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Your search keyword '"Economides, Aris N"' showing total 13 results
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13 results on '"Economides, Aris N"'

1. Garetosmab in fibrodysplasia ossificans progressiva: a randomized, double-blind, placebo-controlled phase 2 trial

Author

Di Rocco, Maja, primary, Forleo-Neto, Eduardo, additional, Pignolo, Robert J., additional, Keen, Richard, additional, Orcel, Philippe, additional, Funck-Brentano, Thomas, additional, Roux, Christian, additional, Kolta, Sami, additional, Madeo, Annalisa, additional, Bubbear, Judith S., additional, Tabarkiewicz, Jacek, additional, Szczepanek, Małgorzata, additional, Bachiller-Corral, Javier, additional, Cheung, Angela M., additional, Dahir, Kathryn M., additional, Botman, Esmée, additional, Raijmakers, Pieter G., additional, Mukaddam, Mona Al, additional, Tile, Lianne, additional, Portal-Celhay, Cynthia, additional, Sarkar, Neena, additional, Hou, Peijie, additional, Musser, Bret J., additional, Boyapati, Anita, additional, Mohammadi, Kusha, additional, Mellis, Scott J., additional, Rankin, Andrew J., additional, Economides, Aris N., additional, Trotter, Dinko Gonzalez, additional, Herman, Gary A., additional, O’Meara, Sarah J., additional, DelGizzi, Richard, additional, Weinreich, David M., additional, Yancopoulos, George D., additional, Eekhoff, E. Marelise W., additional, and Kaplan, Frederick S., additional

Published
2023
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2. Odd skipped-related 1 controls the pro-regenerative response of fibro-adipogenic progenitors

Author

Kotsaris, Georgios, primary, Qazi, Taimoor H., additional, Bucher, Christian H., additional, Zahid, Hafsa, additional, Pöhle-Kronawitter, Sophie, additional, Ugorets, Vladimir, additional, Jarassier, William, additional, Börno, Stefan, additional, Timmermann, Bernd, additional, Giesecke-Thiel, Claudia, additional, Economides, Aris N., additional, Le Grand, Fabien, additional, Vallecillo-García, Pedro, additional, Knaus, Petra, additional, Geissler, Sven, additional, and Stricker, Sigmar, additional

Published
2023
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3. Multiancestry exome sequencing reveals INHBE mutations associated with favorable fat distribution and protection from diabetes

Author

Akbari, Parsa, Sosina, Olukayode A., Bovijn, Jonas, Landheer, Karl, Nielsen, Jonas B., Kim, Minhee, Aykul, Senem, De, Tanima, Haas, Mary E., Hindy, George, Lin, Nan, Dinsmore, Ian R., Luo, Jonathan Z., Hectors, Stefanie, Geraghty, Benjamin, Germino, Mary, Panagis, Lampros, Parasoglou, Prodromos, Walls, Johnathon R., Halasz, Gabor, Atwal, Gurinder S., Della Gatta, Giusy, Jones, Marcus, LeBlanc, Michelle G., Still, Christopher D., Carey, David J., Giontella, Alice, Orho-Melander, Marju, Berumen, Jaime, Kuri-Morales, Pablo, Alegre-Díaz, Jesus, Torres, Jason M., Emberson, Jonathan R., Collins, Rory, Rader, Daniel J., Zambrowicz, Brian, Murphy, Andrew J., Balasubramanian, Suganthi, Overton, John D., Reid, Jeffrey G., Shuldiner, Alan R., Cantor, Michael, Abecasis, Goncalo R., Ferreira, Manuel A. R., Sleeman, Mark W., Gusarova, Viktoria, Altarejos, Judith, Harris, Charles, Economides, Aris N., Idone, Vincent, Karalis, Katia, Mirshahi, Tooraj, Yancopoulos, George D., Melander, Olle, Marchini, Jonathan, Tapia-Conyer, Roberto, Locke, Adam E., Baras, Aris, Verweij, Niek, and Lotta, Luca A.

Subjects
Multidisciplinary, Adipose Tissue, Diabetes Mellitus, Type 2, Mutation, Humans, General Physics and Astronomy, Exome, General Chemistry, General Biochemistry, Genetics and Molecular Biology, Adiposity, Inhibin-beta Subunits
Abstract

Body fat distribution is a major, heritable risk factor for cardiometabolic disease, independent of overall adiposity. Using exome-sequencing in 618,375 individuals (including 160,058 non-Europeans) from the UK, Sweden and Mexico, we identify 16 genes associated with fat distribution at exome-wide significance. We show 6-fold larger effect for fat-distribution associated rare coding variants compared with fine-mapped common alleles, enrichment for genes expressed in adipose tissue and causal genes for partial lipodystrophies, and evidence of sex-dimorphism. We describe an association with favorable fat distribution (p = 1.8 × 10−09), favorable metabolic profile and protection from type 2 diabetes (~28% lower odds; p = 0.004) for heterozygous protein-truncating mutations in INHBE, which encodes a circulating growth factor of the activin family, highly and specifically expressed in hepatocytes. Our results suggest that inhibin βE is a liver-expressed negative regulator of adipose storage whose blockade may be beneficial in fat distribution-associated metabolic disease.

Published
2022

4. Regulation of sensorimotor gating via Disc1/Huntingtin-mediated Bdnf transport in the cortico-striatal circuit

Author

Jaaro-Peled, Hanna, primary, Kumar, Sunil, additional, Hughes, Dalton, additional, Sumitomo, Akiko, additional, Kim, Sun-Hong, additional, Zoubovsky, Sandra, additional, Hirota-Tsuyada, Yuki, additional, Zala, Diana, additional, Bruyere, Julie, additional, Katz, Brittany M., additional, Huang, Beverly, additional, Flores, Rafael, additional, Narayan, Soumya, additional, Hou, Zhipeng, additional, Economides, Aris N., additional, Hikida, Takatoshi, additional, Wetsel, William C., additional, Deisseroth, Karl, additional, Mori, Susumu, additional, Brandon, Nicholas J., additional, Tanaka, Motomasa, additional, Ishizuka, Koko, additional, Houslay, Miles D., additional, Saudou, Frédéric, additional, Dzirasa, Kafui, additional, Sawa, Akira, additional, and Tomoda, Toshifumi, additional

Published
2022
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8. Erratum: High-throughput engineering of the mouse genome coupled with high-resolution expression analysis

Author

Valenzuela, David M, primary, Murphy, Andrew J, additional, Frendewey, David, additional, Gale, Nicholas W, additional, Economides, Aris N, additional, Auerbach, Wojtek, additional, Poueymirou, William T, additional, Adams, Niels C, additional, Rojas, Jose, additional, Yasenchak, Jason, additional, Chernomorski, Rostislav, additional, Boucher, Marylene, additional, Elsasser, Andrea L, additional, Esau, Lakeisha, additional, Zheng, Jenny, additional, Griffiths, Jennifer, additional, Wang, Xiaorong, additional, Su, Hong, additional, Xue, Yingzi, additional, Dominguez, Melissa G, additional, Noguera, Irene, additional, Torres, Richard, additional, Macdonald, Lynn E, additional, Stewart, A Francis, additional, DeChiara, Thomas M, additional, and Yancopoulos, George D, additional

Published
2003
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9. High-throughput engineering of the mouse genome coupled with high-resolution expression analysis

Author

Valenzuela, David M, primary, Murphy, Andrew J, additional, Frendewey, David, additional, Gale, Nicholas W, additional, Economides, Aris N, additional, Auerbach, Wojtek, additional, Poueymirou, William T, additional, Adams, Niels C, additional, Rojas, Jose, additional, Yasenchak, Jason, additional, Chernomorsky, Rostislav, additional, Boucher, Marylene, additional, Elsasser, Andrea L, additional, Esau, Lakeisha, additional, Zheng, Jenny, additional, Griffiths, Jennifer A, additional, Wang, Xiaorong, additional, Su, Hong, additional, Xue, Yingzi, additional, Dominguez, Melissa G, additional, Noguera, Irene, additional, Torres, Richard, additional, Macdonald, Lynn E, additional, Stewart, A Francis, additional, DeChiara, Thomas M, additional, and Yancopoulos, George D, additional

Published
2003
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11. Cytokine traps: multi-component, high-affinity blockers of cytokine action

Author

Economides, Aris N., primary, Carpenter, Laura Rocco, additional, Rudge, John S., additional, Wong, Vivien, additional, Koehler-Stec, Ellen M., additional, Hartnett, Christopher, additional, Pyles, Erica A., additional, Xu, Xiaobing, additional, Daly, Thomas J., additional, Young, Michael R., additional, Fandl, James P., additional, Lee, Frank, additional, Carver, Scott, additional, McNay, Jennifer, additional, Bailey, Kevin, additional, Ramakanth, Swayampakula, additional, Hutabarat, Renta, additional, Huang, Tammy T., additional, Radziejewski, Czeslaw, additional, Yancopoulos, George D., additional, and Stahl, Neil, additional

Published
2002
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