1. RETRACTED ARTICLE: Juvenile-onset myasthenia gravis: autoantibody status, clinical characteristics and genetic polymorphisms
- Author
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Socrates J. Tzartos, Hai-Feng Li, Katerina Karagiorgou, Yu Hong, Yao-Xian Yue, Geir Olve Skeie, Xiang Gao, Xu Zhang, Nils Erik Gilhus, Fredrik Romi, and Paraskevi Zisimopoulou
- Subjects
0301 basic medicine ,biology ,Autoantibody ,medicine.disease ,Neuromuscular junction ,Myasthenia gravis ,03 medical and health sciences ,030104 developmental biology ,0302 clinical medicine ,medicine.anatomical_structure ,Neurology ,Immunology ,medicine ,Genetic predisposition ,biology.protein ,Juvenile ,Neurology (clinical) ,Thymus hyperplasia ,Antibody ,Young adult ,030217 neurology & neurosurgery - Abstract
Myasthenia gravis (MG) is an autoimmune disorder mediated by antibodies against proteins at the neuromuscular junction. Juvenile-onset MG (JMG) has been reported to have special characteristics. It is still unclear whether there are any pathogenic and genetic differences between juvenile and adult MG. In this study, we evaluated the clinical characteristics, autoantibody status (antibodies against AChR, MuSK, LRP4, titin and RyR) and genetic susceptibility (CHRNA1, CTLA4 and AIRE) in 114 Chinese JMG patients, and compared with 207 young adult MG patients (onset age 18–40 years). JMG patients were classified into two subgroups: the very early onset group (
- Published
- 2017