1. Cytoplasmic VDR expression as an independent risk factor for ovarian cancer
- Author
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Sven Mahner, Cornelia Sattler, Thomas Kolben, Bastian Czogalla, Yue Liao, Udo Jeschke, Anna Hester, Alexander Burges, Eileen Deuster, Elisa Schmoeckel, Sophie Fürst, Doris Mayr, and Fabian Trillsch
- Subjects
Adult ,0301 basic medicine ,Cytoplasm ,Histology ,Calcitriol receptor ,03 medical and health sciences ,0302 clinical medicine ,Risk Factors ,Ovarian cancer ,Vitamin D and neurology ,Humans ,Medicine ,ddc:610 ,Vitamin D ,Receptor ,Molecular Biology ,Aged ,VDR ,Aged, 80 and over ,Ovarian Neoplasms ,Original Paper ,Staining and Labeling ,business.industry ,Cell Biology ,Middle Aged ,medicine.disease ,Immunohistochemistry ,Medical Laboratory Technology ,Serous fluid ,030104 developmental biology ,030220 oncology & carcinogenesis ,Cancer research ,Receptors, Calcitriol ,Female ,Risk factor ,Signal transduction ,business ,Clear cell - Abstract
The vitamin D receptor (VDR), primarily known as a crucial mediator of calcium homeostasis and metabolism, has been shown to play a significant role in various cancer entities. Previous studies have focused on vitamin D and its receptor in gynecological cancers, noting that the receptor is upregulated in epithelial ovarian cancer (EOC). The aim of this study is to analyze the prognostic impact of VDR and its functional significance in ovarian cancer. Through immunohistochemistry, VDR staining was examined in 156 ovarian cancer samples. Evaluation of VDR staining was conducted in the nucleus and the cytoplasm using the semi-quantitative immunoreactive score, and the scores were classified into high- and low-level expressions. Expression levels were correlated with clinical and pathological parameters as well as with overall survival to assess for prognostic impact. Differences in cytoplasmic VDR expression were identified between the histological subtypes (p = 0.001). Serous, clear cell, and endometrioid subtypes showed the highest staining, while the mucinous subtype showed the lowest. Cytoplasmic VDR correlated with higher FIGO stage (p = 0.013;Cc = 0.203), positive lymph node status (p = 0.023;Cc = 0.236), high-grade serous histology (p = 0.000;Cc = 0.298) and grading from the distinct histological subtypes (p = 0.006;Cc = − 0.225). Nuclear VDR did not correlate with clinicopathological data. High cytoplasmic expression of VDR was associated with impaired overall survival (HR 2.218, 32.5 months vs. median not reached;p
- Published
- 2020