
- Published
- 2017
- Full Text
- View/download PDF
3. BAX inhibitor-1 is a Ca2+ channel critically important for immune cell function and survival
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Lisak, D, primary, Schacht, T, additional, Gawlitza, A, additional, Albrecht, P, additional, Aktas, O, additional, Koop, B, additional, Gliem, M, additional, Hofstetter, H H, additional, Zanger, K, additional, Bultynck, G, additional, Parys, J B, additional, De Smedt, H, additional, Kindler, T, additional, Adams-Quack, P, additional, Hahn, M, additional, Waisman, A, additional, Reed, J C, additional, Hövelmeyer, N, additional, and Methner, A, additional
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- 2015
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4. 21. Mainzer Allergie-Workshop
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Rennert, S., primary, Krause, S., additional, Becker, W., additional, Petersen, A., additional, Schocker, F., additional, Papenfuß, K., additional, Jappe, U., additional, Brehler, R., additional, Lange, L., additional, Riffelmann, F., additional, Nemat, K., additional, Hompes, S., additional, Holzhauser, T., additional, Lidholm, J., additional, Reese, G., additional, Vieths, S., additional, Seismann, H., additional, Blank, S., additional, Braren, I., additional, Greunke, K., additional, Cifuentes, L., additional, Grunwald, T., additional, Bredehorst, R., additional, Ollert, M., additional, Spillner, E., additional, von der Gathen, Y., additional, Sander, I., additional, Flagge, A., additional, Brüning, T., additional, Raulf-Heimsoth, M., additional, Zahradnik, E., additional, Fleischer, C., additional, Schierl, R., additional, Sültz, J., additional, Nowak, D., additional, Buters, J., additional, Weichenmeier, I., additional, Ochs, S., additional, Kreyling, W., additional, Boere, A., additional, Schober, W., additional, Behrendt, H., additional, Jaeger, T., additional, Kerzl, R., additional, Huss-Marp, J., additional, Ring, J., additional, Darsow, U., additional, Roeschmann, K., additional, Vroling, A., additional, van Drunen, C., additional, Ulmer, A., additional, Gilles, S., additional, Mariani, V., additional, Zhang, X., additional, Jakob, T., additional, Müller, M., additional, Pastore, S., additional, Traidl-Hoffmann, C., additional, Oeder, S., additional, Dietrich, S., additional, Fromme, H., additional, Schäfer, V., additional, Renne, J., additional, Werfel, T., additional, Wittmann, M., additional, Grusser, M., additional, Maurer, M., additional, Dudeck, A., additional, Suender, C., additional, Heydrich, S., additional, Bros, M., additional, Wiechmann, N., additional, Besche, V., additional, Hövelmeyer, N., additional, Reissig, S., additional, Massoumi, R., additional, Grabbe, S., additional, Waisman, A., additional, Reske-Kunz, A., additional, Gschwandtner, M., additional, Roßbach, K., additional, Bäumer, W., additional, Kietzmann, M., additional, Dijkstra, D., additional, Stark, H., additional, Gutzmer, R., additional, Höhn, Y., additional, Thamsen, M., additional, Trojandt, S., additional, Bovensiepen, C., additional, Bellinghausen, I., additional, Hilmenyuk, T., additional, Saloga, J., additional, Luxemburger, U., additional, Türeci, Ö., additional, Wiesner, H., additional, Kohlrautz, V., additional, Wahn, U., additional, Stock, P., additional, Mommert, S., additional, Köther, G., additional, Sudowe, S., additional, Barwig, C., additional, Montermann, E., additional, Milovanovic, M., additional, Koch, C., additional, Hilt, K., additional, Hartmann, B., additional, Heine, G., additional, Worm, M., additional, Ambach, A., additional, Hoefeld-Fegeler, M., additional, Besser, C., additional, Weren, A., additional, Schraven, B., additional, Bonekoh, B., additional, Gollnick, H., additional, Raap, M., additional, Bruder, M., additional, Kapp, A., additional, Raap, U., additional, Grosber, M., additional, Hausteiner, C., additional, Bubel, E., additional, Groben, S., additional, Bornschein, S., additional, Lahmann, C., additional, Zilker, T., additional, Eberlein, B., additional, Henningsen, P., additional, Huber, D., additional, Biedermann, T., additional, Kunz, J., additional, Fischer, J., additional, Kempf, W., additional, Wölbing, F., additional, Alexopoulou, A., additional, Albert, A., additional, Pfaar, O., additional, Distler, A., additional, Hörmann, K., additional, Klimek, L., additional, Wieczorek, D., additional, Büsing, M., additional, Wedi, B., additional, Rerinck, H.-C., additional, Przybilla, B., additional, Ruëff, F., additional, Weigert, C., additional, Ghoreschi, K., additional, Röcken, M., additional, Muhr, P., additional, Zeitvogel, J., additional, Ott, H., additional, Wiederholt, T., additional, Andresen-Bergström, M., additional, Skazik, C., additional, Merk, H., additional, Karlberg, A., additional, Zwadlo-Klarwasser, G., additional, Baron, J., additional, Frankenberg, U., additional, Lorenz, N., additional, Steinbrink, K., additional, Pföhler, C., additional, Dietrich, K.-A., additional, Thomas, P., additional, Baran, W., additional, Hänsel, A., additional, Meurer, M., additional, Schäkel, K., additional, Mamerow, D., additional, Niebuhr, M., additional, Bonnekoh, B., additional, Bunselmeyer, B., additional, Laubach, H., additional, Schiller, M., additional, Stanke, M., additional, Luger, T., additional, Böcking, C., additional, Köllisch, G., additional, Pfefferle, P., additional, Renz, H., additional, Conrad, M., additional, Teich, R., additional, Ferstl, R., additional, Brand, S., additional, Yildirim, A., additional, Kirschning, C., additional, Garn, H., additional, Eilbacher, I., additional, Stein, K., additional, Hanuszkiewicz, A., additional, Holst, O., additional, Heine, H., additional, Guenova, E., additional, Hoetzenecker, W., additional, Mailhammer, R., additional, Weindl, G., additional, Sauer, K., additional, Schaller, M., additional, Hiller, J., additional, Förster, S., additional, Eyerich, K., additional, Hofmann, H., additional, Ilchmann, A., additional, Burgdorf, S., additional, Waibler, Z., additional, Kurts, C., additional, Scheurer, S., additional, Kalinke, U., additional, Toda, M., additional, Adler, H. S., additional, Hofmann, C., additional, Becker, C., additional, Hemmer, W., additional, Focke, M., additional, Marzban, G., additional, Mayer, D., additional, Laimer, M., additional, Jarisch, R., additional, McIntyre, M., additional, Thiebes, V., additional, Mempel, M., additional, Jeßberger, B., additional, Vrtala, S., additional, Mauss, V., additional, Eben, R., additional, Walker, A. I., additional, Herzinger, T., additional, Berking, C., additional, Reese, I., additional, Sonar, S., additional, Ehmke, M., additional, Dietze, J., additional, Nockher, W., additional, Reuter, S., additional, Dehzad, N., additional, Martin, H., additional, Jung, M., additional, Heinz, A., additional, Stassen, M., additional, Buhl, R., additional, Taube, C., additional, Lingner, S., additional, Hennig, C., additional, Remke, J., additional, Hansen, G., additional, Dittrich, A., additional, Peters, M., additional, Bufe, A., additional, Polte, T., additional, Schütze, N., additional, Simon, J., additional, Lehmann, I., additional, Albrecht, M., additional, Preston-Hurlburt, P., additional, Bottomoly, H., additional, Pilzner, C., additional, Bühling, F., additional, Reinheckel, T., additional, Lauenstein, H., additional, Braun, A., additional, Welte, T., additional, Groneberg, D., additional, Greiner, T., additional, Zimmer, A., additional, Abram, M., additional, Fokuhl, V., additional, Luger, E., additional, Radbruch, A., additional, Zemlin, M., additional, Kilic, A., additional, Yildirim, A. Ö., additional, Alrifai, M., additional, Hagner, S., additional, Renzing, A., additional, Closs, E., additional, Bopp, T., additional, Schmitt, E., additional, Dicke, T., additional, Seyfarth, F., additional, Hipler, U., additional, Elsner, P., additional, Schliemann, S., additional, Konakovsky, V., additional, Moser, P., additional, Wantke, F., additional, Sesztak-Greinecker, G., additional, Götz, M., additional, Schmid, R., additional, and Hoffmann-Sommergruber, K., additional
- Published
- 2009
- Full Text
- View/download PDF
5. Erratum: CORRIGENDUM: Experimental autoimmune encephalomyelitis repressed by microglial paralysis
- Author
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Heppner, F L, primary, Greter, M, additional, Marino, D, additional, Falsig, J, additional, Raivich, G, additional, Hövelmeyer, N, additional, Waisman, A, additional, Rülicke, T, additional, Prinz, M, additional, Priller, J, additional, Becher, B, additional, and Aguzzi, A, additional
- Published
- 2005
- Full Text
- View/download PDF
6. Aberrant splicing of the tumor suppressor CYLD promotes the development of chronic lymphocytic leukemia via sustained NF-κB signaling
- Author
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Sabrina Klebow, Claude P. Muller, Frank Wunderlich, Michael Hallek, Matthias Hahn, Thorsten Buch, Mona Al-Maarri, Ari Waisman, Christian P. Pallasch, Sonja Reißig, Nadine Hövelmeyer, Luttenberger Ca, Jean-Philippe Bürckert, Michael Hess, Merly C. Vogt, Anke Wienecke-Baldacchino, University of Zurich, and Hövelmeyer, N
- Subjects
0301 basic medicine ,Cancer Research ,Tumor suppressor gene ,Cell Survival ,RNA Splicing ,Chronic lymphocytic leukemia ,2720 Hematology ,610 Medicine & health ,Biology ,CD5 Antigens ,law.invention ,Pathogenesis ,Mice ,03 medical and health sciences ,immune system diseases ,law ,hemic and lymphatic diseases ,medicine ,Animals ,Humans ,10239 Institute of Laboratory Animal Science ,1306 Cancer Research ,Genes, Tumor Suppressor ,Gene ,Cell Proliferation ,B-Lymphocytes ,Alternative splicing ,NF-kappa B ,Ubiquitination ,Hematology ,medicine.disease ,Leukemia, Lymphocytic, Chronic, B-Cell ,Deubiquitinating Enzyme CYLD ,Leukemia ,030104 developmental biology ,Oncology ,Immunology ,Cancer research ,570 Life sciences ,biology ,Suppressor ,2730 Oncology ,CD5 ,Signal Transduction - Abstract
The pathogenesis of chronic lymphocytic leukemia (CLL) has been linked to constitutive NF-κB activation but the underlying mechanisms are poorly understood. Here we show that alternative splicing of the negative regulator of NF-κB and tumor suppressor gene CYLD regulates the pool of CD5+ B cells through sustained canonical NF-κB signaling. Reinforced canonical NF-κB activity leads to the development of B1 cell-associated tumor formation in aging mice by promoting survival and proliferation of CD5+ B cells, highly reminiscent of human B-CLL. We show that a substantial number of CLL patient samples express sCYLD, strongly implicating a role for it in human B-CLL. We propose that our new CLL-like mouse model represents an appropriate tool for studying ubiquitination-driven canonical NF-κB activation in CLL. Thus, inhibition of alternative splicing of this negative regulator is essential for preventing NF-κB-driven clonal CD5+ B-cell expansion and ultimately CLL-like disease.
- Published
- 2017
- Full Text
- View/download PDF
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