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Cut-off low (COL) weather systems that are associated with rainfall over the Eastern Cape are considered in this study. COLs are objectively identified and tracked over a 31-year period. Daily rainfall data of 22 evenly distributed stations over the Eastern Cape are utilized. Only COLs with a minimum spatial distribution, defined as more than a third of the rainfall stations that need to report rainfall on at least 1 day of a COL event, are considered for analysis of rainfall attributes. These attributes include the occurrence of COL rain days of different magnitudes, the distribution of the depth and temperature of the COL centres for the rain days of different magnitudes, the associated spatial distribution of rainfall as well as the associated atmospheric circulation. The frequency of COLs over the Eastern Cape has a winter maximum and a summer minimum. COL rain days of small, medium and large magnitudes occur most frequently during the winter, while small- and medium-magnitude COL rain days experience peaks in autumn and spring, respectively. The low-level flow, and in particular the position of the low/trough, seems to be the determinant factor in the occurrence, magnitude and spatial extent of COL-induced rainfall.

International audience; Satellite remote sensing provides important observational constraints for monitoring dust life cycle and improving the understanding of its effects on local to global scales. The present work analyzes the dust aerosol patterns over the arid environment of the Sistan region in southeastern Iran, by means of multiple satellite platforms aiming to reveal the spatio-temporal distribution and trends. The dataset includes records of Aerosol Index (AI) from Total Ozone Mapping Spectrometer (TOMS) (1978-2001) and 6-year AI records from the Ozone Monitoring Instrument (OMI) aboard Aura. Moreover, the aerosol optical depth is analyzed through 11-year records from Multi-angle Imaging Spectroradiometer (MISR) aboard Terra (2000-2010) and from Moderate-resolution Imaging Spectroradiometer (MODIS) onboard Terra (2000-2007) and Aqua (2002-2011). The main focus is to determine the similarities and differences in dust variability over southwest Asia, in general, and the Sistan region, in particular. The results show a marked seasonal cycle with high aerosol loading during summer and lower in winter, while MISR, MODIS, and TOMS/OMI observations agree in both terms of monthly and seasonally mean spatial and temporal patterns. The higher aerosol concentrations during summer are interpreted as a result of the combined effect of the seasonal drying of the Hamoun lakes and the strong northerly Levar winds favoring dust erosion from the alluvial deposits in Sistan. After prolonged drought period, the dust aerosol load over the area has increased in the beginning of the 2000 s and decreased after 2004, thereby leading to an overall declining trend during the last decade. Such a trend is absent during the winter period when dust emission over the region is minimal.

Austral summer rainfall over the period 1991/1992 to 2010/2011 was dynamically downscaled by the weather research and forecasting (WRF) model at 9 km resolution for South Africa. Lateral boundary conditions for WRF were provided from the European Centre for medium-range weather (ECMWF) reanalysis (ERA) interim data. The model biases for the rainfall were evaluated over the South Africa as a whole and its nine provinces separately by employing three different convective parameterization schemes, namely the (1) Kain–Fritsch (KF), (2) Betts–Miller–Janjic (BMJ) and (3) Grell–Devenyi ensemble (GDE) schemes. All three schemes have generated positive rainfall biases over South Africa, with the KF scheme producing the largest biases and mean absolute errors. Only the BMJ scheme could reproduce the intensity of rainfall anomalies, and also exhibited the highest correlation with observed interannual summer rainfall variability. In the KF scheme, a significantly high amount of moisture was transported from the tropics into South Africa. The vertical thermodynamic profiles show that the KF scheme has caused low level moisture convergence, due to the highly unstable atmosphere, and hence contributed to the widespread positive biases of rainfall. The negative bias in moisture, along with a stable atmosphere and negative biases of vertical velocity simulated by the GDE scheme resulted in negative rainfall biases, especially over the Limpopo Province. In terms of rain rate, the KF scheme generated the lowest number of low rain rates and the maximum number of moderate to high rain rates associated with more convective unstable environment. KF and GDE schemes overestimated the convective rain and underestimated the stratiform rain. However, the simulated convective and stratiform rain with BMJ scheme is in more agreement with the observations. This study also documents the performance of regional model in downscaling the large scale climate mode such as El Nino Southern Oscillation (ENSO) and subtropical dipole modes. The correlations between the simulated area averaged rainfalls over South Africa and Nino3.4 index were −0.66, −0.69 and −0.49 with KF, BMJ and GDE scheme respectively as compared to the observed correlation of −0.57. The model could reproduce the observed ENSO-South Africa rainfall relationship and could successfully simulate three wet (dry) years that are associated with La Nina (El Nino) and the BMJ scheme is closest to the observed variability. Also, the model showed good skill in simulating the excess rainfall over South Africa that is associated with positive subtropical Indian Ocean Dipole for the DJF season 2005/2006.

A highly differentiated rat glucose-responsive insulin producing cell line INS-1 expresses high levels of insulin-like growth factor-II (IGF-II). Basal levels of IGF-II gene mRNA were expressed in cells cultured at 1-6 mmol/l glucose. At glucose concentrations of 10-20 mmol/l, IGF-II mRNA was increased more than threefold after 44 h of incubation. Levels of IGF-II mRNA in INS-1 cells incubated at 5.6 and 20 mmol/l glucose in the presence of 4 micrograms/ml actinomycin D are comparable and are not reduced during 20 h of treatment, indicating the high stability of IGF-II mRNA in this cell line. From the three rat IGF-II promoters, promoter 3 is by far the most active in INS-1 cells. The IGF-II promoter 3 activity and IGF-II mRNA production at high glucose concentrations increased threefold over their respective levels at low glucose concentration, suggesting that the glucose-induced IGF-II gene expression in this beta-cell line might be transcriptionally controlled. The up-regulation of IGF-II mRNA by glucose was not due to the increased intracellular cyclic AMP levels or protein kinase C activation. A protein kinase C activator had no effect on IGF-II gene expression, and an adenylate cyclase activator (forskolin), suppressed the stimulatory effects of glucose on the IGF-II mRNA. Under all the experimental conditions examined, the IGF-II and insulin genes were differentially regulated in INS-1 cells. The IGF-II gene expression and DNA synthesis, however, were regulated in parallel, suggesting that these two cellular activities are closely associated.

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