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2. Stress–strain curve and elastic behavior of the fibrotic lung with usual interstitial pneumonia pattern during protective mechanical ventilation

Author

Tonelli, Roberto, primary, Rizzoni, Raffaella, additional, Grasso, Salvatore, additional, Cortegiani, Andrea, additional, Ball, Lorenzo, additional, Samarelli, Anna Valeria, additional, Fantini, Riccardo, additional, Bruzzi, Giulia, additional, Tabbì, Luca, additional, Cerri, Stefania, additional, Manicardi, Linda, additional, Andrisani, Dario, additional, Gozzi, Filippo, additional, Castaniere, Ivana, additional, Smit, Marry R., additional, Paulus, Frederique, additional, Bos, Lieuwe D. J., additional, Clini, Enrico, additional, and Marchioni, Alessandro, additional

Published
2024
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4. A multi-modal, asymmetric, weighted, and signed description of anatomical connectivity.

Author

Tanner, J, Faskowitz, J, Teixeira, AS, Seguin, C, Coletta, L, Gozzi, A, Mišić, B, Betzel, RF, Tanner, J, Faskowitz, J, Teixeira, AS, Seguin, C, Coletta, L, Gozzi, A, Mišić, B, and Betzel, RF

Abstract

The macroscale connectome is the network of physical, white-matter tracts between brain areas. The connections are generally weighted and their values interpreted as measures of communication efficacy. In most applications, weights are either assigned based on imaging features-e.g. diffusion parameters-or inferred using statistical models. In reality, the ground-truth weights are unknown, motivating the exploration of alternative edge weighting schemes. Here, we explore a multi-modal, regression-based model that endows reconstructed fiber tracts with directed and signed weights. We find that the model fits observed data well, outperforming a suite of null models. The estimated weights are subject-specific and highly reliable, even when fit using relatively few training samples, and the networks maintain a number of desirable features. In summary, we offer a simple framework for weighting connectome data, demonstrating both its ease of implementation while benchmarking its utility for typical connectome analyses, including graph theoretic modeling and brain-behavior associations.

Published
2024

11. Physiological effects of lung-protective ventilation in patients with lung fibrosis and usual interstitial pneumonia pattern versus primary ARDS: a matched-control study

Author

Tonelli, Roberto, primary, Grasso, Salvatore, additional, Cortegiani, Andrea, additional, Ball, Lorenzo, additional, Castaniere, Ivana, additional, Tabbì, Luca, additional, Fantini, Riccardo, additional, Andrisani, Dario, additional, Gozzi, Filippo, additional, Moretti, Antonio, additional, Bruzzi, Giulia, additional, Manicardi, Linda, additional, Cerri, Stefania, additional, Samarelli, Anna Valeria, additional, Raineri, Giulia, additional, Murgolo, Francesco, additional, Carzoli, Andrea, additional, Di Mussi, Rossella, additional, Busani, Stefano, additional, Rizzoni, Raffaella, additional, Grasselli, Giacomo, additional, Clini, Enrico, additional, and Marchioni, Alessandro, additional

Published
2023
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17. Quality of life and intrinsic capacity in patients with post-acute COVID-19 syndrome is in relation to frailty and resilience phenotypes

Author

Guaraldi, Giovanni, primary, Milic, Jovana, additional, Barbieri, Sara, additional, Marchiò, Tommaso, additional, Caselgrandi, Agnese, additional, Motta, Federico, additional, Beghè, Bianca, additional, Verduri, Alessia, additional, Belli, Michela, additional, Gozzi, Licia, additional, Iadisernia, Vittorio, additional, Faltoni, Matteo, additional, Burastero, Giulia, additional, Dessilani, Andrea, additional, Del Monte, Martina, additional, Dolci, Giovanni, additional, Bacca, Erica, additional, Franceschi, Giacomo, additional, Yaacoub, Dina, additional, Volpi, Sara, additional, Mazzochi, Alice, additional, Clini, Enrico, additional, and Mussini, Cristina, additional

Published
2023
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18. Frequency and associated symptoms of isthmoceles in women 6 months after caesarean section: a prospective cohort study

Author

P. Gozzi, K. A. Hees, C. Berg, M. David, K.-D. Wernecke, L. Hellmeyer, and D. Schlembach

Subjects
Obstetrics and Gynecology, General Medicine
Abstract

Purpose The purpose of this study was to determine the frequency of detection of isthmoceles by ultrasound 6 months after caesarean section (CS) and which symptoms associated with isthmocele formation occur after CS. Subsequently, it was determined how often the ultrasound finding “isthmocele” coincided with the presence of complaints. Methods A prospective multicentre cohort study was conducted with 546 patients from four obstetric centres in Berlin, who gave birth by primary or secondary CS from October 2019 to June 2020. 461 participants were questioned on symptoms 3 months after CS; 329 participants were included in the final follow-up 6 months after CS. The presence of isthmoceles was determined by transvaginal sonography (TVS) 6 months after CS, while symptoms were identified by questionnaire. Results Of the 329 women, 146 (44.4%) displayed an isthmocele in the TVS. There was no statistically significant difference in the manifestation of symptoms between the two groups of women with and without isthmocele; however, when expressed on a scale from 1 to 10 the intensity of both scar pain and lower abdominal pain was significantly higher in the set of women that had shown to have developed an isthmocele (p = 0.014 and p = 0.031, respectively). Conclusion The prevalence of isthmoceles 6 months after CS was 44.4%. Additionally, scar pain and lower abdominal pain were more pronounced when an isthmocele was also observed in the TVS. Trial registration Trial registration number DRKS00024977. Date of registration 17.06.2021, retrospectively registered.

Published
2022

19. Relationship between hyponatremia at hospital admission and cardiopulmonary profile at follow-up in patients with SARS-CoV-2 (COVID-19) infection

Author

D, Malandrino, A, Berni, B, Fibbi, B, Borellini, D, Cozzi, D, Norello, F, Fattirolli, F, Lavorini, I, Olivotto, C, Fumagalli, C, Zocchi, L, Tassetti, L, Gozzi, N, Marchionni, M, Maggi, A, Peri, and Maria Vittoria, Silverii

Subjects
Endocrinology, Endocrinology, Diabetes and Metabolism
Abstract

Purpose Hyponatremia occurs in about 30% of patients with pneumonia, including those with SARS-CoV-2 (COVID-19) infection. Hyponatremia predicts a worse outcome in several pathologic conditions and in COVID-19 has been associated with a higher risk of non-invasive ventilation, ICU transfer and death. The main objective of this study was to determine whether early hyponatremia is also a predictor of long-term sequelae at follow-up. Methods In this observational study, we collected 6-month follow-up data from 189 laboratory-confirmed COVID-19 patients previously admitted to a University Hospital. About 25% of the patients (n = 47) had hyponatremia at the time of hospital admission. Results Serum [Na+] was significantly increased in the whole group of 189 patients at 6 months, compared to the value at hospital admission (141.4 ± 2.2 vs 137 ± 3.5 mEq/L, p 2/FiO2 increased. Accordingly, pulmonary involvement, evaluated at the chest X-ray by the RALE score, decreased. However, in patients with hyponatremia at hospital admission, higher levels of LDH, fibrinogen, troponin T and NT-ProBNP were detected at follow-up, compared to patients with normonatremia at admission. In addition, hyponatremia at admission was associated with worse echocardiography parameters related to right ventricular function, together with a higher RALE score. Conclusion These results suggest that early hyponatremia in COVID-19 patients is associated with the presence of laboratory and imaging parameters indicating a greater pulmonary and right-sided heart involvement at follow-up.

Published
2022

21. Author Correction: A consensus protocol for functional connectivity analysis in the rat brain

Author

Grandjean, Joanes, primary, Desrosiers-Gregoire, Gabriel, additional, Anckaerts, Cynthia, additional, Angeles-Valdez, Diego, additional, Ayad, Fadi, additional, Barrière, David A., additional, Blockx, Ines, additional, Bortel, Aleksandra, additional, Broadwater, Margaret, additional, Cardoso, Beatriz M., additional, Célestine, Marina, additional, Chavez-Negrete, Jorge E., additional, Choi, Sangcheon, additional, Christiaen, Emma, additional, Clavijo, Perrin, additional, Colon-Perez, Luis, additional, Cramer, Samuel, additional, Daniele, Tolomeo, additional, Dempsey, Elaine, additional, Diao, Yujian, additional, Doelemeyer, Arno, additional, Dopfel, David, additional, Dvořáková, Lenka, additional, Falfán-Melgoza, Claudia, additional, Fernandes, Francisca F., additional, Fowler, Caitlin F., additional, Fuentes-Ibañez, Antonio, additional, Garin, Clément M., additional, Gelderman, Eveline, additional, Golden, Carla E. M., additional, Guo, Chao C. G., additional, Henckens, Marloes J. A. G., additional, Hennessy, Lauren A., additional, Herman, Peter, additional, Hofwijks, Nita, additional, Horien, Corey, additional, Ionescu, Tudor M., additional, Jones, Jolyon, additional, Kaesser, Johannes, additional, Kim, Eugene, additional, Lambers, Henriette, additional, Lazari, Alberto, additional, Lee, Sung-Ho, additional, Lillywhite, Amanda, additional, Liu, Yikang, additional, Liu, Yanyan Y., additional, López -Castro, Alejandra, additional, López-Gil, Xavier, additional, Ma, Zilu, additional, MacNicol, Eilidh, additional, Madularu, Dan, additional, Mandino, Francesca, additional, Marciano, Sabina, additional, McAuslan, Matthew J., additional, McCunn, Patrick, additional, McIntosh, Alison, additional, Meng, Xianzong, additional, Meyer-Baese, Lisa, additional, Missault, Stephan, additional, Moro, Federico, additional, Naessens, Daphne M. P., additional, Nava-Gomez, Laura J., additional, Nonaka, Hiroi, additional, Ortiz, Juan J., additional, Paasonen, Jaakko, additional, Peeters, Lore M., additional, Pereira, Mickaël, additional, Perez, Pablo D., additional, Pompilus, Marjory, additional, Prior, Malcolm, additional, Rakhmatullin, Rustam, additional, Reimann, Henning M., additional, Reinwald, Jonathan, additional, Del Rio, Rodrigo Triana, additional, Rivera-Olvera, Alejandro, additional, Ruiz-Pérez, Daniel, additional, Russo, Gabriele, additional, Rutten, Tobias J., additional, Ryoke, Rie, additional, Sack, Markus, additional, Salvan, Piergiorgio, additional, Sanganahalli, Basavaraju G., additional, Schroeter, Aileen, additional, Seewoo, Bhedita J., additional, Selingue, Erwan, additional, Seuwen, Aline, additional, Shi, Bowen, additional, Sirmpilatze, Nikoloz, additional, Smith, Joanna A. B., additional, Smith, Corrie, additional, Sobczak, Filip, additional, Stenroos, Petteri J., additional, Straathof, Milou, additional, Strobelt, Sandra, additional, Sumiyoshi, Akira, additional, Takahashi, Kengo, additional, Torres-García, Maria E., additional, Tudela, Raul, additional, van den Berg, Monica, additional, van der Marel, Kajo, additional, van Hout, Aran T. B., additional, Vertullo, Roberta, additional, Vidal, Benjamin, additional, Vrooman, Roël M., additional, Wang, Victora X., additional, Wank, Isabel, additional, Watson, David J. G., additional, Yin, Ting, additional, Zhang, Yongzhi, additional, Zurbruegg, Stefan, additional, Achard, Sophie, additional, Alcauter, Sarael, additional, Auer, Dorothee P., additional, Barbier, Emmanuel L., additional, Baudewig, Jürgen, additional, Beckmann, Christian F., additional, Beckmann, Nicolau, additional, Becq, Guillaume J. P. C., additional, Blezer, Erwin L. A., additional, Bolbos, Radu, additional, Boretius, Susann, additional, Bouvard, Sandrine, additional, Budinger, Eike, additional, Buxbaum, Joseph D., additional, Cash, Diana, additional, Chapman, Victoria, additional, Chuang, Kai-Hsiang, additional, Ciobanu, Luisa, additional, Coolen, Bram F., additional, Dalley, Jeffrey W., additional, Dhenain, Marc, additional, Dijkhuizen, Rick M., additional, Esteban, Oscar, additional, Faber, Cornelius, additional, Febo, Marcelo, additional, Feindel, Kirk W., additional, Forloni, Gianluigi, additional, Fouquet, Jérémie, additional, Garza-Villarreal, Eduardo A., additional, Gass, Natalia, additional, Glennon, Jeffrey C., additional, Gozzi, Alessandro, additional, Gröhn, Olli, additional, Harkin, Andrew, additional, Heerschap, Arend, additional, Helluy, Xavier, additional, Herfert, Kristina, additional, Heuser, Arnd, additional, Homberg, Judith R., additional, Houwing, Danielle J., additional, Hyder, Fahmeed, additional, Ielacqua, Giovanna Diletta, additional, Jelescu, Ileana O., additional, Johansen-Berg, Heidi, additional, Kaneko, Gen, additional, Kawashima, Ryuta, additional, Keilholz, Shella D., additional, Keliris, Georgios A., additional, Kelly, Clare, additional, Kerskens, Christian, additional, Khokhar, Jibran Y., additional, Kind, Peter C., additional, Langlois, Jean-Baptiste, additional, Lerch, Jason P., additional, López-Hidalgo, Monica A., additional, Manahan-Vaughan, Denise, additional, Marchand, Fabien, additional, Mars, Rogier B., additional, Marsella, Gerardo, additional, Micotti, Edoardo, additional, Muñoz-Moreno, Emma, additional, Near, Jamie, additional, Niendorf, Thoralf, additional, Otte, Willem M., additional, Pais-Roldán, Patricia, additional, Pan, Wen-Ju, additional, Prado-Alcalá, Roberto A., additional, Quirarte, Gina L., additional, Rodger, Jennifer, additional, Rosenow, Tim, additional, Sampaio-Baptista, Cassandra, additional, Sartorius, Alexander, additional, Sawiak, Stephen J., additional, Scheenen, Tom W. J., additional, Shemesh, Noam, additional, Shih, Yen-Yu Ian, additional, Shmuel, Amir, additional, Soria, Guadalupe, additional, Stoop, Ron, additional, Thompson, Garth J., additional, Till, Sally M., additional, Todd, Nick, additional, Van Der Linden, Annemie, additional, van der Toorn, Annette, additional, van Tilborg, Geralda A. F., additional, Vanhove, Christian, additional, Veltien, Andor, additional, Verhoye, Marleen, additional, Wachsmuth, Lydia, additional, Weber-Fahr, Wolfgang, additional, Wenk, Patricia, additional, Yu, Xin, additional, Zerbi, Valerio, additional, Zhang, Nanyin, additional, Zhang, Baogui B., additional, Zimmer, Luc, additional, Devenyi, Gabriel A., additional, Chakravarty, M. Mallar, additional, and Hess, Andreas, additional

Published
2023
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23. A consensus protocol for functional connectivity analysis in the rat brain

Author

Grandjean, Joanes, primary, Desrosiers-Gregoire, Gabriel, additional, Anckaerts, Cynthia, additional, Angeles-Valdez, Diego, additional, Ayad, Fadi, additional, Barrière, David A., additional, Blockx, Ines, additional, Bortel, Aleksandra, additional, Broadwater, Margaret, additional, Cardoso, Beatriz M., additional, Célestine, Marina, additional, Chavez-Negrete, Jorge E., additional, Choi, Sangcheon, additional, Christiaen, Emma, additional, Clavijo, Perrin, additional, Colon-Perez, Luis, additional, Cramer, Samuel, additional, Daniele, Tolomeo, additional, Dempsey, Elaine, additional, Diao, Yujian, additional, Doelemeyer, Arno, additional, Dopfel, David, additional, Dvořáková, Lenka, additional, Falfán-Melgoza, Claudia, additional, Fernandes, Francisca F., additional, Fowler, Caitlin F., additional, Fuentes-Ibañez, Antonio, additional, Garin, Clément M., additional, Gelderman, Eveline, additional, Golden, Carla E. M., additional, Guo, Chao C. G., additional, Henckens, Marloes J. A. G., additional, Hennessy, Lauren A., additional, Herman, Peter, additional, Hofwijks, Nita, additional, Horien, Corey, additional, Ionescu, Tudor M., additional, Jones, Jolyon, additional, Kaesser, Johannes, additional, Kim, Eugene, additional, Lambers, Henriette, additional, Lazari, Alberto, additional, Lee, Sung-Ho, additional, Lillywhite, Amanda, additional, Liu, Yikang, additional, Liu, Yanyan Y., additional, López -Castro, Alejandra, additional, López-Gil, Xavier, additional, Ma, Zilu, additional, MacNicol, Eilidh, additional, Madularu, Dan, additional, Mandino, Francesca, additional, Marciano, Sabina, additional, McAuslan, Matthew J., additional, McCunn, Patrick, additional, McIntosh, Alison, additional, Meng, Xianzong, additional, Meyer-Baese, Lisa, additional, Missault, Stephan, additional, Moro, Federico, additional, Naessens, Daphne M. P., additional, Nava-Gomez, Laura J., additional, Nonaka, Hiroi, additional, Ortiz, Juan J., additional, Paasonen, Jaakko, additional, Peeters, Lore M., additional, Pereira, Mickaël, additional, Perez, Pablo D., additional, Pompilus, Marjory, additional, Prior, Malcolm, additional, Rakhmatullin, Rustam, additional, Reimann, Henning M., additional, Reinwald, Jonathan, additional, Del Rio, Rodrigo Triana, additional, Rivera-Olvera, Alejandro, additional, Ruiz-Pérez, Daniel, additional, Russo, Gabriele, additional, Rutten, Tobias J., additional, Ryoke, Rie, additional, Sack, Markus, additional, Salvan, Piergiorgio, additional, Sanganahalli, Basavaraju G., additional, Schroeter, Aileen, additional, Seewoo, Bhedita J., additional, Selingue, Erwan, additional, Seuwen, Aline, additional, Shi, Bowen, additional, Sirmpilatze, Nikoloz, additional, Smith, Joanna A. B., additional, Smith, Corrie, additional, Sobczak, Filip, additional, Stenroos, Petteri J., additional, Straathof, Milou, additional, Strobelt, Sandra, additional, Sumiyoshi, Akira, additional, Takahashi, Kengo, additional, Torres-García, Maria E., additional, Tudela, Raul, additional, van den Berg, Monica, additional, van der Marel, Kajo, additional, van Hout, Aran T. B., additional, Vertullo, Roberta, additional, Vidal, Benjamin, additional, Vrooman, Roël M., additional, Wang, Victora X., additional, Wank, Isabel, additional, Watson, David J. G., additional, Yin, Ting, additional, Zhang, Yongzhi, additional, Zurbruegg, Stefan, additional, Achard, Sophie, additional, Alcauter, Sarael, additional, Auer, Dorothee P., additional, Barbier, Emmanuel L., additional, Baudewig, Jürgen, additional, Beckmann, Christian F., additional, Beckmann, Nicolau, additional, Becq, Guillaume J. P. C., additional, Blezer, Erwin L. A., additional, Bolbos, Radu, additional, Boretius, Susann, additional, Bouvard, Sandrine, additional, Budinger, Eike, additional, Buxbaum, Joseph D., additional, Cash, Diana, additional, Chapman, Victoria, additional, Chuang, Kai-Hsiang, additional, Ciobanu, Luisa, additional, Coolen, Bram F., additional, Dalley, Jeffrey W., additional, Dhenain, Marc, additional, Dijkhuizen, Rick M., additional, Esteban, Oscar, additional, Faber, Cornelius, additional, Febo, Marcelo, additional, Feindel, Kirk W., additional, Forloni, Gianluigi, additional, Fouquet, Jérémie, additional, Garza-Villarreal, Eduardo A., additional, Gass, Natalia, additional, Glennon, Jeffrey C., additional, Gozzi, Alessandro, additional, Gröhn, Olli, additional, Harkin, Andrew, additional, Heerschap, Arend, additional, Helluy, Xavier, additional, Herfert, Kristina, additional, Heuser, Arnd, additional, Homberg, Judith R., additional, Houwing, Danielle J., additional, Hyder, Fahmeed, additional, Ielacqua, Giovanna Diletta, additional, Jelescu, Ileana O., additional, Johansen-Berg, Heidi, additional, Kaneko, Gen, additional, Kawashima, Ryuta, additional, Keilholz, Shella D., additional, Keliris, Georgios A., additional, Kelly, Clare, additional, Kerskens, Christian, additional, Khokhar, Jibran Y., additional, Kind, Peter C., additional, Langlois, Jean-Baptiste, additional, Lerch, Jason P., additional, López-Hidalgo, Monica A., additional, Manahan-Vaughan, Denise, additional, Marchand, Fabien, additional, Mars, Rogier B., additional, Marsella, Gerardo, additional, Micotti, Edoardo, additional, Muñoz-Moreno, Emma, additional, Near, Jamie, additional, Niendorf, Thoralf, additional, Otte, Willem M., additional, Pais-Roldán, Patricia, additional, Pan, Wen-Ju, additional, Prado-Alcalá, Roberto A., additional, Quirarte, Gina L., additional, Rodger, Jennifer, additional, Rosenow, Tim, additional, Sampaio-Baptista, Cassandra, additional, Sartorius, Alexander, additional, Sawiak, Stephen J., additional, Scheenen, Tom W. J., additional, Shemesh, Noam, additional, Shih, Yen-Yu Ian, additional, Shmuel, Amir, additional, Soria, Guadalupe, additional, Stoop, Ron, additional, Thompson, Garth J., additional, Till, Sally M., additional, Todd, Nick, additional, Van Der Linden, Annemie, additional, van der Toorn, Annette, additional, van Tilborg, Geralda A. F., additional, Vanhove, Christian, additional, Veltien, Andor, additional, Verhoye, Marleen, additional, Wachsmuth, Lydia, additional, Weber-Fahr, Wolfgang, additional, Wenk, Patricia, additional, Yu, Xin, additional, Zerbi, Valerio, additional, Zhang, Nanyin, additional, Zhang, Baogui B., additional, Zimmer, Luc, additional, Devenyi, Gabriel A., additional, Chakravarty, M. Mallar, additional, and Hess, Andreas, additional

Published
2023
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24. A simple planning problem for COVID-19 lockdown: a dynamic programming approach

Author

Alessandro Calvia, Fausto Gozzi, Francesco Lippi, and Giovanni Zanco

Subjects
Optimality conditions, Economics and Econometrics, Optimization and Control (math.OC), Controlled SIRD model, Optimal lockdown policies, Optimal control with state space constraints, Optimality conditions, Viscosity solutions, Viscosity solutions, FOS: Mathematics, Optimal lockdown policies, Optimal control with state space constraints, 49K15, 49L20, 49L25, Mathematics - Optimization and Control, Controlled SIRD model
Abstract

A large number of recent studies consider a compartmental SIR model to study optimal control policies aimed at containing the diffusion of COVID-19 while minimizing the economic costs of preventive measures. Such problems are non-convex and standard results need not to hold. We use a Dynamic Programming approach and prove some continuity properties of the value function of the associated optimization problem. We study the corresponding Hamilton–Jacobi–Bellman equation and show that the value function solves it in the viscosity sense. Finally, we discuss some optimality conditions. Our paper represents a first contribution towards a complete analysis of non-convex dynamic optimization problems, within a Dynamic Programming approach.

Published
2023

25. Non-conventional Stabilization for Fruit and Vegetable Juices: Overview, Technological Constraints, and Energy Cost Comparison

Author

Giuseppe Vignali, Mario Gozzi, Massimiliano Pelacci, and Roberta Stefanini

Subjects
Process Chemistry and Technology, Safety, Risk, Reliability and Quality, Industrial and Manufacturing Engineering, Food Science
Abstract

This study will provide an overview and a description of the most promising alternatives to conventional thermal treatments for juice stabilization, as well as a review of the literature data on fruit and vegetable juice processing in terms of three key parameters in juice production, which are microbial reduction, enzyme inactivation, and nutrient-compound retention. The alternatives taken into consideration in this work can be divided, according to the action mechanism upon which these are based, in non-conventional thermal treatments, among which microwave heating (MWH) and ohmic heating (OH), and non-thermal treatments, among which electrical treatments, i.e., pulsed electric fields (PEF), high-pressure processing (HPP), radiation treatments such as ultraviolet light (UVL) and high-intensity pulsed light (PL), and sonication (HIUS) treatment, and inert-gas treatments, i.e., the pressure change technology (PCT) and supercritical carbon dioxide (SC-CO2) treatments. For each technology, a list of the main critical process parameters (CPP), advantages (PROS), and disadvantages (CONS) will be provided. In addition, for the non-thermal technologies, a summary of the most relevant published result of their application on fruit and vegetable juices will be presented. On top of that, a comparison of typical specific working energy costs for the main effective and considered technologies will be reported in terms of KJ per kilograms of processed product.

Published
2022

26. Brain mapping across 16 autism mouse models reveals a spectrum of functional connectivity subtypes

Author

Michela Fagiolini, Fritjof Helmchen, Jason P. Lerch, Davide Pozzi, Michela Matteoli, Alberto Galbusera, Marco Pagani, Giovanni Provenzano, Abhishek Banerjee, J. Ellegood, Maria Luisa Scattoni, Marija Markicevic, Markus Rudin, Nicole Wenderoth, Valerio Zerbi, Alessandro Gozzi, M. Albert Basson, Yuri Bozzi, University of Zurich, and Gozzi, A

Subjects
Autism Spectrum Disorder, Personalized treatment, Population, 2804 Cellular and Molecular Neuroscience, 610 Medicine & health, Biology, Brain mapping, 2738 Psychiatry and Mental Health, Mice, Cellular and Molecular Neuroscience, Functional brain, Neural Pathways, mental disorders, 1312 Molecular Biology, medicine, Animals, 10064 Neuroscience Center Zurich, Autistic Disorder, education, Molecular Biology, Brain Mapping, education.field_of_study, 10242 Brain Research Institute, Functional connectivity, Brain, medicine.disease, Magnetic Resonance Imaging, Psychiatry and Mental health, Autism spectrum disorder, 570 Life sciences, biology, Autism, Identification (biology), Neuroscience
Abstract

Autism Spectrum Disorder (ASD) is characterized by substantial, yet highly heterogeneous abnormalities in functional brain connectivity. However, the origin and significance of this phenomenon remain unclear. To unravel ASD connectopathy and relate it to underlying etiological heterogeneity, we carried out a bi-center cross-etiological investigation of fMRI-based connectivity in the mouse, in which specific ASD-relevant mutations can be isolated and modeled minimizing environmental contributions. By performing brain-wide connectivity mapping across 16 mouse mutants, we show that different ASD-associated etiologies cause a broad spectrum of connectional abnormalities in which diverse, often diverging, connectivity signatures are recognizable. Despite this heterogeneity, the identified connectivity alterations could be classified into four subtypes characterized by discrete signatures of network dysfunction. Our findings show that etiological variability is a key determinant of connectivity heterogeneity in ASD, hence reconciling conflicting findings in clinical populations. The identification of etiologically-relevant connectivity subtypes could improve diagnostic label accuracy in the non-syndromic ASD population and paves the way for personalized treatment approaches., Molecular Psychiatry, 26 (12), ISSN:1359-4184, ISSN:1476-5578

Published
2021

29. Mobility decisions, economic dynamics and epidemic

Author

Giorgio Fabbri, Salvatore Federico, Davide Fiaschi, and Fausto Gozzi

Subjects
FOS: Economics and business, Economics and Econometrics, General Economics (econ.GN), Economics - Theoretical Economics, Theoretical Economics (econ.TH), Economics - General Economics
Abstract

In this paper we propose a theoretical model including a susceptible-infected-recovered-dead (SIRD) model of epidemic in a dynamic macroeconomic general equilibrium framework with agents' mobility. The latter affect both their income (and consumption) and their probability of infecting and of being infected. Strategic complementarities among individual mobility choices drive the evolution of aggregate economic activity, while infection externalities caused by individual mobility affect disease diffusion. Rational expectations of forward looking agents on the dynamics of aggregate mobility and epidemic determine individual mobility decisions. The model allows to evaluate alternative scenarios of mobility restrictions, especially policies dependent on the state of epidemic. We prove the existence of an equilibrium and provide a recursive construction method for finding equilibrium(a), which also guides our numerical investigations. We calibrate the model by using Italian experience on COVID-19 epidemic in the period February 2020 - May 2021. We discuss how our economic SIRD (ESIRD) model produces a substantially different dynamics of economy and epidemic with respect to a SIRD model with constant agents' mobility. Finally, by numerical explorations we illustrate how the model can be used to design an efficient policy of state-of-epidemic-dependent mobility restrictions, which mitigates the epidemic peaks stressing health system, and allows for trading-off the economic losses due to reduced mobility with the lower death rate due to the lower spread of epidemic.

Published
2023

30. A common variant close to the 'tripwire' linker region of NLRP1 contributes to severe COVID-19

Author

Vinicius N C, Leal, Leandro M, Paulino, Raylane A G, Cambui, Thiago G, Zupelli, Suemy M, Yamada, Leonardo A T, Oliveira, Valéria de F, Dutra, Carolina B, Bub, Araci M, Sakashita, Ana Paula H, Yokoyama, José M, Kutner, Camila A, Vieira, Wellyngton M de S, Santiago, Milena M S, Andrade, Franciane M E, Teixeira, Ricardo W, Alberca, Sarah C, Gozzi-Silva, Tatiana M, Yendo, Lucas C, Netto, Alberto J S, Duarte, Maria N, Sato, James, Venturini, and Alessandra, Pontillo

Subjects
Pharmacology, ENZIMAS PROTEOLÍTICAS, Immunology
Abstract

The heterogeneity of response to SARS-CoV-2 infection is directly linked to the individual genetic background. Genetic variants of inflammasome-related genes have been pointed as risk factors for several inflammatory sterile and infectious disease. In the group of inflammasome receptors, NLRP1 stands out as a good novel candidate as severity factor for COVID-19 disease.To address this question, we performed an association study of NLRP1, DPP9, CARD8, IL1B, and IL18 single nucleotide variants (SNVs) in a cohort of 945 COVID-19 patients.The NLRP1 p.Leu155His in the linker region, target of viral protease, was significantly associated to COVID-19 severity, which could contribute to the excessive cytokine release reported in severe cases.Inflammasome genetic background contributes to individual response to SARS-CoV-2.

Published
2022

31. A common variant close to the “tripwire” linker region of NLRP1 contributes to severe COVID-19

Author

Leal, Vinicius N. C., primary, Paulino, Leandro M., additional, Cambui, Raylane A. G., additional, Zupelli, Thiago G., additional, Yamada, Suemy M., additional, Oliveira, Leonardo A. T., additional, Dutra, Valéria de F., additional, Bub, Carolina B., additional, Sakashita, Araci M., additional, Yokoyama, Ana Paula H., additional, Kutner, José M., additional, Vieira, Camila A., additional, Santiago, Wellyngton M. de S., additional, Andrade, Milena M. S., additional, Teixeira, Franciane M. E., additional, Alberca, Ricardo W., additional, Gozzi-Silva, Sarah C., additional, Yendo, Tatiana M., additional, Netto, Lucas C., additional, Duarte, Alberto J. S., additional, Sato, Maria N., additional, Venturini, James, additional, and Pontillo, Alessandra, additional

Published
2022
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33. State-of-the-art of FAPI-PET imaging: a systematic review and meta-analysis

Author

Noemi Gozzi, Martina Sollini, Fabrizia Gelardi, Arturo Chiti, Margarita Kirienko, and Francesco Fiz

Subjects
Oncology, medicine.medical_specialty, 030218 nuclear medicine & medical imaging, 03 medical and health sciences, 0302 clinical medicine, Fibroblast activation protein, alpha, Fluorodeoxyglucose F18, Positron Emission Tomography Computed Tomography, Internal medicine, Endopeptidases, medicine, Humans, Radiology, Nuclear Medicine and imaging, Radiation treatment planning, PET-CT, medicine.diagnostic_test, business.industry, Serine Endopeptidases, Head and neck cancer, Membrane Proteins, Cancer, General Medicine, medicine.disease, Study heterogeneity, Gelatinases, Head and Neck Neoplasms, Positron emission tomography, Positron-Emission Tomography, 030220 oncology & carcinogenesis, Meta-analysis, business
Abstract

Introduction Fibroblast Activation Protein-α (FAPα) is overexpressed on cancer-associated fibroblasts in approximately 90% of epithelial neoplasms, representing an appealing target for therapeutic and molecular imaging applications. [68Ga]Ga-labelled radiopharmaceuticals-FAP-inhibitors (FAPI) - have been developed for PET. We systematically reviewed and meta-analysed published literature to provide an overview of its clinical role.Materials and Methods The search, limited to January 1st, 2018 - March 31st 2021, was performed on MedLine and Embase databases using all the possible combinations of terms "FAP", FAPI", "PET/CT", "positron emission tomography", "fibroblast", “cancer-associated fibroblasts”, “CAF”, “molecular imaging”, and “fibroblast imaging”. Study quality was assessed using the QUADAS-2 criteria. Patient-based and lesion-based pooled sensitivities/specificities of FAPI PET were computed using a random-effects model directly from the STATA “metaprop” command. Between-study statistical heterogeneity was tested (I2-statistics).Results Twenty-three studies were selected for systematic review. Investigations on staging or restaging head and neck cancer (n=2, 29 patients), abdominal malignancies (n=6, 171 patients), various cancers (n=2, 143 patients), and radiation treatment planning (n=4, 56 patients) were included in the metanalysis. On patient-based analysis, pooled sensitivity was 0.99 (95% CI 0.97-1.00) with negligible heterogeneity; pooled specificity was 0.87 (95% CI 0.62-1.00), with negligible heterogeneity. On lesion-based analysis, sensitivity and specificity had high heterogeneity (I2=88.56% and I2=97.20%, respectively). Pooled sensitivity for the primary tumour was 1.00 (95% CI 0.98-1.00) with negligible heterogeneity. Pooled sensitivity/specificity of nodal metastases had high heterogeneity (I2=89.18% and I2=95.74%, respectively). Pooled sensitivity in distant metastases was good (0.93 with 95% CI 0.88-0.97) with negligible heterogeneity.Conclusions FAPI-PET appears promising, especially in imaging cancers unsuitable for [18F]FDG imaging, particularly primary lesions and distant metastases. However, high-level evidence is needed to define its’ role, specifically to identify cancer types, non-oncological diseases and clinical settings for its’ applications.

Published
2021

34. Molecular and cellular immune features of aged patients with severe COVID-19 pneumonia

Author

Domenico Lo Tartaro, Anita Neroni, Annamaria Paolini, Rebecca Borella, Marco Mattioli, Lucia Fidanza, Andrew Quong, Carlene Petes, Geneve Awong, Samuel Douglas, Dongxia Lin, Jordan Nieto, Licia Gozzi, Erica Franceschini, Stefano Busani, Milena Nasi, Anna Vittoria Mattioli, Tommaso Trenti, Marianna Meschiari, Giovanni Guaraldi, Massimo Girardis, Cristina Mussini, Lara Gibellini, Andrea Cossarizza, and Sara De Biasi

Subjects
T Follicular Helper Cells, SARS-CoV-2, Mononuclear, COVID-19, Medicine (miscellaneous), Aged, Cytokines, Humans, Leukocytes, Mononuclear, General Biochemistry, Genetics and Molecular Biology, Leukocytes, General Agricultural and Biological Sciences
Abstract

Aging is a major risk factor for developing severe COVID-19, but few detailed data are available concerning immunological changes after infection in aged individuals. Here we describe main immune characteristics in 31 patients with severe SARS-CoV-2 infection who were >70 years old, compared to 33 subjects + T cells, specific antibodies are reported along with features of lung macrophages. Elderly subjects have higher levels of pro-inflammatory cytokines, more circulating plasmablasts, reduced plasmatic level of anti-S and anti-RBD IgG3 antibodies, lower proportions of central memory CD4+ T cells, more immature monocytes and CD56+ pro-inflammatory monocytes, lower percentages of circulating follicular helper T cells (cTfh), antigen-specific cTfh cells with a less activated transcriptomic profile, lung resident activated macrophages that promote collagen deposition and fibrosis. Our study underlines the importance of inflammation in the response to SARS-CoV-2 and suggests that inflammaging, coupled with the inability to mount a proper anti-viral response, could exacerbate disease severity and the worst clinical outcome in old patients.

Published
2022

35. Environmentally Friendly, Semi-transparent, Screen Printed Antenna for RFID Tag Applications

Author

Tiago Carneiro Gomes, Giovani Gozzi, Alisson Henrique Ferreira Marques, Paula Valerio, Danilo Marcelo Aires dos Santos, Vinicius Ferro, Henry Fellegara, Kayo de Oliveira Vieira, Elson dos Santos, Pedro Rebello, Lucas Fugikawa-Santos, Matheus Henrique Quadros, Indústria de Tintas Condutivas TICON, Flextronics Instituto de Tecnologia (FIT), and Universidade Estadual Paulista (Unesp)

Subjects
RFID Antenna, media_common.quotation_subject, General Physics and Astronomy, Barcode, 01 natural sciences, law.invention, Conductive ink, law, Reading (process), 0103 physical sciences, Wireless, 010306 general physics, media_common, Physics, Environmentally friendly, 010308 nuclear & particles physics, business.industry, Printed electronics, Identification (information), Transparent ink, Antenna (radio), business, Computer hardware
Abstract

Made available in DSpace on 2021-06-25T10:27:43Z (GMT). No. of bitstreams: 0 Previous issue date: 2021-06-01 Wireless communication employing radio-frequency identification (RFID) tags is progressively more widespread in a variety of industrial and commercial sectors. Aspects as demanding specific needs regarding reading distance, production cost, and processability are requested for commercial applications. Nowadays, printing of optical barcodes is the most economically technology for short distance (up to ~30 cm) reading applications. However, the large-scale and low-cost printing of RFID tags would be a competitive alternative to barcode technology because it allows quicker identification with much less reading errors. Here we demonstrate a semi-transparent, screen printed RFID antennas using a non-metallic and environmentally friendly conductive paste. The variation of the film thickness (from 2.5 up to 15 µm) permitted the fabrication of antennas with reading range (0.84–3.29 m), sheet resistance (6.2–36 Ω/sq), and optical transmittance (0–32.3%), which are compatible to commercial or industrial applications aiming short to moderate reading distances. Indústria de Tintas Condutivas TICON Flextronics Instituto de Tecnologia (FIT) Institute of Geosciences and Exact Sciences Department of Physics São Paulo State University (Unesp) Institute of Geosciences and Exact Sciences Department of Physics São Paulo State University (Unesp)

Published
2021

36. mTOR-related synaptic pathology causes autism spectrum disorder-associated functional hyperconnectivity

Author

Ieva Miseviciute, Alice Bertero, Kaustubh Supekar, Stavros Trakoshis, Massimo Pasqualetti, Gustavo Deco, Alberto Galbusera, Raffaella Tonini, Alessandro Gozzi, Marco Pagani, Carola Canella, Michael V. Lombardo, Alessia De Felice, Andrea Locarno, Laura Ulysse, Vinod Menon, Noemi Barsotti, Pagani, Marco [0000-0002-6052-6931], Galbusera, Alberto [0000-0001-7213-0013], Tonini, Raffaella [0000-0003-1652-4709], Lombardo, Michael V. [0000-0001-6780-8619], Pasqualetti, Massimo [0000-0002-0844-8139], Gozzi, Alessandro [0000-0002-5731-4137], Apollo - University of Cambridge Repository, and Lombardo, Michael V [0000-0001-6780-8619]

Subjects
Male, Postmortem studies, Autism Spectrum Disorder, Synaptic pruning, General Physics and Astronomy, Haploinsufficiency, spectrum, Mice, autism, connectivity, inhibition, pathology, Child, health care economics and organizations, Cerebral Cortex, Mice, Knockout, Multidisciplinary, 631/378/3920, TOR Serine-Threonine Kinases, 9/74, article, food and beverages, Brain, Hyperconnectivity, Autism spectrum disorders, Magnetic Resonance Imaging, medicine.anatomical_structure, Autism spectrum disorder, 59/36, Synaptopathy, Female, 64/60, 38/39, Adolescent, Science, 631/378/1689/1373, Biology, Neural circuits, behavioral disciplines and activities, General Biochemistry, Genetics and Molecular Biology, Tuberous Sclerosis Complex 2 Protein, mental disorders, medicine, Animals, Humans, PI3K/AKT/mTOR pathway, General Chemistry, medicine.disease, Mice, Inbred C57BL, Synapses, Autism, Neuroscience
Abstract

Postmortem studies have revealed increased density of excitatory synapses in the brains of individuals with autism spectrum disorder (ASD), with a putative link to aberrant mTOR-dependent synaptic pruning. ASD is also characterized by atypical macroscale functional connectivity as measured with resting-state fMRI (rsfMRI). These observations raise the question of whether excess of synapses causes aberrant functional connectivity in ASD. Using rsfMRI, electrophysiology and in silico modelling in Tsc2 haploinsufficient mice, we show that mTOR-dependent increased spine density is associated with ASD -like stereotypies and cortico-striatal hyperconnectivity. These deficits are completely rescued by pharmacological inhibition of mTOR. Notably, we further demonstrate that children with idiopathic ASD exhibit analogous cortical-striatal hyperconnectivity, and document that this connectivity fingerprint is enriched for ASD-dysregulated genes interacting with mTOR or Tsc2. Finally, we show that the identified transcriptomic signature is predominantly expressed in a subset of children with autism, thereby defining a segregable autism subtype. Our findings causally link mTOR-related synaptic pathology to large-scale network aberrations, revealing a unifying multi-scale framework that mechanistically reconciles developmental synaptopathy and functional hyperconnectivity in autism., Autism spectrum disorder (ASD) is characterised by synaptic surplus and atypical functional connectivity. Here, the authors show that synaptic pathology in Tsc2 haploinsufficient mice is associated with autism-like behavior and cortico-striatal hyperconnectivity, and that analogous functional hyperconnectivity signatures can be linked to mTOR-pathway dysfunction in subgroups of children with idiopathic ASD.

Published
2021

37. D-aspartate oxidase gene duplication induces social recognition memory deficit in mice and intellectual disabilities in humans

Author

Lombardo, Barbara, primary, Pagani, Marco, additional, De Rosa, Arianna, additional, Nunziato, Marcella, additional, Migliarini, Sara, additional, Garofalo, Martina, additional, Terrile, Marta, additional, D’Argenio, Valeria, additional, Galbusera, Alberto, additional, Nuzzo, Tommaso, additional, Ranieri, Annaluisa, additional, Vitale, Andrea, additional, Leggiero, Eleonora, additional, Di Maio, Anna, additional, Barsotti, Noemi, additional, Borello, Ugo, additional, Napolitano, Francesco, additional, Mandarino, Alessandra, additional, Carotenuto, Marco, additional, Heresco-Levy, Uriel, additional, Pasqualetti, Massimo, additional, Malatesta, Paolo, additional, Gozzi, Alessandro, additional, Errico, Francesco, additional, Salvatore, Francesco, additional, Pastore, Lucio, additional, and Usiello, Alessandro, additional

Published
2022
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38. Could different aqueous humor and plasma cytokine profiles help differentiate between ocular sarcoidosis and ocular tuberculosis?

Author

De Simone, L., primary, Bonacini, M., additional, Aldigeri, R., additional, Alessandrello, F., additional, Mastrofilippo, V., additional, Gozzi, F., additional, Bolletta, E., additional, Adani, C., additional, Zerbini, A., additional, Cavallini, G. M., additional, Fontana, L., additional, Salvarani, C., additional, Croci, S., additional, and Cimino, L., additional

Published
2022
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39. Molecular and cellular immune features of aged patients with severe COVID-19 pneumonia

Author

Lo Tartaro, Domenico, primary, Neroni, Anita, additional, Paolini, Annamaria, additional, Borella, Rebecca, additional, Mattioli, Marco, additional, Fidanza, Lucia, additional, Quong, Andrew, additional, Petes, Carlene, additional, Awong, Geneve, additional, Douglas, Samuel, additional, Lin, Dongxia, additional, Nieto, Jordan, additional, Gozzi, Licia, additional, Franceschini, Erica, additional, Busani, Stefano, additional, Nasi, Milena, additional, Mattioli, Anna Vittoria, additional, Trenti, Tommaso, additional, Meschiari, Marianna, additional, Guaraldi, Giovanni, additional, Girardis, Massimo, additional, Mussini, Cristina, additional, Gibellini, Lara, additional, Cossarizza, Andrea, additional, and De Biasi, Sara, additional

Published
2022
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40. Vibrational spectroscopy to study ancient Roman funerary practices at the 'Hypogeum of the Garlands' (Italy)

Author

Festa, G, Rubini, M, Zaio, P, Gozzi, A, Libianchi, N, Parker, Sf, Romanelli, G, de Carvalho, Laeb, and Marques, Mpm

Subjects
Adult, Male, Multidisciplinary, Italy, Settore FIS/07, Spectroscopy, Fourier Transform Infrared, Humans, Female, Middle Aged, Spectrum Analysis, Raman, Bone and Bones, History, Ancient
Abstract

The “Hypogeum of the Garlands” is a sepulchral site, recently found in Grottaferrata (Lazio, Italy), dating back to the first-second century AD. Two sarcophagi were discovered inside, hosting the human remains of Aebutia Quarta, a rich Roman woman, and her son Carvilius Gemellus. While the body of Carvilius is exceptionally well-preserved, following its embalming and perfect sealing of the sarcophagus, in the case of Aebutia only the bones were preserved because of the sarcophagus’s seal breaking down, although she was covered with perfectly preserved flower garlands. Embalming of the body was a rare ritual in the Imperial Roman times when corpses were more often cremated. The remains of Aebutia showed possible traces of heating. Burned bones from a third individual were discovered on the chamber’s floor and preliminary anthropological survey showed that this individual was a male of 40–50 years old. Here, a combination of spectroscopic techniques, including non-destructive inelastic neutron scattering and Raman spectroscopy, and minimally destructive Fourier transform infrared spectroscopy, were applied to the analysis of these bone samples to give information about ancient Roman funerary practices. The temperature and burning conditions were thus determined, showing that Aebutia Quarta was exposed to mild temperatures (200 °C) only in the upper part of the body, while the third individual was likely cremated as its bones were exposed to temperatures up to 900 °C in quasi-anaerobic conditions.

Published
2022

43. Nasal pressure swings as the measure of inspiratory effort in spontaneously breathing patients with de novo acute respiratory failure

Author

Tonelli, Roberto, primary, Cortegiani, Andrea, additional, Marchioni, Alessandro, additional, Fantini, Riccardo, additional, Tabbì, Luca, additional, Castaniere, Ivana, additional, Biagioni, Emanuela, additional, Busani, Stefano, additional, Nani, Chiara, additional, Cerbone, Caterina, additional, Vermi, Morgana, additional, Gozzi, Filippo, additional, Bruzzi, Giulia, additional, Manicardi, Linda, additional, Pellegrino, Maria Rosaria, additional, Beghè, Bianca, additional, Girardis, Massimo, additional, Pelosi, Paolo, additional, Gregoretti, Cesare, additional, Ball, Lorenzo, additional, and Clini, Enrico, additional

Published
2022
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44. Correction: Brain mapping across 16 autism mouse models reveals a spectrum of functional connectivity subtypes

Author

Zerbi, V., primary, Pagani, M., additional, Markicevic, M., additional, Matteoli, M., additional, Pozzi, D., additional, Fagiolini, M., additional, Bozzi, Y., additional, Galbusera, A., additional, Scattoni, M. L., additional, Provenzano, G., additional, Banerjee, A., additional, Helmchen, F., additional, Basson, M. A., additional, Ellegood, J., additional, Lerch, J. P., additional, Rudin, M., additional, Gozzi, A., additional, and Wenderoth, N., additional

Published
2022
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45. The enemy release hypothesis and Callosciurus erythraeus in Argentina: combining community and biogeographical parasitological studies

Author

M. Laura Guichón, Graciela Teresa Navone, Marcela Lareschi, and Ana Cecilia Gozzi

Subjects
0106 biological sciences, education.field_of_study, Ecology, Erythraeus, Biología, 010604 marine biology & hydrobiology, Population, Zoology, Introduced species, Biology, Generalist and specialist species, biology.organism_classification, 010603 evolutionary biology, 01 natural sciences, Population density, Parasite release, Macroparasite, Invasion success, Invasion working hypotheses, Species richness, Introduced squirrels, education, Callosciurus erythraeus, Ecology, Evolution, Behavior and Systematics
Abstract

The enemy release hypothesis (ERH) postulates that during the invasion process an introduced species is released from the natural enemies that regulate its populations, promoting its invasion success in the new environment. Callosciurus erythraeus is a sciurid native to Southeast Asia that has been successfully introduced into Argentina and other Asian and European countries. The aim of this study was to provide new parasitological data on this species and to compare it with studies in native and other introduced ranges under the framework of the ERH. We proposed two working hypotheses: (1) an analysis at the community level to compare the prevalence, abundance and identity of parasites of C. erythraeus and sympatric native mammals in the main invasion focus of Argentina, and (2) an analysis at the biogeographical level to compare parasite richness in native and introduced ranges of C. erythraeus and parasite prevalence and richness among introduced regions with different invasion success (using population density and spread as proxy variables). The community analyses indicated that C. erythraeus has lost its specific parasites in Argentina and that it has a lower level of parasitism than other native mammals. The biogreographical analyses indicated a lower macroparasite richness of C. erythraeus in introduced ranges compared to its native range. However, parasite richness in introduced ranges was not associated with population density and spread. The negative correlation between parasite prevalence and population parameters was mainly due to the low parasite prevalence of C. erythraeus in Argentina where this species shows high density and spread. The release of parasites of C. erythraeus in comparison to its native and other introduced ranges, the low acquisition of generalist parasites and the high population density and spread reached in Argentina are mostly in agreement with the expected outcomes based on the ERH. Further studies are needed to better understand the role of the ERH in the invasion success of this species., Centro de Estudios Parasitológicos y de Vectores

Published
2020

46. Correction: Endobronchial valve positioning for alveolar-pleural fistula following ICU management complicating COVID-19 pneumonia

Author

Pierluigi Donatelli, Fabiana Trentacosti, Maria Rosaria Pellegrino, Roberto Tonelli, Giulia Bruzzi, Alessandro Andreani, Gaia Francesca Cappiello, Dario Andrisani, Filippo Gozzi, Cristina Mussini, Stefano Busani, Gilda Valentina Cavaliere, Massimo Girardis, Elisabetta Bertellini, Enrico Clini, and Alessandro Marchioni

Subjects
Pulmonary and Respiratory Medicine, Diseases of the respiratory system, RC705-779
Published
2022

47. Increased fMRI connectivity upon chemogenetic inhibition of the mouse prefrontal cortex

Author

Rocchi, Federico, primary, Canella, Carola, additional, Noei, Shahryar, additional, Gutierrez-Barragan, Daniel, additional, Coletta, Ludovico, additional, Galbusera, Alberto, additional, Stuefer, Alexia, additional, Vassanelli, Stefano, additional, Pasqualetti, Massimo, additional, Iurilli, Giuliano, additional, Panzeri, Stefano, additional, and Gozzi, Alessandro, additional

Published
2022
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49. Correction: Endobronchial valve positioning for alveolar-pleural fistula following ICU management complicating COVID-19 pneumonia

Author

Donatelli, Pierluigi, primary, Trentacosti, Fabiana, additional, Pellegrino, Maria Rosaria, additional, Tonelli, Roberto, additional, Bruzzi, Giulia, additional, Andreani, Alessandro, additional, Cappiello, Gaia Francesca, additional, Andrisani, Dario, additional, Gozzi, Filippo, additional, Mussini, Cristina, additional, Busani, Stefano, additional, Cavaliere, Gilda Valentina, additional, Girardis, Massimo, additional, Bertellini, Elisabetta, additional, Clini, Enrico, additional, and Marchioni, Alessandro, additional

Published
2022
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50. Race disparities in mortality by breast cancer from 2000 to 2017 in São Paulo, Brazil: a population-based retrospective study

Author

Luiz Carlos Zeferino, Helymar da Costa Machado, Cassio Cardoso-Filho, Diama Bhadra Vale, Ana Cláudia Marcelino, and Bruno Gozzi

Subjects
Adult, Cancer Research, Healthcare disparities, Population, Race/ethnicity, Race (biology), Breast cancer, Black women, Health care, Ethnicity, Genetics, Humans, Medicine, Racial disparities, Mortality, education, RC254-282, Aged, Retrospective Studies, education.field_of_study, White (horse), business.industry, Research, Mortality rate, Racial Groups, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, Cancer, Retrospective cohort study, Health Status Disparities, Middle Aged, Prognosis, medicine.disease, Survival Rate, Socioeconomic Factors, Oncology, Female, Breast neoplasms, business, Brazil, Follow-Up Studies, Demography
Abstract

Background In Brazil, inequalities in access may interfere with cancer care. This study aimed to evaluate the influence of race on breast cancer mortality in the state of São Paulo, from 2000 to 2017, contextualizing with other causes of death. Methods A population-based retrospective study using mortality rates, age and race as variables. Information on deaths was collected from the Ministry of Health Information System. Only white and black categories were used. Mortality rates were age-adjusted by the standard method. For statistical analysis, linear regression was carried out. Results There were 60,940 deaths registered as breast cancer deaths, 46,365 in white and 10,588 in black women. The mortality rates for 100,000 women in 2017 were 16.46 in white and 9.57 in black women, a trend to reduction in white (p = 0.002), and to increase in black women (p = 0.010). This effect was more significant for white women (p p = 0.031) and to increase in black women (p p Conclusion The declared race influenced mortality rates due to breast cancer in São Paulo. The divergences observed between white and black women also were evident in all cancer causes of death, which may indicate inequities in access to highly complex health care in our setting.

Published
2021

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