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82 results on '"Gaudenzi, A."'

1. Current territorial organization for access to revascularization therapies for acute ischemic stroke in the Veneto region (Italy) from 2017 to 2021

Author

Manuel Cappellari, Bruno Bonetti, Claudio Baracchini, Maurizio Corbetta, Antonella De Boni, Adriana Critelli, Simone Tonello, Valentina Codemo, Michela Marcon, Emanuele Turinese, Roberto Bombardi, Anna Maria Basile, Giampietro Ruzza, Morena Cadaldini, Edoardo Mampreso, Sandro Zambito Marsala, Roberta Padoan, Bruno Marini, Anna Gaudenzi, Agnese Tonon, Maela Masa, Antonio Baldi, Michelangelo Turazzini, Giampietro Zanette, Alessandro Adami, Mario Saia, and Paolo Bovi

Subjects
Stroke, Psychiatry and Mental health, Hub-and-spoke model, Thrombectomy, Thrombolysis, Neurology (clinical), Dermatology, General Medicine
Published
2023
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3. Current territorial organization for access to revascularization therapies for acute ischemic stroke in the Veneto region (Italy) from 2017 to 2021

Author

Cappellari, Manuel, primary, Bonetti, Bruno, additional, Baracchini, Claudio, additional, Corbetta, Maurizio, additional, De Boni, Antonella, additional, Critelli, Adriana, additional, Tonello, Simone, additional, Codemo, Valentina, additional, Marcon, Michela, additional, Turinese, Emanuele, additional, Bombardi, Roberto, additional, Basile, Anna Maria, additional, Ruzza, Giampietro, additional, Cadaldini, Morena, additional, Mampreso, Edoardo, additional, Marsala, Sandro Zambito, additional, Padoan, Roberta, additional, Marini, Bruno, additional, Gaudenzi, Anna, additional, Tonon, Agnese, additional, Masa, Maela, additional, Baldi, Antonio, additional, Turazzini, Michelangelo, additional, Zanette, Giampietro, additional, Adami, Alessandro, additional, Saia, Mario, additional, and Bovi, Paolo, additional

Published
2023
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4. Investigation of unaged and long-term aged bio-based asphalt mixtures containing lignin according to the VECD theory

Author

Elena Gaudenzi, Lorenzo Paolo Ingrassia, Fabrizio Cardone, Xiaohu Lu, and Francesco Canestrari

Subjects
Mechanics of Materials, General Materials Science, Building and Construction, Civil and Structural Engineering
Abstract

In the near future, the world of civil and building engineering will be dominated by the advent of bio-materials. Even the road paving sector is involved in the transition towards more sustainable solutions, promoting at the same time environmental benefits and economic savings. Currently, one of the main goals is to ensure that bio-binders offer good performance, at least comparable with that offered by conventional materials. In the last decades, the exponential increase in traffic volumes has led to various types of asphalt pavement distresses, among which fatigue cracking is one of the most common. Within this context, this study presents the characterization of a bio-based asphalt mixture obtained by replacing 30% of bitumen with lignin, which was compared with a reference asphalt mixture containing a plain bitumen characterised by the same penetration grade. Laboratory produced and compacted specimens were subjected to complex modulus and cyclic fatigue tests with the Asphalt Mixture Performance Tester (AMPT). Both unaged and long-term aging conditions were investigated. The tests and the subsequent analyses were based on the simplified viscoelastic continuum damage (S-VECD) approach. Overall, the results showed that the presence of lignin led to a lower aging susceptibility, but also caused a slight reduction in fatigue life due to an increase in the material stiffness. Furthermore, the obtained results confirmed previous findings deriving from the study of the two binders and from the conventional characterization of the same asphalt mixtures as well.

Published
2023
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5. Low in-hospital mortality rate in patients with COVID-19 receiving thromboprophylaxis: data from the multicentre observational START-COVID Register

Author

Rossella, Marcucci, Poli, Daniela, SOD Malattie Aterotrombotiche, Azienda Ospedaliero Universitaria-Careggi, Walter Ageno, Firenze., Giovanna, Colombo, UOSD Degenza Breve, e Internistica, Centro trombosi Ospedale di Circolo, Chiara Ambaglio, Varese., UOSD SIMT Servizio di Immunoematologia, e Medicina Trasfusionale, Ospedale di Treviglio, – Caravaggio, ASST Bergamo Ovest, Guido Arpaia, Bergamo., Giovanni Barillari, U. O. Medicina Interna Carate Brianza ASST-Vimercate., SOS di Dipartimento 'Malattie Emorragiche, e Trombotiche, Azienda Sanitaria Universitaria Friuli Centrale, Giuseppina Bitti, Presidio Ospedaliero Universitario 'Santa Maria della Misericordia'. Udine., Giuseppe Pio Martino Medicina Interna Ospedale Civile di Fermo, Eugenio Bucherini, Fermo (Ancona)., Antonio Chistolini, Monica Vastola— SS Az. le di Angiologia Faenza (RA) AUSL Romagna., Alessandra, Serrao, Dipartimento di Medicina Traslazionale, e di Precisione, Egidio De Gaudenzi, Sapienza Universita di Roma., Valeria De Micheli, SOC Medicina Interna Ospedale San Biagio – Domodossola., Anna Falanga, Ambulatorio Emostasi—Azienda Ospedaliera Di Lecco., Teresa, Lerede, Luca, Barcella, Laura, Russo, Usc, Simt, Centro Emostasi, e Trombosi, Ospedale Papa Giovanni XXIII, Vittorio Fregoni, Bergamo., Medicina Generale, U. O. C., Silvia Galliazzo, ASST Valtellina e Alto Lario Ospedale di Sondalo., UOC Medicina Generale, Ospedale San Valentino, Alberto Gandolfo, Montebelluna (TV)., Gianni, Biolo, Valentina, Trapletti, SC (UCO) Clinica Medica, Azienda sanitaria universitaria Giuliano Isontina (ASU GI)—Ospedale di Cattinara, Trieste, Ghigliotti, Giorgio, Elisa Grifoni, Clinica Delle Malattie Dell'apparato Cardiovascolare Policlinico San Martino Genova., Luca, Masotti, Medicina Interna, 2, Ospedale San Giuseppe, Egidio Imbalzano, Empoli (Fi)., UOC Medicina Interna, Gianfranco Lessiani, Policlinico di Messina., Unita, Angiologica, Dipartimento di Medicina, e Geriatria, Ospedale, Citta, Sant'Angelo, Niccolo Marchionni, Pescara., SOD Cardiologia Generale, Dipartimento, Cardiotoracovascolare, Aou, Careggi, Giuliana Martini, Firenze., Sara, Merelli, Nicola Portesi Centro Emostasi, Spedali Civili Di Brescia, Franco, Mastroianni, Giovanni, Larizza, Covid, Unit, Miulli, EE Ospedale Generale F., Carlo Nozzoli, Acquaviva delle Fonti (Ba)., SOD Medicina Interna, 1, Dipartimento di Emergenza AOU- Careggi, Serena Panarello, Firenze., Fioravanti, Chiara, SC Medicina Interna, Galliera, Eo, Simona Pedrini, Genova., Federica, Bertola, Servizio di Laboratorio, Istituto Ospedaliero Fondazione Poliambulanza, Raffaele Pesavento, Brescia., Filippo Pieralli, Davide Ceccato UO Clinica Medica 3 Azienda Ospedaliero Universitaria Padova., SOD Medicina Interna ad alta intensita, Dipartimento di Emergenza, AOU-, Careggi, Pasquale Pignatelli, Firenze., Daniele, Pastori, Centro, Trombosi, Clinica Medica, I, Paola Preti, Universita La Sapienza Roma., Centro Emostasi, e Trombosi Medicina Generale II, Matteo, IRCCS Fondazione Policlinico S., Elias Romano, Pavia., Alessandro, Morettini, Girolamo Sala, AOU-Careggi Firenze., Fabrizio, Foieni, Michela, Provisone, UOC Medicina II, Luca Sarti, Ospedale di Circolo Busto Arsizio (Va)., Antonella, Caronna, Struttura complessa di medicina interna ed area critica, Federico Simonetti, Ospedale di Baggiovara (Mo)., Ilaria, Bertaggia, Piera Sivera, UOC Ematologia Aziendale – Ospedale Versilia –Lido di Camaiore (Lucca)., Carmen, Fava, Ematologia e terapie cellulari, S. C. D. U., Viviana Scancassani, AO Ordine Mauriziano Umberto 1° Torino., Michele Spinicci, ASST Valtellina UOC di Medicina Sondrio., Alessio, Bartoloni, SOD Malattie Infettive, e Tropicali, Adriana Visona, Firenze., Beniamino, Zalunardo, Uoc, Angiologia, Ospedale San Giacomo Apostolo, Sabina Villalta, Castelfranco Veneto (Treviso)., and Castelfranco Veneto, (Treviso).

Subjects
Heparin, Anticoagulants, COVID-19, Antithrombotic, COVID-19 disease, Mortality, Hemorrhage, Venous Thromboembolism, Heparin, Low-Molecular-Weight, Im - Original, COVID-19 disease, Antithrombotic, Heparin, Mortality, Fibrinolytic Agents, Emergency Medicine, Internal Medicine, Humans, Hospital Mortality, Pulmonary Embolism, Retrospective Studies
Abstract

COVID-19 infection causes respiratory pathology with severe interstitial pneumonia and extra-pulmonary complications; in particular, it may predispose to thromboembolic disease. The current guidelines recommend the use of thromboprophylaxis in patients with COVID-19, however, the optimal heparin dosage treatment is not well-established. We conducted a multicentre, Italian, retrospective, observational study on COVID-19 patients admitted to ordinary wards, to describe clinical characteristic of patients at admission, bleeding and thrombotic events occurring during hospital stay. The strategies used for thromboprophylaxis and its role on patient outcome were, also, described. 1091 patients hospitalized were included in the START-COVID-19 Register. During hospital stay, 769 (70.7%) patients were treated with antithrombotic drugs: low molecular weight heparin (the great majority enoxaparin), fondaparinux, or unfractioned heparin. These patients were more frequently affected by comorbidities, such as hypertension, atrial fibrillation, previous thromboembolism, neurological disease, and cancer with respect to patients who did not receive thromboprophylaxis. During hospital stay, 1.2% patients had a major bleeding event. All patients were treated with antithrombotic drugs; 5.4%, had venous thromboembolism [30.5% deep vein thrombosis (DVT), 66.1% pulmonary embolism (PE), and 3.4% patients had DVT + PE]. In our cohort the mortality rate was 18.3%. Heparin use was independently associated with survival in patients aged ≥ 59 years at multivariable analysis. We confirmed the high mortality rate of COVID-19 in hospitalized patients in ordinary wards. Treatment with antithrombotic drugs is significantly associated with a reduction of mortality rates especially in patients older than 59 years.

Published
2022
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7. Performance assessment of asphalt mixtures produced with a bio-binder containing 30% of lignin

Author

Elena Gaudenzi, Fabrizio Cardone, Xiaohu Lu, and Francesco Canestrari

Subjects
Mechanics of Materials, General Materials Science, Building and Construction, Civil and Structural Engineering
Abstract

Lignin is one of major by-product from wood and paper industry. As natural biopolymer, it could be a valid alternative as bitumen replacement and/or modifier to enhance the relevant performance of asphalt mixtures, promoting concurrently environmental benefits. In this context, the study focused on the effects of two different binders containing 30% of lignin (by weight) on the mechanical properties of bio-asphalt mixtures. Specifically, two different lignins were blended with two plain bitumens having different consistencies so obtaining two bio-binders with a similar consistency to that of a reference plain bitumen. The two bio-binders and the reference bitumen were used to produce in the laboratory three dense graded asphalt mixtures for binder courses according to the Italian Technical Specifications. The binder-aggregate adhesion, Indirect Tensile Strength, Stiffness Modulus, thermal susceptibility, fatigue resistance, and low-temperature cracking of mixtures were analysed in both unaged and long-term aged conditions. Overall, this investigation demonstrates that bio-mixtures containing lignin offer comparable results to the reference asphalt mixture. Moreover, the bio-asphalt mixtures exhibit a lower thermal susceptibility, as well as lower aging susceptibility. The findings of this research highly encourage the use of lignin as partial replacement of bitumen in asphalt pavements.

Published
2022
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8. Long-term effects of somatostatin analogues in rat GH-secreting pituitary tumor cell lines

Author

Germano Gaudenzi, Davide Saronni, Giovanni Vitale, Alessandra Dicitore, Maria Celeste Cantone, Luca Persani, Maria Orietta Borghi, and S. Carra

Subjects
Adenoma, Embryo, Nonmammalian, Time Factors, Endocrinology, Diabetes and Metabolism, Apoptosis, 030209 endocrinology & metabolism, Octreotide, Peptides, Cyclic, Animals, Genetically Modified, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Endocrinology, Acromegaly, Tumor Cells, Cultured, medicine, Animals, Propidium iodide, Viability assay, Zebrafish, Long-term treatment, Pituitary tumors, Cell cycle, medicine.disease, Somatotrophs, Growth hormone secretion, Rats, Somatostatin, chemistry, Somatostatin analogs, 030220 oncology & carcinogenesis, Cancer research, Original Article, GH-secreting pituitary tumor, Growth Hormone-Secreting Pituitary Adenoma
Abstract

Purpose First-generation somatostatin analogs, octreotide (OCT) and lanreotide, are the cornerstone for the medical treatment of growth hormone (GH)-secreting pituitary tumors. A new multireceptor analog, such as pasireotide (PAS), showed better activity than OCT in long-term treatment of patients with acromegaly, but modulation of intracellular key processes is still unclear in vitro. In this study, we evaluated the antitumor activity of OCT and PAS in two GH-secreting pituitary tumor cell lines, GH3 and GH4C1, after a long-term incubation. Methods The effects of PAS and OCT on the cell viability, cell cycle, apoptosis, GH secretion, and tumor-induced angiogenesis have been evaluated through a colorimetric method (MTS Assay), DNA flow cytometry with propidium iodide, and Annexin V-FITC/propidium iodide staining, ELISA assay and zebrafish platform, respectively. Results PAS showed a more potent antitumor activity compared to OCT in GH3 cell line exerted through inhibition of cell viability, perturbation of cell cycle progression, and induction of apoptosis after 6 days of incubation. A concomitant decrease in GH secretion has been observed after 2 days of incubation only with PAS. No effect on tumor-induced angiogenesis has been reported after treatment with OCT or PAS in zebrafish/tumor xenograft model. Conclusion Long-term incubation with PAS showed a more potent antitumor activity than that reported after OCT in GH3 cells, mainly modulated by a cell cycle perturbation and a relevant induction in apoptosis.

Published
2021
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11. Polypharmacy in older people: lessons from 10 years of experience with the REPOSI register

Author

Mannucci, Pier Mannuccio, Nobili, Alessandro, Pasina, Luca, Tettamanti, Mauro, Franchi, Carlotta, Corrao, Salvatore, Marengoni, Alessandra, Salerno, Francesco, Cesari, Matteo, Perticone, Francesco, Licata, Giuseppe, Violi, Francesco, Corazza, Gino Roberto, Cortesi, Laura, Ardoino, Ilaria, Prisco, Domenico, Silvestri, Elena, Cenci, Caterina, Emmi, Giacomo, Biolo, Gianni, Zanetti, Michela, Guadagni, Martina, Zaccari, Michele, Vanoli, Massimo, Grignani, Giulia, Pulixi, Edoardo Alessandro, Bernardi, Mauro, Bassi, Silvia Li, Santi, Luca, Zaccherini, Giacomo, Mannarino, Elmo, Lupattelli, Graziana, Bianconi, Vanessa, Paciullo, Francesco, Nuti, Ranuccio, Valenti, Roberto, Ruvio, Martina, Cappelli, Silvia, Palazzuoli, Alberto, Olivieri, Oliviero, Girelli, Domenico, Matteazzi, Thomas, Barbagallo, Mario, Dominguez, Ligia, Cocita, Floriana, Beneduce, Vincenza, Plances, Lidia, Zoli, Marco, Lazzari, Ilaria, Brunori, Mattia, Pasini, Franco Laghi, Capecchi, Pier Leopoldo, Palasciano, Giuseppe, Modeo, Maria Ester, Di Gennaro, Carla, Cappellini, Maria Domenica, Maira, Diletta, Di Stefano, Valeria, Fabio, Giovanna, Seghezzi, Sonia, Mancarella, Marta, Rossi, Paolo Dionigi, Damanti, Sarah, Clerici, Marta, Conti, Federica, Miceli, Emanuela, Lenti, Marco Vincenzo, Pisati, Martina, Dominioni, Costanza Caccia, Murialdo, Giovanni, Marra, Alessio, Cattaneo, Federico, Secchi, Maria Beatrice, Ghelfi, Davide, Anastasio, Luigi, Sofia, Lucia, Carbone, Maria, Cipollone, Francesco, Guagnano, Maria Teresa, Angelucci, Ermanno, Valeriani, Emanuele, Mancuso, Gerardo, Calipari, Daniela, Bartone, Mosè, Delitala, Giuseppe, Berria, Maria, Muscaritoli, Maurizio, Molfino, Alessio, Petrillo, Enrico, Zuccalà, Giuseppe, D’Aurizio, Gabriella, Romanelli, Giuseppe, Zucchelli, Alberto, Picardi, Antonio, Gentilucci, Umberto Vespasiani, Gallo, Paolo, Dell’Unto, Chiara, Annoni, Giorgio, Corsi, Maurizio, Bellelli, Giuseppe, Zazzetta, Sara, Mazzola, Paolo, Szabo, Hajnalka, Bonfanti, Alessandra, Arturi, Franco, Succurro, Elena, Rubino, Mariangela, Serra, Maria Grazia, Bleve, Maria Antonietta, Gasbarrone, Laura, Sajeva, Maria Rosaria, Brucato, Antonio, Ghidoni, Silvia, Fabris, Fabrizio, Bertozzi, Irene, Bogoni, Giulia, Rabuini, Maria Victoria, Cosi, Elisabetta, Manfredini, Roberto, Fabbian, Fabio, Boari, Benedetta, De Giorgi, Alfredo, Tiseo, Ruana, Paolisso, Giuseppe, Rizzo, Maria Rosaria, Borghi, Claudio, Strocchi, Enrico, De Sando, Valeria, Pareo, Ilenia, Sabbà, Carlo, Vella, Francesco Saverio, Suppressa, Patrizia, Agosti, Pasquale, Schilardi, Andrea, Loparco, Francesca, Fenoglio, Luigi, Bracco, Christian, Giraudo, Alessia Valentina, Fargion, Silvia, Periti, Giulia, Porzio, Marianna, Tiraboschi, Slivia, Peyvandi, Flora, Rossio, Raffaella, Ferrari, Barbara, Colombo, Giulia, Monzani, Valter, Savojardo, Valeria, Folli, Christian, Ceriani, Giuliana, Pallini, Giada, Dallegri, Franco, Ottonello, Luciano, Liberale, Luca, Caserza, Lara, Salam, Kassem, Liberato, Nicola Lucio, Tognin, Tiziana, Bianchi, Giovanni Battista, Giaquinto, Sabrina, Purrello, Francesco, Di Pino, Antonino, Piro, Salvatore, Rozzini, Renzo, Falanga, Lina, Spazzini, Elena, Ferrandina, Camillo, Montrucchio, Giuseppe, Petitti, Paolo, Salmi, Raffaella, Gaudenzi, Piergiorgio, Perri, Ludovica, Landolfi, Raffaele, Montalto, Massimo, Mirijello, Antonio, Guasti, Luigina, Castiglioni, Luana, Maresca, Andrea, Squizzato, Alessandro, Molaro, Marta, Grossi, Alessandra, Bertolotti, Marco, Mussi, Chiara, Libbra, Maria Vittoria, Dondi, Giulia, Pellegrini, Elisa, Carulli, Lucia, COLANGELO, LIDIA, Falbo, Tania, Stanghellini, Vincenzo, De Giorgio, Roberto, Ruggeri, Eugenio, del Vecchio, Sara, Salvi, Andrea, LEONARDI, ROBERTO, Damiani, Giampaolo, Gabrielli, Armando, Capeci, William, Mattioli, Massimo, Martino, Giuseppe Pio, Biondi, Lorenzo, Pettinari, Pietro, Ghio, Riccardo, Col, Anna Dal, Minisola, Salvatore, Colangelo, Luciano, Afeltra, Antonella, Marigliano, Benedetta, Pipita, Maria Elena, Castellino, Pietro, Blanco, Julien, Zanoli, Luca, Pignataro, Samuele, Saracco, Valter, Fogliati, Marisa, Bussolino, Carlo, Mete, Francesca, Gino, Miriam, Cittadini, Antonio, Vigorito, Carlo, Arcopinto, Michele, Salzano, Andrea, Bobbio, Emanuele, Marra, Alberto Maria, Sirico, Domenico, Moreo, Guido, Gasparini, Francesca, Prolo, Silvia, Pina, Gloria, Ballestrero, Alberto, Ferrando, Fabio, Berra, Sergio, Dassi, Simonetta, Nava, Maria Cristina, Graziella, Bruno, Baldassarre, Stefano, Fragapani, Salvatore, Gruden, Gabriella, Galanti, Giorgio, Mascherini, Gabriele, Petri, Cristian, Stefani, Laura, Girino, Margherita, Piccinelli, Valeria, Nasso, Francesco, Gioffrè, Vincenza, DI PASQUALE, MARIA GRAZIA, Scattolin, Giuseppe, Martinelli, Sergio, Turrin, Mauro, Sechi, Leonardo, Catena, Cristina, Colussi, Gianluca, Passariello, Nicola, Rinaldi, Luca, Berti, Franco, Famularo, Giuseppe, Patrizia, Tarsitani, Castello, Roberto, Pasino, Michela, Ceda, Gian Paolo, Maggio, Marcello Giuseppe, Morganti, Simonetta, Artoni, Andrea, Del Giacco, Stefano, Firinu, Davide, Losa, Francesca, Paoletti, Giovanni, Montalto, Giuseppe, Licata, Anna, Malerba, Valentina, Antonino, Lasco, Basile, Giorgio, Antonino, Catalano, Malatino, Lorenzo, Stancanelli, Benedetta, Terranova, Valentina, Di Marca, Salvatore, Mecocci, Patrizia, Ruggiero, Carmelinda, Boccardi, Virginia, Meschi, Tiziana, Lauretani, Fulvio, Ticinesi, Andrea, Minuz, Pietro, Fondrieschi, Luigi, Pirisi, Mario, Fra, Gian Paolo, Sola, Daniele, Porta, Massimo, Riva, Piero, Quadri, Roberto, Scanzi, Giorgio, Mengoli, Caterina, Provini, Stella, Ricevuti, Laura, Simeone, Emilio, Scurti, Rosa, Tolloso, Fabio, Tarquini, Roberto, Valoriani, Alice, Dolenti, Silvia, Vannini, Giulia, Tedeschi, Alberto, Trotta, Lucia, Volpi, Riccardo, Bocchi, Pietro, Vignali, Alessandro, Harari, Sergio, Lonati, Chiara, Cattaneo, Mara, Nieves, Ramirez Duque, Alberto, Muela Molinero, Pedro, Abad Requejo, Vanessa, Lopez Pelaez, Lara, Tamargo, Xavier, Corbella Viros, Francesc, Formiga, Jesus, Diez Manglano, Esperanza, Bejarano Tello, Esther, Del Corral Behamonte, Maria, Sevil Puras, Romero, Manuel, Blanca, Pinilla Llorente, Cristina, Lopez Gonzalez-Cobos, Victoria, Villalba Garcia M., Saez, Lopez, Bosco, Juan, Susana, Sanz Baena, Marta, Arroyo Gallego, Concepcion, Gonzalez Becerra, Antonio, Fernandez Moyano, Hernandez, Mercedes Gomez, Borrego, Manuel Poyato, Raquel, Pacheco Cuadros, Florencia, Perez Rojas, Beatriz, Garcia Olid, Sara, Carrascosa Garcia, Alfonso, Gonzalez-Cruz Cervellera, Marta, Peinado Martinez, Garcia, Sara Carrascosa, Alberto, Ruiz Cantero, Antonio, Albarracín Arraigosa, Montserrat, Godoy Guerrero, Ángel, Barón Ramos Miguel, Manuel, Machin Jose, Ignacio, Novo Veleiro, Lucía, Alvela Suarez, Alfonso, Lopez, David, Rubal Bran, Iria, Iñiguez Vazquez, Monica, Rios Prego, Mannucci, Pier Mannuccio, Nobili, Alessandro, Pasina, Luca, Tettamanti, Mauro, Franchi, Carlotta, Corrao, Salvatore, Marengoni, Alessandra, Salerno, Francesco, Cesari, Matteo, Perticone, Francesco, Licata, Giuseppe, Violi, Francesco, Corazza, Gino Roberto, Cortesi, Laura, Ardoino, Ilaria, Prisco, Domenico, Silvestri, Elena, Cenci, Caterina, Emmi, Giacomo, Biolo, Gianni, Zanetti, Michela, Guadagni, Martina, Zaccari, Michele, Vanoli, Massimo, Grignani, Giulia, Pulixi, Edoardo Alessandro, Bernardi, Mauro, Bassi, Silvia Li, Santi, Luca, Zaccherini, Giacomo, Mannarino, Elmo, Lupattelli, Graziana, Bianconi, Vanessa, Paciullo, Francesco, Nuti, Ranuccio, Valenti, Roberto, Ruvio, Martina, Cappelli, Silvia, Palazzuoli, Alberto, Olivieri, Oliviero, Girelli, Domenico, Matteazzi, Thoma, Barbagallo, Mario, Dominguez, Ligia, Cocita, Floriana, Beneduce, Vincenza, Plances, Lidia, Zoli, Marco, Lazzari, Ilaria, Brunori, Mattia, Pasini, Franco Laghi, Capecchi, Pier Leopoldo, Palasciano, Giuseppe, Modeo, Maria Ester, Di Gennaro, Carla, Cappellini, Maria Domenica, Maira, Diletta, Di Stefano, Valeria, Fabio, Giovanna, Seghezzi, Sonia, Mancarella, Marta, Rossi, Paolo Dionigi, Damanti, Sarah, Clerici, Marta, Conti, Federica, Miceli, Emanuela, Lenti, Marco Vincenzo, Pisati, Martina, Dominioni, Costanza Caccia, Murialdo, Giovanni, Marra, Alessio, Cattaneo, Federico, Secchi, Maria Beatrice, Ghelfi, Davide, Anastasio, Luigi, Sofia, Lucia, Carbone, Maria, Cipollone, Francesco, Guagnano, Maria Teresa, Angelucci, Ermanno, Valeriani, Emanuele, Mancuso, Gerardo, Calipari, Daniela, Bartone, Mosè, Delitala, Giuseppe, Berria, Maria, Muscaritoli, Maurizio, Molfino, Alessio, Petrillo, Enrico, Zuccalà, Giuseppe, D’Aurizio, Gabriella, Romanelli, Giuseppe, Zucchelli, Alberto, Picardi, Antonio, Gentilucci, Umberto Vespasiani, Gallo, Paolo, Dell’Unto, Chiara, Annoni, Giorgio, Corsi, Maurizio, Bellelli, Giuseppe, Zazzetta, Sara, Mazzola, Paolo, Szabo, Hajnalka, Bonfanti, Alessandra, Arturi, Franco, Succurro, Elena, Rubino, Mariangela, Serra, Maria Grazia, Bleve, Maria Antonietta, Gasbarrone, Laura, Sajeva, Maria Rosaria, Brucato, Antonio, Ghidoni, Silvia, Fabris, Fabrizio, Bertozzi, Irene, Bogoni, Giulia, Rabuini, Maria Victoria, Cosi, Elisabetta, Manfredini, Roberto, Fabbian, Fabio, Boari, Benedetta, De Giorgi, Alfredo, Tiseo, Ruana, Paolisso, Giuseppe, Rizzo, Maria Rosaria, Borghi, Claudio, Strocchi, Enrico, De Sando, Valeria, Pareo, Ilenia, Sabbà, Carlo, Vella, Francesco Saverio, Suppressa, Patrizia, Agosti, Pasquale, Schilardi, Andrea, Loparco, Francesca, Fenoglio, Luigi, Bracco, Christian, Giraudo, Alessia Valentina, Fargion, Silvia, Periti, Giulia, Porzio, Marianna, Tiraboschi, Slivia, Peyvandi, Flora, Rossio, Raffaella, Ferrari, Barbara, Colombo, Giulia, Monzani, Valter, Savojardo, Valeria, Folli, Christian, Ceriani, Giuliana, Pallini, Giada, Dallegri, Franco, Ottonello, Luciano, Liberale, Luca, Caserza, Lara, Salam, Kassem, Liberato, Nicola Lucio, Tognin, Tiziana, Bianchi, Giovanni Battista, Giaquinto, Sabrina, Purrello, Francesco, Di Pino, Antonino, Piro, Salvatore, Rozzini, Renzo, Falanga, Lina, Spazzini, Elena, Ferrandina, Camillo, Montrucchio, Giuseppe, Petitti, Paolo, Salmi, Raffaella, Gaudenzi, Piergiorgio, Perri, Ludovica, Landolfi, Raffaele, Montalto, Massimo, Mirijello, Antonio, Guasti, Luigina, Castiglioni, Luana, Maresca, Andrea, Squizzato, Alessandro, Molaro, Marta, Grossi, Alessandra, Bertolotti, Marco, Mussi, Chiara, Libbra, Maria Vittoria, Dondi, Giulia, Pellegrini, Elisa, Carulli, Lucia, Colangelo, Lidia, Falbo, Tania, Stanghellini, Vincenzo, De Giorgio, Roberto, Ruggeri, Eugenio, del Vecchio, Sara, Salvi, Andrea, Leonardi, Roberto, Damiani, Giampaolo, Gabrielli, Armando, Capeci, William, Mattioli, Massimo, Martino, Giuseppe Pio, Biondi, Lorenzo, Pettinari, Pietro, Ghio, Riccardo, Col, Anna Dal, Minisola, Salvatore, Colangelo, Luciano, Afeltra, Antonella, Marigliano, Benedetta, Pipita, Maria Elena, Castellino, Pietro, Blanco, Julien, Zanoli, Luca, Pignataro, Samuele, Saracco, Valter, Fogliati, Marisa, Bussolino, Carlo, Mete, Francesca, Gino, Miriam, Cittadini, Antonio, Vigorito, Carlo, Arcopinto, Michele, Salzano, Andrea, Bobbio, Emanuele, Marra, Alberto Maria, Sirico, Domenico, Moreo, Guido, Gasparini, Francesca, Prolo, Silvia, Pina, Gloria, Ballestrero, Alberto, Ferrando, Fabio, Berra, Sergio, Dassi, Simonetta, Nava, Maria Cristina, Graziella, Bruno, Baldassarre, Stefano, Fragapani, Salvatore, Gruden, Gabriella, Galanti, Giorgio, Mascherini, Gabriele, Petri, Cristian, Stefani, Laura, Girino, Margherita, Piccinelli, Valeria, Nasso, Francesco, Gioffrè, Vincenza, Pasquale, Maria, Scattolin, Giuseppe, Martinelli, Sergio, Turrin, Mauro, Sechi, Leonardo, Catena, Cristina, Colussi, Gianluca, Passariello, Nicola, Rinaldi, Luca, Berti, Franco, Famularo, Giuseppe, Patrizia, Tarsitani, Castello, Roberto, Pasino, Michela, Ceda, Gian Paolo, Maggio, Marcello Giuseppe, Morganti, Simonetta, Artoni, Andrea, Del Giacco, Stefano, Firinu, Davide, Losa, Francesca, Paoletti, Giovanni, Montalto, Giuseppe, Licata, Anna, Malerba, Valentina, Antonino, Lasco, Basile, Giorgio, Antonino, Catalano, Malatino, Lorenzo, Stancanelli, Benedetta, Terranova, Valentina, Di Marca, Salvatore, Mecocci, Patrizia, Ruggiero, Carmelinda, Boccardi, Virginia, Meschi, Tiziana, Lauretani, Fulvio, Ticinesi, Andrea, Minuz, Pietro, Fondrieschi, Luigi, Pirisi, Mario, Fra, Gian Paolo, Sola, Daniele, Porta, Massimo, Riva, Piero, Quadri, Roberto, Scanzi, Giorgio, Mengoli, Caterina, Provini, Stella, Ricevuti, Laura, Simeone, Emilio, Scurti, Rosa, Tolloso, Fabio, Tarquini, Roberto, Valoriani, Alice, Dolenti, Silvia, Vannini, Giulia, Tedeschi, Alberto, Trotta, Lucia, Volpi, Riccardo, Bocchi, Pietro, Vignali, Alessandro, Harari, Sergio, Lonati, Chiara, Cattaneo, Mara, Nieves, Ramirez Duque, Alberto, Muela Molinero, Pedro, Abad Requejo, Vanessa, Lopez Pelaez, Lara, Tamargo, Xavier, Corbella Viro, Francesc, Formiga, Jesus, Diez Manglano, Esperanza, Bejarano Tello, Esther, Del Corral Behamonte, Maria, Sevil Pura, Romero, Manuel, Blanca, Pinilla Llorente, Cristina, Lopez Gonzalez-Cobo, Victoria, Villalba Garcia M., Saez, Lopez, Bosco, Juan, Susana, Sanz Baena, Marta, Arroyo Gallego, Concepcion, Gonzalez Becerra, Antonio, Fernandez Moyano, Hernandez, Mercedes Gomez, Borrego, Manuel Poyato, Raquel, Pacheco Cuadro, Florencia, Perez Roja, Beatriz, Garcia Olid, Sara, Carrascosa Garcia, Alfonso, Gonzalez-Cruz Cervellera, Marta, Peinado Martinez, Garcia, Sara Carrascosa, Alberto, Ruiz Cantero, Antonio, Albarracín Arraigosa, Montserrat, Godoy Guerrero, Ángel, Barón Ramos Miguel, Manuel, Machin Jose, Ignacio, Novo Veleiro, Lucía, Alvela Suarez, Alfonso, Lopez, David, Rubal Bran, Iria, Iñiguez Vazquez, Monica, Rios Prego, Pier Mannuccio Mannucci, Alessandro Nobili, Luca Pasina, REPOSI Collaborators [.., Gino Roberto Corazza, Elena Silvestri, Mauro Bernardi, Silvia Li Bassi, Luca Santi, Giacomo Zaccherini, Marco Zoli, Ilaria Lazzari, Mattia Brunori, Claudio Borghi, Enrico Strocchi, Valeria De Sando, Ilenia Pareo, Vincenzo Stanghellini, Roberto De Giorgio, Eugenio Ruggeri, Sara del Vecchio, ], Mannucci, P, Nobili, A, Pasina, L, Dominguez Rodriguez, L, Barbagallo, M, Licata, A, Tettamanti, M, Franchi, C, Corrao, S, Marengoni, A, Salerno, F, Cesari, M, Perticone, F, Licata, G, Violi, F, Corazza, G, Cortesi, L, Ardoino, I, Prisco, D, Silvestri, E, Cenci, C, Emmi, G, Biolo, G, Zanetti, M, Guadagni, M, Zaccari, M, Vanoli, M, Grignani, G, Pulixi, E, Bernardi, M, Bassi, S, Santi, L, Zaccherini, G, Mannarino, E, Lupattelli, G, Bianconi, V, Paciullo, F, Nuti, R, Valenti, R, Ruvio, M, Cappelli, S, Palazzuoli, A, Olivieri, O, Girelli, D, Matteazzi, T, Dominguez, L, Cocita, F, Beneduce, V, Plances, L, Zoli, M, Lazzari, I, Brunori, M, Pasini, F, Capecchi, P, Palasciano, G, Modeo, M, di Gennaro, C, Cappellini, M, Maira, D, di Stefano, V, Fabio, G, Seghezzi, S, Mancarella, M, Rossi, P, Damanti, S, Clerici, M, Conti, F, Miceli, E, Lenti, M, Pisati, M, Dominioni, C, Murialdo, G, Marra, A, Cattaneo, F, Secchi, M, Ghelfi, D, Anastasio, L, Sofia, L, Carbone, M, Cipollone, F, Guagnano, M, Angelucci, E, Valeriani, E, Mancuso, G, Calipari, D, Bartone, M, Delitala, G, Berria, M, Muscaritoli, M, Molfino, A, Petrillo, E, Zuccala, G, D'Aurizio, G, Romanelli, G, Zucchelli, A, Picardi, A, Gentilucci, U, Gallo, P, Dell'Unto, C, Annoni, G, Corsi, M, Bellelli, G, Zazzetta, S, Mazzola, P, Szabo, H, Bonfanti, A, Arturi, F, Succurro, E, Rubino, M, Serra, M, Bleve, M, Gasbarrone, L, Sajeva, M, Brucato, A, Ghidoni, S, Fabris, F, Bertozzi, I, Bogoni, G, Rabuini, M, Cosi, E, Manfredini, R, Fabbian, F, Boari, B, de Giorgi, A, Tiseo, R, Paolisso, G, Rizzo, M, Borghi, C, Strocchi, E, de Sando, V, Pareo, I, Sabba, C, Vella, F, Suppressa, P, Agosti, P, Schilardi, A, Loparco, F, Fenoglio, L, Bracco, C, Giraudo, A, Fargion, S, Periti, G, Porzio, M, Tiraboschi, S, Peyvandi, F, Rossio, R, Ferrari, B, Colombo, G, Monzani, V, Savojardo, V, Folli, C, Ceriani, G, Pallini, G, Dallegri, F, Ottonello, L, Liberale, L, Caserza, L, Salam, K, Liberato, N, Tognin, T, Bianchi, G, Giaquinto, S, Purrello, F, di Pino, A, Piro, S, Rozzini, R, Falanga, L, Spazzini, E, Ferrandina, C, Montrucchio, G, Petitti, P, Salmi, R, Gaudenzi, P, Perri, L, Landolfi, R, Montalto, M, Mirijello, A, Guasti, L, Castiglioni, L, Maresca, A, Squizzato, A, Molaro, M, Grossi, A, Bertolotti, M, Mussi, C, Libbra, M, Dondi, G, Pellegrini, E, Carulli, L, Colangelo, L, Falbo, T, Stanghellini, V, De Giorgio, R, Ruggeri, E, del Vecchio, S, Salvi, A, Leonardi, R, Damiani, G, Gabrielli, A, Capeci, W, Mattioli, M, Martino, G, Biondi, L, Pettinari, P, Ghio, R, Col, A, Minisola, S, Afeltra, A, Marigliano, B, Pipita, M, Castellino, P, Blanco, J, Zanoli, L, Pignataro, S, Saracco, V, Fogliati, M, Bussolino, C, Mete, F, Gino, M, Cittadini, A, Vigorito, C, Arcopinto, M, Salzano, A, Bobbio, E, Sirico, D, Moreo, G, Gasparini, F, Prolo, S, Pina, G, Ballestrero, A, Ferrando, F, Berra, S, Dassi, S, Nava, M, Graziella, B, Baldassarre, S, Fragapani, S, Gruden, G, Galanti, G, Mascherini, G, Petri, C, Stefani, L, Girino, M, Piccinelli, V, Nasso, F, Gioffre, V, Pasquale, M, Scattolin, G, Martinelli, S, Turrin, M, Sechi, L, Catena, C, Colussi, G, Passariello, N, Rinaldi, L, Berti, F, Famularo, G, Patrizia, T, Castello, R, Pasino, M, Ceda, G, Maggio, M, Morganti, S, Artoni, A, Giacco, S, Firinu, D, Losa, F, Paoletti, G, Montalto, G, Malerba, V, Antonino, L, Basile, G, Antonino, C, Malatino, L, Stancanelli, B, Terranova, V, di Marca, S, Mecocci, P, Ruggiero, C, Boccardi, V, Meschi, T, Lauretani, F, Ticinesi, A, Minuz, P, Fondrieschi, L, Pirisi, M, Fra, G, Sola, D, Porta, M, Riva, P, Quadri, R, Scanzi, G, Mengoli, C, Provini, S, Ricevuti, L, Simeone, E, Scurti, R, Tolloso, F, Tarquini, R, Valoriani, A, Dolenti, S, Vannini, G, Tedeschi, A, Trotta, L, Volpi, R, Bocchi, P, Vignali, A, Harari, S, Lonati, C, Cattaneo, M, Nieves, R, Alberto, M, Pedro, A, Vanessa, L, Lara, T, Xavier, C, Francesc, F, Jesus, D, Esperanza, B, Esther, D, Maria, S, Romero, M, Blanca, P, Cristina, L, Victoria, V, Saez, L, Bosco, J, Susana, S, Marta, A, Concepcion, G, Antonio, F, Hernandez, M, Borrego, M, Raquel, P, Florencia, P, Beatriz, G, Sara, C, Alfonso, G, Marta, P, Garcia, S, Alberto, R, Antonio, A, Montserrat, G, Angel, B, Manuel, M, Ignacio, N, Lucia, A, Alfonso, L, David, R, Iria, I, Monica, R, DI PASQUALE, MARIA GRAZIA, di Gennaro, Carla, di Stefano, Valeria, de Giorgi, Alfredo, de Sando, Valeria, di Pino, Antonino, Giacco, Stefano Del, and di Marca, Salvatore

Subjects
Male, medicine.medical_specialty, Population ageing, Deprescribing, Inappropriate prescription, Medication reconciliation, Multimorbidity, Polypharmacy, Population, Socio-culturale, 030204 cardiovascular system & hematology, 03 medical and health sciences, 0302 clinical medicine, Risk Factors, 80 and over, Internal Medicine, Emergency Medicine, medicine, Deprescribing, Inappropriate prescription, Medication reconciliation, Multimorbidity, Polypharmacy, Humans, Registries, 030212 general & internal medicine, Medical prescription, Adverse effect, education, Aged, Aged, 80 and over, Geriatrics, education.field_of_study, business.industry, Patient Discharge, Hospitalization, Female, Italy, Family medicine, business
Abstract

As a consequence of population aging, we have witnessed in internal medicine hospital wards a progressive shift from a population of in-patients relatively young and mainly affected by a single ailment to one of ever older and more and more complex patients with multiple chronic diseases, followed as out-patients by many different specialists with poor integration andinevitably treated with multiple medications. Polypharmacy (defined as the chronic intake of five or more drugs) is associated with increased risks of drug-drug interactions and related adverse effects, prescription and intake errors, poor compliance, re-hospitalization and mortality. With this background, the Italian Society of Internal Medicine chose to start in 2008 a prospective register called REPOSI (REgistro POliterapie SIMI, Società Italiana di Medicina Interna) in internal medicine and geriatric hospital wards. The country wide register is an ongoing observatory on multimorbidity and polypharmacy in the oldest old, with the goal to improve prescription appropriateness and, thus to avoid potentially inappropriate medications. The main findings of the register, that has accrued so far, 7005 older patients throughout a 10year period, are summarized herewith, with special emphasis on the main patterns of poor prescription appropriateness and related risks of adverse events.

Published
2018
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12. The PDE4 inhibitor tanimilast shows distinct immunomodulatory properties associated with a type 2 endotype and CD141 upregulation

Author

Nguyen, Hoang Oanh, primary, Salvi, Valentina, additional, Tiberio, Laura, additional, Facchinetti, Fabrizio, additional, Govoni, Mirco, additional, Villetti, Gino, additional, Civelli, Maurizio, additional, Barbazza, Ilaria, additional, Gaudenzi, Carolina, additional, Passari, Mauro, additional, Schioppa, Tiziana, additional, Sozio, Francesca, additional, Del Prete, Annalisa, additional, Sozzani, Silvano, additional, and Bosisio, Daniela, additional

Published
2022
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13. There Is a Great Future in Plastics: Personalized Approach to the Management of Hilar Cholangiocarcinoma Using a 3-D-Printed Liver Model

Author

Quirino Lai, Paolo Gaudenzi, Simone Novelli, Gianluca Mennini, Zoe Larghi Laureiro, Raj Mookarje, Vito D'Andrea, Franco Marinozzi, Massimo Rossi, Dimitri A. Raptis, Rajiv Jalan, and Cornelius Engelmann

Subjects
Adult, Models, Anatomic, medicine.medical_specialty, Physiology, Portal vein, Surgical planning, Klatskin tumor, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, medicine, Humans, Precision Medicine, Thrombus, 3-D printing, Thrombosis, business.industry, Gastroenterology, Hepatology, medicine.disease, Surgical training, Bile Duct Neoplasms, 030220 oncology & carcinogenesis, Printing, Three-Dimensional, Main portal vein, Female, 030211 gastroenterology & hepatology, Radiology, business, Vascular Surgical Procedures
Abstract

In recent years, three-dimensional (3-D) printing technology has become a standard tool that is used in several medical applications such as education, surgical training simulation and planning, and doctor-patient communication. Although liver surgery is ideally complemented by the use of preoperative 3-D-printed models, only a few publications have addressed this topic. We report the case of a 29-year-old Caucasian woman admitted for a Klatskin tumor infiltrating the right portal vein requiring surgery that required complex vascular reconstruction. A life-sized liver model with colorful plastic vessels and realistic looking tumor was created with the aim of planning an optimal surgical approach. According to the 3-D model, we performed a right hepatic trisectionectomy, also removing enbloc the tract of portal vein encased by the tumor and the neoplastic thrombus, followed by a complex vascular reconstruction between the main portal vein and the left portal branch. After 22 months of follow-up, the patient was alive and continuing chemotherapy. The use of the 3-D models in liver surgery helps clarify several useful preoperative issues. The accuracy of the model regarding anatomical findings was high. In the case of complex vascular reconstruction strategies, rational use of 3-D printing technology should be implemented.

Published
2020
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15. Analytical Prediction of High-Velocity Impact Resistance of Plane and Curved Thin Composite Targets

Author

Paolo Gaudenzi and Michele Pasquali

Subjects
Work (thermodynamics), Materials science, Plane (geometry), Composite number, Perforation (oil well), Mechanical engineering, Curvature, Principal curvature, curvature, Electromagnetic shielding, Ballistic limit, Pharmacology (medical), composite targets, high-velocity impacts
Abstract

Resistance to ballistic impacts is a key requirement for an effective use of composite structures in many engineering applications. In fact, when fiber-reinforced composites are subject to high-velocity impacts (HVI), they are likely to suffer complete perforation, eventually causing the dramatic failure of the overall system. Moreover, elements with shielding requirements often feature nontrivial curvatures, so that their use in many engineering applications must undergo a precise evaluation of the effects of curvature on their resistance to impacts. The objective of the present work is to present an analytic formulation to model high-velocity impacts on both plane and curved (cylindrical and spherical) thin woven fabric composite targets, relying on the geometric and the elastodynamic characteristics of the target.

Published
2019
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17. Introduction of direct oral anticoagulant within 7 days of stroke onset: a nomogram to predict the probability of 3-month modified Rankin Scale score > 2

Author

Carolina Gentile, Anna Gaudenzi, Alessandro Adami, Bruno Bonetti, Nicola Micheletti, Gianni Turcato, Roberto Eleopra, Giovanni Merlino, Manuel Cappellari, Sandro Bruno, Monia Russo, Paolo Bovi, Roberto L’Erario, Giampaolo Tomelleri, and Stefano Forlivesi

Subjects
Male, medicine.medical_specialty, Time Factors, 030204 cardiovascular system & hematology, Logistic regression, Severity of Illness Index, Nomogram, law.invention, Direct oral anticoagulants, 03 medical and health sciences, 0302 clinical medicine, Randomized controlled trial, Risk Factors, Modified Rankin Scale, law, Internal medicine, Atrial Fibrillation, medicine, Humans, Prospective Studies, cardiovascular diseases, Prospective cohort study, Stroke, Outcome, Aged, Aged, 80 and over, Receiver operating characteristic, business.industry, Anticoagulants, Atrial fibrillation, Hematology, Middle Aged, Prognosis, medicine.disease, Nomograms, Treatment Outcome, ROC Curve, Cardiology, Female, Cardiology and Cardiovascular Medicine, business, 030217 neurology & neurosurgery
Abstract

In clinical practice, direct oral anticoagulants (DOACs) are often started earlier (≤ 7 days) than in randomized clinical trials after stroke. We aimed to develop a nomogram model incorporating time of DOAC introduction ≤ 7 days of stroke onset in combination with different degrees of stroke radiological/neurological severity at the time of treatment to predict the probability of unfavorable outcome. We conducted a multicenter prospective study including 344 patients who started DOAC 1–7 days after atrial fibrillation-related stroke onset. Computed tomography scan 24–36 h after stroke onset was performed in all patients before starting DOAC. Unfavorable outcome was defined as modified Rankin Scale (mRS) score > 2 at 3 months. Based on multivariate logistic model, the nomogram was generated. We assessed the discriminative performance by using the area under the receiver operating characteristic curve (AUC–ROC) and calibration of risk prediction model by using the Hosmer–Lemeshow test. Onset-to-treatment time for DOAC (OR: 1.21, p = 0.030), NIH Stroke Scale (NIHSS) score at the time of treatment (OR: 1.00 for NIHSS = 0–5; OR: 2.67, p = 0.016 for NIHSS = 6–9; OR: 26.70, p

Published
2018
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18. Piezoelectric thermo electromechanical energy harvester for reconnaissance satellite structure

Author

Madiha Gul, Paolo Gaudenzi, Hassan Elahi, R. F. Swati, and Marco Eugeni

Subjects
010302 applied physics, Materials science, business.industry, electronic, Electric potential energy, Mechanical engineering, 02 engineering and technology, 021001 nanoscience & nanotechnology, Condensed Matter Physics, 01 natural sciences, Piezoelectricity, Electronic, Optical and Magnetic Materials, Electricity generation, Hardware and Architecture, 0103 physical sciences, electronic, optical and magnetic materials, condensed matter physics, hardware and architecture, electrical and electronic engineering, optical and magnetic materials, Electronics, Electrical and Electronic Engineering, 0210 nano-technology, business, Energy (signal processing), Thermal energy, Electronic circuit, Voltage
Abstract

Piezoelectric materials are widely used in aerospace industry as a source of alternate energy for micro or nanoscale electronics because of voltage dependent actuation ability. This phenomena is of absolute importance in cubic reconnaissance satellites as they have maximum number of piezoelectric patches integrated in structure. In this research work, PZT patches in the satellite structure absorbs the mechanical and thermal energy from external environment as well as from internal fluctuations and convert them into electrical energy. This electrical energy can be utilized on the spot or can be stored in batteries for wireless sensors. The experimental setup and electronic circuit is designed in order to mimic the real time conditions based on direct effect of piezoelectricity. The effect of energy generation with respect to fatigue mechanical loading condition is analyzed based on equivalent circuit method. A numerical simulation model based on commercial software ABAQUS Standard has been developed. The developed model has predicted the experimental outcome with less than $$3\%$$ error. The analytical results are in good agreement with experimental as well as with numerical calculations with less than $$5\%$$ error. The maximum output energy obtained in this study is 0.8 nJ.

Published
2018
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19. Stroke management during the coronavirus disease 2019 (COVID-19) pandemic: experience from three regions of the north east of Italy (Veneto, Friuli-Venezia-Giulia, Trentino-Alto-Adige)

Author

Manganotti, Paolo, primary, Naccarato, Marcello, additional, Scali, Ilario, additional, Cappellari, Manuel, additional, Bonetti, Bruno, additional, Burlina, Alessandro, additional, Turinese, Emanuele, additional, Bogo, Sabrina, additional, Teatini, Francesco, additional, Franchini, Enrica, additional, Caneve, Giorgio, additional, Ruzza, Giampietro, additional, Gaudenzi, Anna, additional, Bombardi, Roberto, additional, Bozzato, Giulio, additional, Padoan, Roberta, additional, Gentile, Carolina, additional, Rana, Michele, additional, Turazzini, Michelangelo, additional, Alessandra, Danese, additional, Brigo, Francesco, additional, Nardone, Raffaele, additional, Quatrale, Rocco, additional, Menegazzo, Elisabetta, additional, Masato, Maela, additional, Novello, Stefano, additional, Passadore, Paolo, additional, Baldi, Antonio, additional, Valentinis, Luca, additional, Baracchini, Claudio, additional, Pieroni, Alessio, additional, Basile, Anna Maria, additional, Semplicini, Claudio, additional, Piffer, Silvio, additional, Giometto, Bruno, additional, Tonello, Simone, additional, Bonifatti, Domenico Marco, additional, Lorenzut, Simone, additional, Merlino, Giovanni, additional, Valente, Maria Rosaria, additional, Paladin, Francesco, additional, Tonon, Agnese, additional, de Luca, Cristina, additional, Perini, Francesco, additional, Centonze, Sandro, additional, and Bovi, Paolo, additional

Published
2021
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21. There Is a Great Future in Plastics: Personalized Approach to the Management of Hilar Cholangiocarcinoma Using a 3-D-Printed Liver Model

Author

Larghi Laureiro, Zoe, primary, Novelli, Simone, additional, Lai, Quirino, additional, Mennini, Gianluca, additional, D’andrea, Vito, additional, Gaudenzi, Paolo, additional, Marinozzi, Franco, additional, Engelmann, Cornelius, additional, Mookarje, Raj, additional, Raptis, Dimitri, additional, Rossi, Massimo, additional, and Jalan, Rajiv, additional

Published
2020
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22. Acute revascularization treatments for ischemic stroke in the Stroke Units of Triveneto, northeast Italy: time to treatment and functional outcomes

Author

Cappellari, Manuel, primary, Bonetti, Bruno, additional, Forlivesi, Stefano, additional, Sajeva, Giulia, additional, Naccarato, Marcello, additional, Caruso, Paola, additional, Lorenzut, Simone, additional, Merlino, Giovanni, additional, Viaro, Federica, additional, Pieroni, Alessio, additional, Giometto, Bruno, additional, Bignamini, Valeria, additional, Perini, Francesco, additional, De Boni, Antonella, additional, Morra, Michele, additional, Critelli, Adriana, additional, Tamborino, Carmine, additional, Tonello, Simone, additional, Guidoni, Silvia Vittoria, additional, L’Erario, Roberto, additional, Russo, Monia, additional, Burlina, Alessandro, additional, Turinese, Emanuele, additional, Passadore, Paolo, additional, Zanet, Luca, additional, Polo, Alberto, additional, Turazzini, Michelangelo, additional, Basile, Anna Maria, additional, Atzori, Matteo, additional, Marini, Bruno, additional, Bruno, Martina, additional, Carella, Simona, additional, Campagnaro, Alessandro, additional, Baldi, Antonio, additional, Corazza, Elisa, additional, Zanette, Giampietro, additional, Idone, Domenico, additional, Gaudenzi, Anna, additional, Bombardi, Roberto, additional, Cadaldini, Morena, additional, Lanzafame, Salvatore, additional, Ferracci, Franco, additional, Zambito, Sandro, additional, Ruzza, Giampietro, additional, Simonetto, Marco, additional, Menegazzo, Elisabetta, additional, Masato, Maela, additional, Padoan, Roberta, additional, Bozzato, Giulio, additional, Paladin, Francesco, additional, Tonon, Agnese, additional, and Bovi, Paolo, additional

Published
2020
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23. Irradiation-induced changes in neural progenitor cells are reversed by lithium: Immature newborn dentate granule neurons display dendritic processes that are either tangential or parallel to the granule cell layer of the dentate gyrus of the hippocampus

Author

Antonios Stamatakis, Adamantia F. Fragopoulou, Klas Blomgren, Cecilia A. Dominguez, Giulia Gaudenzi, Ola Hermanson, Paula Merino-Serrais, Elena Di Martino, Angel Cedazo-Minguez, Giulia Zanni, Shinobu Goto, Olga Dethlefsen, Vinogran Naidoo, and Gabriel Levy

Subjects
Lithium (medication), Chemistry, Dentate gyrus, Granule (cell biology), Hippocampus, Granule cell, Neural stem cell, Cell biology, Cellular and Molecular Neuroscience, Psychiatry and Mental health, medicine.anatomical_structure, medicine, Irradiation, Molecular Biology, Layer (electronics), medicine.drug
Published
2021
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24. Effects of variable resistance on smart structures of cubic reconnaissance satellites in various thermal and frequency shocking conditions

Author

Paolo Gaudenzi, Asif Israr, Zubair Butt, Marco Eugnei, and Hassan Elahi

Subjects
Engineering, Satellites, Acoustics, Inverse, Mechanical engineering, 02 engineering and technology, Smart material, Lead zirconate titanate, Cubic reconnaissance, 01 natural sciences, Thermal shocking, chemistry.chemical_compound, 0103 physical sciences, Thermal, 010302 applied physics, business.industry, Frequency shocking, Smart structure, Mechanics of Materials, Mechanical Engineering, Variable resistance, 021001 nanoscience & nanotechnology, Piezoelectricity, chemistry, Physics::Space Physics, Equivalent circuit method, 0210 nano-technology, business, Voltage
Abstract

Piezoelectric materials are widely used as smart structures in cubic reconnaissance satellites because of their sensing, actuating, and energy-harvesting abilities. In this study, an analytical model is developed in specific mechanical thermal shocking conditions. A special circuit and apparatus is designed for experimentation on the basis of the inverse piezoelectric effect. An equivalent circuit method is used to establish the relationship between the resistance and peak-to-peak voltage of lead zirconate titanate used as smart materials for cubic reconnaissance satellites. Various frequencies and resistance were applied in different mechanical thermal shocking conditions. Moreover, numerical simulations are conducted in various mechanical loading conditions to determine the accumulative effect. The model provides a novel mechanism to characterize the smart structures in cubic reconnaissance satellites. A rise in temperature increases peak-to-peak voltage; a rise in frequency decreases peak-to-peak voltage; and intensified resistance decreases peak-to-peak voltage. Based on experimentation and simulation, the optimum resistance is predicted for the various frequencies and temperatures. The various conditions may correspond to the different applications of smart structures for cubic reconnaissance satellites. The analytical calculations are in good agreement with experimental and numerical calculations.

Published
2017
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25. The cAMP analogs have potent anti-proliferative effects on medullary thyroid cancer cell lines

Author

Giovanni Vitale, Maria Orietta Borghi, Elisa Stellaria Grassi, Leo J. Hofland, Germano Gaudenzi, Michele Caraglia, Luca Persani, Alessandra Dicitore, Internal Medicine, Dicitore, Alessandra, Grassi, Elisa Stellaria, Caraglia, Michele, Borghi, Maria Orietta, Gaudenzi, Germano, Hofland, Leo J., Persani, Luca, and Vitale, Giovanni

Subjects
0301 basic medicine, 2-Chloroadenosine, Endocrinology, Diabetes and Metabolism, Cell, 8-Bromo Cyclic Adenosine Monophosphate, Apoptosis, Proto-Oncogene Mas, Antineoplastic Agent, chemistry.chemical_compound, Endocrinology, Piperidines, Annexin, Cyclic AMP, Amines, Thyroid Neoplasm, education.field_of_study, Medullary thyroid cancer, Cell Cycle, Cell cycle, medicine.anatomical_structure, Cyclic AMP-Dependent Protein Kinase, Human, medicine.medical_specialty, MAP Kinase Signaling System, Population, Antineoplastic Agents, Biology, 03 medical and health sciences, Piperidine, SDG 3 - Good Health and Well-being, Cell Line, Tumor, Internal medicine, medicine, Humans, Thyroid Neoplasms, Propidium iodide, Protein kinase A, education, Amine, Cell Proliferation, Apoptosi, cAMP-dependent protein kinase A (PKA) pathway, Cyclic AMP-Dependent Protein Kinases, Molecular biology, cAMP analog, Carcinoma, Neuroendocrine, 030104 developmental biology, chemistry, Cell culture
Abstract

The oncogenic activation of the rearranged during transfection (RET) proto-oncogene has a main role in the pathogenesis of medullary thyroid cancer (MTC). Several lines of evidence suggest that RET function could be influenced by cyclic AMP (cAMP)-dependent protein kinase A (PKA) activity. We evaluated the in vitro anti-tumor activity of 8-chloroadenosine-3',5'-cyclic monophosphate (8-Cl-cAMP) and PKA type I-selective cAMP analogs [equimolar combination of the 8-piperidinoadenosine-3',5'-cyclic monophosphate (8-PIP-cAMP) and 8-hexylaminoadenosine-3',5'-cyclic monophosphate (8-HA-cAMP) in MTC cell lines (TT and MZ-CRC-1)]. 8-Cl-cAMP and the PKA I-selective cAMP analogs showed a potent anti-proliferative effect in both cell lines. In detail, 8-Cl-cAMP blocked significantly the transition of TT cell population from G2/M to G0/G1 phase and from G0/G1 to S phase and of MZ-CRC-1 cells from G0/G1 to S phase. Moreover, 8-Cl-cAMP induced apoptosis in both cell lines, as demonstrated by FACS analysis for annexin V-FITC/propidium iodide, the activation of caspase-3 and PARP cleavage. On the other hand, the only effect induced by PKA I-selective cAMP analogs was a delay in G0/G1-S and S-G2/M progression in TT and MZ-CRC-1 cells, respectively. In conclusion, these data demonstrate that cAMP analogs, particularly 8-Cl-cAMP, significantly suppress in vitro MTC proliferation and provide rationale for a potential clinical use of cAMP analogs in the treatment of advanced MTC.

Published
2015
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26. Patient-derived xenograft in zebrafish embryos: a new platform for translational research in neuroendocrine tumors

Author

Alessandra Dicitore, Manuela Albertelli, Germano Gaudenzi, Tullio Florio, Diego Ferone, Roberto Würth, Franco Cotelli, Federica Barbieri, Giovanni Vitale, Federico Gatto, and Luca Persani

Subjects
Adult, Male, 0301 basic medicine, Pathology, medicine.medical_specialty, animal structures, Angiogenesis, Endocrinology, Diabetes and Metabolism, Primary Cell Culture, Cell, Drug Evaluation, Preclinical, Neuroendocrine tumors, Green fluorescent protein, Translational Research, Biomedical, 03 medical and health sciences, 0302 clinical medicine, Endocrinology, In vivo, medicine, Animals, Humans, Zebrafish, Aged, Patient-derived xenografts, Neovascularization, Pathologic, biology, Venous plexus, Middle Aged, biology.organism_classification, medicine.disease, Diabetes and Metabolism, Neuroendocrine Tumors, 030104 developmental biology, medicine.anatomical_structure, 030220 oncology & carcinogenesis, Heterografts, Female, Immortalised cell line, Neoplasm Transplantation
Abstract

Preclinical research on neuroendocrine tumors usually involves immortalized cell lines and few animal models. In the present study we described an in vivo model based on patient-derived xenografts of neuroendocrine tumor cells in zebrafish (Danio rerio) embryos, allowing a rapid analysis of the angiogenic and invasive potential. Patient-derived neuroendocrine tumor cells were transplanted in 48 hours post-fertilization Tg(fli1a:EGFP) y1 zebrafish embryos that express enhanced green fluorescent protein in the entire vasculature. Neuroendocrine tumor cells, stained with CM-Dil, were injected into the subperidermal (perivitelline) space, close to the developing subintestinal venous plexus. A proper control group, represented by zebrafish injected with only D-PBS, was included in this study. Angiogenic and invasive potentials of each patient-derived xenograft were evaluated by both epifluorescence and confocal microscopes. Six out of eight neuroendocrine tumor samples were successfully transplanted in zebrafish embryos. Although the implanted tumor mass had a limited size (about 100 cells for embryos), patient-derived xenografts showed pro-angiogenic (5 cases) and invasive (6 cases) behaviors within 48 hours post injection. Patient-derived xenograft in zebrafish embryos appears to be a reliable in vivo preclinical model for neuroendocrine tumors, tumors with often limited cell availability. The rapidity of this procedure makes our model a promising platform to perform preclinical drug screening and opens a new scenario for personalized treatment in patients with neuroendocrine tumors.

Published
2016
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27. Lithium treatment reverses irradiation-induced changes in rodent neural progenitors and rescues cognition

Author

Zanni, Giulia, primary, Goto, Shinobu, additional, Fragopoulou, Adamantia F., additional, Gaudenzi, Giulia, additional, Naidoo, Vinogran, additional, Di Martino, Elena, additional, Levy, Gabriel, additional, Dominguez, Cecilia A., additional, Dethlefsen, Olga, additional, Cedazo-Minguez, Angel, additional, Merino-Serrais, Paula, additional, Stamatakis, Antonios, additional, Hermanson, Ola, additional, and Blomgren, Klas, additional

Published
2019
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32. Oxygen-Rich Cool Stars in the Cepheus Region. New Observations. III

Author

Roberto Nesci, Gohar V. Petrosyan, S. Gaudenzi, and Corinne Rossi

Subjects
Physics, media_common.quotation_subject, FOS: Physical sciences, Astronomy and Astrophysics, Astrophysics, Stellar classification, Light curve, Spectral line, Photometry (optics), Stars, Astrophysics - Solar and Stellar Astrophysics, Sky, Solar and Stellar Astrophysics, Oxygen rich, Solar and Stellar Astrophysics (astro-ph.SR), media_common
Abstract

We present moderate resolution CCD spectra and R photometry for seven KP2001 stars. We revised the spectral classification of the stars in the range 3900 - 8500 A. On the bases of light curves of the NSVS (Northern Sky Variability Survey) database we classify KP2001-18 as a semi regular and KP2001-176 as Mira type variables. For all observed objects NSVS phase - dependence light curve analysis and variability type classification was performed with the VStar Software. Using period luminosity relation we computed MK magnitudes and the distances to variables., Comment: Nine pages, six figures, in press on Astrophysics (Astrofizika)

Published
2015
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33. Managing Reputational Risk: Insights from an European Survey

Author

Barbara Gaudenzi, Martin Christopher, and Ilenia Confente

Subjects
business.industry, Strategy and Management, Best practice, media_common.quotation_subject, Specific risk, Financial risk management, REPUTATIONAL risk, Reputational risk, RISK assessment, MANUFACTURING industries, QUESTIONNAIRES, IT risk management, Business and International Management, Marketing, business, Risk assessment, Risk management, Reputation, media_common
Abstract

It could be argued that the management of reputational risk should be a key business priority. Yet despite recognition in previous studies that the risk related to reputation is critical, concrete reputational risk management approaches remain poorly developed. This paper presents a theoretical framework with the key steps for companies to become more aware of reputational risk and to protect themselves from it. In addition, the authors describe companies’ perceptions of risks and reputation issues. A questionnaire-based survey focused on risks and reputation issues was conducted among a sample of experts in risk management working for international manufacturing and service firms. Results show that while reputational risk is considered to be critical, in practice there is no particular attention assigned to specific risk sources that might affect reputation.

Published
2015
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35. Intravenous thrombolysis for ischemic stroke in the Veneto region: the gap between eligibility and reality

Author

Forlivesi, Stefano, primary, Cappellari, Manuel, additional, Baracchini, Claudio, additional, Viaro, Federica, additional, Critelli, Adriana, additional, Tamborino, Carmine, additional, Tonello, Simone, additional, Guidoni, Silvia Vittoria, additional, Bruno, Martina, additional, Favaretto, Silvia, additional, Burlina, Alessandro, additional, Turinese, Emanuele, additional, Ferracci, Franco, additional, Zambito Marsala, Sandro, additional, Bazzano, Salvatrice, additional, Orlando, Federica, additional, Turazzini, Michelangelo, additional, Ricci, Silvia, additional, Cadaldini, Morena, additional, De Biasia, Floriana, additional, Bruno, Sandro, additional, Gaudenzi, Anna, additional, Morra, Michele, additional, Danese, Alessandra, additional, L’Erario, Roberto, additional, Russo, Monia, additional, Zanette, Giampietro, additional, Idone, Domenico, additional, Basile, Anna Maria, additional, Atzori, Matteo, additional, Masato, Maela, additional, Menegazzo, Elisabetta, additional, Paladin, Francesco, additional, Tonon, Agnese, additional, Caneve, Giorgio, additional, Bozzato, Giulio, additional, Campagnaro, Alessandro, additional, Carella, Simona, additional, Nicolao, Piero, additional, Padoan, Roberta, additional, Perini, Francesco, additional, De Boni, Antonella, additional, Adami, Alessandro, additional, Bonetti, Bruno, additional, and Bovi, Paolo, additional

Published
2018
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36. A Preliminary Design of a Mission to Triton: A Concurrent Engineering Approach

Author

Pollice, L., primary, Cascioli, G., additional, Federici, L., additional, Iannelli, P., additional, Di Stefano, I., additional, Ciallella, M., additional, Casini, S., additional, De Gasperis, S., additional, Corallo, F., additional, Rasoni, C. A., additional, Filice, V., additional, Eugeni, M., additional, Palermo, G., additional, and Gaudenzi, P., additional

Published
2018
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37. Introduction of direct oral anticoagulant within 7 days of stroke onset: a nomogram to predict the probability of 3-month modified Rankin Scale score > 2

Author

Cappellari, Manuel, primary, Turcato, Gianni, additional, Forlivesi, Stefano, additional, Micheletti, Nicola, additional, Tomelleri, Giampaolo, additional, Bonetti, Bruno, additional, Merlino, Giovanni, additional, Eleopra, Roberto, additional, Russo, Monia, additional, L’Erario, Roberto, additional, Adami, Alessandro, additional, Gentile, Carolina, additional, Gaudenzi, Anna, additional, Bruno, Sandro, additional, and Bovi, Paolo, additional

Published
2018
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42. Feasibility Study of a Vega Launched Geostationary Communication Satellite

Author

S. Atek, Paolo Gaudenzi, and Gilbert Fanchini

Subjects
Engineering, Electrically powered spacecraft propulsion, business.industry, Geostationary orbit, Communications satellite, Vega, Orbit (dynamics), Pharmacology (medical), Satellite, Orbital maneuver, Telecommunications, business, Geocentric orbit
Abstract

This paper covers an analysis on the use of a hybrid propulsion system for the Low Earth Orbits to Geostationary Orbit transfer, while addressing issues related to the environment encountered during the orbit raising. This feasibility study is based on the proposal [1] by La Sapienza for a compact and efficient telecommunications satellite, compatible with a launch of the Vega space transport system and characterized by the use of electric propulsion for the orbital transfer. The idea of a Vega compatible telecommunications satellite mission falls within the lines of re-launch of satellite telecommunications programs by the Italian Space Agency with missions already under development and with a view to enhance and strengthen the domestic industry and the systemic capabilities already pride of the country. In addition, the synergy with the Vega launcher, and its potential developments, encourage developments of great interest for the role of Europe in the launch activities, extending its potentials.

Published
2013
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43. An evolutionary recent neuroepithelial cell adhesion function of huntingtin implicates ADAM10-Ncadherin

Author

Marzia Tartari, Valentina Lo Sardo, Binia Drung, James A. Walker, Franco Cotelli, Barbara Vitali, Catarina Ramos, Scott Zeitlin, Anna Pistocchi, Elena Cattaneo, Germano Gaudenzi, Marta Valenza, Boris Schmidt, Luciano Conti, Chiara Zuccato, James F. Gusella, and Michael A. Myre

Subjects
Embryo, Nonmammalian, Huntingtin, animal diseases, Cellular differentiation, Neuroepithelial Cells, Apoptosis, Hydroxamic Acids, Cerebral Ventricles, Animals, Genetically Modified, Discs Large Homolog 1 Protein, Nestin, ADAM10 Protein, Mice, Intermediate Filament Proteins, Dictyostelium, RNA, Small Interfering, Zebrafish, Cells, Cultured, Neurons, Genetics, Huntingtin Protein, biology, General Neuroscience, Brain, Gene Expression Regulation, Developmental, Nuclear Proteins, Cell Differentiation, Dipeptides, Cadherins, Biological Evolution, Neuroepithelial cell, Drosophila melanogaster, congenital, hereditary, and neonatal diseases and abnormalities, Morpholines, Green Fluorescent Proteins, Nerve Tissue Proteins, Wnt1 Protein, Transfection, mental disorders, Cell Adhesion, Animals, Immunoprecipitation, Hedgehog Proteins, Cell adhesion, Embryonic Stem Cells, Body Patterning, Analysis of Variance, Tissue Inhibitor of Metalloproteinase-1, PAX2 Transcription Factor, Membrane Proteins, Zebrafish Proteins, Embryo, Mammalian, biology.organism_classification, nervous system diseases, ADAM Proteins, NFI Transcription Factors, Neurulation, nervous system, Mutation, Amyloid Precursor Protein Secretases, Guanylate Kinases
Abstract

The Huntington's disease gene product, huntingtin, is indispensable for neural tube formation, but its role is obscure. We studied neurulation in htt-null embryonic stem cells and htt-morpholino zebrafish embryos and found a previously unknown, evolutionarily recent function for this ancient protein. We found that htt was essential for homotypic interactions between neuroepithelial cells; it permitted neurulation and rosette formation by regulating metalloprotease ADAM10 activity and Ncadherin cleavage. This function was embedded in the N terminus of htt and was phenocopied by treatment of htt knockdown zebrafish with an ADAM10 inhibitor. Notably, in htt-null cells, reversion of the rosetteless phenotype occurred only with expression of evolutionarily recent htt heterologues from deuterostome organisms. Conversely, all of the heterologues that we tested, including htt from Drosophila melanogaster and Dictyostelium discoideum, exhibited anti-apoptotic activity. Thus, anti-apoptosis may have been one of htt’s ancestral function(s), but, in deuterostomes, htt evolved to acquire a unique regulatory activity for controlling neural adhesion via ADAM10-Ncadherin, with implications for brain evolution and development.

Published
2012
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44. Author Correction: Quantum Landauer erasure with a molecular nanomagnet

Author

Fernando Luis, H. S. J. van der Zant, Enrique Burzurí, Rocco Gaudenzi, and Satoru Maegawa

Subjects
Physics, Quantum mechanics, 0103 physical sciences, Key (cryptography), General Physics and Astronomy, Erasure, 010306 general physics, 01 natural sciences, Nanomagnet, Quantum, 010305 fluids & plasmas
Abstract

In the version of this Letter originally published, the key to the green and open circles in Fig. 4 was reversed; it should have shown that the green circles correspond to ‘From χ versus T’ and the open circles correspond to ‘From χ versus H y ’. This has now been corrected in all versions of the Letter.

Published
2018
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45. Oxygen and carbon rich cool stars in the Cepheus region: classification of selected objects from KP2001 catalogue. I

Author

Gohar V. Petrosyan, Corinne Rossi, S. Sclavi, Roberto Nesci, and S. Gaudenzi

Subjects
stars, Physics, Absolute magnitude, variability, media_common.quotation_subject, distances, Astrophysics::Instrumentation and Methods for Astrophysics, Astronomy, Astronomy and Astrophysics, Astrophysics::Cosmology and Extragalactic Astrophysics, Astrophysics, Stellar classification, Light curve, absolute magnitudes, Carbon star, Spectral line, Photometry (optics), stars: spectral classification: variability: absolute magnitudes: distances, Stars, Sky, Astrophysics::Solar and Stellar Astrophysics, spectral classification, Astrophysics::Galaxy Astrophysics, media_common
Abstract

We present moderate resolution CCD spectra and R photometry for seven KP2001 stars. We revised the spectral classification of the stars in the range λλ4000−8700A . Our photometric data confirmed the behavior of the light curves downloaded from the NSVS (Northern Sky Variability Survey) database. For KP2001-32, presented as a Mira-type variable in NSVS, we estimated absolute bolometric M b and K-band M K magnitudes as well as the distance using the period-luminosity relations. We also estimated the mass loss rate using the calibration relations between mass loss rate and K - [12] index. From the position in infrared color-color diagrams, we confirmed the photometric classification of KP2001-221 as a semiregular variable, based on the light curve of the NSVS database. For the N-type carbon star KP2001-77 we estimated distance and absolute magnitude M K using different calibration methods. For the remaining four objects we derived the absolute magnitudes and distances using our CCD spectra and published JHK S magnitudes. We discuss the nature of these objects on the basis of the obtained results.

Published
2009
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50. Massive Thrombosis of Brachiocephalic Veins and Superior Vena Cava Syndrome in a Patient with Non-Small Cell Lung Cancer Treated with the Epidermal Growth Factor Receptor Inhibitor Erlotinib

Author

Piergiorgio Gaudenzi, Raffaella Salmi, Filippo Di Todaro, Roberto Manfredini, Ingrid Nielsen, and Pierluigi Morandi

Subjects
Superior Vena Cava Syndrome, medicine.medical_specialty, Lung Neoplasms, medicine.medical_treatment, Antineoplastic Agents, Syncope, Erlotinib Hydrochloride, Gefitinib, Superior vena cava, Carcinoma, Non-Small-Cell Lung, Humans, Medicine, Pharmacology (medical), Lung cancer, Brachiocephalic Veins, Cyanosis, Venous Thrombosis, Superior vena cava syndrome, business.industry, Cancer, General Medicine, Middle Aged, medicine.disease, Thrombosis, Surgery, ErbB Receptors, Quinazolines, Female, Radiology, Erlotinib, medicine.symptom, Tomography, X-Ray Computed, business, Central venous catheter, medicine.drug
Abstract

The superior vena cava (SVC) syndrome occurs when obstruction of this vessel interrupts venous return of blood from the head, upper extremities and thorax to the right atrium. Most cases of SVC syndrome result from neoplasia, especially from lung cancer, but other non-cancer-associated causes may include fibrosis caused by radiotherapy, collagen-vascular diseases, arteriovenous shunts or thrombosis as a complication of use of central venous catheters or devices. We report here the case of a 60-year-old woman with non-small cell lung cancer who was treated, after three lines of chemotherapy, with the epidermal growth factor receptor inhibitor erlotinib and subsequently presented to the hospital with abrupt onset of syncope, shortness of breath and cyanosis (face, neck and trunk). A CT scan of the chest demonstrated a massive thrombosis of both brachiocephalic veins and the SVC. The patient was treated with the systemic thrombolytic agent urokinase, with resolution of the clinical picture and no bleeding complications. The possible pathogenetic causes of thrombosis of the brachiocephalic veins and SVC syndrome in this case are discussed. It is possible that acute thrombosis may be associated with erlotinib use, even if it is likely that cancer may be the main cause of the thrombotic complication.

Published
2007
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