Search

In patients with different neurological diseases with blood-brain barrier dysfunction subjected to diagnostic CSF-tap, simultaneous determinations of ofloxacin concentrations in serum and in CSF were carried out. The results show that ofloxacin penetrates well into the CSF achieving adequate bactericidal concentrations against most of the common causative pathogens of meningitis.

Ten strains of Pseudomonas aeruginosa isolated from different clinical sources were incubated with immunoglobulin preparations for i.v. use. This resulted in the release of beta-lactamases normally cell-bound in the periplasmic space. The amount of released beta-lactamases - depending on the degree of cell wall alteration - was spectrophotometrically determined by the use of nitrocefin as an indicator substance. beta-lactamase release varies according to strain specificity and depends on the chemical modification of the immunoglobulins used.