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362 results on '"Guo, Fang"'

3. Astrocytic ALKBH5 in stress response contributes to depressive-like behaviors in mice

Author

Guo, Fang, primary, Fan, Jun, additional, Liu, Jin-Ming, additional, Kong, Peng-Li, additional, Ren, Jing, additional, Mo, Jia-Wen, additional, Lu, Cheng-Lin, additional, Zhong, Qiu-Ling, additional, Chen, Liang-Yu, additional, Jiang, Hao-Tian, additional, Zhang, Canyuan, additional, Wen, You-Lu, additional, Gu, Ting-Ting, additional, Li, Shu-Ji, additional, Fang, Ying-Ying, additional, Pan, Bing-Xing, additional, Gao, Tian-Ming, additional, and Cao, Xiong, additional

Published
2024
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7. Correction: A scoping review on the links between sustainable development goal 14 and early childhood caries

Author

Folayan, Morenike Oluwatoyin, primary, Ayouni, Imen, additional, Nguweneza, Arthemon, additional, Al-Batayneh, Ola B., additional, Virtanen, Jorma I., additional, Gaffar, Balgis, additional, Duangthip, Duangporn, additional, Sun, Ivy Guo Fang, additional, Onyejaka, Nneka Kate, additional, Daryanavard, Hamideh, additional, Mfolo, Tshepiso, additional, Feldens, Carlos A., additional, Schroth, Robert J., additional, and Tantawi, Maha El, additional

Published
2024
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12. A scoping review on the links between sustainable development goal 14 and early childhood caries

Author

Folayan, Morenike Oluwatoyin, primary, Ayouni, Imen, additional, Nguweneza, Arthemon, additional, Al-Batayneh, Ola Barakat, additional, Virtanen, Jorma I., additional, Gaffar, Balgis, additional, Duangthip, Duangporn, additional, Sun, Ivy Guo Fang, additional, Onyejaka, Nneka Kate, additional, Daryanavard, Hamideh, additional, Mfolo, Tshepiso, additional, Feldens, Carlos A., additional, Schroth, Robert J., additional, and Tantawi, Maha El, additional

Published
2023
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16. Prevalence of propionic acidemia in China

Author

Zhang, Yixing, primary, Peng, Chuwen, additional, Wang, Lifang, additional, Chen, Sitong, additional, Wang, Junwei, additional, Tian, Ziheng, additional, Wang, Chuangong, additional, Chen, Xiaoxin, additional, Zhu, Suhong, additional, Zhang, Guo-Fang, additional, and Wang, You, additional

Published
2023
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20. Low 15d-PGJ2 status is associated with oxidative stress in chronic obstructive pulmonary disease patients

Author

Shi-Xue, Ma, Guo-Fang, Xie, Pu, Fang, Min-Min, Tang, You-Peng, Deng, Yu-Jin, Lu, Wei, Cao, and Lin, Fu

Subjects
Pharmacology, Immunology
Abstract

Peroxisome proliferator-activated receptor γ (PPARγ) is a ligand-dependent nuclear receptor and highly expressed in human and rodent lungs. 15-Deoxy-delta-All 130 fasting blood samples and 40 lung specimens were obtained from COPD patients and control subjects. Serum 15d-PGJ2 was detected by ELISA. The expressions of oxidative stress indicators were measured using western blotting and PPARγ nuclei were evaluated with immunohistochemistry in lungs. The associations among serum 15d-PGJ2, pulmonary PPARγ and oxidative stress indicators, and COPD were estimated.Serum 15d-PGJ2 was reduced in COPD patients compared with healthy volunteers. Linear and logistic regression analysis indicated that serum 15d-PGJ2 was positively associated with pulmonary function in COPD patients. In addition, PPARγ-positive nuclei were reduced and oxidative stress indicators, included HO-1 and NOX-4, were increased in lungs of COPD patients. Further correlative analysis suggested that pulmonary function parameters was positively correlated with serum 15d-PGJ2 and pulmonary PPARγ-positive nuclei, inversely related to oxidative stress indicators in lungs of COPD patients. Pretreatment with 15d-PGJ2 obviously attenuated TNFα-induced oxidative stress in BEAS-2B cells.Serum 15d-PGJ2 and pulmonary PPARγ are reduced, and oxidative stress is elevated in COPD patients. Serum 15d-PGJ2 is inversely associated with oxidative stress in COPD patients.

Published
2022

21. Analysis of urinary C–C motif chemokine ligand 14 (CCL14) and first-generation urinary biomarkers for predicting renal recovery from acute kidney injury: a prospective exploratory study

Author

Qian, Ben-Shu, primary, Jia, Hui-Miao, additional, Weng, Yi-Bing, additional, Li, Xin-Cheng, additional, Chen, Chao-Dong, additional, Guo, Fang-Xing, additional, Han, Yu-Zhen, additional, Huang, Li-Feng, additional, Zheng, Yue, additional, and Li, Wen-Xiong, additional

Published
2023
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33. Nitrogen contaminants damage on intestinal epithelial tight junctions: a review

Author

Guo-Ping Zhao, Guo-Fang Pang, Fazheng Ren, Jinwang Li, Yixuan Li, Fang-Wei Yang, and Xiaoyu Wang

Subjects
chemistry.chemical_classification, Reactive oxygen species, Oxidase test, Tight junction, Cytochrome, biology, Inflammation, Intestinal epithelium, Cell biology, chemistry.chemical_compound, chemistry, medicine, biology.protein, Environmental Chemistry, medicine.symptom, Digestion, Nicotinamide adenine dinucleotide phosphate
Abstract

During food digestion, the intestinal epithelial barrier is essential for health. The intestinal epithelial is typically maintained by normal tight junctions. Barrier dysfunction and increased permeability have been observed for many diseases and, more recently, after ingestion of nitrogen contaminants such as nitrogen heterocycles, amine, and nitro. Mechanisms by which these contaminants disrupt the intestinal epithelial barrier remain poorly understood. Here, we review the chemical disruption of intestinal epithelium permeability of tight junction proteins, to propose a common mechanism involving the production of reactive oxygen species (ROS) followed by inflammation. Specifically, nitrogen-containing chemicals promote ROS generation, which disrupts the activity of the metabolic enzyme cytochrome P450s, leading to the activation of nicotinamide adenine dinucleotide phosphate oxidase.

Published
2021

34. HMGB1 in the mPFC governs comorbid anxiety in neuropathic pain

Author

Du, Yu, primary, Xu, Ceng-Lin, additional, Yu, Jie, additional, Liu, Keyue, additional, Lin, Shi-Da, additional, Hu, Ting-Ting, additional, Qu, Feng-Hui, additional, Guo, Fang, additional, Lou, Guo-Dong, additional, Nishibori, Masahiro, additional, Hu, Wei-Wei, additional, Chen, Zhong, additional, and Zhang, Shi-Hong, additional

Published
2022
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37. Characteristics of the accessory tendon of the extensor hallucis longus muscle: a Taiwanese study

Author

Li-Jin Chen, Kuen-Cherng Lai, Hsu-Wen Tan, Han-Chen Ho, Pei-Hsin Liu, and Guo-Fang Tseng

Subjects
Male, Metatarsophalangeal Joint, musculoskeletal diseases, medicine.medical_specialty, Proximal phalanx, Taiwan, Pathology and Forensic Medicine, Tendons, 03 medical and health sciences, Sex Factors, Cadaver, Joint capsule, medicine, Humans, Radiology, Nuclear Medicine and imaging, Muscle, Skeletal, Aged, Aged, 80 and over, 0303 health sciences, business.industry, Dissection, Age Factors, Anatomic Variation, Muscle belly, Anatomy, Middle Aged, Extensor hallucis longus muscle, Phalanx, musculoskeletal system, Tendon, body regions, medicine.anatomical_structure, 030301 anatomy & morphology, Orthopedic surgery, Hallux, Female, Surgery, business, Joint Capsule
Abstract

The main tendon of the extensor hallucis longus (EHL) muscle attaches to the dorsal aspect of the distal phalanx of the great toe. One or multiple accessory tendons of the EHL have been reported in several ethnic/regional groups, except Taiwan. This study aimed to investigate the incidence, length, and insertion of the accessory tendon of the EHL in Taiwanese people. Anatomical dissection was performed on 48 feet of 24 formalin-embalmed cadavers. The occurrence and morphological characteristics of the accessory tendon of the EHL were recorded and analyzed. The accessory tendon of the EHL was found in 97.92% (47/48) of the legs that were dissected. In one male cadaver, an independent muscle belly was identified in each leg, whereas all the other accessory tendons originated from the main tendon of the EHL. In this study, the insertion of the accessory tendon were classified into four patterns. The most common insertion sites were the first metatarsophalangeal (MTP) joint capsule and proximal phalanx of the great toe. The length of the accessory tendons did not correlate with age or with sex when the two tendons with independent muscle belly were excluded. The accessory tendon of the EHL appears to be a regular feature in Taiwanese people. Most accessory tendons of the EHL (85.7%) attached on the first MTP joint capsule may play a role in the prevention of capsular impingement during great toe extension.

Published
2021

38. Statin therapy inhibits fatty acid synthase via dynamic protein modifications

Author

Alec G. Trub, Gregory R. Wagner, Kristin A. Anderson, Scott B. Crown, Guo-Fang Zhang, J. Will Thompson, Olga R. Ilkayeva, Robert D. Stevens, Paul A. Grimsrud, Rhushikesh A. Kulkarni, Donald S. Backos, Jordan L. Meier, and Matthew D. Hirschey

Subjects
Cholesterol, Multidisciplinary, Cardiovascular Diseases, Humans, Mevalonic Acid, General Physics and Astronomy, Hydroxymethylglutaryl CoA Reductases, General Chemistry, Fatty Acid Synthases, Hydroxymethylglutaryl-CoA Reductase Inhibitors, General Biochemistry, Genetics and Molecular Biology
Abstract

Statins are a class of drug widely prescribed for the prevention of cardiovascular disease, with pleiotropic cellular effects. Statins inhibit HMG-CoA reductase (HMGCR), which converts the metabolite HMG-CoA into mevalonate. Recent discoveries have shown HMG-CoA is a reactive metabolite that can non-enzymatically modify proteins and impact their activity. Therefore, we predicted that inhibition of HMGCR by statins might increase HMG-CoA levels and protein modifications. Upon statin treatment, we observe a strong increase in HMG-CoA levels and modification of only a single protein. Mass spectrometry identifies this protein as fatty acid synthase (FAS), which is modified on active site residues and, importantly, on non-lysine side-chains. The dynamic modifications occur only on a sub-pool of FAS that is located near HMGCR and alters cellular signaling around the ER and Golgi. These results uncover communication between cholesterol and lipid biosynthesis by the substrate of one pathway inhibiting another in a rapid and reversible manner.

Published
2022

39. Statin therapy inhibits fatty acid synthase via dynamic protein modifications

Author

Trub, Alec G., primary, Wagner, Gregory R., additional, Anderson, Kristin A., additional, Crown, Scott B., additional, Zhang, Guo-Fang, additional, Thompson, J. Will, additional, Ilkayeva, Olga R., additional, Stevens, Robert D., additional, Grimsrud, Paul A., additional, Kulkarni, Rhushikesh A., additional, Backos, Donald S., additional, Meier, Jordan L., additional, and Hirschey, Matthew D., additional

Published
2022
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46. Distributed color QR code with high-capability and fast decoding

Author

Rui Sun, Bin Yu, Sijia Liu, Li-guo Fang, and Zhengxin Fu

Subjects
Computer Networks and Communications, Hardware and Architecture, Computer science, 0202 electrical engineering, electronic engineering, information engineering, Media Technology, 020207 software engineering, 02 engineering and technology, Secret sharing, Algorithm, Software, Decoding methods
Abstract

Considering incompatibility between the color QR code and the standard QR code decoder and insecurity of information storage in the open network environment, this paper proposes a distributed color QR code by analyzing the decoding process of the QR code, which employs the Shamir’s (k, n) secret sharing algorithm to ensure the security of the secret information and sets threshold to achieve compatibility with the standard decoder. Furthermore, we analyze the influence of threshold values on the performance of the proposed scheme, and determine the valid threshold value interval of the algorithm. Experimental results show that the proposed scheme is feasible with a fast reading speed and high secret storage capacity within the threshold interval.

Published
2020

47. Effects of connecting sequences of building blocks on reticular synthesis of covalent organic frameworks

Author

Xin Zhao, Guo-Fang Jiang, De-Li Ma, Zhong-Ri Zhong, Cheng Qian, and Qiao-Yan Qi

Subjects
Pore size, Materials science, Nanotechnology, Model system, 02 engineering and technology, 010402 general chemistry, 021001 nanoscience & nanotechnology, Condensed Matter Physics, 01 natural sciences, Atomic and Molecular Physics, and Optics, 0104 chemical sciences, Covalent bond, Reticular connective tissue, General Materials Science, Metal-organic framework, Electrical and Electronic Engineering, 0210 nano-technology, Covalent organic framework
Abstract

The principle of reticular chemistry has been widely used to guide the design of crystalline porous materials such as metal organic frameworks (MOFs) and covalent organic frameworks (COFs). While in the early strategies only the symmetries of the building blocks were considered for reticular synthesis of COFs, recently a few researches on COFs with hierarchical porosities indicate that connecting sequence of building blocks also plays a crucial role in determining crystalline structures of COFs. However, this important phenomenon has not been systematically investigated yet. In this article, a model system has been established to demonstrate how different connecting sequences of two C2V-symmetric building blocks lead to the formation of four two-dimensional (2D) COFs with distinct framework structures. To verify this concept, target synthesis was conducted to produce three COFs, whose structures were confirmed by powder X-ray diffraction and pore size distribution analysis.

Published
2020

48. Rostral intralaminar thalamic deep brain stimulation ameliorates memory deficits and dendritic regression in β-amyloid-infused rats

Author

Guo Fang Tseng, Sheng-Tzung Tsai, Shinn Zong Lin, and Shin-Yuan Chen

Subjects
Male, Histology, Dendritic spine, Spatial Learning, Prefrontal Cortex, Hippocampus, Morris water navigation task, Hippocampal formation, Biology, 050105 experimental psychology, 03 medical and health sciences, Glutamatergic, 0302 clinical medicine, Alzheimer Disease, Neuroplasticity, Animals, 0501 psychology and cognitive sciences, Rats, Wistar, Prefrontal cortex, Injections, Intraventricular, Spatial Memory, Amyloid beta-Peptides, Intralaminar Thalamic Nuclei, General Neuroscience, 05 social sciences, Dendrites, Electric Stimulation, Disease Models, Animal, nervous system, Synaptic plasticity, Anatomy, Neuroscience, 030217 neurology & neurosurgery
Abstract

Rostral intralaminar thalamic deep brain stimulation (ILN-DBS) has been shown to enhance attention and cognition through neuronal activation and brain plasticity. We examined whether rostral ILN-DBS can also attenuate memory deficits and impaired synaptic plasticity and protect glutamatergic transmission in the rat intraventricular β-amyloid (Aβ) infusion model of Alzheimer's disease (AD). Spatial memory was tested in the Morris water maze (MWM), while structural synaptic plasticity and glutamatergic transmission strength were estimated by measuring dendritic spine densities in dye-injected neurons and tissue expression levels of postsynaptic density protein 95 (PSD-95) in medial prefrontal cortex (mPFC) and hippocampus. All these assessments were compared among the naïve control rats, AD rats, and AD rats with ILN-DBS. We found that a single rostral ILN-DBS treatment significantly improved MWM performance and reversed PSD-95 expression reductions in the mPFC and hippocampal region of Aβ-infused rats. In addition, ILN-DBS preserved dendritic spine densities on mPFC and hippocampal pyramidal neurons. In fact, MWM performance, PSD-95 expression levels, and dendritic spine densities did not differ between naïve control and rostral ILN-DBS treatment groups, indicating near complete amelioration of Aβ-induced spatial memory impairments and dendritic regression. These findings suggest that the ILN is critical for modulating glutamatergic transmission, neural plasticity, and spatial memory functions through widespread effects on distributed brain regions. Further, these findings provide a rationale for examining the therapeutic efficacy of ILN-DBS in AD patients.

Published
2020

49. Cell cycle arrest biomarkers for predicting renal recovery from acute kidney injury: a prospective validation study

Author

Jia, Hui-Miao, primary, Cheng, Li, additional, Weng, Yi-Bing, additional, Wang, Jing-Yi, additional, Zheng, Xi, additional, Jiang, Yi-Jia, additional, Xin, Xin, additional, Guo, Shu-Yan, additional, Chen, Chao-Dong, additional, Guo, Fang-Xing, additional, Han, Yu-Zhen, additional, Zhang, Tian-En, additional, and Li, Wen-Xiong, additional

Published
2022
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