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Mining causes extreme heavy metal (HM) contamination to surrounding environments and poses threats to soil microbial community. The effects of HMs on soil microbial communities are not only related to their total amounts but also associated with the distribution of chemical fractions. However, the effects of chemical fractions on soil microbes and their interactions remain largely unclear. Here we investigated soil physicochemical properties and bacterial and fungal communities of soil samples from the control area and lightly (L), moderately (M), and heavily (H) contaminated areas, respectively, which were collected from long-term Pb-Zn slag contamination area in the southern China. The results showed that bacterial and fungal community composition and structure were significantly affected by HMs, while community diversity was not significantly affected by HMs. The critical environmental factor affecting bacterial and fungal communities was pH, and the impacts of chemical fractions on their changes were more significant than the total amounts of HMs. Variance partitioning analysis (VPA) revealed fungal community changes were mostly driven by HM total amounts, but bacterial community changes were mostly driven by soil chemical properties. Co-occurrence network indicated that interactions among species of fungal network were sparser than that of bacterial network, but fungal network was more stable, due to a more significant number of keystone taxa and a lower percentage of positive associations. These illustrated that the fungal community might serve as indicator taxa for HM-contaminated status, and specific HM-responsive fungal species such as Triangularia mangenotii, Saitozyma podzolica, and Cladosporium endophytica, and genus Rhizophagus can be considered relevant bioindicators due to their less relative abundance in contaminated areas. Additionally, HM-responsive bacterial OTUs representing five genera within Sulfurifustis, Thiobacillus, Sphingomonas, Qipengyuania, and Sulfurirhabdus were found to be tolerant to HM stress due to their high relative abundance in contaminated levels.

Cytogenetic abnormalities have been proven to be the most valuable parameter for risk stratification of childhood acute lymphoblastic leukemia (ALL). However, studies on the prevalence of cytogenetic abnormalities and their correlation to clinical features in Chinese pediatric patients are limited, especially large-scale studies.We collected the cytogenetics and clinical data of 1541 children newly diagnosed with ALL between 2001 and 2014 in four Chinese hospitals, and retrospectively analyzed their clinical features, prognosis and risk factors associated with pediatric ALL.All of these patients had karyotyping results, and some of them were tested for fusion genes by fluorescence in situ hybridization or reverse-transcription polymerase chain reaction. Overall, 930 cases (60.4%) had abnormal cytogenetics in this study, mainly including high hyperdiploidy (HHD, n=276, 17.9%), hypodiploidy (n=74, 4.8%), t(12;21)/TEL-AML1 (n=260, 16.9%), t(1;19)/E2A-PBX1 (n=72, 4.7%), t(9;22)/BCR-ABL (n=64, 4.2%), and t(v;11q23)/MLL rearrangements (n=40, 2.6%). The distribution of each cytogenetic abnormality was correlated with gender, age, white blood cell count at diagnosis, and immunophenotype. In addition, multivariate analysis suggested that t(v;11q23)/MLL rearrangements (OR: 2.317, 95%CI: 1.219-3.748, P=0.008) and t(9;22)/BCR-ABL (OR: 2.519, 95%CI: 1.59-3.992, P0.001) were independent risk factors for a lower event-free survival (EFS) rate in children with ALL, while HHD (OR: 0.638, 95%CI: 0.455-0.894, P=0.009) and t(12;21)/TEL-AML1 (OR: 0.486, 95%CI: 0.333-0.707, P0.001) were independent factors of a favorable EFS.The cytogenetic characteristics presented in our study resembled other research groups, emphasizing the important role of cytogenetic and molecular genetic classification in ALL, especially in B-ALL.

Liquids and solids are two fundamental states of matter. However, our understanding of their three-dimensional atomic structure is mostly based on physical models. Here we use atomic electron tomography to experimentally determine the three-dimensional atomic positions of monatomic amorphous solids, namely a Ta thin film and two Pd nanoparticles. We observe that pentagonal bipyramids are the most abundant atomic motifs in these amorphous materials. Instead of forming icosahedra, the majority of pentagonal bipyramids arrange into pentagonal bipyramid networks with medium-range order. Molecular dynamics simulations further reveal that pentagonal bipyramid networks are prevalent in monatomic metallic liquids, which rapidly grow in size and form more icosahedra during the quench from the liquid to the glass state. These results expand our understanding of the atomic structures of amorphous solids and will encourage future studies on amorphous–crystalline phase and glass transitions in non-crystalline materials with three-dimensional atomic resolution. Atomic electron tomography is used to determine the three-dimensional atomic structure of monatomic amorphous solids with liquid-like structure, which is characterized by the existence of pentagonal bipyramid networks with medium-range order.

Amorphous solids such as glass, plastics and amorphous thin films are ubiquitous in our daily life and have broad applications ranging from telecommunications to electronics and solar cells1-4. However, owing to the lack of long-range order, the three-dimensional (3D) atomic structure of amorphous solids has so far eluded direct experimental determination5-15. Here we develop an atomic electron tomography reconstruction method to experimentally determine the 3D atomic positions of an amorphous solid. Using a multi-component glass-forming alloy as proof of principle, we quantitatively characterize the short- and medium-range order of the 3D atomic arrangement. We observe that, although the 3D atomic packing of the short-range order is geometrically disordered, some short-range-order structures connect with each other to form crystal-like superclusters and give rise to medium-range order. We identify four types of crystal-like medium-range order-face-centred cubic, hexagonal close-packed, body-centred cubic and simple cubic-coexisting in the amorphous sample, showing translational but not orientational order. These observations provide direct experimental evidence to support the general framework of the efficient cluster packing model for metallic glasses10,12-14,16. We expect that this work will pave the way for the determination of the 3D structure of a wide range of amorphous solids, which could transform our fundamental understanding of non-crystalline materials and related phenomena.

Soil microorganisms play an important role in the circulation of materials and nutrients between plants and soil ecosystems, but the drivers of microbial community composition and diversity remain uncertain in different vegetation restoration patterns. We studied soil physicochemical properties (i.e., soil moisture, bulk density, pH, soil nutrients, available nutrients), plant characteristics (i.e., Shannon index [HPlant] and Richness index [SPlant], litter biomass [LB], and fine root biomass [FRB]), and microbial variables (biomass, enzyme activity, diversity, and composition of bacterial and fungal communities) in different plant succession patterns (Robinia pseudoacacia [MF], Caragana korshinskii [SF], and grassland [GL]) on the Loess Plateau. The herb communities, soil microbial biomass, and enzyme activities were strongly affected by vegetation restoration, and soil bacterial and fungal communities were significantly different from each other at the sites. Correlation analysis showed that LB and FRB were significantly positively correlated with the Chao index of soil bacteria, soil microbial biomass, enzyme activities, Proteobacteria, Zygomycota, and Cercozoa, while negatively correlated with Actinobacteria and Basidiomycota. In addition, soil water content (SW), pH, and nutrients have important effects on the bacterial and fungal diversities, as well as Acidobacteria, Proteobacteria, Actinobacteria, Nitrospirae, Zygomycota, and microbial biomass. Furthermore, plant characteristics and soil properties modulated the composition and diversity of soil microorganisms, respectively. Overall, the relative contribution of vegetation and soil to the diversity and composition of soil bacterial and fungal communities illustrated that plant characteristics and soil properties may synergistically modulate soil microbial communities, and the composition and diversity of soil bacterial and fungal communities mainly depend on plant biomass and soil nutrients.

A set containment join operates on two set-valued attributes with a subset ( $$\subseteq $$ ) relationship as the join condition. It has many real-world applications, such as in publish/subscribe services and inclusion dependency discovery. Existing solutions can be broadly classified into union-oriented and intersection-oriented methods. Based on several recent studies, union-oriented methods are not competitive as they involve an expensive subset enumeration step. Intersection-oriented methods build an inverted index on one attribute and perform inverted list intersection on another attribute. Existing intersection-oriented methods intersect inverted lists one-by-one. In contrast, in this paper, we propose to intersect all the inverted lists simultaneously while skipping many irrelevant entries in the lists. To share computation, we utilize the prefix tree structure and extend our novel list intersection method to operate on the prefix tree. To further improve the efficiency, we propose to partition the data and process each partition separately. Each partition will be associated with a much smaller inverted index, and the set containment join cost can be significantly reduced. Moreover, to support large-scale datasets that are beyond the available memory space, we develop a novel adaptive data partition method that is designed to fully leverage the available memory and achieve high I/O efficiency, and thereby exhibiting outstanding performance for external memory set containment join. We evaluate our methods using both real-world and synthetic datasets. Experimental results demonstrate that our method outperforms state-of-the-art methods by up to 10 $$\times $$ when the dataset is completely resided in memory. Furthermore, our approach achieves up to two orders of magnitude improvement on I/O efficiency compared with a baseline method when the dataset size exceeds the main memory space.

The eruption of the Anak Krakatau volcano, Indonesia, on 22 December 2018 induced a destructive tsunami (the Sunda Strait tsunami), which was recorded by four nearby tidal gauges. In this study we invert the tsunami records and recover the tsunami generation process. Two tsunami sources are obtained, a static one of instant initial water elevation and a time-dependent one accounting for the continuous evolution of water height. The time-dependent results are found to reproduce the tsunami recordings more satisfactorily. The complete tsunami generation process lasts approximately 9 min and features a two-stage evolution with similar intensity. Each stage lasts about 3.5 min and elevates a water volume of about 0.15 km 3 . The time, duration and volume of the volcano eruption in general agree with seismic records and geomorphological interpretations. We also test different sizes of the potential source region, which lead to different maximum wave height in the source area, but all the results of time-dependent tsunami sources show the robust feature of two stages of wave generation. Our results imply a time-dependent and complex process of tsunami generation during the volcano eruption.

Human endogenous retrovirus W family envelope protein (HERV-W env) is associated with several neurological and psychiatric disorders, including multiple sclerosis (MS) and schizophrenia. Clinical studies have demonstrated a common link between inflammatory abnormalities and HERV-W env in neuropsychiatric diseases. Nonetheless, the molecular mechanisms by which HERV-W env mediates neuroinflammation are still unclear. In this study, we found that HERV-W env significantly increased the mRNA and protein levels of TNF-α and IL-10 in U251 and A172 cells. HERV-W env also induced a notable increase in Toll-like receptor 4 (TLR4). Knockdown of TLR4 impaired the expressions of TNF-α and IL-10 induced by HERV-W env. Overexpression of HERV-W env led to the upregulation of MyD88 but caused a decrease in MyD88s. MyD88s overexpression suppressed the expressions of TNF-α and IL-10 induced by HERV-W env. These findings indicate that HERV-W env upregulates the expressions of IL-10 and TNF-α by inhibiting the production of MyD88s in glial cells. This work sheds light on the immune pathogenesis of HERV-W env in neuropsychiatric disorders.

Whether metabolites derived from injured renal tubular epithelial cells (TECs) participate in renal fibrosis is poorly explored. After TEC injury, various metabolites are released and among the most potent is adenosine triphosphate (ATP), which is released via ATP-permeable channels. In these hemichannels, connexin 43 (Cx43) is the most common member. However, its role in renal interstitial fibrosis (RIF) has not been fully examined. We analyzed renal samples from patients with obstructive nephropathy and mice with unilateral ureteral obstruction (UUO). Cx43-KSP mice were generated to deplete Cx43 in TECs. Through transcriptomics, metabolomics, and single-cell sequencing multi-omics analysis, the relationship among tubular Cx43, ATP, and macrophages in renal fibrosis was explored. The expression of Cx43 in TECs was upregulated in both patients and mice with obstructive nephropathy. Knockdown of Cx43 in TECs or using Cx43-specific inhibitors reduced UUO-induced inflammation and fibrosis in mice. Single-cell RNA sequencing showed that ATP specific receptors, including P2rx4 and P2rx7, were distributed mainly on macrophages. We found that P2rx4- or P2rx7-positive macrophages underwent pyroptosis after UUO, and in vitro ATP directly induced pyroptosis by macrophages. The administration of P2 receptor or P2X7 receptor blockers to UUO mice inhibited macrophage pyroptosis and demonstrated a similar degree of renoprotection as Cx43 genetic depletion. Further, we found that GAP 26 (a Cx43 hemichannel inhibitor) and A-839977 (an inhibitor of the pyroptosis receptor) alleviated UUO-induced fibrosis, while BzATP (the agonist of pyroptosis receptor) exacerbated fibrosis. Single-cell sequencing demonstrated that the pyroptotic macrophages upregulated the release of CXCL10, which activated intrarenal fibroblasts. Cx43 mediates the release of ATP from TECs during renal injury, inducing peritubular macrophage pyroptosis, which subsequently leads to the release of CXCL10 and activation of intrarenal fibroblasts and acceleration of renal fibrosis.

Natural granular materials such as sands often possess complex microstructural features including cleavage and minerals interfaces. Those features bring apparent mechanical anisotropy to particles and are known to have pronounced influence on particle crushing characteristics. This paper presents a multiscale simulation of continuous crushing of granular sand under one-dimensional compression in consideration of particle-scale anisotropy through modeling planes of weakness inside individual particles, with reference to granular materials rich in minerals and containing cleavages. The multiscale modeling is based on a coupled peridynamics and non-smooth contact dynamics method where peridynamics is used to model crushing of individual particles and non-smooth contact dynamics is employed to simulate discrete granular system. Weak microstructural planes are simulated by breaking a fraction of peridynamic bonds as an initial condition. Simulation results show that anisotropic particles containing weak planes result in larger number of fragments and exhibit relatively higher fractal dimension with respect to particle size. Particle shape is found to approach a steady state profile with continuous crushing. Anisotropic particles generally bear smaller sphericity, aspect ratio, elongation and flatness than those isotropic particles. The anisotropy in particles seems to mitigate shape effect on particle strength and crushing energy. Macromechanical yield stress of the sample is related to single particle strength monotonically, but the relationship appears to be nonlinear when different microstructural features are involved.

Epidermal growth factor (EGF) has been shown to improve piglet intestinal morphology and epithelial recovery. In an attempt to further understand the mechanisms behind these improvements, this study tested the hypothesis that dietary EGF may affect intestinal morphology by stimulating the proliferation and differentiation of enterocytes in weaning piglets. In piglets receiving 200 µg kg–1 EGF, crypt depth and villus height increased ( P 400 µg kg–1 EGF increased villus height-to-crypt depth ratio ( P P 200 µg kg–1 EGF significantly increased the number of Ki67-positive cells ( P P P 400 µg kg–1 EGF had an increased mRNA level of intestinal alkaline phosphatase ( P 200 µg kg–1 EGF group. These results suggest that dietary supplementation with a low level of EGF improved piglet intestinal morphology through stimulating the proliferation and differentiation of enterocytes, and the mTOR signaling pathway may partly be involved in this process.

Cloud-free moderate-resolution imaging spectroradiometer (MODIS) images of the Zhujiang (Pearl) River Estuary (ZRE) taken between 2002 and 2012 are retrieved and used to study the spatial and temporal patterns of suspended sediment concentrations (SSCs) across the estuary under runoff, wind, and tropical storm conditions. Five typical dispersal patterns of suspended sediments in the estuary are defined: Case I shows generally low SSCs under low dynamics; Case II shows a river-dominant dispersal pattern of suspended sediments from the outlets, particularly from Modaomen, Jiaomen, Hengmen, and others; Case III shows wind-dominant dispersal of high SSCs derived from the west shoal and southwesterly transport under a strong NE wind; Case IV is the combination of relatively large runoff and wind; and Case V is caused by a strong tropical storm with high river discharge and wind, which is characterized by the high SSCs across the entire estuary that are transported eastward by winddriven and buoyancy currents outside the estuary. Runoff is a dominant factor that controls seasonal and annual SSC variations in the ZRE, with the area of high SSCs being largest in the summer and smallest in the spring. The correlation coefficients between the monthly averaged river-suspended sediment discharge and the area of the high SSCs are approximately 0.6. The wind power over the west shoal increases with a wind speed, which induces more sediment resuspension and shows a close relationship between the wind speed and high SSC area.

Nitrate is the predominant nitrogen source for plant growth and development. However, sugarcane, globally used as the primary sugar crop and biofuel feedstock, displays a low nitrate use efficiency due to a low capacity in storing nitrate in shoots. It is well studied that the nitrate transporter (NRT/NPF) family functions as the gatekeeper in governing nitrogen uptake and distribution, and optimizing nitrogen utilization in plants. This makes it a promising target for improving nitrogen use efficiency in sugarcane. Here, we carried out a comprehensive analysis of NRT/NPF genes at a genome-wide scale in Saccharum spontaneum. A BLAST search of NRT/NPF genes was initially performed against recently released sugarcane genome, followed by phylogenetic, gene structure and protein motif analysis. Additionally, NRT/NPF gene expression profile from various tissues was obtained from RNA-seq data analysis. As a result, we identified 178 NPF, 20 NRT2, and 6 NRT3 genes which spread across all 8 monoploid chromosomes. NPF and NRT3 exhibit high levels of genetic diversities as opposed to NRT2 which is more evolutionarily conserved. Interestingly, several SsNPF genes are products of gene fusions of several tandem duplications, which provide valuable structural resources for functional characterization of nitrate transporters. Moreover, several genes are tissue-specific expressed, indicating roles in tissue-specific nitrate translocations. A substantial number of NRT/NPF genes are heterogeneous in terms of their gene structures and mRNA abundance. Taken together, our work provides a genetic foundation for future investigations of molecular and physiological functions of sugarcane nitrate transporters.

In the core of a molten salt fast reactor (MSFR), heavy metal fuel and fission products can be dissolved in a molten fluoride salt to form a eutectic mixture that acts as both fuel and coolant. Fission energy is released from the fuel salt and transferred to the second loop by fuel salt circulation. Therefore, the MSFR is characterized by strong interaction between the neutronics and the thermal hydraulics. Moreover, recirculation flow occurs, and nuclear heat is accumulated near the fertile blanket, which significantly affects both the flow and the temperature fields in the core. In this work, to further optimize the conceptual geometric design of the MSFR, three geometries of the core and fertile blanket are proposed, and the thermal–hydraulic characteristics, including the three-dimensional flow and temperature fields of the fuel and fertile salts, are simulated and analyzed using a coupling scheme between the open source codes OpenMC and OpenFOAM. The numerical results indicate that a flatter core temperature distribution can be obtained and the hot spot and flow stagnation zones that appear in the upper and lower parts of the core center near the reflector can be eliminated by curving both the top and bottom walls of the core. Moreover, eight cooling loops with a total flow rate of 0.0555 m3 s−1 ensure an acceptable temperature distribution in the fertile blanket.

Modern sugarcanes are polyploid interspecific hybrids, combining high sugar content from Saccharum officinarum with hardiness, disease resistance and ratooning of Saccharum spontaneum. Sequencing of a haploid S. spontaneum, AP85-441, facilitated the assembly of 32 pseudo-chromosomes comprising 8 homologous groups of 4 members each, bearing 35,525 genes with alleles defined. The reduction of basic chromosome number from 10 to 8 in S. spontaneum was caused by fissions of 2 ancestral chromosomes followed by translocations to 4 chromosomes. Surprisingly, 80% of nucleotide binding site-encoding genes associated with disease resistance are located in 4 rearranged chromosomes and 51% of those in rearranged regions. Resequencing of 64 S. spontaneum genomes identified balancing selection in rearranged regions, maintaining their diversity. Introgressed S. spontaneum chromosomes in modern sugarcanes are randomly distributed in AP85-441 genome, indicating random recombination among homologs in different S. spontaneum accessions. The allele-defined Saccharum genome offers new knowledge and resources to accelerate sugarcane improvement.

Li4Mn5O12 nanorods were successfully prepared by using β-MnO2 nanorod precursors as self-templates. The obtained Li4Mn5O12 nanorods were approximately 0.8–1.5 μm in length and 0.15 μm in width, and were employed as electrode materials and applied in supercapacitors. The results show that Li4Mn5O12 nanorods can deliver 211 F g−1 within the potential range of 0–1.4 V at a scan rate of 5 mV s−1 in 1 mol L−1 Li2SO4 solution, which presents a good electrochemical performance.

Contamination by heavy metals has become a serious environmental pollution issue today due to its potential threat to plant, wildlife, and human health. Photosynthesis, a process in which light energy is used to produce sugar and other organic compounds, is sensitive to heavy metals. In the present study, the response of photosynthetic process and carbon assimilation of Schima superba was investigated under cadmium (Cd) stress. Three Cd concentrations (0, 300, and 600 mg kg−1) were used designated as control (CK), low Cd (L1), and high Cd treatment (L2) of plants. Results showed that photosystem II (PSII) acceptor and donor side electron transport were more easily blocked in treatment compared to control, and L2 have more significant changes than L1. A substantial decrease of 820 nm reflection curve absorption was observed both in L1 and L2 treatments. Special energy fluxes showed significant difference between the control group and the treated group, which indicated that low concentration Cd stress can cause decrease in quantum yield of PSII in plants studied. Non-stomatal factors resulted in a decrease in net photosynthetic rate and a decrease in photosystem activity. Our results suggested that Cd can damage structure and function of the photosynthesis of S. superba young plants.

This review summarised the compositional, thermal, and rheological properties and food applications of chestnut (Castanea spp.) flour systems. The compositional, structural, and physicochemical properties of chestnut starch, which is a major determinant for product quality, were also reviewed. Future research directions on how to better utilise chestnut flour and starch for food product developments were suggested. Chestnuts are important food items for many people around the world. The world production of chestnuts has kept increasing during the last decade. There has been growing interest to utilise chestnut flour for various food applications (e.g. gluten-free food products). The major component of chestnut is starch which amounts to over 50% of the dry weight of the fruit. Chestnut starch may as well have potential for food and non-food applications. Overall, this review provides a scientific basis to develop chestnuts as sustainable and cash crops.

This study was to investigate the influence of spray drying conditions on the physicochemical characteristics and sensory evaluation of mandarin (Citrus unshiu) beverage powder. The results show that moisture content, color, pH, vitamin C, water solubility index and drying yield were significantly affected by the carrier agent concentrations and the inlet air temperatures. However, water activity and water absorption index were not significantly influenced by the spray drying conditions. Sensory evaluation results of taste, color and overall acceptability of mandarin beverage powders added with corn syrup were higher than those added with maltodextrin. As the result of process suitability for spray drying mandarin beverage by using different parameters, it is concluded that 35% corn syrup concentration and 135 °C inlet temperature were suitable to produce mandarin beverage powder with preferable taste and color.

Pineapple is a crassulacean acid metabolism (CAM) plant with high economic value. Originated at semi-arid regions where water is limited, CAM plant is known for its high water use efficiency (WUE). Aquaporin regulates whole plant level water usage and transportation, which are critical for many physiological processes, including photosynthesis. Systematically identification and analyses of the aquaporin family resulted in detailed annotation of this gene family in pineapple. Among the 36 aquaporins identified in pineapple genome, 10 members were found in the TIP subfamily, 10 members were found in the PIP subfamily, 11 members were found in the NIP subfamily, and 3 members were found in the SIP subfamily. Additionally, there was also one TIP1-like aquaporin and one NIP1-like aquaporin that shared sequence similarity to TIP1 and NIP1 aquaporins respectively. Using transcriptome data from leaf tissues sampled every 2 hs in 24 h, we discovered aquaporin genes with circadian expression patterns in the domesticated pineapple and revealed the potential functions of all aquaporin genes for pineapple and CAM plants in general. To understand the domestication history of aquaporin, we compared the aquaporins from wild pineapple and cultivars, and found that the aquaporin expression profile in domesticated pineapple fruit development is very different from the wild pineapple, implicating the importance of aquaporin genes in the process of domesticated fruit development, such as rapid fruit expansion and ripening. This research has also targeted aquaporin subfamily nodulin26-like intrinsic protein5-1 (NIP5-1) gene in pineapple, which plays an important role in boron transportation, and had not yet been revealed in any monocot species. CAM plant has unique circadian regulation mechanisms for aquaporin genes in comparison with C3 plants, which might be critical for its effective plant water utilization. Our result provided new insights into evolution and functional diversification of the CAM aquaporin family, and yielded genomic resources for improving WUE and boron transportation in C3 and cereal crops.

Jet launching in radio loud (RL) quasars is one of the fundamental problems in astrophysics. Exploring the differences in the inner accretion disk properties between RL and radio quiet (RQ) quasars might yield helpful clues to this puzzle. We previously discovered that the shorter term UV/optical variations of quasars are bluer than the longer term ones, i.e., the so-called timescale-dependent color variation. This is consistent with the scheme that the faster variations come from the inner and hotter disk regions, thus providing a useful tool to map the accretion disk which is otherwise unresolvable. In this work we compare the UV/optical variations of RL quasars in SDSS Stripe 82 to those of several RQ samples, including those matched in redshift-luminosity-black hole mass and/or color-magnitude. We find that while both RL and RQ populations appear bluer when they brighten, RL quasars potentially show a weaker/flatter dependence on timescale in their color variation. We further find that while both RL and RQ populations on average show similar variation amplitudes at long timescales, fast variations of RL sources appear weaker/smaller (at timescales of ~ 25 -- 300 days in the observer's frame), and the difference is more prominent in the g-band than in the r-band. Inhomogeneous disk simulations can qualitatively reproduce these observed differences if the inner accretion disk of RL quasars fluctuates less based on simple toy models. Though the implications are likely model dependent, the discovery points to an interesting diagram that magnetic fields in RL quasars may be prospectively stronger and play a key role in both jet launching and the stabilization of the inner accretion disk., Comment: Accepted by Science China: Physics, Mechanics & Astronomy; Figures 4, 14, and 15 are the main results

Biomass is a renewable energy resource derived from all organic materials produced by both human and natural activities. Total biomass is amounted to be 58,010 Gg yr−1 from agricultural sector during 2013 in Korea: livestock manure, crop residues, and agro-industrial wastes. Potential methane production from agricultural biomass was calculated based on IPCC guidelines using manipulated equations. The main parameters were emission factor, total waste amount, and physico-chemical properties of each waste to estimate methane production. Calculated total potential methane production from the different categories for livestock, crop residues, and agro-industrial wastes was 502 Gg yr−1 in Korea. Poultry waste generated the highest methane potential with 227 Gg yr−1 followed by 80 Gg yr−1 from cattle waste. For crop residues and agro-industrial wastes, estimated methane production was 1 and 126 Gg yr−1, respectively. Results of this study show that livestock manure gave the highest methane emission in the agricultural sector. With this, more effective management of livestock wastes is necessary to develop and maximize technology on harnessing methane as alternative energy.

Chestnut (Castanea spp.) is an important food crop mostly cultivated in Asia, America, and southern Europe. Understanding the effect of diverse processing operations on the quality of chestnut is critical for better utilisation of this crop. Chestnuts of Castanea sativa and Castanea molissima have been subjected to roasting, boiling, drying, osmotic dehydration, γ-irradiation, electron beam irradiation, radio frequency treatment, storage, extrusion, and candying. These processing operations make the chestnut palatable, increase the shelf life, and improve the quality. This mini-review summarises the influence of processing steps on diverse quality attributes of chestnut and provides suggestions to better process chestnut for quality improvement.

Blending diverse starches is green and easy to diversify starch functionalities and to lower the cost of food production. Mung bean starch is commonly used to make starch noodles with good quality. Other starches may replace the mung bean starch to reduce the production cost. Four common starches (potato, sweet potato, rice, and sorghum) were added to mung bean starch with the mixing ratio up to 100 %. The gelling, thermal, pasting, steady shear, and dynamic rheological properties of these starch systems were studied and compared. One thermal endotherm was found in all starch blends, but individual components still tended to gelatinize separately based on calculations of melting enthalpy data. However, nonlinear changes in rheological and gelling properties were mostly found, and the data can be fitted by polynomial equations (order 2), indicating the existence of interactions among components during these tests. Granule size and amylose content of starch played important roles in the nonadditive behaviors.

Different microhabitats along dune slope were found to affect the distribution of plant performances and soil properties in desertified ecosystems. However, the ground-active arthropod responses to rainfall-induced dune microhabitats were largely unknown in desertified regions. At dune top, midslope and bottom, ground-active arthropods were sampled by the method of pitfall traps in addition to the herbaceous and soil measurements during spring, summer and autumn from 2012 to 2013. Ground-active arthropod had a strong dynamics in time, seasonally and yearly in responses to rainfall-induced dune microhabitats and the variations were significant higher than those of soil and herbaceous properties. The abundance distribution of dominant taxa (i.e. Melolonthidae, Carabidae, Glaphyridae, Tenebrionidae and Formicidae families) among dune microhabitats was similar between seasons within the same year, whereas they differed markedly between two sampling years with varying rainfall patterns. A significant (P 0.05) differences were found among dune microhabitats when averaged on three sampling seasons within the year of either 2012 or 2013. In all, the taxonomical structure differed considerably from the community structure in ground-active arthropod response to rainfall-induced dune microhabitats. The spatial distribution of taxonomical groups among dune microhabitats was significantly affected by inter-annual rainfall changes, whereas that of community structure was affected by both intra- and inter-annual rainfall changes in desertified ecosystems.

Soluble sugar and organic acid levels are important evaluation indices for breeding new varieties of pear. In order to investigate the inheritance of sugars and acids, this study analyzed the inheritance of soluble sugar and organic acid in pear fruit using the reciprocal crossing populations ‘Dangshansuli’ and ‘Housui’ over two successive years. The results showed that the content of most individual acids and sugars, total acid and total sugar content were higher than that of ‘Dangshansuli’ and lower than that of ‘Housui’, trending to an average between the parents. The content of oxalate, quinate, malate, shikimate, and total acid in progenies were higher when ‘Housui’ was the maternal parent, suggesting that the selection of the maternal parent during the breeding process has important effects on the acid content. Conversely, individual and total sugar content did not show significant effects of the maternal parent. In addition, glucose content in progenies showed the increasing trend and sorbitol content showing the transgressive inheritance trait. The correlations for total sugar and total acid of the two populations between 2 years were significant and positive, showing stable sugar and acid traits for fruit in different years. Significant and positive correlations were also found between different components, including oxalate and malate, shikimate and quinate, and citrate and shikimate. Principal component analysis also revealed that oxalate, quinate, malate and shikimate components are closely correlated. Our study thus offers useful information for future pear breeding to improve sugar and acidity quality.

On the basis of the classical Runge-Kutta method and the complete discretization method, a Runge-Kutta-based complete discretization method (RKCDM) is proposed in the paper to predict the chatter stability of milling process, in which the regenerative effect is taken into consideration. Firstly, the dynamics model of milling process is simplified as a 2-DOF vibration system in the two orthogonal directions, which can be expressed as coefficient-varying periodic differential equations with a single time delay. Then, all parts of the delay differential equation (DDE), including delay term, time-domain term, parameter matrices, and most of all the differential terms are discretized using the classical fourth-order Runge-Kutta iteration method to replace the direct integration scheme used in the classical semi-discretization method (C-SDM) and the classical complete discretization scheme with the Euler method (C-CDSEM), which can simplify the complexity of the discretization iteration formula greatly. Lastly, the Floquet theory is adopted to predict the stability of milling process by judging the eigenvalues of the state transition matrix corresponding to certain cutting conditions. Comparing RKCDM with C-SDM and C-CDSEM, the numerical simulation results show that RKCDM has the highest convergence rate, computation accuracy, and computation efficiency. As dichotomy search rather than sequential search is used in the algorithm, the calculation time for obtaining the stability lobe diagrams (SLDs) is greatly reduced. As a result, it is practical to determine the optimal chatter-free cutting conditions for milling operation in shop floor applications.

Phytoremediation is a cost-effective and environmentally friendly technology using plants for the cleanup of both inorganic and organic contaminated sites. In this study, a pot culture experiment has been conducted for 180 days in a greenhouse to examine the capability of Koelreuteria paniculata on pyrene (Pyr) dissipation in contaminated soil. Three treatments were employed and they were: (1) polluted soil with K. paniculata fine roots addition (T1), (2) polluted soil with planted seedlings (T2), and (3) polluted soil (C). Results showed Pyr concentration in soils was reduced by 21.4, 36.2, and 86.4% by natural losses, fine roots addition, and planted K. paniculata treatments, respectively, meaning plants substantially enhanced the dissipation of Pyr from soil. Cultivated K. paniculata seedlings significantly increased soil total nitrogen (TN), total organic carbon, dissolved organic carbon (DOC), and microbial biomass carbon, but not total phosphorus, when compared to the control. The removal efficiency of Pyr was lower in the adding of fine roots treatment than in the planted K. paniculata treatment. The principal component analysis indicated the promotional dissipation of Pyr in soil by planted K. paniculata was likely attributed to increased microbial quantity and activity, DOC, and TN content in the rhizosphere. Our results suggest that K. paniculata is a suitable plant species used in phytoremediation for Pyr-contaminated soils and the efficiency on the dissipation of Pyr is considerably enhanced using living plants than adding dead organic matters. The study provided a reference for the application of K. paniculata in the remediation of Pyr-contaminated soil.

The mechanical properties of crystalline materials can be quantitatively described by crystal defects of solute atoms, dislocations, twins, and grain boundaries with the models of solid solution strengthening, Taylor strain hardening and Hall–Petch grain boundary strengthening. However, for metallic glasses, a well-defined structure feature which dominates the mechanical properties of the disordered materials is still missing. Here, we report that nanoscale spatial heterogeneity is the inherent structural feature of metallic glasses. It has an intrinsic correlation with the strength and deformation behavior. The strength and Young’s modulus of metallic glasses can be defined by the function of the square root reciprocal of the characteristic length of the spatial heterogeneity. Moreover, the stretching exponent of time-dependent strain relaxation can be quantitatively described by the characteristic length. Our study provides compelling evidence that the spatial heterogeneity is a feasible structural indicator for portraying mechanical properties of metallic glasses., Directly relating the mechanical properties of metallic glasses to their atomic structure remains a challenge. Here, the authors use high resolution microscopy to show many mechanical properties of metallic glasses depend on a single structural parameter, the characteristic length of spatial heterogeneity.

Sugarcane is a highly productive, first generation biofuel feedstock, known for its remarkable efficiency in accumulating biomass. Hormones are important regulators for many biological processes in plants, especially in plant development and plant growth, which are crucial for plant biomass traits. To understand how hormones regulatory mechanisms contribute to sugarcane lignocellulose yield, we studied the transgressive segregation on biomass yield in the F2 population derived from a cross between Saccharum officinarum ‘LA Purple’ and Saccharum robustum ‘MOL5829’. Gene expression profiling was used to detect genes involved in three important hormone-related pathways, auxin, ethylene and gibberellin, to find out how they are differently regulated between the extreme segregants of high and low biomass yield groups. We identified seventeen differentially expressed genes in auxin, one in ethylene and one in gibberellin related signaling and biosynthesis pathways, which could potentially regulate biomass yield. Differentially expressed genes, PIF3 and EIL5, involved in gibberellin and ethylene pathway could play an important role in biomass accumulation. These plant hormone-related genes could serve as candidate genes in genetic modification and breeding programs to develop high yielding energy cane.

Diverse functional properties and gluten-free feature grant quinoa uniqueness among grain-related foods. This generates great scientific enthusiasms for quinoa-related product development worldwide. This review characterizes a wide variety of quinoa products launched during the last 5 years, including breads (sourdough and non-sourdough), Chinese-steamed bread, pasta, cookies, breakfast cereals, snacks, edible films and emulsion stabilizers. The focus is given to the impact of quinoa on diverse quality attributes of the products. Innovative approaches for counteracting the negative alterations in product properties caused by adding quinoa are discussed. Research directions on how to develop unique quinoa-based products are suggested.

Four new 9,19-cycloartane triterpenoids, cimilactone E (1), cimilactone F (2), 2′-O-(E)-butenoyl-23-epi-26-deoxyactein (3), and 2′,12β-O-diacetylcimiracemonol-3-O-β-d-xylopyranoside (4), together with four known constituents (5–8) were isolated from the roots of Cimicifuga foetida. The new structures were elucidated by extensive spectroscopic analysis. In addition, compounds 7 and 8 showed significant Wnt signaling pathway inhibitory activity, with IC50 values of 3.33 and 13.34 μM, respectively, using the luciferase reporter gene assay.

The dipole (γ,γ) method, which is the inelastic X-ray scattering operated at a negligibly small momentum transfer, has been developed to determine the absolute optical oscillator strengths of the valence-shell excitations of atoms and molecules. This new method is free from the line saturation effect, and its Bethe-Born conversion factor varies much more slowly with the excitation energy than that of the dipole (e, e) method. Thus the dipole (γ,γ) method provides a reliable approach to obtain the benchmark optical oscillator strengths of the valence-shell excitations for gaseous atoms and molecules. In this paper, we give a review of the dipole (γ,γ) method and some recent measurements of absolute optical oscillator strengths of gaseous atoms and molecules.

Staphylococcus aureus has been shown to bind to human platelets through a variety of surface molecules, including serine-rich adhesin for platelets (SraP). The SraP mutant strain of S. aureus is significantly impaired in its ability to initiate infection compared with the wild strain. SraP is a cell wall-anchored, glycosylated protein. A previous study revealed that SecY2, Asp1, Asp2, Asp3, and SecA2 in the SraP operon were required for the efficient transport of glycosylated SraP from the cytoplasm to the bacterial cell surface. However, no glycosyltransferase (Gtf) was found to be involved in the glycosylation of SraP. In this study, SraP was found in all of the 55 clinical isolates of S. aureus using a real-time polymerase chain reaction assay. Sequence and phylogenetic analysis showed that GtfA and GtfB in the SraP operon were highly conserved in most of these clinical isolates. Conserved domains analysis revealed that both GtfA and GtfB contained a GT1_GtfA-like domain. Structural homology analysis inferred that they are both Gtfs. We then constructed an in vivo glycosylation system in Escherichia coli using SraP1–743 as the substrate and GtfA and GtfB as the Gtfs. Using this system, we found that GtfA and GtfB were the Gtfs that transferred the N-acetylglucosamine-containing oligosaccharides to the recombinant SraP1–743. Deletion of either one or both of the Gtfs abolished the glycosylation of SraP. In summary, GtfA and GtfB in the SraP operon are highly conserved in most clinical isolates of S. aureus, and both GtfA and GtfB are required for SraP glycosylation.

We address the visual categorization problem and present a method that utilizes weakly labeled data from other visual domains as the auxiliary source data for enhancing the original learning system. The proposed method aims to expand the intra-class diversity of original training data through the collaboration with the source data. In order to bring the original target domain data and the auxiliary source domain data into the same feature space, we introduce a weakly-supervised cross-domain dictionary learning method, which learns a reconstructive, discriminative and domain-adaptive dictionary pair and the corresponding classifier parameters without using any prior information. Such a method operates at a high level, and it can be applied to different cross-domain applications. To build up the auxiliary domain data, we manually collect images from Web pages, and select human actions of specific categories from a different dataset. The proposed method is evaluated for human action recognition, image classification and event recognition tasks on the UCF YouTube dataset, the Caltech101/256 datasets and the Kodak dataset, respectively, achieving outstanding results.