Search

Your search keyword '"Elders, A"' showing total 287 results
Start Over Author "Elders, A" Publisher springer science and business media llc
287 results on '"Elders, A"'

5. An omics-based machine learning approach to predict diabetes progression: a RHAPSODY study

Author

Slieker, Roderick C., primary, Münch, Magnus, additional, Donnelly, Louise A., additional, Bouland, Gerard A., additional, Dragan, Iulian, additional, Kuznetsov, Dmitry, additional, Elders, Petra J. M., additional, Rutter, Guy A., additional, Ibberson, Mark, additional, Pearson, Ewan R., additional, ’t Hart, Leen M., additional, van de Wiel, Mark A., additional, and Beulens, Joline W. J., additional

Published
2024
Full Text
View/download PDF

7. A meta-analysis of previous falls and subsequent fracture risk in cohort studies

Author

Vandenput, Liesbeth, primary, Johansson, Helena, additional, McCloskey, Eugene V., additional, Liu, Enwu, additional, Schini, Marian, additional, Åkesson, Kristina E., additional, Anderson, Fred A., additional, Azagra, Rafael, additional, Bager, Cecilie L., additional, Beaudart, Charlotte, additional, Bischoff-Ferrari, Heike A., additional, Biver, Emmanuel, additional, Bruyère, Olivier, additional, Cauley, Jane A., additional, Center, Jacqueline R., additional, Chapurlat, Roland, additional, Christiansen, Claus, additional, Cooper, Cyrus, additional, Crandall, Carolyn J., additional, Cummings, Steven R., additional, da Silva, José A. P., additional, Dawson-Hughes, Bess, additional, Diez-Perez, Adolfo, additional, Dufour, Alyssa B., additional, Eisman, John A., additional, Elders, Petra J. M., additional, Ferrari, Serge, additional, Fujita, Yuki, additional, Fujiwara, Saeko, additional, Glüer, Claus-Christian, additional, Goldshtein, Inbal, additional, Goltzman, David, additional, Gudnason, Vilmundur, additional, Hall, Jill, additional, Hans, Didier, additional, Hoff, Mari, additional, Hollick, Rosemary J., additional, Huisman, Martijn, additional, Iki, Masayuki, additional, Ish-Shalom, Sophia, additional, Jones, Graeme, additional, Karlsson, Magnus K., additional, Khosla, Sundeep, additional, Kiel, Douglas P., additional, Koh, Woon-Puay, additional, Koromani, Fjorda, additional, Kotowicz, Mark A., additional, Kröger, Heikki, additional, Kwok, Timothy, additional, Lamy, Olivier, additional, Langhammer, Arnulf, additional, Larijani, Bagher, additional, Lippuner, Kurt, additional, McGuigan, Fiona E. A., additional, Mellström, Dan, additional, Merlijn, Thomas, additional, Nguyen, Tuan V., additional, Nordström, Anna, additional, Nordström, Peter, additional, O’Neill, Terence W., additional, Obermayer-Pietsch, Barbara, additional, Ohlsson, Claes, additional, Orwoll, Eric S., additional, Pasco, Julie A., additional, Rivadeneira, Fernando, additional, Schott, Anne-Marie, additional, Shiroma, Eric J., additional, Siggeirsdottir, Kristin, additional, Simonsick, Eleanor M., additional, Sornay-Rendu, Elisabeth, additional, Sund, Reijo, additional, Swart, Karin M. A., additional, Szulc, Pawel, additional, Tamaki, Junko, additional, Torgerson, David J., additional, van Schoor, Natasja M., additional, van Staa, Tjeerd P., additional, Vila, Joan, additional, Wareham, Nicholas J., additional, Wright, Nicole C., additional, Yoshimura, Noriko, additional, Zillikens, MCarola, additional, Zwart, Marta, additional, Harvey, Nicholas C., additional, Lorentzon, Mattias, additional, Leslie, William D., additional, and Kanis, John A., additional

Published
2024
Full Text
View/download PDF

8. Microvascular endothelial dysfunction in skin is associated with higher risk of heart failure with preserved ejection fraction in women with type 2 diabetes: the Hoorn Diabetes Care System Cohort

Author

Canto, Elisa Dal, primary, van Deursen, L., additional, Hoek, A. G., additional, Elders, P. J. M., additional, den Ruijter, H. M., additional, van der Velden, J., additional, van Empel, V., additional, Serné, E. H., additional, Eringa, E. C., additional, and Beulens, J. W.J., additional

Published
2023
Full Text
View/download PDF

9. Previous fracture and subsequent fracture risk: a meta-analysis to update FRAX

Author

Kanis, J.A., primary, Johansson, H., additional, McCloskey, E.V., additional, Liu, E., additional, Åkesson, K.E., additional, Anderson, F.A., additional, Azagra, R., additional, Bager, C.L., additional, Beaudart, C., additional, Bischoff-Ferrari, H.A., additional, Biver, E., additional, Bruyère, O., additional, Cauley, J.A., additional, Center, J.R., additional, Chapurlat, R., additional, Christiansen, C., additional, Cooper, C., additional, Crandall, C.J., additional, Cummings, S.R., additional, da Silva, J.A.P., additional, Dawson-Hughes, B., additional, Diez-Perez, A., additional, Dufour, A.B., additional, Eisman, J.A., additional, Elders, P.J.M., additional, Ferrari, S., additional, Fujita, Y., additional, Fujiwara, S., additional, Glüer, C.-C., additional, Goldshtein, I., additional, Goltzman, D., additional, Gudnason, V., additional, Hall, J., additional, Hans, D., additional, Hoff, M., additional, Hollick, R.J., additional, Huisman, M., additional, Iki, M., additional, Ish-Shalom, S., additional, Jones, G., additional, Karlsson, M.K., additional, Khosla, S., additional, Kiel, D.P., additional, Koh, W.-P., additional, Koromani, F., additional, Kotowicz, M.A., additional, Kröger, H., additional, Kwok, T., additional, Lamy, O., additional, Langhammer, A., additional, Larijani, B., additional, Lippuner, K., additional, Mellström, D., additional, Merlijn, T., additional, Nordström, A., additional, Nordström, P., additional, O’Neill, T.W., additional, Obermayer-Pietsch, B., additional, Ohlsson, C., additional, Orwoll, E.S., additional, Pasco, J.A., additional, Rivadeneira, F., additional, Schott, A.-M., additional, Shiroma, E.J., additional, Siggeirsdottir, K., additional, Simonsick, E.M., additional, Sornay-Rendu, E., additional, Sund, R., additional, Swart, K.M.A., additional, Szulc, P., additional, Tamaki, J., additional, Torgerson, D.J., additional, van Schoor, N.M., additional, van Staa, T.P., additional, Vila, J., additional, Wareham, N.J., additional, Wright, N.C., additional, Yoshimura, N., additional, Zillikens, M.C., additional, Zwart, M., additional, Vandenput, L., additional, Harvey, N.C., additional, Lorentzon, M., additional, and Leslie, W.D., additional

Published
2023
Full Text
View/download PDF

10. Kidney function measures and cardiovascular outcomes in people with diabetes: the Hoorn Diabetes Care System cohort

Author

Elisa Dal Canto, Petra J. M. Elders, Amber A. van der Heijden, Adriana J. van Ballegooijen, Birgit I. Lissenberg-Witte, Femke Rutters, Joline W. J. Beulens, Epidemiology and Data Science, ACS - Diabetes & metabolism, General practice, APH - Health Behaviors & Chronic Diseases, APH - Methodology, APH - Aging & Later Life, and ACS - Heart failure & arrhythmias

Subjects
Endocrinology, Diabetes and Metabolism, Internal Medicine
Abstract

Aims/hypothesis Both manifestations of kidney disease in diabetes, reduced eGFR (ml/min per 1.73 m2) and increased urinary albumin/creatinine ratio (UACR, mg/mmol), may increase the risk of specific CVD subtypes in adults with diabetes. Methods We assessed the prospective association between annually recorded measures of eGFR and UACR and the occurrence of myocardial infarction (MI), CHD, stroke, heart failure (HF) and cardiovascular mortality in 13,657 individuals with diabetes (53.6% male, age 62.3±12.1 years) from the Hoorn Diabetes Care System cohort, using data obtained between 1998 and 2018. Multivariate time-dependent Cox regression models adjusted for cardiovascular risk factors were used to estimate HRs and 95% CI. Associations of eGFR were adjusted for UACR values and vice versa. Effect modification by sex was investigated for all associations. Results After a mean follow-up period of 7 years, event rates per 1000 person-years were 3.08 for MI, 3.72 for CHD, 1.12 for HF, 0.84 for stroke and 6.25 for cardiovascular mortality. Mildly reduced eGFR (60–90 ml/min per 1.73 m2) and moderately to severely reduced eGFR (2) were associated with higher risks of MI (HR 1.52; 95% CI 1.10, 2.12 and HR 1.69; 95% CI 1.09, 2.64) and CHD (HR 1.67; 95% CI 1.23, 2.26 and HR 2.01; 95% CI 1.34, 3.02) compared with normal eGFR (>90 ml/min per 1.73 m2). Mildly reduced eGFR was associated with a higher risk of stroke (HR 2.53; 95% CI 1.27, 5.03). Moderately increased UACR (3–30 mg/mmol) and severely increased UACR (>30 mg/mmol) were prospectively associated with a higher cardiovascular mortality risk in men and women (HR 1.87; 95% CI 1.41, 2.47 and HR 2.78; 95% CI 1.78, 4.34) compared with normal UACR (30 mg/mmol, categories were combined into UACR 3.0 mg/mmol in the stratified analysis. Women but not men with UACR >3.0 mg/mmol had a significantly higher risk of HF compared with normal UACR (HR 2.79; 95% CI 1.47, 5.28). Conclusions/interpretation This study showed differential and independent prospective associations between manifestations of early kidney damage in diabetes and several CVD subtypes, suggesting that regular monitoring of both kidney function measures may help to identify individuals at higher risk of specific cardiovascular events. Graphical abstract

Published
2022

12. Patient-reported outcomes for people with diabetes: what and how to measure? A narrative review

Author

Terwee, Caroline B., primary, Elders, Petra J. M., additional, Blom, Marieke T., additional, Beulens, Joline W., additional, Rolandsson, Olaf, additional, Rogge, Alize A., additional, Rose, Matthias, additional, Harman, Nicola, additional, Williamson, Paula R., additional, Pouwer, Frans, additional, Mokkink, Lidwine B., additional, and Rutters, Femke, additional

Published
2023
Full Text
View/download PDF

13. Identification of biomarkers for glycaemic deterioration in type 2 diabetes

Author

Slieker, Roderick C., primary, Donnelly, Louise A., additional, Akalestou, Elina, additional, Lopez-Noriega, Livia, additional, Melhem, Rana, additional, Güneş, Ayşim, additional, Abou Azar, Frederic, additional, Efanov, Alexander, additional, Georgiadou, Eleni, additional, Muniangi-Muhitu, Hermine, additional, Sheikh, Mahsa, additional, Giordano, Giuseppe N., additional, Åkerlund, Mikael, additional, Ahlqvist, Emma, additional, Ali, Ashfaq, additional, Banasik, Karina, additional, Brunak, Søren, additional, Barovic, Marko, additional, Bouland, Gerard A., additional, Burdet, Frédéric, additional, Canouil, Mickaël, additional, Dragan, Iulian, additional, Elders, Petra J. M., additional, Fernandez, Celine, additional, Festa, Andreas, additional, Fitipaldi, Hugo, additional, Froguel, Phillippe, additional, Gudmundsdottir, Valborg, additional, Gudnason, Vilmundur, additional, Gerl, Mathias J., additional, van der Heijden, Amber A., additional, Jennings, Lori L., additional, Hansen, Michael K., additional, Kim, Min, additional, Leclerc, Isabelle, additional, Klose, Christian, additional, Kuznetsov, Dmitry, additional, Mansour Aly, Dina, additional, Mehl, Florence, additional, Marek, Diana, additional, Melander, Olle, additional, Niknejad, Anne, additional, Ottosson, Filip, additional, Pavo, Imre, additional, Duffin, Kevin, additional, Syed, Samreen K., additional, Shaw, Janice L., additional, Cabrera, Over, additional, Pullen, Timothy J., additional, Simons, Kai, additional, Solimena, Michele, additional, Suvitaival, Tommi, additional, Wretlind, Asger, additional, Rossing, Peter, additional, Lyssenko, Valeriya, additional, Legido Quigley, Cristina, additional, Groop, Leif, additional, Thorens, Bernard, additional, Franks, Paul W., additional, Lim, Gareth E., additional, Estall, Jennifer, additional, Ibberson, Mark, additional, Beulens, Joline W. J., additional, ’t Hart, Leen M, additional, Pearson, Ewan R., additional, and Rutter, Guy A., additional

Published
2023
Full Text
View/download PDF

14. PROSPECT: 4- and 6-year follow-up of a randomised trial of surgery for vaginal prolapse

Author

Reid, Fiona M., Aucott, Lorna, Glazener, Cathryn M. A., Elders, Andrew, Hemming, Christine, Cooper, Kevin G., Freeman, Robert M., Smith, Anthony R. B., Hagen, Suzanne, Kilonzo, Mary, Boyers, Dwayne, MacLennan, Graeme, Norrie, John, and Breeman, Suzanne

Subjects
Randomised trial, Manchester Cancer Research Centre, Xenograft, ResearchInstitutes_Networks_Beacons/mcrc, Urology, Prolapse, Obstetrics and Gynecology, Polypropylene mesh
Abstract

Introduction and hypothesis Our aim was to compare the mid-term results of native tissue, biological xenograft and polypropylene mesh surgery for women with vaginal wall prolapse. Methods A total of 1348 women undergoing primary transvaginal repair of an anterior and/or posterior prolapse were recruited between January 2010 and August 2013 from 35 UK centres. They were randomised by remote allocation to native tissue surgery, biological xenograft or polypropylene mesh. We performed both 4- and 6-year follow-up using validated patient-reported outcome measures. Results At 4 and 6 years post-operation, there was no clinically important difference in Pelvic Organ Prolapse Symptom Score for any of the treatments. Using a strict composite outcome to assess functional cure at 6 years, we found no difference in cure among the three types of surgery. Half the women were cured at 6 years but only 10.3 to 12% of women had undergone further surgery for prolapse. However, 8.4% of women in the mesh group had undergone further surgery for mesh complications. There was no difference in the incidence of chronic pain or dyspareunia between groups. Conclusions At the mid-term outcome of 6 years, there is no benefit from augmenting primary prolapse repairs with polypropylene mesh inlays or biological xenografts. There was no evidence that polypropylene mesh inlays caused greater pain or dyspareunia than native tissue repairs.

Published
2022

15. Long-term effects and costs of pelvic floor muscle training for prolapse: trial follow-up record-linkage study

Author

Linda Fenocchi, Catherine Best, Helen Mason, Andrew Elders, Suzanne Hagen, and Margaret Maxwell

Subjects
Urology, Obstetrics and Gynecology
Abstract

Introduction and hypothesis Pelvic organ prolapse affects around 40% of women aged over 50 years. A multicentre parallel group randomised trial (the Pelvic Organ Prolapse PhysiotherapY (POPPY) trial) demonstrated that pelvic floor muscle training (PFMT) was effective in reducing prolapse symptoms compared with no treatment. However, insight into the long-term impact of PFMT on health outcomes and health-service utilisation is scarce. Methods This study utilised linkage of Scottish administrative health records to follow-up POPPY trial participants resident in Scotland over 11 years. Mixed effects logistic regression determined the likelihood of receiving further prolapse treatment for those in the PFMT and control groups. Analyses were adjusted for age group, prolapse stage, baseline symptom severity and attitude towards surgery. A cost assessment estimated longitudinal costs to the UK National Health Service (in Scotland) of accessing further prolapse treatment for each trial group. Results Two hundred and ninety-three women, aged 25 to 79 years, were followed up. One hundred and forty-one women (48.1%) had received further prolapse treatment: 65 (of 149; 43.6%) in the PFMT group compared with 76 (of 144; 52.8%) in the control group. PFMT was associated with a reduction in the odds of any prolapse treatment during follow-up (AOR 0.61; 95% CI 0.37 to 0.99). Total cost of secondary care was £154,544 (GBP) in the PFMT group and £172,549 (GBP) in the control group. Conclusions Although PFMT did not lead to significant differences in total costs for further prolapse treatment over a post-intervention period of more than 10 years, it reduced the overall long-term risk of requiring hospital-based treatment for pelvic floor disorders.

Published
2022

17. Altered blood gene expression in the obesity-related type 2 diabetes cluster may be causally involved in lipid metabolism: a Mendelian randomisation study

Author

de Klerk, Juliette A., primary, Beulens, Joline W. J., additional, Mei, Hailiang, additional, Bijkerk, Roel, additional, van Zonneveld, Anton Jan, additional, Koivula, Robert W., additional, Elders, Petra J. M., additional, ’t Hart, Leen M., additional, and Slieker, Roderick C., additional

Published
2023
Full Text
View/download PDF

19. Implicating genes, pleiotropy, and sexual dimorphism at blood lipid loci through multi-ancestry meta-analysis

Author

Kanoni, Stavroula, primary, Graham, Sarah E., additional, Wang, Yuxuan, additional, Surakka, Ida, additional, Ramdas, Shweta, additional, Zhu, Xiang, additional, Clarke, Shoa L., additional, Bhatti, Konain Fatima, additional, Vedantam, Sailaja, additional, Winkler, Thomas W., additional, Locke, Adam E., additional, Marouli, Eirini, additional, Zajac, Greg J. M., additional, Wu, Kuan-Han H., additional, Ntalla, Ioanna, additional, Hui, Qin, additional, Klarin, Derek, additional, Hilliard, Austin T., additional, Wang, Zeyuan, additional, Xue, Chao, additional, Thorleifsson, Gudmar, additional, Helgadottir, Anna, additional, Gudbjartsson, Daniel F., additional, Holm, Hilma, additional, Olafsson, Isleifur, additional, Hwang, Mi Yeong, additional, Han, Sohee, additional, Akiyama, Masato, additional, Sakaue, Saori, additional, Terao, Chikashi, additional, Kanai, Masahiro, additional, Zhou, Wei, additional, Brumpton, Ben M., additional, Rasheed, Humaira, additional, Havulinna, Aki S., additional, Veturi, Yogasudha, additional, Pacheco, Jennifer Allen, additional, Rosenthal, Elisabeth A., additional, Lingren, Todd, additional, Feng, QiPing, additional, Kullo, Iftikhar J., additional, Narita, Akira, additional, Takayama, Jun, additional, Martin, Hilary C., additional, Hunt, Karen A., additional, Trivedi, Bhavi, additional, Haessler, Jeffrey, additional, Giulianini, Franco, additional, Bradford, Yuki, additional, Miller, Jason E., additional, Campbell, Archie, additional, Lin, Kuang, additional, Millwood, Iona Y., additional, Rasheed, Asif, additional, Hindy, George, additional, Faul, Jessica D., additional, Zhao, Wei, additional, Weir, David R., additional, Turman, Constance, additional, Huang, Hongyan, additional, Graff, Mariaelisa, additional, Choudhury, Ananyo, additional, Sengupta, Dhriti, additional, Mahajan, Anubha, additional, Brown, Michael R., additional, Zhang, Weihua, additional, Yu, Ketian, additional, Schmidt, Ellen M., additional, Pandit, Anita, additional, Gustafsson, Stefan, additional, Yin, Xianyong, additional, Luan, Jian’an, additional, Zhao, Jing-Hua, additional, Matsuda, Fumihiko, additional, Jang, Hye-Mi, additional, Yoon, Kyungheon, additional, Medina-Gomez, Carolina, additional, Pitsillides, Achilleas, additional, Hottenga, Jouke Jan, additional, Wood, Andrew R., additional, Ji, Yingji, additional, Gao, Zishan, additional, Haworth, Simon, additional, Yousri, Noha A., additional, Mitchell, Ruth E., additional, Chai, Jin Fang, additional, Aadahl, Mette, additional, Bjerregaard, Anne A., additional, Yao, Jie, additional, Manichaikul, Ani, additional, Hwu, Chii-Min, additional, Hung, Yi-Jen, additional, Warren, Helen R., additional, Ramirez, Julia, additional, Bork-Jensen, Jette, additional, Kårhus, Line L., additional, Goel, Anuj, additional, Sabater-Lleal, Maria, additional, Noordam, Raymond, additional, Mauro, Pala, additional, Matteo, Floris, additional, McDaid, Aaron F., additional, Marques-Vidal, Pedro, additional, Wielscher, Matthias, additional, Trompet, Stella, additional, Sattar, Naveed, additional, Møllehave, Line T., additional, Munz, Matthias, additional, Zeng, Lingyao, additional, Huang, Jianfeng, additional, Yang, Bin, additional, Poveda, Alaitz, additional, Kurbasic, Azra, additional, Lamina, Claudia, additional, Forer, Lukas, additional, Scholz, Markus, additional, Galesloot, Tessel E., additional, Bradfield, Jonathan P., additional, Ruotsalainen, Sanni E., additional, Daw, EWarwick, additional, Zmuda, Joseph M., additional, Mitchell, Jonathan S., additional, Fuchsberger, Christian, additional, Christensen, Henry, additional, Brody, Jennifer A., additional, Vazquez-Moreno, Miguel, additional, Feitosa, Mary F., additional, Wojczynski, Mary K., additional, Wang, Zhe, additional, Preuss, Michael H., additional, Mangino, Massimo, additional, Christofidou, Paraskevi, additional, Verweij, Niek, additional, Benjamins, Jan W., additional, Engmann, Jorgen, additional, Tsao, Noah L., additional, Verma, Anurag, additional, Slieker, Roderick C., additional, Lo, Ken Sin, additional, Zilhao, Nuno R., additional, Le, Phuong, additional, Kleber, Marcus E., additional, Delgado, Graciela E., additional, Huo, Shaofeng, additional, Ikeda, Daisuke D., additional, Iha, Hiroyuki, additional, Yang, Jian, additional, Liu, Jun, additional, Demirkan, Ayşe, additional, Leonard, Hampton L., additional, Marten, Jonathan, additional, Frank, Mirjam, additional, Schmidt, Börge, additional, Smyth, Laura J., additional, Cañadas-Garre, Marisa, additional, Wang, Chaolong, additional, Nakatochi, Masahiro, additional, Wong, Andrew, additional, Hutri-Kähönen, Nina, additional, Sim, Xueling, additional, Xia, Rui, additional, Huerta-Chagoya, Alicia, additional, Fernandez-Lopez, Juan Carlos, additional, Lyssenko, Valeriya, additional, Nongmaithem, Suraj S., additional, Bayyana, Swati, additional, Stringham, Heather M., additional, Irvin, Marguerite R., additional, Oldmeadow, Christopher, additional, Kim, Han-Na, additional, Ryu, Seungho, additional, Timmers, Paul R. H. J., additional, Arbeeva, Liubov, additional, Dorajoo, Rajkumar, additional, Lange, Leslie A., additional, Prasad, Gauri, additional, Lorés-Motta, Laura, additional, Pauper, Marc, additional, Long, Jirong, additional, Li, Xiaohui, additional, Theusch, Elizabeth, additional, Takeuchi, Fumihiko, additional, Spracklen, Cassandra N., additional, Loukola, Anu, additional, Bollepalli, Sailalitha, additional, Warner, Sophie C., additional, Wang, Ya Xing, additional, Wei, Wen B., additional, Nutile, Teresa, additional, Ruggiero, Daniela, additional, Sung, Yun Ju, additional, Chen, Shufeng, additional, Liu, Fangchao, additional, Yang, Jingyun, additional, Kentistou, Katherine A., additional, Banas, Bernhard, additional, Nardone, Giuseppe Giovanni, additional, Meidtner, Karina, additional, Bielak, Lawrence F., additional, Smith, Jennifer A., additional, Hebbar, Prashantha, additional, Farmaki, Aliki-Eleni, additional, Hofer, Edith, additional, Lin, Maoxuan, additional, Concas, Maria Pina, additional, Vaccargiu, Simona, additional, van der Most, Peter J., additional, Pitkänen, Niina, additional, Cade, Brian E., additional, van der Laan, Sander W., additional, Chitrala, Kumaraswamy Naidu, additional, Weiss, Stefan, additional, Bentley, Amy R., additional, Doumatey, Ayo P., additional, Adeyemo, Adebowale A., additional, Lee, Jong Young, additional, Petersen, Eva R. B., additional, Nielsen, Aneta A., additional, Choi, Hyeok Sun, additional, Nethander, Maria, additional, Freitag-Wolf, Sandra, additional, Southam, Lorraine, additional, Rayner, Nigel W., additional, Wang, Carol A., additional, Lin, Shih-Yi, additional, Wang, Jun-Sing, additional, Couture, Christian, additional, Lyytikäinen, Leo-Pekka, additional, Nikus, Kjell, additional, Cuellar-Partida, Gabriel, additional, Vestergaard, Henrik, additional, Hidalgo, Bertha, additional, Giannakopoulou, Olga, additional, Cai, Qiuyin, additional, Obura, Morgan O., additional, van Setten, Jessica, additional, Li, Xiaoyin, additional, Liang, Jingjing, additional, Tang, Hua, additional, Terzikhan, Natalie, additional, Shin, Jae Hun, additional, Jackson, Rebecca D., additional, Reiner, Alexander P., additional, Martin, Lisa Warsinger, additional, Chen, Zhengming, additional, Li, Liming, additional, Kawaguchi, Takahisa, additional, Thiery, Joachim, additional, Bis, Joshua C., additional, Launer, Lenore J., additional, Li, Huaixing, additional, Nalls, Mike A., additional, Raitakari, Olli T., additional, Ichihara, Sahoko, additional, Wild, Sarah H., additional, Nelson, Christopher P., additional, Campbell, Harry, additional, Jäger, Susanne, additional, Nabika, Toru, additional, Al-Mulla, Fahd, additional, Niinikoski, Harri, additional, Braund, Peter S., additional, Kolcic, Ivana, additional, Kovacs, Peter, additional, Giardoglou, Tota, additional, Katsuya, Tomohiro, additional, de Kleijn, Dominique, additional, de Borst, Gert J., additional, Kim, Eung Kweon, additional, Adams, Hieab H. H., additional, Ikram, M. Arfan, additional, Zhu, Xiaofeng, additional, Asselbergs, Folkert W., additional, Kraaijeveld, Adriaan O., additional, Beulens, Joline W. J., additional, Shu, Xiao-Ou, additional, Rallidis, Loukianos S., additional, Pedersen, Oluf, additional, Hansen, Torben, additional, Mitchell, Paul, additional, Hewitt, Alex W., additional, Kähönen, Mika, additional, Pérusse, Louis, additional, Bouchard, Claude, additional, Tönjes, Anke, additional, Chen, Yii-Der Ida, additional, Pennell, Craig E., additional, Mori, Trevor A., additional, Lieb, Wolfgang, additional, Franke, Andre, additional, Ohlsson, Claes, additional, Mellström, Dan, additional, Cho, Yoon Shin, additional, Lee, Hyejin, additional, Yuan, Jian-Min, additional, Koh, Woon-Puay, additional, Rhee, Sang Youl, additional, Woo, Jeong-Taek, additional, Heid, Iris M., additional, Stark, Klaus J., additional, Zimmermann, Martina E., additional, Völzke, Henry, additional, Homuth, Georg, additional, Evans, Michele K., additional, Zonderman, Alan B., additional, Polasek, Ozren, additional, Pasterkamp, Gerard, additional, Hoefer, Imo E., additional, Redline, Susan, additional, Pahkala, Katja, additional, Oldehinkel, Albertine J., additional, Snieder, Harold, additional, Biino, Ginevra, additional, Schmidt, Reinhold, additional, Schmidt, Helena, additional, Bandinelli, Stefania, additional, Dedoussis, George, additional, Thanaraj, Thangavel Alphonse, additional, Kardia, Sharon L. R., additional, Peyser, Patricia A., additional, Kato, Norihiro, additional, Schulze, Matthias B., additional, Girotto, Giorgia, additional, Böger, Carsten A., additional, Jung, Bettina, additional, Joshi, Peter K., additional, Bennett, David A., additional, De Jager, Philip L., additional, Lu, Xiangfeng, additional, Mamakou, Vasiliki, additional, Brown, Morris, additional, Caulfield, Mark J., additional, Munroe, Patricia B., additional, Guo, Xiuqing, additional, Ciullo, Marina, additional, Jonas, Jost B., additional, Samani, Nilesh J., additional, Kaprio, Jaakko, additional, Pajukanta, Päivi, additional, Tusié-Luna, Teresa, additional, Aguilar-Salinas, Carlos A., additional, Adair, Linda S., additional, Bechayda, Sonny Augustin, additional, de Silva, H. Janaka, additional, Wickremasinghe, Ananda R., additional, Krauss, Ronald M., additional, Wu, Jer-Yuarn, additional, Zheng, Wei, additional, Hollander, Anneke Iden, additional, Bharadwaj, Dwaipayan, additional, Correa, Adolfo, additional, Wilson, James G., additional, Lind, Lars, additional, Heng, Chew-Kiat, additional, Nelson, Amanda E., additional, Golightly, Yvonne M., additional, Wilson, James F., additional, Penninx, Brenda, additional, Kim, Hyung-Lae, additional, Attia, John, additional, Scott, Rodney J., additional, Rao, D. C., additional, Arnett, Donna K., additional, Hunt, Steven C., additional, Walker, Mark, additional, Koistinen, Heikki A., additional, Chandak, Giriraj R., additional, Mercader, Josep M., additional, Costanzo, Maria C., additional, Jang, Dongkeun, additional, Burtt, Noël P., additional, Villalpando, Clicerio Gonzalez, additional, Orozco, Lorena, additional, Fornage, Myriam, additional, Tai, EShyong, additional, van Dam, Rob M., additional, Lehtimäki, Terho, additional, Chaturvedi, Nish, additional, Yokota, Mitsuhiro, additional, Liu, Jianjun, additional, Reilly, Dermot F., additional, McKnight, Amy Jayne, additional, Kee, Frank, additional, Jöckel, Karl-Heinz, additional, McCarthy, Mark I., additional, Palmer, Colin N. A., additional, Vitart, Veronique, additional, Hayward, Caroline, additional, Simonsick, Eleanor, additional, van Duijn, Cornelia M., additional, Jin, Zi-Bing, additional, Qu, Jia, additional, Hishigaki, Haretsugu, additional, Lin, Xu, additional, März, Winfried, additional, Gudnason, Vilmundur, additional, Tardif, Jean-Claude, additional, Lettre, Guillaume, additional, Hart, Leen M.‘t, additional, Elders, Petra J. M., additional, Damrauer, Scott M., additional, Kumari, Meena, additional, Kivimaki, Mika, additional, van der Harst, Pim, additional, Spector, Tim D., additional, Loos, Ruth J. F., additional, Province, Michael A., additional, Parra, Esteban J., additional, Cruz, Miguel, additional, Psaty, Bruce M., additional, Brandslund, Ivan, additional, Pramstaller, Peter P., additional, Rotimi, Charles N., additional, Christensen, Kaare, additional, Ripatti, Samuli, additional, Widén, Elisabeth, additional, Hakonarson, Hakon, additional, Grant, Struan F. A., additional, Kiemeney, Lambertus A. L. M., additional, de Graaf, Jacqueline, additional, Loeffler, Markus, additional, Kronenberg, Florian, additional, Gu, Dongfeng, additional, Erdmann, Jeanette, additional, Schunkert, Heribert, additional, Franks, Paul W., additional, Linneberg, Allan, additional, Jukema, J. Wouter, additional, Khera, Amit V., additional, Männikkö, Minna, additional, Jarvelin, Marjo-Riitta, additional, Kutalik, Zoltan, additional, Francesco, Cucca, additional, Mook-Kanamori, Dennis O., additional, van Dijk, Ko Willems, additional, Watkins, Hugh, additional, Strachan, David P., additional, Grarup, Niels, additional, Sever, Peter, additional, Poulter, Neil, additional, Chuang, Lee-Ming, additional, Rotter, Jerome I., additional, Dantoft, Thomas M., additional, Karpe, Fredrik, additional, Neville, Matt J., additional, Timpson, Nicholas J., additional, Cheng, Ching-Yu, additional, Wong, Tien-Yin, additional, Khor, Chiea Chuen, additional, Li, Hengtong, additional, Sabanayagam, Charumathi, additional, Peters, Annette, additional, Gieger, Christian, additional, Hattersley, Andrew T., additional, Pedersen, Nancy L., additional, Magnusson, Patrik K. E., additional, Boomsma, Dorret I., additional, Willemsen, Allegonda H. M., additional, Cupples, LAdrienne, additional, van Meurs, Joyce B. J., additional, Ghanbari, Mohsen, additional, Gordon-Larsen, Penny, additional, Huang, Wei, additional, Kim, Young Jin, additional, Tabara, Yasuharu, additional, Wareham, Nicholas J., additional, Langenberg, Claudia, additional, Zeggini, Eleftheria, additional, Kuusisto, Johanna, additional, Laakso, Markku, additional, Ingelsson, Erik, additional, Abecasis, Goncalo, additional, Chambers, John C., additional, Kooner, Jaspal S., additional, de Vries, Paul S., additional, Morrison, Alanna C., additional, Hazelhurst, Scott, additional, Ramsay, Michèle, additional, North, Kari E., additional, Daviglus, Martha, additional, Kraft, Peter, additional, Martin, Nicholas G., additional, Whitfield, John B., additional, Abbas, Shahid, additional, Saleheen, Danish, additional, Walters, Robin G., additional, Holmes, Michael V., additional, Black, Corri, additional, Smith, Blair H., additional, Baras, Aris, additional, Justice, Anne E., additional, Buring, Julie E., additional, Ridker, Paul M., additional, Chasman, Daniel I., additional, Kooperberg, Charles, additional, Tamiya, Gen, additional, Yamamoto, Masayuki, additional, van Heel, David A., additional, Trembath, Richard C., additional, Wei, Wei-Qi, additional, Jarvik, Gail P., additional, Namjou, Bahram, additional, Hayes, M. Geoffrey, additional, Ritchie, Marylyn D., additional, Jousilahti, Pekka, additional, Salomaa, Veikko, additional, Hveem, Kristian, additional, Åsvold, Bjørn Olav, additional, Kubo, Michiaki, additional, Kamatani, Yoichiro, additional, Okada, Yukinori, additional, Murakami, Yoshinori, additional, Kim, Bong-Jo, additional, Thorsteinsdottir, Unnur, additional, Stefansson, Kari, additional, Zhang, Jifeng, additional, Chen, YEugene, additional, Ho, Yuk-Lam, additional, Lynch, Julie A., additional, Rader, Daniel J., additional, Tsao, Philip S., additional, Chang, Kyong-Mi, additional, Cho, Kelly, additional, O’Donnell, Christopher J., additional, Gaziano, John M., additional, Wilson, Peter W. F., additional, Frayling, Timothy M., additional, Hirschhorn, Joel N., additional, Kathiresan, Sekar, additional, Mohlke, Karen L., additional, Sun, Yan V., additional, Morris, Andrew P., additional, Boehnke, Michael, additional, Brown, Christopher D., additional, Natarajan, Pradeep, additional, Deloukas, Panos, additional, Willer, Cristen J., additional, Assimes, Themistocles L., additional, and Peloso, Gina M., additional

Published
2022
Full Text
View/download PDF

21. Effectiveness and cost-effectiveness of text messages with or without endowment incentives for weight management in men with obesity (Game of Stones): study protocol for a randomised controlled trial

Author

Macaulay, Lisa, O’Dolan, Catriona, Avenell, Alison, Carroll, Paula, Cotton, Seonaidh, Dombrowski, Stephan, Elders, Andrew, Goulao, Beatriz, Gray, Cindy, Harris, Fiona M, Hunt, Kate, Kee, Frank, Torrens, Claire, van der Pol, Marjon, and Hoddinott, Pat

Subjects
Randomised controlled trial, Men with obesity, Weight management, Text messages, Financial incentives, Cost-effectiveness, Process evaluation, Health inequalities
Abstract

Background Obesity increases the risk of type 2 diabetes, heart disease, stroke, mobility problems and some cancers, and its prevalence is rising. Men engage less than women in existing weight loss interventions. Game of Stones builds on a successful feasibility study and aims to find out if automated text messages with or without endowment incentives are effective and cost-effective for weight loss at 12 months compared to a waiting list comparator arm in men with obesity. Methods A 3-arm, parallel group, assessor-blind superiority randomised controlled trial with process evaluation will recruit 585 adult men with body mass index of 30 kg/m2 or more living in and around three UK centres (Belfast, Bristol, Glasgow), purposively targeting disadvantaged areas. Intervention groups: (i) automated, theory-informed text messages daily for 12 months plus endowment incentives linked to verified weight loss targets at 3, 6 and 12 months; (ii) the same text messages and weight loss assessment protocol; (iii) comparator group: 12 month waiting list, then text messages for 3 months. The primary outcome is percentage weight change at 12 months from baseline. Secondary outcomes at 12 months are as follows: quality of life, wellbeing, mental health, weight stigma, behaviours, satisfaction and confidence. Follow-up includes weight at 24 months. A health economic evaluation will measure cost-effectiveness over the trial and over modelled lifetime: including health service resource-use and quality-adjusted life years. The cost-utility analysis will report incremental cost per quality-adjusted life years gained. Participant and service provider perspectives will be explored via telephone interviews, and exploratory mixed methods process evaluation analyses will focus on mental health, multiple long-term conditions, health inequalities and implementation strategies. Discussion The trial will report whether text messages (with and without cash incentives) can help men to lose weight over 1 year and maintain this for another year compared to a comparator group; the costs and benefits to the health service; and men’s experiences of the interventions. Process analyses with public involvement and service commissioner input will ensure that this open-source digital self-care intervention could be sustainable and scalable by a range of NHS or public services.

Published
2022

22. Geophysical model generation with generative adversarial networks

Author

Vladimir Puzyrev, Tristan Salles, Greg Surma, and Chris Elders

Subjects
General Earth and Planetary Sciences
Abstract

With the rapid development of deep learning technologies, data-driven methods have become one of the main research focuses in geophysical inversion. Applications of various neural network architectures to the inversion of seismic, electromagnetic, gravity and other types of data confirm the potential of these methods in real-time parameter estimation without dependence on the starting subsurface model. At the same time, deep learning methods require large training datasets which are often difficult to acquire. In this paper, we present a generator of 2D subsurface models based on deep generative adversarial networks. Several networks are trained separately on realistic density and stratigraphy models to reach a sufficient degree of accuracy in generation of new highly detailed and varied models in real-time. This allows for creation of large synthetic training datasets in a cost-effective manner, thus facilitating the development of better deep learning algorithms for real-time inversion and interpretation.

Published
2022

23. A personalised intervention programme aimed at improving adherence to oral antidiabetic and/or antihypertensive medication in people with type 2 diabetes mellitus, the INTENSE study: study protocol for a randomised controlled trial

Author

Langendoen-Gort, Marlous, primary, Al-Jabr, Hiyam, additional, Hugtenburg, Jacqueline G., additional, Rutters, Femke, additional, de Wit, Maartje, additional, Bhattacharya, Debi, additional, Abu-Hanna, Ameen, additional, Farmer, Andrew, additional, and Elders, Petra J. M., additional

Published
2022
Full Text
View/download PDF

25. Effectiveness and cost-effectiveness of text messages with or without endowment incentives for weight management in men with obesity (Game of Stones): study protocol for a randomised controlled trial

Author

Lisa Macaulay, Catriona O’Dolan, Alison Avenell, Paula Carroll, Seonaidh Cotton, Stephan Dombrowski, Andrew Elders, Beatriz Goulao, Cindy Gray, Fiona M. Harris, Kate Hunt, Frank Kee, Graeme MacLennan, Matthew David McDonald, Michelle McKinley, Rebecca Skinner, Claire Torrens, Martin Tod, Katrina Turner, Marjon van der Pol, and Pat Hoddinott

Subjects
Adult, Male, Men With Obesity, Motivation, Text Messaging, Financial Management, Cost-Benefit Analysis, Medicine (miscellaneous), Health Inequalities, Weight Management, Financial Incentives, Diabetes Mellitus, Type 2, SDG 3 - Good Health and Well-being, Weight Loss, Quality of Life, Humans, Cost-effectiveness, Pharmacology (medical), Obesity, Process Evaluation, Text Messages, Randomised Controlled Trial, Randomized Controlled Trials as Topic
Abstract

Background Obesity increases the risk of type 2 diabetes, heart disease, stroke, mobility problems and some cancers, and its prevalence is rising. Men engage less than women in existing weight loss interventions. Game of Stones builds on a successful feasibility study and aims to find out if automated text messages with or without endowment incentives are effective and cost-effective for weight loss at 12 months compared to a waiting list comparator arm in men with obesity. Methods A 3-arm, parallel group, assessor-blind superiority randomised controlled trial with process evaluation will recruit 585 adult men with body mass index of 30 kg/m2 or more living in and around three UK centres (Belfast, Bristol, Glasgow), purposively targeting disadvantaged areas. Intervention groups: (i) automated, theory-informed text messages daily for 12 months plus endowment incentives linked to verified weight loss targets at 3, 6 and 12 months; (ii) the same text messages and weight loss assessment protocol; (iii) comparator group: 12 month waiting list, then text messages for 3 months. The primary outcome is percentage weight change at 12 months from baseline. Secondary outcomes at 12 months are as follows: quality of life, wellbeing, mental health, weight stigma, behaviours, satisfaction and confidence. Follow-up includes weight at 24 months. A health economic evaluation will measure cost-effectiveness over the trial and over modelled lifetime: including health service resource-use and quality-adjusted life years. The cost-utility analysis will report incremental cost per quality-adjusted life years gained. Participant and service provider perspectives will be explored via telephone interviews, and exploratory mixed methods process evaluation analyses will focus on mental health, multiple long-term conditions, health inequalities and implementation strategies. Discussion The trial will report whether text messages (with and without cash incentives) can help men to lose weight over 1 year and maintain this for another year compared to a comparator group; the costs and benefits to the health service; and men’s experiences of the interventions. Process analyses with public involvement and service commissioner input will ensure that this open-source digital self-care intervention could be sustainable and scalable by a range of NHS or public services. Trial registration ISRCTN 91974895. Registered on 14/04/2021.

Published
2022

27. Content Validity of Patient-Reported Outcome Measures Developed for Assessing Health-Related Quality of Life in People with Type 2 Diabetes Mellitus: a Systematic Review

Author

Terwee, Caroline B., primary, Elders, Petra J. M., additional, Langendoen-Gort, Marlous, additional, Elsman, Ellen B. M., additional, Prinsen, Cecilia A. C., additional, van der Heijden, Amber A., additional, de Wit, Maartje, additional, Beulens, Joline W. J., additional, Mokkink, Lidwine B., additional, and Rutters, Femke, additional

Published
2022
Full Text
View/download PDF

31. Update of the fracture risk prediction tool FRAX: a systematic review of potential cohorts and analysis plan

Author

Vandenput, L., primary, Johansson, H., additional, McCloskey, E. V., additional, Liu, E., additional, Åkesson, K. E., additional, Anderson, F. A., additional, Azagra, R., additional, Bager, C. L., additional, Beaudart, C., additional, Bischoff-Ferrari, H. A., additional, Biver, E., additional, Bruyère, O., additional, Cauley, J. A., additional, Center, J. R., additional, Chapurlat, R., additional, Christiansen, C., additional, Cooper, C., additional, Crandall, C. J., additional, Cummings, S. R., additional, da Silva, J. A. P., additional, Dawson-Hughes, B., additional, Diez-Perez, A., additional, Dufour, A. B., additional, Eisman, J. A., additional, Elders, P. J. M., additional, Ferrari, S., additional, Fujita, Y., additional, Fujiwara, S., additional, Glüer, C.-C., additional, Goldshtein, I., additional, Goltzman, D., additional, Gudnason, V., additional, Hall, J., additional, Hans, D., additional, Hoff, M., additional, Hollick, R. J., additional, Huisman, M., additional, Iki, M., additional, Ish-Shalom, S., additional, Jones, G., additional, Karlsson, M. K., additional, Khosla, S., additional, Kiel, D. P., additional, Koh, W.-P., additional, Koromani, F., additional, Kotowicz, M. A., additional, Kröger, H., additional, Kwok, T., additional, Lamy, O., additional, Langhammer, A., additional, Larijani, B., additional, Lippuner, K., additional, Mellström, D., additional, Merlijn, T., additional, Nordström, A., additional, Nordström, P., additional, O’Neill, T. W., additional, Obermayer-Pietsch, B., additional, Ohlsson, C., additional, Orwoll, E. S., additional, Pasco, J. A., additional, Rivadeneira, F., additional, Schei, B., additional, Schott, A.-M., additional, Shiroma, E. J., additional, Siggeirsdottir, K., additional, Simonsick, E. M., additional, Sornay-Rendu, E., additional, Sund, R., additional, Swart, K. M. A., additional, Szulc, P., additional, Tamaki, J., additional, Torgerson, D. J., additional, van Schoor, N. M., additional, van Staa, T. P., additional, Vila, J., additional, Wareham, N. J., additional, Wright, N. C., additional, Yoshimura, N., additional, Zillikens, M. C., additional, Zwart, M., additional, Harvey, N. C., additional, Lorentzon, M., additional, Leslie, W. D., additional, and Kanis, J. A., additional

Published
2022
Full Text
View/download PDF

37. Magnesium intake and vascular structure and function: the Hoorn Study

Author

Vermeulen, Emma A., primary, de Jong, Hanne B. T., additional, Blomjous, Alexander G. A., additional, Eelderink, Coby, additional, Hoekstra, Tiny, additional, Elders, Petra J. M., additional, de Borst, Martin H., additional, Vervloet, Marc G., additional, van Ballegooijen, Adriana J., additional, and Beulens, Joline W., additional

Published
2021
Full Text
View/download PDF

39. Implementation fidelity of an intervention programme to enhance adherence to antihypertensive medication in Dutch community pharmacies

Author

Marlous Langendoen-Gort, Petra J. M. Elders, Christel C. L. M. Boons, Jacqueline G. Hugtenburg, Danielle M. van der Laan, and Giel Nijpels

Subjects
Counseling, medicine.medical_specialty, Pharmacist, Psychological intervention, Pharmaceutical Science, Pharmacy, Qualitative property, Community Pharmacy Services, Toxicology, Process evaluation, 030226 pharmacology & pharmacy, Medication Adherence, law.invention, 03 medical and health sciences, Professional Role, 0302 clinical medicine, Implementation fidelity, Randomized controlled trial, law, Intervention (counseling), medicine, Humans, Pharmacology (medical), Medication non-adherence, Patient-tailored intervention, 030212 general & internal medicine, Antihypertensive Agents, Netherlands, Pharmacology, business.industry, Health Plan Implementation, The Netherlands, Tailored Intervention, Conceptual framework, Family medicine, Self Report, Community pharmacies, business, Research Article
Abstract

Background Insight into the delivery of interventions is necessary to gain a better understanding of what caused an intervention to succeed or fail. The Cardiovascular medication non-Adherence Tailored Intervention (CATI) study failed to show effectiveness of a patient-tailored, pharmacist-led intervention programme on self-reported adherence to antihypertensive medication. Objective To evaluate the implementation fidelity of the CATI intervention programme. Setting Twenty Dutch community pharmacies. Method The process of a randomised controlled trial was evaluated. Both quantitative and qualitative data were collected and analysed according to Carrolls’ Conceptual Framework for Implementation Fidelity. Implementation fidelity is defined as the degree to which the intervention was implemented as intended. Main outcome measure Four key intervention components of the intervention programme (i.e., first consultation: barrier identification, information and advice, written summary, and follow-up consultation). Results For most participants the key intervention components were implemented as intended. The training of pharmacists, intensive monitoring during the study and structured and easy-to-use intervention materials facilitated the implementation of the intervention. The method to select participants for the intervention programme was considered insufficient and pharmacists questioned the eligibility of some participants because of a low degree of intake non-adherence. Conclusion Implementation fidelity was moderate to high for all key intervention components. Therefore, the absence of effectiveness of the CATI intervention programme on self-reported medication adherence cannot be explained by poor implementation of the intervention. However, the limited genuine eligibility of some participants resulted in a limited potential for improvement in medication adherence.

Published
2019

40. Meer aandacht nodig voor interventie, evaluatie en preventie

Author

Ernst-Paul van Etten and Leo Elders

Subjects
030222 orthopedics, 03 medical and health sciences, 0302 clinical medicine, Health (social science), Health Information Management, Health Policy, 030229 sport sciences
Abstract

In 2017 werden 4619 werknemers met een beroepsziekte gemeld bij het Nederlands Centrum voor Beroepsziekten (NCvB). Het aandeel psychische beroepsziekten was 57% met vooral overspannenheid en burn-out als diagnose. Beroepsziekten van het bewegingsapparaat (26%) en gehoor (7,4%) stonden op plaats twee en drie.1 Dit is slechts het topje van de ijsberg. Geschat wordt dat ieder jaar 30.000 werknemers in Nederland een beroepsziekte ontwikkelen. Omdat in Nederland geen verschil wordt gemaakt tussen risque social en risque professionel is er geen noodzaak om uitgebreid onderzoek te doen naar de oorzaak van de beroepsziekte. Het sociale vangnet (ZW/WW/WIA) compenseert immers beide risico’s. Dit staat echter in schril contrast met de gangbare praktijk in de ons omringende landen waar wel dit onderscheid wordt gemaakt en compensatie voor geleden schade mogelijk is. Het melden van beroepsziekten heeft verder geen consequenties voor de werkgevers. Maar hoe zit het nu met de onderbouwing van de melding van de beroepsziekte, is deze adequaat? Met de introductie van de nieuwe Arbowet op 1 juli van dit jaar, krijgt de bedrijfsarts in ieder geval weer expliciet toegang tot de werkplek en dat maakt een goede blootstellingsanalyse mogelijk.2 Daarnaast moet er meer oog komen voor stap 6 in het zes-stappenplan voor het melden van beroepsziekten van het NCvB.3 immers een diagnose stellen moet ook consequenties hebben. Dat vormt nog een uitdaging van formaat en dat is ook het onderwerp van dit artikel.

Published
2018

43. The TOPSY pessary self-management intervention for pelvic organ prolapse: a study protocol for the process evaluation

Author

Bugge, Carol, Kearney, Rohna, Dembinsky, Melanie, Khunda, Aethele, Graham, Margaret, Agur, Wael, Breeman, Suzanne, Dwyer, Lucy, Elders, Andrew, Forrest, Mark, Goodman, Kirsteen, Guerrero, Karen, Hemming, Christine, Mason, Helen, and McClurg, Doreen

Subjects
Randomised controlled trial, Pessary, Prolapse, Self-management, Process evaluation
Abstract

Background Process evaluations have become a valued component, alongside clinical trials, of the wider evaluation of complex health interventions. They support understanding of implementation, and fidelity, related to the intervention and provide valuable insights into what is effective in a practical setting by examining the context in which interventions are implemented. The TOPSY study consists of a large multi-centre randomised controlled trial comparing the effectiveness of pessary self-management with clinic-based care in improving women’s condition-specific quality of life, and a nested process evaluation. The process evaluation aims to examine and maximise recruitment to the trial, describe intervention fidelity and explore participants’ and healthcare professionals’ experiences. Methods The trial will recruit 330 women from approximately 17 UK centres. The process evaluation uses a mixed-methods approach. Semi-structured interviews will be conducted with randomised women (18 per randomised group/n = 36), women who declined trial participation but agreed to interview (non-randomised women) (n = 20) and healthcare professionals recruiting to the trial (n ~ 17) and delivering self-management and clinic-based care (n ~ 17). The six internal pilot centres will be asked to record two to three recruitment discussions each (total n = 12–18). All participating centres will be asked to record one or two self-management teaching appointments (n = 30) and self-management 2-week follow-up telephone calls (n = 30). Process data (quantitative and qualitative) will be gathered in participant completed trial questionnaires. Interviews will be analysed thematically and recordings using an analytic grid to identify fidelity to the intervention. Quantitative analysis will be predefined within the process evaluation analysis plan. Discussion The wide variety of pessary care delivered across the UK for women with pelvic organ prolapse presents specific localised contexts in which the TOPSY interventions will be implemented. Understanding this contextual variance is central to understanding how and in what circumstances pessary self-management can be implemented (should it be effective). The inclusion of non-randomised women provides an innovative way of collecting indispensable information about eligible women who decline trial participation, allowing broader contextualisation and considerations of generalisability of trial findings. Methodological insights from examination of recruitment processes and mechanisms have the potential to inform recruitment mechanisms and future recruitment strategies and study designs.

Published
2020

45. The TOPSY pessary self-management intervention for pelvic organ prolapse: a study protocol for the process evaluation

Author

Suzanne Breeman, Andrew Elders, Melanie Dembinsky, Suzanne Hagen, Mark Forrest, Helen Mason, Rohna Kearney, Kirsteen Goodman, Lynn Melone, Margaret C. Graham, John Norrie, Karen Guerrero, Lucy Dwyer, Carol Bugge, Christine Hemming, Ranee Thakar, Doreen McClurg, Aethele Khunda, and Wael Agur

Subjects
Pessary, media_common.quotation_subject, Psychological intervention, Medicine (miscellaneous), Fidelity, Context (language use), Process evaluation, Pelvic Organ Prolapse, law.invention, Study Protocol, Quality of life (healthcare), Nursing, Randomized controlled trial, law, Surveys and Questionnaires, Prolapse, Self-management, Humans, Multicenter Studies as Topic, Medicine, Pharmacology (medical), Randomized Controlled Trials as Topic, media_common, Randomised controlled trial, lcsh:R5-920, business.industry, Self-Management, Clinical study design, Pessaries, Clinical trial, Quality of Life, Female, lcsh:Medicine (General), business
Abstract

Background Process evaluations have become a valued component, alongside clinical trials, of the wider evaluation of complex health interventions. They support understanding of implementation, and fidelity, related to the intervention and provide valuable insights into what is effective in a practical setting by examining the context in which interventions are implemented. The TOPSY study consists of a large multi-centre randomised controlled trial comparing the effectiveness of pessary self-management with clinic-based care in improving women’s condition-specific quality of life, and a nested process evaluation. The process evaluation aims to examine and maximise recruitment to the trial, describe intervention fidelity and explore participants’ and healthcare professionals’ experiences. Methods The trial will recruit 330 women from approximately 17 UK centres. The process evaluation uses a mixed-methods approach. Semi-structured interviews will be conducted with randomised women (18 per randomised group/n = 36), women who declined trial participation but agreed to interview (non-randomised women) (n = 20) and healthcare professionals recruiting to the trial (n ~ 17) and delivering self-management and clinic-based care (n ~ 17). The six internal pilot centres will be asked to record two to three recruitment discussions each (total n = 12–18). All participating centres will be asked to record one or two self-management teaching appointments (n = 30) and self-management 2-week follow-up telephone calls (n = 30). Process data (quantitative and qualitative) will be gathered in participant completed trial questionnaires. Interviews will be analysed thematically and recordings using an analytic grid to identify fidelity to the intervention. Quantitative analysis will be predefined within the process evaluation analysis plan. Discussion The wide variety of pessary care delivered across the UK for women with pelvic organ prolapse presents specific localised contexts in which the TOPSY interventions will be implemented. Understanding this contextual variance is central to understanding how and in what circumstances pessary self-management can be implemented (should it be effective). The inclusion of non-randomised women provides an innovative way of collecting indispensable information about eligible women who decline trial participation, allowing broader contextualisation and considerations of generalisability of trial findings. Methodological insights from examination of recruitment processes and mechanisms have the potential to inform recruitment mechanisms and future recruitment strategies and study designs. Trial registration ISRCTN62510577. Registered on 6 October 2017.

Published
2020

46. Author Correction: Heritability estimates for 361 blood metabolites across 40 genome-wide association studies

Author

Hagenbeek, Fiona A., Pool, René, van Dongen, Jenny, Draisma, H. M., Jan Hottenga, Jouke, Willemsen, Gonneke, Abdellaoui, Abdel, Fedko, Iryna O., den Braber, Anouk, Visser, Pieter Jelle, de Geus, Eco J.C.N., Willems van Dijk, Ko, Verhoeven, Aswin, Suchiman, H. Eka, Beekman, Marian, Slagboom, P. Eline, van Duijn, Cornelia M., Barkey Wolf, J. J.H., Cats, D., Amin, N., Beulens, J. W., van der Bom, J. A., Bomer, N., Demirkan, A., van Hilten, J. A., Meessen, J. M.T.A., Moed, M. H., Fu, J., Onderwater, G. L.J., Rutters, F., So-Osman, C., van der Flier, W. M., van der Heijden, A. A.W.A., van der Spek, A., Asselbergs, F. W., Boersma, E., Elders, P. M., Geleijnse, J. M., Ikram, M. A., Kloppenburg, M., Meulenbelt, I., Mooijaart, S. P., Nelissen, R. G.H.H., Netea, M. G., Penninx, B. W.J.H., Stehouwer, C. D.A., Teunissen, C. E., Terwindt, G. M., ‘t Hart, L. M., van den Maagdenberg, A. M.J.M., van der Harst, P., van der Horst, I. C.C., van der Kallen, C. J.H., van Greevenbroek, M. M.J., van Spil, W. E., Wijmenga, C., Zwinderman, A. H., Zhernikova, A., Jukema, J. W., Mei, H., Slofstra, M., Swertz, M., van den Akker, E. B., Deelen, J., Reinders, M. J.T., Harms, Amy C., Hankemeier, Thomas, Bartels, Meike, Nivard, Michel G., and Boomsma, Dorret I.

Subjects
0301 basic medicine, Quantitative trait loci, Science, Twins, General Physics and Astronomy, Genome-wide association study, 02 engineering and technology, computer.software_genre, Genome-wide association studies, Column (database), General Biochemistry, Genetics and Molecular Biology, Cohort Studies, 03 medical and health sciences, Metabolomics, Humans, lcsh:Science, Author Correction, Mathematics, Supplementary data, Multidisciplinary, business.industry, General Chemistry, Heritability, 021001 nanoscience & nanotechnology, 3. Good health, Blood, 030104 developmental biology, Lipidomics, Delimiter, lcsh:Q, Artificial intelligence, 0210 nano-technology, business, computer, Blood Chemical Analysis, Natural language processing, Genome-Wide Association Study
Abstract

The original version of the Supplementary Information associated with this Article included an incorrect Supplementary Data 1 file, in which additional delimiters were included in the first column for a number of rows, resulting in column shifts for some of these rows. The HTML has been updated to include a corrected version of Supplementary Data 1; the original incorrect version of Supplementary Data 1 can be found as Supplementary Information associated with this Correction. In addition, the original version of this Article contained an error in the author affiliations. An affiliation of Abdel Abdellaoui with Department of Psychiatry, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands was inadvertently omitted. This has now been corrected in both the PDF and HTML versions of the Article.

Published
2020

47. Diagnosing sea ice from the north american multi model ensemble and implications on mid-latitude winter climate

Author

Kathy Pegion and Akiko Elders

Subjects
Atmospheric Science, geography, geography.geographical_feature_category, 010504 meteorology & atmospheric sciences, Climate change, Weather and climate, 010502 geochemistry & geophysics, 01 natural sciences, Arctic ice pack, Proxy (climate), Sea surface temperature, Arctic, Middle latitudes, Climatology, Sea ice, Environmental science, 0105 earth and related environmental sciences
Abstract

Arctic sea ice plays an important role in the climate system, moderating the exchange of energy and moisture between the ocean and the atmosphere. An emerging area of research investigates how changes, particularly declines, in sea ice extent (SIE) impact climate in regions local to and remote from the Arctic. Therefore, both observations and model estimates of sea ice become important. This study investigates the skill of sea ice predictions from models participating in the North American Multi-Model Ensemble (NMME) project. Three of the models in this project provide sea-ice predictions. The ensemble average of these models is used to determine seasonal climate impacts on surface air temperature (SAT) and sea level pressure (SLP) in remote regions such as the mid-latitudes. It is found that declines in fall SIE are associated with cold temperatures in the mid-latitudes and pressure patterns across the Arctic and mid-latitudes similar to the negative phase of the Arctic Oscillation (AO). These findings are consistent with other studies that have investigated the relationship between declines in SIE and mid-latitude weather and climate. In an attempt to include additional NMME models for sea-ice predictions, a proxy for SIE is used to estimate ice extent in the remaining models, using sea surface temperature (SST). It is found that SST is a reasonable proxy for SIE estimation when compared to model SIE forecasts and observations. The proxy sea-ice estimates also show similar relationships to mid-latitude temperature and pressure as the actual sea-ice predictions.

Published
2017

48. Correction to: Adherence to a food group-based dietary guideline and incidence of prediabetes and type 2 diabetes

Author

Braver, Nicolette R.den, primary, Rutters, Femke, additional, van der Spek, Andrea L. J. Kortlever, additional, Ibi, Dorina, additional, Looman, Moniek, additional, Geelen, Anouk, additional, Elders, Petra, additional, van der Heijden, Amber A., additional, Brug, Johannes, additional, Lakerveld, Jeroen, additional, Soedamah-Muthu, Sabita S., additional, and Beulens, Joline W. J., additional

Published
2021
Full Text
View/download PDF

49. Whole blood co-expression modules associate with metabolic traits and type 2 diabetes: an IMI-DIRECT study

Author

Gudmundsdottir, Valborg, primary, Pedersen, Helle Krogh, additional, Mazzoni, Gianluca, additional, Allin, Kristine H., additional, Artati, Anna, additional, Beulens, Joline W., additional, Banasik, Karina, additional, Brorsson, Caroline, additional, Cederberg, Henna, additional, Chabanova, Elizaveta, additional, De Masi, Federico, additional, Elders, Petra J., additional, Forgie, Ian, additional, Giordano, Giuseppe N., additional, Grallert, Harald, additional, Gupta, Ramneek, additional, Haid, Mark, additional, Hansen, Torben, additional, Hansen, Tue H., additional, Hattersley, Andrew T., additional, Heggie, Alison, additional, Hong, Mun-Gwan, additional, Jones, Angus G., additional, Koivula, Robert, additional, Kokkola, Tarja, additional, Laakso, Markku, additional, Løngreen, Peter, additional, Mahajan, Anubha, additional, Mari, Andrea, additional, McDonald, Timothy J., additional, McEvoy, Donna, additional, Musholt, Petra B., additional, Pavo, Imre, additional, Prehn, Cornelia, additional, Ruetten, Hartmut, additional, Ridderstråle, Martin, additional, Rutters, Femke, additional, Sharma, Sapna, additional, Slieker, Roderick C., additional, Syed, Ali, additional, Tajes, Juan Fernandez, additional, Thomas, Cecilia Engel, additional, Thomsen, Henrik S., additional, Vangipurapu, Jagadish, additional, Vestergaard, Henrik, additional, Viñuela, Ana, additional, Wesolowska-Andersen, Agata, additional, Walker, Mark, additional, Adamski, Jerzy, additional, Schwenk, Jochen M., additional, McCarthy, Mark I., additional, Pearson, Ewan, additional, Dermitzakis, Emmanouil, additional, Franks, Paul W., additional, Pedersen, Oluf, additional, and Brunak, Søren, additional

Published
2020
Full Text
View/download PDF

50. Sleep characteristics across the lifespan in 1.1 million people from the Netherlands, United Kingdom and United States: a systematic review and meta-analysis

Author

Kocevska, Desana, primary, Lysen, Thom S., additional, Dotinga, Aafje, additional, Koopman-Verhoeff, M. Elisabeth, additional, Luijk, Maartje P. C. M., additional, Antypa, Niki, additional, Biermasz, Nienke R., additional, Blokstra, Anneke, additional, Brug, Johannes, additional, Burk, Wiliam J., additional, Comijs, Hannie C., additional, Corpeleijn, Eva, additional, Dashti, Hassan S., additional, de Bruin, Eduard J., additional, de Graaf, Ron, additional, Derks, Ivonne P. M., additional, Dewald-Kaufmann, Julia F., additional, Elders, Petra J. M., additional, Gemke, Reinoldus J. B. J., additional, Grievink, Linda, additional, Hale, Lauren, additional, Hartman, Catharina A., additional, Heijnen, Cobi J., additional, Huisman, Martijn, additional, Huss, Anke, additional, Ikram, M. Arfan, additional, Jones, Samuel E., additional, Velderman, Mariska Klein, additional, Koning, Maaike, additional, Meijer, Anne Marie, additional, Meijer, Kim, additional, Noordam, Raymond, additional, Oldehinkel, Albertine J., additional, Groeniger, Joost Oude, additional, Penninx, Brenda W. J. H., additional, Picavet, H. Susan J., additional, Pieters, Sara, additional, Reijneveld, Sijmen A., additional, Reitz, Ellen, additional, Renders, Carry M., additional, Rodenburg, Gerda, additional, Rutters, Femke, additional, Smith, Matt C., additional, Singh, Amika S., additional, Snijder, Marieke B., additional, Stronks, Karien, additional, ten Have, Margreet, additional, Twisk, Jos W. R., additional, Van de Mheen, Dike, additional, van der Ende, Jan, additional, van der Heijden, Kristiaan B., additional, van der Velden, Peter G., additional, van Lenthe, Frank J., additional, van Litsenburg, Raphaële R. L., additional, van Oostrom, Sandra H., additional, van Schalkwijk, Frank J., additional, Sheehan, Connor M., additional, Verheij, Robert A., additional, Verhulst, Frank C., additional, Vermeulen, Marije C. M., additional, Vermeulen, Roel C. H., additional, Verschuren, W. M. Monique, additional, Vrijkotte, Tanja G. M., additional, Wijga, Alet H., additional, Willemen, Agnes M., additional, ter Wolbeek, Maike, additional, Wood, Andrew R., additional, Xerxa, Yllza, additional, Bramer, Wichor M., additional, Franco, Oscar H., additional, Luik, Annemarie I., additional, Van Someren, Eus J. W., additional, and Tiemeier, Henning, additional

Published
2020
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results