1. Meat and Fish Consumption, APCGene Mutations and hMLH1 Expression in Colon and Rectal Cancer: a Prospective Cohort Study (The Netherlands)
- Author
-
Petra A. Wark, Marjolein H.F.M. Lentjes, Pieter van 't Veer, Margreet Lüchtenborg, R. Alexandra Goldbohm, Matty P. Weijenberg, Mirian Brink, Guido M.J.M. Roemen, Anton F.P.M. de Goeij, Piet A. van den Brandt, Adriaan P. de Bruïne, TNO Kwaliteit van Leven TNO Voeding, Epidemiologie, Pathologie, RS: NUTRIM School of Nutrition and Translational Research in Metabolism, RS: CAPHRI School for Public Health and Primary Care, and RS: GROW - School for Oncology and Reproduction
- Subjects
tumors ,Questionnaires ,Male ,Cancer Research ,Pathology ,Nutrition and Disease ,carcinomas ,DNA Repair ,Meat packing industry ,cluster region ,Colorectal cancer ,Department of Plant Sciences ,Gene Expression ,Gene mutation ,Beef cattle ,Rate ratio ,Gastroenterology ,Cancer risk ,Food intake ,Voeding en Ziekte ,Surveys and Questionnaires ,Epidemiology of cancer ,Prospective Studies ,Prospective cohort study ,Priority journal ,Netherlands ,biology ,Fishes ,Nuclear Proteins ,Middle Aged ,adenomatous polyposis ,Colon cancer ,APC protein ,DNA-Binding Proteins ,k-ras ,Adenomatous Polyposis Coli ,Oncology ,Rectum cancer ,Colonic Neoplasms ,Female ,dietary factors ,MutL Protein Homolog 1 ,Departement Plantenwetenschappen ,Adult ,medicine.medical_specialty ,Genes, APC ,Meat ,Meat industry ,Adenomatous polyposis coli ,Lamb ,Adenomatous Polyposis Coli Protein ,Food and Chemical Risk Analysis ,Protein MLH1 ,Major clinical study ,hMLH1 ,Cancer epidemiology ,Disease association ,Internal medicine ,medicine ,Animals ,Humans ,VLAG ,sporadic colon ,Adaptor Proteins, Signal Transducing ,Aged ,Rectal Neoplasms ,business.industry ,Confidence interval ,colorectal-cancer ,medicine.disease ,Diet ,scale prospective cohort ,Health Nutrition ,Mutation ,biology.protein ,microsatellite instability ,Carrier Proteins ,business ,Controlled study - Abstract
Objective: The aim of this study was to investigate the associations between meat and fish consumption and APC mutation status and hMLH1 expression in colon and rectal cancer. Methods: The associations were investigated in the Netherlands Cohort Study, and included 434 colon and 154 rectal cancer patients on whom case-cohort analyses (subcohort n = 2948) were performed. Results: Total meat consumption was not associated with the endpoints studied. Meat product (i.e. processed meat) consumption showed a positive association with colon tumours harbouring a truncating APC mutation, whereas beef consumption was associated with an increased risk of colon tumours without a truncating APC mutation (incidence rate ratio (RR) highest versus lowest quartile of intake 1.61, 95% confidence interval (CI) 0.96-2.71, p-trend = 0.04 and 1.58, 95% CI 1.10-2.25, p-trend = 0.01, respectively). Consumption of other meat (horsemeat, lamb, mutton, frankfurters and deep-fried meat rolls) was associated with an increased risk of rectal cancer without a truncating APC mutation (RR intake versus no intake 1.79, 95% CI 1.10-2.90). No associations were observed for meat consumption and tumours lacking hMLH1 expression. Conclusions: Our data indicate that several types of meat may contribute differently to the aetiology of colon and rectal cancer, depending on APC mutation status but not hMLH1 expression of the tumour. © Springer 2005.
- Published
- 2005