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8 results on '"Gao Jiahong"'

1. Longitudinal development of the human white matter structural connectome and its association with brain transcriptomic and cellular architecture

Author

Feng, Guozheng, primary, Chen, Rui, additional, Zhao, Rui, additional, Li, Yuanyuan, additional, Ma, Leilei, additional, Wang, Yanpei, additional, Men, Weiwei, additional, Gao, Jiahong, additional, Tan, Shuping, additional, Cheng, Jian, additional, He, Yong, additional, Qin, Shaozheng, additional, Dong, Qi, additional, Tao, Sha, additional, and Shu, Ni, additional

Published
2023
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4. The olfactory route is a potential way for SARS-CoV-2 to invade the central nervous system of rhesus monkeys

Author

Jiao, Li, primary, Yang, Yun, additional, Yu, Wenhai, additional, Zhao, Yuan, additional, Long, Haiting, additional, Gao, Jiahong, additional, Ding, Kaiyun, additional, Ma, Chunxia, additional, Li, Jingmei, additional, Zhao, Siwen, additional, Wang, Haixuan, additional, Li, Haiyan, additional, Yang, Mengli, additional, Xu, Jingwen, additional, Wang, Junbin, additional, Yang, Jing, additional, Kuang, Dexuan, additional, Luo, Fangyu, additional, Qian, Xingli, additional, Xu, Longjiang, additional, Yin, Bin, additional, Liu, Wei, additional, Liu, Hongqi, additional, Lu, Shuaiyao, additional, and Peng, Xiaozhong, additional

Published
2021
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5. Susceptibility of tree shrew to SARS-CoV-2 infection

Author

Zhao, Yuan, primary, Wang, Junbin, additional, Kuang, Dexuan, additional, Xu, Jingwen, additional, Yang, Mengli, additional, Ma, Chunxia, additional, Zhao, Siwen, additional, Li, Jingmei, additional, Long, Haiting, additional, Ding, Kaiyun, additional, Gao, Jiahong, additional, Liu, Jiansheng, additional, Wang, Haixuan, additional, Li, Haiyan, additional, Yang, Yun, additional, Yu, Wenhai, additional, Yang, Jing, additional, Zheng, Yinqiu, additional, Wu, Daoju, additional, Lu, Shuaiyao, additional, Liu, Hongqi, additional, and Peng, Xiaozhong, additional

Published
2020
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6. Comparison of nonhuman primates identified the suitable model for COVID-19

Author

Lu, Shuaiyao, primary, Zhao, Yuan, additional, Yu, Wenhai, additional, Yang, Yun, additional, Gao, Jiahong, additional, Wang, Junbin, additional, Kuang, Dexuan, additional, Yang, Mengli, additional, Yang, Jing, additional, Ma, Chunxia, additional, Xu, Jingwen, additional, Qian, Xingli, additional, Li, Haiyan, additional, Zhao, Siwen, additional, Li, Jingmei, additional, Wang, Haixuan, additional, Long, Haiting, additional, Zhou, Jingxian, additional, Luo, Fangyu, additional, Ding, Kaiyun, additional, Wu, Daoju, additional, Zhang, Yong, additional, Dong, Yinliang, additional, Liu, Yuqin, additional, Zheng, Yinqiu, additional, Lin, Xiaochen, additional, Jiao, Li, additional, Zheng, Huanying, additional, Dai, Qing, additional, Sun, Qiangming, additional, Hu, Yunzhang, additional, Ke, Changwen, additional, Liu, Hongqi, additional, and Peng, Xiaozhong, additional

Published
2020
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7. Motor Function in MPTP-Treated Tree Shrews (Tupaia belangeri chinensis)

Author

Ying Zhang, Gao Jiahong, Jie-Jie Dai, Juan Xu, Yuanyuan Han, Qinfang Jiang, Xiao-Yan Huang, Huang Zhangqiong, Pinfen Tong, Xing-Xiao Yin, Dexuan Kuang, Wenguang Wang, Li Cong, and Ma Kaili

Subjects
Nervous system, medicine.medical_specialty, Parkinson's disease, animal diseases, Substantia nigra, Biology, medicine.disease_cause, Biochemistry, Midbrain, Cellular and Molecular Neuroscience, chemistry.chemical_compound, Dopamine, Internal medicine, medicine, cardiovascular diseases, MPTP, General Medicine, medicine.disease, Malondialdehyde, nervous system diseases, Endocrinology, medicine.anatomical_structure, nervous system, chemistry, cardiovascular system, Neuroscience, Oxidative stress, medicine.drug
Abstract

The tree shrew, a new experimental animal model, has been used to study a variety of diseases, especially diseases of the nervous system. 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) is the gold standard for toxin-based animal models of Parkinson's disease (PD) because MPTP treatment replicates almost all of the pathological hallmarks of PD. Therefore, in this study, the effects of MPTP on the motor function of the tree shrew were examined. After five daily injections of a 3 mg/kg dose of MPTP, the motor function of MPTP-injected tree shrews decreased significantly, and the classic Parkinsonian symptoms of action and resting tremor, bradykinesia, posture abnormalities, and gait instability were observed in most MPTP-injected tree shrews. HPLC results also showed significantly reduced striatal dopamine and 3,4-dihydroxyphenylacetic acid levels in tree shrews after MPTP injection. Increased oxidative stress levels are usually considered to be the cause of dopaminergic neuron depletion in the presence of MPTP and were observed in the substantia nigra of MPTP-treated tree shrews, as indicated by a significant reduction in superoxide dismutase and glutathione peroxidase activity and increased levels of malondialdehyde. In addition, elevated α-synuclein mRNA levels in the midbrain of MPTP-treated tree shrews were observed. Furthermore, MPTP-treated tree shrews showed the classic Parkinsonian symptoms at a lower MPTP dosage compared with other animal models. Thus, the MPTP-treated tree shrew may be a potential animal model for studying the pathogenesis of PD.

Published
2013
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