Search

Your search keyword '"Edith Hofer"' showing total 4 results
Start Over Author "Edith Hofer" Publisher springer science and business media llc
4 results on '"Edith Hofer"'

1. Inclusivity insights: two urban development projects in Johannesburg

Author

Edith Hofer, Walter Musakwa, Sander van Lanen, Trynos Gumbo, Stefan Netsch, and Katharina Gugerell

Subjects
Urban Studies, Geography, Planning and Development, Fleurhof, Johannesburg, Urban development, Inclusivity, Waterfall city, Spatial inclusion
Abstract

Johannesburg, which is South Africa’s largest city and economic center, is still influenced by patterns of inequality of the past. Although spatial transformation has been rapid since 1994, spatial divisions along class lines are still prevalent long after the apartheid era. This is despite the fact that societal values such as inclusivity, spatial justice and equal access to resources have become the core goals of Johannesburg’s spatial and urban development. This is particularly true when addressing housing, public open spaces, transport and social infrastructure embedded in a suitable land-use mix. However, despite the adoption of numerous policies by government, this research indicates that even recent urban development projects such as Fleurhof and Waterfall are falling short in delivering those objectives. Based on a case study analysis, we show that significant dysfunctionalities become evident when evaluating these two projects, despite their meeting relevant indicators of spatial inclusion on paper. Tensions are identified between theoretical approaches and the implementation of societally relevant policy goals. These include inclusivity and spatial justice by mostly privatized provision of housing and services, and deficiencies in public maintenance of infrastructure. The research reveals, that ‘ticking-the-boxes’ behavior on policy and project level does not produce equitable, inclusive neighborhoods and urban spatial patterns, but rather reproduces spatial inequalities of the past. If these policies are to result in real spatial change and improvement in the lives of Johannesburg residents, a more proactive approach by the public sector at different levels will be necessary.

Published
2021

2. A genome-wide association study identifies genetic loci associated with specific lobar brain volumes

Author

Diana van Heemst, Lisa R. Yanek, Tamara B. Harris, Fabrice Crivello, Hieab H.H. Adams, Paul A. Nyquist, Bernard Mazoyer, Najaf Amin, Pauline Maillard, Diane M. Becker, Marian Beekman, Shuo Li, Ganesh Chauhan, Charles DeCarli, Wanting Zhao, Neda Jahanshad, Rasika A. Mathias, Cornelia M. van Duijn, Manon Bernard, Derrek P. Hibar, Alexa S. Beiser, Meike W. Vernooij, Vilmundur Gudnason, Joshua C. Bis, Tomáš Paus, Edith Hofer, Lei Yu, Stéphanie Debette, Helena Schmidt, M. Kamran Ikram, P. Eline Slagboom, Erik B. van den Akker, Lenore J. Launer, Stefan Boehringer, Kent D. Taylor, Maria J. Knol, Wiro J. Niessen, Kenneth Rice, Zdenka Pausova, Gennady V. Roshchupkin, Sven J. van der Lee, Philip L. De Jager, Ching-Yu Cheng, Sudha Seshadri, Qiong Yang, Konstantinos Arfanakis, Yasaman Saba, Jeroen van der Grond, W. T. Longstreth, Albert V. Smith, Claudia L. Satizabal, Oscar L. Lopez, Bruce M. Psaty, Christopher Chen, Philippe Amouyel, Josh W. Cheung, M. Arfan Ikram, Tien Yin Wong, Reinhold Schmidt, David A. Bennett, Saima Hilal, Paul M. Thompson, Erasmus University Medical Center [Rotterdam] (Erasmus MC), Bordeaux population health (BPH), Université de Bordeaux (UB)-Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Institut National de la Santé et de la Recherche Médicale (INSERM), Department of Medicine, University of Washington [Seattle], Keck School of Medicine [Los Angeles], University of Southern California (USC), National University of Singapore (NUS), Rush University Medical Center [Chicago], Groupe d'imagerie neurofonctionnelle (GIN), Institut des Maladies Neurodégénératives [Bordeaux] (IMN), Université de Bordeaux (UB)-Centre National de la Recherche Scientifique (CNRS)-Université de Bordeaux (UB)-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Facteurs de Risque et Déterminants Moléculaires des Maladies liées au Vieillissement - U 1167 (RID-AGE), Institut Pasteur de Lille, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Los Angeles Biomedical Research Institute (LA BioMed), School of Public Health [Boston], Boston University [Boston] (BU), Columbia University Medical Center (CUMC), Columbia University [New York], University of Glasgow, Leiden University Medical Center (LUMC), University of Texas Health Science Center, The University of Texas Health Science Center at Houston (UTHealth), Epidémiologie et Biostatistique [Bordeaux], Université Bordeaux Segalen - Bordeaux 2-Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Institut National de la Santé et de la Recherche Médicale (INSERM), Epidemiology, Radiology & Nuclear Medicine, Medical Informatics, Neurology, Clinical Genetics, Læknadeild (HÍ), Faculty of Medicine (UI), Heilbrigðisvísindasvið (HÍ), School of Health Sciences (UI), Háskóli Íslands, University of Iceland, [GIN] Grenoble Institut des Neurosciences (GIN), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), and Universiteit Leiden

Subjects
Pathology, Heredity, Neurology, [SDV.NEU.NB]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology, Medicine (miscellaneous), Genome-wide association study, Genome-wide association studies, Taugasjúkdómar, 0302 clinical medicine, Parietal Lobe, 2.1 Biological and endogenous factors, Developmental, Aetiology, lcsh:QH301-705.5, 0303 health sciences, Parietal lobe, Gene Expression Regulation, Developmental, Organ Size, Magnetic Resonance Imaging, Temporal Lobe, Frontal Lobe, 3. Good health, Phenotype, Mental Health, Neurological, symbols, Occipital Lobe, Erfðarannsóknir, General Agricultural and Biological Sciences, medicine.medical_specialty, Genotype, 1.1 Normal biological development and functioning, Biology, Article, General Biochemistry, Genetics and Molecular Biology, Temporal lobe, 03 medical and health sciences, symbols.namesake, Underpinning research, Genetics, medicine, Humans, Gene, 030304 developmental biology, Genetic association, [SDV.GEN.GPO]Life Sciences [q-bio]/Genetics/Populations and Evolution [q-bio.PE], Human Genome, Heilinn, Neurosciences, Genetic Variation, United Kingdom, Brain Disorders, Gene Expression Regulation, lcsh:Biology (General), Genetic Loci, Mendelian inheritance, Occipital lobe, Biomarkers, 030217 neurology & neurosurgery, Genome-Wide Association Study
Abstract

Publisher's version (útgefin grein)., Brain lobar volumes are heritable but genetic studies are limited. We performed genome-wide association studies of frontal, occipital, parietal and temporal lobe volumes in 16,016 individuals, and replicated our findings in 8,789 individuals. We identified six genetic loci associated with specific lobar volumes independent of intracranial volume. Two loci, associated with occipital (6q22.32) and temporal lobe volume (12q14.3), were previously reported to associate with intracranial and hippocampal volume, respectively. We identified four loci previously unknown to affect brain volumes: 3q24 for parietal lobe volume, and 1q22, 4p16.3 and 14q23.1 for occipital lobe volume. The associated variants were located in regions enriched for histone modifications (DAAM1 and THBS3), or close to genes causing Mendelian brain-related diseases (ZIC4 and FGFRL1). No genetic overlap between lobar volumes and neurological or psychiatric diseases was observed. Our findings reveal part of the complex genetics underlying brain development and suggest a role for regulatory regions in determining brain volumes., 23Laboratory of Epidemiology and Population Sciences, National Institute on Aging, Intramural Research Program, National Institutes of Health, Bethesda, MD 20892, USA. 24Research Unit-Genetic Epidemiology, Gottfried Schatz Research Centre for Cell Signaling, Metabolism and Aging, Molecular Biology and Biochemistry, Medical University of Graz, 8010 Graz, Austria. 25Department of Neurology, University of Pittsburgh, Pittsburgh, PA 15260, USA. 26Department of Biostatistics, School of Public Health, Boston University, Boston, MA 02118, USA. 27Department of Radiology, Leiden University Medical Center, Leiden 2333ZA, the Netherlands. 28Bloorview Research Institute, Holland Bloorview Kids Rehabilitation Hospital, Toronto M4G 1R8, Canada. 29Departments of Psychology and Psychiatry, University of Toronto, Toronto M5S 1A1, Canada.

Published
2019

3. Genome-wide association study of 23,500 individuals identifies 7 loci associated with brain ventricular volume

Author

Charles DeCarli, Vilmundur Gudnason, Debra A. Fleischman, Henning Tiemeier, Rebecca F. Gottesman, William S. Kremen, Xueqiu Jian, Henry Brodaty, Maria del C. Valdés Hernández, Markus Loeffler, Reinhold Schmidt, Shahzad Ahmad, Paul A. Nyquist, Oscar L. Lopez, Anbupalam Thalamuthu, Helena Schmidt, Peter R. Schofield, Tonya White, Edith Hofer, Philip L. De Jager, David Ames, Qiong Yang, Ole A. Andreassen, Cora E. Lewis, Matthias Nauck, David S. Knopman, Anders M. Dale, Sven J. van der Lee, Jeroen van der Grond, Konstantinos Arfanakis, Margaret J. Wright, Jingyun Yang, John B.J. Kwok, Hieab H.H. Adams, Matthew S. Panizzon, Meike W. Vernooij, Yasaman Saba, David A. Bennett, Cornelia M. van Duijn, Tamara B. Harris, Pauline Maillard, Frauke Beyer, M. Arfan Ikram, Jerome I. Rotter, Ryan L. Muetzel, Tomáš Paus, Pamela J. Schreiner, Zdenka Pausova, Katharina Wittfeld, Diane M. Becker, Bruce M. Psaty, Alexander Teumer, Wei Wen, A. Veronica Witte, Karen A. Mather, Hanan El Marroun, William T. Longstreth, Perminder S. Sachdev, Mark E. Bastin, Nathan A. Gillespie, Kenneth Rice, Stella Trompet, Lisa R. Yanek, David J. Stott, Alexa S. Beiser, R. Nick Bryan, Alexander Neumann, Natalie A. Royle, Myriam Fornage, Manon Bernard, Dina Vojinovic, Najaf Amin, Ian J. Deary, Arno Villringer, Georg Homuth, Nicola J. Armstrong, Stephen Sidney, Sudha Seshadri, Joanna M. Wardlaw, Thomas H. Mosley, Hans J. Grabe, Michelle Luciano, Lenore J. Launer, J. Wouter Jukema, Robin Bülow, Markus Scholz, André G. Uitterlinden, Albert V. Smith, Shuo Li, Claudia L. Satizabal, Joshua C. Bis, Epidemiology, Radiology & Nuclear Medicine, Child and Adolescent Psychiatry / Psychology, Clinical Psychology, Internal Medicine, Psychiatry, Neurology, Faculty of Medicine (UI), Læknadeild (HÍ), Heilbrigðisvísindasvið (HÍ), School of Health Sciences (UI), Háskóli Íslands (HÍ), and University of Iceland (UI)

Subjects
0301 basic medicine, Genetics of the nervous system, Cytoskeleton organization, General Physics and Astronomy, Genome-wide association study, Mental disorders, Genome-wide association studies, Genome, Lateral ventricles, 0302 clinical medicine, Lateral Ventricles, Ventricle (lateral), lcsh:Science, Genetics, anatomy & histology [Lateral Ventricles], education.field_of_study, Enlargement, Multidisciplinary, Brain, Organ Size, Middle Aged, Schizophrenia, ddc:500, Science, Population, Elderly people, Biology, Article, General Biochemistry, Genetics and Molecular Biology, 03 medical and health sciences, medicine, Erfðafræði, Humans, Genomes, education, Aged, Genetic association, genetics [Organ Size], Genome, Human, Heilinn, Brain morphometry, Litningarannsóknir, Rannsóknir, General Chemistry, medicine.disease, 030104 developmental biology, Heritable quantitative trait, lcsh:Q, 030217 neurology & neurosurgery, Genome-Wide Association Study
Abstract

Publisher's version (útgefin grein) Publisher's note: Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations., The volume of the lateral ventricles (LV) increases with age and their abnormal enlargement is a key feature of several neurological and psychiatric diseases. Although lateral ventricular volume is heritable, a comprehensive investigation of its genetic determinants is lacking. In this meta-analysis of genome-wide association studies of 23,533 healthy middle-aged to elderly individuals from 26 population-based cohorts, we identify 7 genetic loci associated with LV volume. These loci map to chromosomes 3q28, 7p22.3, 10p12.31, 11q23.1, 12q23.3, 16q24.2, and 22q13.1 and implicate pathways related to tau pathology, S1P signaling, and cytoskeleton organization. We also report a significant genetic overlap between the thalamus and LV volumes (ρgenetic = −0.59, p-value = 3.14 × 10−6), suggesting that these brain structures may share a common biology. These genetic associations of LV volume provide insights into brain morphology., See Supplementary Note 2 for information on funding sources.

Published
2018

4. Correction: Corrigendum: 1000 Genomes-based meta-analysis identifies 10 novel loci for kidney function

Author

Albertine J. Oldehinkel, Tõnu Esko, Antonietta Robino, Ingrid B. Borecki, Dragana Vuckovic, Zoltán Kutalik, Douglas M. Ruderfer, Daniel I. Chasman, Daniel Taliun, Henry Völzke, Daniela Ruggiero, Kurt Lohman, Adrienne Tin, Jorma Viikari, Qiong Yang, Martin H. de Borst, Oscar H. Franco, Yongmei Liu, Giorgia Girotto, Vladan Mijatovic, Nicole Probst-Hensch, John Attia, Adamo Pio d. Adamo, Peter P. Pramstaller, Iris M. Heid, Brenda W.J.H. Penninx, Jingzhong Ding, Caroline S. Fox, Edith Hofer, Man Li, Josef Coresh, Frank B. Hu, Abbas Dehghan, Christian Fuchsberger, Albert Hofman, Evelin Mihailov, Elizabeth G. Holliday, Gerjan Navis, Yingchang Lu, Christian Gieger, Murielle Bochud, Lenore J. Launer, Jean-Charles Lambert, Vilmundur Gudnason, Eric Boerwinkle, Paul M. Ridker, Peter Vollenweider, Anna Köttgen, Tamara B. Harris, Ilja M. Nolte, Medea Imboden, Mary F. Feitosa, Ruth J. F. Loos, Simon Höllerer, Massimiliano Cocca, Nina Hutri-Kähönen, Audrey Y. Chu, Karlhans Endlich, Thomas Meitinger, Sylvia Stracke, Cornelia Huth, Reiner Biffar, Cristian Pattaro, Jie Jin Wang, Omri Gottesman, Morris A. Swertz, Shih-Jen Hwang, Marie Metzger, Albert V. Smith, Ming-Huei Chen, Yong Li, Christa Meisinger, Bernhard K. Krämer, Laura Dengler, Daniela Toniolo, Olli T. Raitakari, Rossella Sorice, Bénédicte Stengel, Åsa Johansson, Andres Metspalu, Gerard Tromp, Cinzia Sala, Konstantin Strauch, Stefan Enroth, Helena Schmidt, Sylvia E. Rosas, Vincent Chouraki, Alexander Teumer, Ulf Gyllensten, Mathias Gorski, Giorgio Pistis, Holly Kramer, Gary C. Curhan, Peter J. van der Most, Catherine Helmer, Bamidele O. Tayo, Matthias Olden, Mark McEvoy, André G. Uitterlinden, Rainer Rettig, Rodney J. Scott, Mika Kähönen, Wolfgang König, Georg Homuth, Paolo Gasparini, Sanaz Sedaghat, Matthias Nauck, Carsten A. Böger, Sheila Ulivi, Reinhold E. Schmidt, Leo-Pekka Lyytikäinen, Paul Mitchell, Thor Aspelund, Felicia Gomez, Fernando Rivadeneira, Marilyn C. Cornelis, Yasaman Saba, Gudny Eiriksdottir, Ashok Kumar, Erwin P. Bottinger, Marina Ciullo, Terho Lehtimäki, Harold Snieder, Melanie Waldenberger, Uwe Völker, and Stephen Hancock

Subjects
Genetics, Multidisciplinary, Meta-analysis, Published Erratum, MEDLINE, Genome-wide association study, Computational biology, 1000 Genomes Project, Biology, Typographical error, Spelling
Abstract

Scientific Reports 7: Article number: 45040; published online: 28 April 2017; updated: 26 May 2017 The original version of this Article contained a typographical error in the spelling of the author Martin H. de Borst, which was incorrectly given as Martin de Borst. This has now been corrected in both the PDF and HTML versions of the Article.

Published
2017

Catalog

Books, media, physical & digital resources
See catalog results