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We propose a simple clockwork model of flavor which successfully generates the Standard Model flavor hierarchies from random order-one couplings. With very few parameters we achieve distributions of models in excellent agreement with observation. We explain in some detail the interpretation of our mechanism as random localization of zero modes in theory space. The scale of the vectorlike fermions is mostly constrained by lepton flavor violation with secondary constraints arising from rare meson decays., 27 pages + appendices

We develop a systematic analytical approximation scheme for the singular value decompositions of arbitrary complex three dimensional matrices Y with non-degenerate singular values. We derive exact expressions for the errors of this approximation and show that they are bounded from above by very simple ratios of the form (yi/yj)2n where yi < yj are singular values of Y and n is the order of the approximation. The applications we have in mind are the analytical and numerical treatments of arbitrary theories of flavor. We also compute upper bounds for the errors of the Cabbibo Kobayashi Maskawa (CKM) matrix that only depend on the ratios of the masses and the physical CKM angles., 14 pages + Appendix

Patients with end-stage renal disease (ESRD) requiring hemodialysis are typically characterized by multimorbidity and increasingly by advanced age; however, there are few data on their geriatric needs. The aim of the study was to evaluate the clinical characteristics of a large cohort of incident patients in ambulatory hemodialysis units with a particular focus on those aged over 80 years in Germany. The electronic patient registry of the Board of Trustees (Kuratorium) for Dialysis and Kidney Transplantation (KfH) was searched for all patients who began hemodialysis in 1 of the 191 units between 2007 and 2013 and were 65 years and older. Patients were analyzed by age (65–79 years and ≥80 years) for clinical and biochemical characteristics, mortality, quality of life and hospitalizations. Of the 21,355 incident patients, a total of 13,872 (65%) were over 65 years old, with 9998 (46.8%) aged between 65 and 79 years and 3874 (18.1%) patients 80 years or older (oldest old). The spectrum of morbidity was comparable between the two age groups but there was a significantly higher prevalence of anemia, hypoalbuminemia and multimorbidity (>four comorbidities) in the older age group. Median survival was 4.5 years (1638 days) in the younger age group and 2.7 years (978 days) in the older group. Almost half of the patients experienced at least one episode of hospitalization during the first year but there were no significant differences between the age groups (45.9% in younger vs. 47% in older patients). In the older age group 463 (12%) patients survived more than 5 years after initiation of hemodialysis despite the presence of multiple risk factors for adverse clinical outcome. More than half of the chronic ambulatory hemodialysis patients were of advanced age and had a very high burden of multimorbidity. Nevertheless, a subgroup of ERSD patients over 80 years old survived at least 5 years on hemodialysis despite the presence of multiple risk factors for adverse clinical outcome. Identification of these patients as well as optimized care for frail hemodialysis patients will require application of geriatric assessment tools in addition to traditional parameters in nephrology. The development and validation of such tools should be the subject of further clinical studies.

It has long been known that the female sex is associated with a better clinical outcome in chronic renal diseases. Although many experimental, clinical, and epidemiological studies in adults have attempted to explain the difference in disease progression between females and males, a definitive understanding of the underlying mechanisms is still lacking. Hormone-modulating therapies are being increasingly used for various indications (such as post-menopausal hormone replacement, estrogen- or androgen-receptor antagonists for cancer therapy). Therefore, a deeper knowledge of the interaction between sexual hormones and progression of kidney disease is important, as hormone-modulating therapy for non-renal indication may influence both kidney structure and function. In addition, specific modulation of the sexual hormone system, such as the use of selective estrogen receptor modulators, may represent a therapeutic option for patients with renal diseases. Although conclusive data on this topic in the pediatric population are still lacking, the aim of this review is to familiarize pediatric nephrologists with gender-specific differences in renal physiology, pathophysiology, and the progression of kidney diseases. Experimental models that analyze the effects of sexual hormones on renal structure and function are discussed. It is hoped that this review will stimulate researchers to focus on pediatric studies that will provide a deeper insight into the interaction of gender hormones and the kidney both before and during puberty.

We present a simple microscopic realization of a pseudo-Nambu-Goldstone (pNGB) boson Higgs scenario arising from the breaking of $SO(5) \rightarrow SO(4)$. The Higgs constituents are explicitly identified as well as the interactions responsible for forming the bound state and breaking the electroweak symmetry. This outcome follows from the presence of four-fermion interactions with a super-critical coupling, and uses the Nambu-Jona-Lasinio mechanism to break the global $SO(5)$ symmetry. The Higgs potential is found to be insensitive to high energy scales due to the existence of an approximate infrared fixed point. The appearance of vector resonances is described and the correspondence with other proposals in the literature established. The model described here is significantly simpler than other recent ultraviolet completions of pNGB scenarios. The observed Higgs mass can be accommodated, and agreement with electroweak precision tests achieved in certain regions of parameter space. There are also new vector-like fermions, some of which may lie within reach of the LHC. In addition, we predict a heavy standard model singlet scalar in the multi-TeV range. The amount of fine-tuning required in the model is studied. Finally, we show that such a scheme can be completed in the ultraviolet by a renormalizable theory., 32 pages plus appendices, 7 figures - reference added

We discuss the discovery potential of light-by-light scattering at the Large Hadron Collider (LHC), induced by the Standard Model (SM) and by new exotic charged particles. Our simulation relies on intact proton detection in the planned forward detectors of CMS and ATLAS. The full four-photon amplitudes generated by any electrically charged particles of spins $1/2$ and $1$, including the SM processes involving loops of leptons, quarks and $W$ bosons are implemented in the Forward Physics Monte Carlo generator. Our method provides model-independent bounds on massive charged particles, only parametrized by the spin, mass and "effective charge" $Q_{\rm eff}$ of the new particle. We find that a new charged vector (fermion) with $Q_{\rm eff}=4$ can be discovered up to $m=640~\rm GeV$ ($m=300~\rm GeV$) with an integrated luminosity of $300~\rm fb^{-1}$ at the LHC. We also discuss the sensitivities to neutral particles such as a strongly-interacting heavy dilaton and warped Kaluza-Klein gravitons, whose effects could be discovered for masses in the multi-TeV range., 27 pages, 11 figures. Updated/final figures and some typo corrected

We compute the effective Kahler potential for matter fields in warped compactifications, starting from five dimensional gauged supergravity, as a function of the matter fields localization. We show that truncation to zero modes is inconsistent and the tree-level exchange of the massive gravitational multiplet is needed for consistency of the four-dimensional theory. In addition to the standard Kahler coming from dimensional reduction, we find the quartic correction coming from integrating out the gravity multiplet. We apply our result to the computation of scalar masses, by assuming that the SUSY breaking field is a bulk hypermultiplet. In the limit of extreme opposite localization of the matter and the spurion fields, we find zero scalar masses, consistent with sequestering arguments. Surprisingly enough, for all the other cases the scalar masses are tachyonic. This suggests the holographic interpretation that a CFT sector always generates operators contributing in a tachyonic way to scalar masses. Viability of warped su- persymmetric compactifications necessarily asks then for additional contributions. We discuss the case of additional bulk vector multiplets with mixed boundary conditions, which is a partic- ularly simple and attractive way to generate large positive scalar masses. We show that in this case successful fermion mass matrices implies highly degenerate scalar masses for the first two generations of squarks and sleptons., 23 pages. v2: References added, new section on effect of additional bulk vector multiplets and phenomenology

We have considered a general 5D warped model with SM fields propagating in the bulk and computed explicit expressions for oblique and non-oblique electroweak observables as well as for flavor and CP violating effective four-fermion operators. We have compared the resulting lower bounds on the Kaluza-Klein (KK) scale in the RS model and a recently proposed model with a metric modified towards the IR brane, which is consistent with oblique parameters without the need for a custodial symmetry. We have randomly generated 40,000 sets of O(1) 5D Yukawa couplings and made a fit of the quark masses and CKM matrix elements in both models. This method allows to identify the percentage of points consistent with a given KK mass, which in turn provides us with a measure for the required fine-tuning. Comparison with current experimental data on Rb, FCNC and CP violating operators exhibits an improved behavior of our model with respect to the RS model. In particular, allowing 10% fine-tuning the combined results point towards upper bounds on the KK gauge boson masses around 3.3 TeV in our model as compared with 13 TeV in the RS model. One reason for this improvement is that fermions in our model are shifted, with respect to fermions in the RS model, towards the UV brane thus decreasing the strength of the modifications of electroweak observables., Comment: 28 pages, 7 figures, 4 tables

We compare theoretical and experimental predictions of two main classes of models addressing fermion mass hierarchies and flavour changing neutral currents (FCNC) effects in supersymmetry: Froggatt-Nielsen (FN) U(1) gauged flavour models and Nelson-Strassler/extra dimensional models with hierarchical wave functions for the families. We show that whereas the two lead to identical predictions in the fermion mass matrices, the second class generates a stronger suppression of FCNC effects. We prove that, whereas at first sight the FN setup is more constrained due to anomaly cancelation conditions, imposing unification of gauge couplings in the second setup generates conditions which precisely match the mixed anomaly constraints in the FN setup. Finally, we provide an economical extra dimensional realisation of the hierarchical wave functions scenario in which the leptonic FCNC can be efficiently suppressed due to the strong coupling (CFT) origin of the electron mass., 23 pages

Hypermultiplets are considered in the five-dimensional interval where all fields are continuous and the boundary conditions are dynamically obtained from the action principle. The orbifold boundary conditions are obtained as particular cases. We can interpret the Scherk-Schwarz supersymmetry breaking as a misalignment of boundary conditions while a new source of supersymmetry breaking corresponding to a mismatch of different boundary parameters is identified. The latter can be viewed as coming from boundary supersymmetry breaking masses for hyperscalars and the nature of the corresponding supersymmetry breaking parameter is analyzed. For some regions of the parameter space where supersymmetry is broken (either by Scherk-Schwarz boundary conditions or by boundary hyperscalar masses) electroweak symmetry breaking can be triggered at the tree level., Comment: 28 pages, 5 figures

We have analyzed the interplay between Scherk-Schwarz supersymmetry breaking and general fermion (gaugino or gravitino) mass terms localized on the fixed point branes of the S^1/Z_2 orbifold. Analytic solutions for eigenfunctions and eigenvalues are found in all cases. All results are checked by numerical calculations that make use of regularized \delta-functions. Odd and generically also even fermions are discontinuous at the brane fixed points, but in all cases the combination that couples to the brane is continuous. For CP-even brane mass terms supersymmetry restoration can take place when their effects are cancelled by those of Scherk-Schwarz compactification. However such a cancellation can not occur for CP-odd brane mass terms., Comment: 12 pages, 5 figures