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3 results on '"George McMahon"'

1. A genome-wide association meta-analysis of self-reported allergy identifies shared and allergy-specific susceptibility loci

Author

George McMahon, Beate St Pourcain, Susan M. Ring, Chuong B. Do, Nicholas Eriksson, George Davey-Smith, Uta Francke, David A. Hinds, David M. Evans, Amy K. Kiefer, Joanna L. Mountain, Nicholas J. Timpson, and Joyce Y. Tung

Subjects
Adult, Male, Allergy, Locus (genetics), Genome-wide association study, Disease, Human leukocyte antigen, Biology, Polymorphism, Single Nucleotide, Article, Cohort Studies, Young Adult, 03 medical and health sciences, 0302 clinical medicine, Polymorphism (computer science), Hypersensitivity, Genetics, medicine, Animals, Humans, Genetic Predisposition to Disease, Aged, 030304 developmental biology, Autoimmune disease, 0303 health sciences, Pyroglyphidae, Allergens, Middle Aged, medicine.disease, 3. Good health, Genetic Loci, TLR6, Immunology, Cats, Female, Self Report, Genome-Wide Association Study, 030215 immunology
Abstract

Allergic disease is very common and carries substantial public-health burdens. We conducted a meta-analysis of genome-wide associations with self-reported cat, dust-mite and pollen allergies in 53,862 individuals. We used generalized estimating equations to model shared and allergy-specific genetic effects. We identified 16 shared susceptibility loci with association P

Published
2013

2. Erratum: Corrigendum: Meta-analysis of 375,000 individuals identifies 38 susceptibility loci for migraine

Author

Daniel I. Chasman, Stefan Schreiber, Paul M. Ridker, Salli Vepsäläinen, Antti-Pekka Sarin, Veikko Salomaa, Christopher Sivert Nielsen, Tobias Freilinger, Markus Schürks, John-Anker Zwart, Hartmut Göbel, Lydia Quaye, Cynthia Sandor, Nicholas Eriksson, Tõnu Esko, Hieab H.H. Adams, Thomas Meitinger, Andres Ingason, Lude Franke, Rainer Malik, Brenda W.J.H. Penninx, Verneri Anttila, Julie E. Buring, Thomas Hansen, Tobias Kurth, Tim D. Spector, Padhraig Gormley, Mikko Muona, Maija Wessman, Arpo Aromaa, E. Cuenca-Leon, Marjo-Riitta Järvelin, Mikko Kallela, Nicholas A. Furlotte, Linda M. Pedersen, George Davey Smith, Mitja I. Kurki, Aarno Palotie, Reedik Mägi, David P. Strachan, Hailiang Huang, Eija Hämäläinen, Caleb Webber, Nicholas G. Martin, Arn M. J. M. van den Maagdenberg, Zameel M. Cader, Mart Kals, Stacy Steinberg, Markus Färkkilä, Pamela A. F. Madden, Michel D. Ferrari, Grant W. Montgomery, Caroline Ran, Thomas Werge, Lannie Ligthart, Jouke-Jan Hottenga, Kari Stefansson, Tune H. Pers, Bertram Müller-Myhsok, Anine H. Stam, Susan M. Ring, Andres Metspalu, Terho Lehtimäki, Jes Olesen, Andrea Byrnes, Evelin Mihailov, Andrew Heath, Kauko Heikkilä, Jaakko Kaprio, David A. Hinds, Ville Artto, Jie Huang, Maria Gudlaug Hrafnsdottir, Dale R. Nyholt, Evie Stergiakouli, Benjamin M. Neale, Dorret I. Boomsma, Martin Dichgans, Guntram Borck, Kai-How Farh, Christian Kubisch, Cornelia M. van Duijn, André G. Uitterlinden, Albert Hofman, George McMahon, Audun Stubhaug, Kalle Pärn, Priit Palta, Lynn Cherkas, Mark J. Daly, Mari A. Kaunisto, Phil Lee, Ann-Louise Esserlind, Gisela M. Terwindt, Andrea Carmine Belin, Bendik S. Winsvold, Markku Koiranen, Johan G. Eriksson, Minna Männikkö, Olli T. Raitakari, Hreinn Stefansson, Anne Francke Christensen, Juho Wedenoja, Scott G. Gordon, M. Arfan Ikram, Elizabeth Loehrer, and Lili Milani

Subjects
0301 basic medicine, Genetics, Published Erratum, MEDLINE, Biology, medicine.disease, Article, 03 medical and health sciences, 030104 developmental biology, 0302 clinical medicine, Migraine, Meta-analysis, medicine, Susceptibility locus, 030217 neurology & neurosurgery
Abstract

Migraine is a debilitating neurological disorder affecting around 1 in 7 people worldwide, but its molecular mechanisms remain poorly understood. Some debate exists over whether migraine is a disease of vascular dysfunction or a result of neuronal dysfunction with secondary vascular changes. Genome-wide association (GWA) studies have thus far identified 13 independent loci associated with migraine. To identify new susceptibility loci, we performed the largest genetic study of migraine to date, comprising 59,674 cases and 316,078 controls from 22 GWA studies. We identified 44 independent single nucleotide polymorphisms (SNPs) significantly associated with migraine risk (P < 5 × 10−8) that map to 38 distinct genomic loci, including 28 loci not previously reported and the first locus identified on chromosome X. In subsequent computational analyses, the identified loci showed enrichment for genes expressed in vascular and smooth muscle tissues, consistent with a predominant theory of migraine that highlights vascular etiologies.

Published
2016

3. Erratum: Common variants at 12q15 and 12q24 are associated with infant head circumference

Author

Sudha Seshadri, Gerard H. Koppelman, H.-Erich Wichmann, Meike W. Vernooij, Paul F. O'Reilly, Cecilia E. Kim, Norman Klopp, Inga Prokopenko, Nicholas J. Timpson, Craig E. Pennell, Joachim Heinrich, Rachel M. Freathy, Aarno Palotie, Mark I. McCarthy, Rosetta M. Chiavacci, Elisabeth Widen, Frank Geller, Beate St Pourcain, Jordi Sunyer, Lawrence J. Beilin, Myriam Fornage, Pimphen Charoen, Vilmundur Gudnason, André G. Uitterlinden, George McMahon, Mads Melbye, Anne Mølgaard, John P. Kemp, Marika Kaakinen, Carla M. T. Tiesler, Susan M. Ring, Carmen Iñiguez, Fernando Rivadeneira, Lyle J. Palmer, Hanieh Yaghootkar, Dennis O. Mook-Kanamori, M. Arfan Ikram, Aad van der Lugt, Cornelia M. van Duijn, Bjarke Feenstra, Hakon Hakonarson, Johan G. Eriksson, Stéphanie Debette, Bo L. Chawes, Vincent W. V. Jaddoe, A Pouta, Jonathan P. Bradfield, John P. Newnham, Martina Müller-Nurasyid, Mark Lathrop, Albert Hofman, H. Rob Taal, Thomas H. Mosley, Alexandra I. F. Blakemore, Klaus Bønnelykke, Lenore J. Launer, Marjo-Riitta Järvelin, Hans Bisgaard, Diana L. Cousminer, Monique M.B. Breteler, Frank D. Mentch, Wendy L. McArdle, Mònica Guxens, Shikta Das, David M. Evans, Eskil Kreiner-Møller, Jari Lahti, Struan F.A. Grant, Charles DeCarli, Marjan Kerkhof, Nicole M. Warrington, Nadja Hawwa Vissing, Eric A.P. Steegers, Jessica L. Buxton, Albert V. Smith, Elisabeth Thiering, Marie Standl, Anna-Liisa Hartikainen, Stephen J. Lye, Xavier Estivill, George Davey Smith, Andrew T. Hattersley, Ulla Sovio, Julio Fernandez-Banet, and Albert J. van der Heijden

Subjects
Head circumference, Genetics, Anatomy, Biology
Published
2013

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