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Your search keyword '"Dalel, Ben Nejima"' showing total 2 results
Start Over Author "Dalel, Ben Nejima" Publisher springer science and business media llc
2 results on '"Dalel, Ben Nejima"'

1. Early onset breast cancer: differences in risk factors, tumor phenotype, and genotype between North African and South European women

Author

Paul Vilquin, Virginie Galibert, Hesham El Ghazaly, Marie-Christine Picot, Paul Ihout, Helena Bertet, Asma Mouhout, Ahmed Gaballah, Karen Baudry, David Khayat, Alain Toledano, Yazid Belkacemi, Hamouda Boussen, Jean-Marc Rey, Céline Bourgier, Isabelle Coupier, Carole Corsini, Dalel Ben Nejima, Pascal Pujol, Sarra Henouda, Louise Biquard, Assia Bensalem, Faouzi Habib, Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Université de Montpellier (UM), UNICANCER - Institut régional du Cancer Montpellier Val d'Aurelle (ICM), CRLCC Val d'Aurelle - Paul Lamarque, Service de radiothérapie [Mondor], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Henri Mondor-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), Service d'Oncologie médicale [CHU Pitié-Salpêtrière], CHU Pitié-Salpêtrière [AP-HP], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), and Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)

Subjects
0301 basic medicine, Cancer Research, Genotype, [SDV]Life Sciences [q-bio], Breastfeeding, Breast Neoplasms, 03 medical and health sciences, 0302 clinical medicine, Breast cancer, Africa, Northern, Risk Factors, Humans, Medicine, Prospective Studies, Age of Onset, Neoplasm Staging, Early onset breast cancer, BRCA2 Protein, 2. Zero hunger, biology, BRCA1 Protein, business.industry, Incidence (epidemiology), North Africa, BRCA1, medicine.disease, BRCA2, 3. Good health, Phenotype, 030104 developmental biology, Oncology, 030220 oncology & carcinogenesis, Tumor phenotype, Ki-67, Immunology, Menarche, biology.protein, Female, France, business, Body mass index, Demography
Abstract

International audience; PURPOSE: This report compares the risk factors, the tumor phenotypes, and the BRCA1/BRCA2 genotype of early onset breast cancer (EOBC) patients between Southern Europe and North Africa. METHODS: Four hundred and fifty six women with invasive EOBC (

Published
2017
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2. Prognostic impact of polymorphism of matrix metalloproteinase-2 and metalloproteinase tissue inhibitor-2 promoters in breast cancer in Tunisia: case-control study

Author

Yosr Ben Zarkouna, Mohamed Manai, Dalel Ben Nejima, Hamouda Boussen, and A. Gammoudi

Subjects
Adult, Genotype, Breast Neoplasms, Biology, Polymorphism, Single Nucleotide, Metastasis, Breast cancer, medicine, Humans, Neoplasm Invasiveness, Allele, Promoter Regions, Genetic, Genetic Association Studies, Aged, Neoplasm Staging, Tissue Inhibitor of Metalloproteinase-2, Case-control study, Proteolytic enzymes, General Medicine, Odds ratio, Middle Aged, Prognosis, medicine.disease, Case-Control Studies, Immunology, Cancer research, Matrix Metalloproteinase 2, Female, Restriction fragment length polymorphism
Abstract

Matrix metalloproteinases (MMPs) are proteolytic enzymes that play important roles in tumor invasion and metastasis by degrading extracellular matrix components. Genetic variations in promoter regions of MMP genes, affecting their expression, have been associated with susceptibility to cancers. The aim of this study was to investigate the susceptibility and prognostic implications of the matrix metalloproteinase-2 (MMP-2) and tissue inhibitor of metalloproteinase-2 (TIMP-2) polymorphism in Tunisian breast cancer patients. MMP-2 genotypes were determined by real-time polymerase chain reaction (RT-PCR), and TIMP-2 genotypes were identified using a PCR-restriction fragment length polymorphism (RFLP) method in 210 breast cancer patients and 250 frequency-matched control women. Association of the clinicopathological parameters and the genetic markers with risk of breast cancer was assessed using univariate analyses. We found that the variant MMP-2 genotype (-1306CT or TT) was associated with substantially reduced risk of breast cancer [odds ratio (OR), 0.49; 95 % confidence interval (95 % CI), 0.033-0.73], compared with the CC genotype. For TIMP-2, a moderately reduced risk of the cancer (OR, 0.57; 95 % CI, 0.37-0.87) was also associated with the variant allele (-418GC or CC), compared with the GG common allele. Furthermore, polymorphisms in both genes seem to have additive effects and the highest risk for breast cancer has been observed in those with MMP-2 CC genotype and TIMP-2 GC or CC genotype (p = 0.006). A significant association was also found between the CC genotype and the aggressive forms of breast cancer as defined by advanced stages at the time of diagnosis and metastasis. This is the first report on the association of MMP-2 and TIMP-2 gene polymorphisms in breast cancer in Tunisian population. Our results suggest that the presence of the variant allele in the promoter of MMP-2 or TIMP-2 may be a protective factor for the development of breast cancer.

Published
2015
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