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16 results on '"D'ONOFRIO, NUNZIA"'

2. Chemopreventive effect of a milk whey by-product derived from Buffalo (Bubalus bubalis) in protecting from colorectal carcinogenesis

Author

Cacciola, Nunzio Antonio, primary, Venneri, Tommaso, additional, Salzano, Angela, additional, D’Onofrio, Nunzia, additional, Martano, Manuela, additional, Saggese, Anella, additional, Vinale, Francesco, additional, Neglia, Gianluca, additional, Campanile, Ciro, additional, Baccigalupi, Loredana, additional, Maiolino, Paola, additional, Cuozzo, Mariarosaria, additional, Russo, Roberto, additional, Balestrieri, Maria Luisa, additional, D’Occhio, Michael John, additional, Ricca, Ezio, additional, Borrelli, Francesca, additional, and Campanile, Giuseppe, additional

Published
2023
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4. SGLT-2 inhibitors and in-stent restenosis-related events after acute myocardial infarction: an observational study in patients with type 2 diabetes

Author

Marfella, Raffaele, primary, Sardu, Celestino, additional, D’Onofrio, Nunzia, additional, Fumagalli, Carlo, additional, Scisciola, Lucia, additional, Sasso, Ferdinando Carlo, additional, Siniscalchi, Mario, additional, Marfella, Ludovica Vittoria, additional, D’Andrea, Davide, additional, Minicucci, Fabio, additional, Signoriello, Giuseppe, additional, Cesaro, Arturo, additional, Trotta, Maria Consiglia, additional, Frigé, Chiara, additional, Prattichizzo, Francesco, additional, Balestrieri, Maria Luisa, additional, Ceriello, Antonio, additional, Calabrò, Paolo, additional, Mauro, Ciro, additional, del Viscovo, Luca, additional, and Paolisso, Giuseppe, additional

Published
2023
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5. Glycated ACE2 reduces anti-remodeling effects of renin-angiotensin system inhibition in human diabetic hearts

Author

Marfella, Raffaele, primary, D’Onofrio, Nunzia, additional, Mansueto, Gelsomina, additional, Grimaldi, Vincenzo, additional, Trotta, Maria Consiglia, additional, Sardu, Celestino, additional, Sasso, Ferdinando Carlo, additional, Scisciola, Lucia, additional, Amarelli, Cristiano, additional, Esposito, Salvatore, additional, D’Amico, Michele, additional, Golino, Paolo, additional, De Feo, Marisa, additional, Signoriello, Giuseppe, additional, Paolisso, Pasquale, additional, Gallinoro, Emanuele, additional, Vanderheyden, Marc, additional, Maiello, Ciro, additional, Balestrieri, Maria Luisa, additional, Barbato, Emanuele, additional, Napoli, Claudio, additional, and Paolisso, Giuseppe, additional

Published
2022
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6. Glycaemic control is associated with SARS-CoV-2 breakthrough infections in vaccinated patients with type 2 diabetes

Author

Marfella, Raffaele, primary, Sardu, Celestino, additional, D’Onofrio, Nunzia, additional, Prattichizzo, Francesco, additional, Scisciola, Lucia, additional, Messina, Vincenzo, additional, La Grotta, Rosalba, additional, Balestrieri, Maria Luisa, additional, Maggi, Paolo, additional, Napoli, Claudio, additional, Ceriello, Antonio, additional, and Paolisso, Giuseppe, additional

Published
2022
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7. SARS-COV-2 colonizes coronary thrombus and impairs heart microcirculation bed in asymptomatic SARS-CoV-2 positive subjects with acute myocardial infarction

Author

Marfella, Raffaele, primary, Paolisso, Pasquale, additional, Sardu, Celestino, additional, Palomba, Luciana, additional, D’Onofrio, Nunzia, additional, Cesaro, Arturo, additional, Barbieri, Michelangela, additional, Rizzo, Maria Rosaria, additional, Sasso, Ferdinando Carlo, additional, Scisciola, Lucia, additional, Turriziani, Fabrizio, additional, Galdiero, Massimiliano, additional, Pignataro, Danilo, additional, Minicucci, Fabio, additional, Trotta, Maria Consiglia, additional, D’Amico, Michele, additional, Mauro, Ciro, additional, Calabrò, Paolo, additional, Balestrieri, Maria Luisa, additional, Signioriello, Giuseppe, additional, Barbato, Emanuele, additional, Galdiero, Marilena, additional, and Paolisso, Giuseppe, additional

Published
2021
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8. MicroRNAs modulation and clinical outcomes at 1 year of follow-up in obese patients with pre-diabetes treated with metformin vs. placebo

Author

Sardu, Celestino, primary, Trotta, Maria Consiglia, additional, Pieretti, Gorizio, additional, Gatta, Gianluca, additional, Ferraro, Giuseppe, additional, Nicoletti, Giovanni Francesco, additional, D’ Onofrio, Nunzia, additional, Balestrieri, Maria Luisa, additional, D’ Amico, Michele, additional, Abbatecola, Angela, additional, Ferraraccio, Franca, additional, Panarese, Iacopo, additional, Paolisso, Giuseppe, additional, and Marfella, Raffaele, additional

Published
2021
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9. Glycated ACE2 receptor in diabetes: open door for SARS-COV-2 entry in cardiomyocyte

Author

D’Onofrio, Nunzia, primary, Scisciola, Lucia, additional, Sardu, Celestino, additional, Trotta, Maria Consiglia, additional, De Feo, Marisa, additional, Maiello, Ciro, additional, Mascolo, Pasquale, additional, De Micco, Francesco, additional, Turriziani, Fabrizio, additional, Municinò, Emilia, additional, Monetti, Pasquale, additional, Lombardi, Antonio, additional, Napolitano, Maria Gaetana, additional, Marino, Federica Zito, additional, Ronchi, Andrea, additional, Grimaldi, Vincenzo, additional, Hermenean, Anca, additional, Rizzo, Maria Rosaria, additional, Barbieri, Michelangela, additional, Franco, Renato, additional, Campobasso, Carlo Pietro, additional, Napoli, Claudio, additional, Municinò, Maurizio, additional, Paolisso, Giuseppe, additional, Balestrieri, Maria Luisa, additional, and Marfella, Raffaele, additional

Published
2021
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10. Hyperglycaemia on admission to hospital and COVID-19

Author

Sardu, Celestino, primary, D’Onofrio, Nunzia, additional, Balestrieri, Maria Luisa, additional, Barbieri, Michelangela, additional, Rizzo, Maria Rosaria, additional, Messina, Vincenzo, additional, Maggi, Paolo, additional, Coppola, Nicola, additional, Paolisso, Giuseppe, additional, and Marfella, Raffaele, additional

Published
2020
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12. Pericoronary fat inflammation and Major Adverse Cardiac Events (MACE) in prediabetic patients with acute myocardial infarction: effects of metformin

Author

Sardu, Celestino, primary, D’Onofrio, Nunzia, additional, Torella, Michele, additional, Portoghese, Michele, additional, Loreni, Francesco, additional, Mureddu, Simone, additional, Signoriello, Giuseppe, additional, Scisciola, Lucia, additional, Barbieri, Michelangela, additional, Rizzo, Maria Rosaria, additional, Galdiero, Marilena, additional, De Feo, Marisa, additional, Balestrieri, Maria Luisa, additional, Paolisso, Giuseppe, additional, and Marfella, Raffaele, additional

Published
2019
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14. Transcriptomic profiles of the ruminal wall in Italian Mediterranean dairy buffaloes fed green forage

Author

Salzano A, Fioriniello S, D'Onofrio N, Balestrieri ML, Aiese Cigliano R, Neglia G, Della Ragione F, Campanile G., Salzano, Angela, Fioriniello, Salvatore, D'Onofrio, Nunzia, Balestrieri, Maria Luisa, Aiese Cigliano, Riccardo, Neglia, Gianluca, Della Ragione, Floriana, Campanile, Giuseppe, Salzano, A, Fioriniello, S, D'Onofrio, N, Balestrieri, Ml, Aiese Cigliano, R, Neglia, G, Della Ragione, F, and Campanile, G.

Subjects
Transcriptome, Rumen, Green feed, Genetics, Buffalo, RNA-seq, Biotechnology
Abstract

Background Green feed diet in ruminants exerts a beneficial effect on rumen metabolism and enhances the content of milk nutraceutical quality. At present, a comprehensive analysis focused on the identification of genes, and therefore, biological processes modulated by the green feed in buffalo rumen has never been reported. We performed RNA-sequencing in the rumen of buffaloes fed a total mixed ration (TMR) + the inclusion of 30% of ryegrass green feed (treated) or TMR (control), and identified differentially expressed genes (DEGs) using EdgeR and NOISeq tools. Results We found 155 DEGs using EdgeR (p-values Gene Ontology analysis of DEGs identified using EdgeR revealed that green feed modulates biological processes relevant for the rumen physiology and, then, health and well-being of buffaloes, such as lipid metabolism, response to the oxidative stress, immune response, and muscle structure and function. Accordingly, we found: (i) up-regulation of HSD17B13, LOC102410803 (or PSAT1) and HYKK, and down-regulation of CDO1, SELENBP1 and PEMT, encoding factors involved in energy, lipid and amino acid metabolism; (ii) enhanced expression of SIM2 and TRIM14, whose products are implicated in the immune response and defense against infections, and reduced expression of LOC112585166 (or SAAL1), ROR2, SMOC2, and S100A11, encoding pro-inflammatory factors; (iii) up-regulation of NUDT18, DNAJA4 and HSF4, whose products counteract stressful conditions, and down-regulation of LOC102396388 (or UGT1A9) and LOC102413340 (or MRP4/ABCC4), encoding detoxifying factors; (iv) increased expression of KCNK10, CACNG4, and ATP2B4, encoding proteins modulating Ca2+ homeostasis, and reduced expression of the cytoskeleton-related MYH11 and DES. Conclusion Although statistically unpowered, this study suggests that green feed modulates the expression of genes involved in biological processes relevant for rumen functionality and physiology, and thus, for welfare and quality production in Italian Mediterranean dairy buffaloes. These findings, that need to be further confirmed through the validation of additional DEGs, allow to speculate a role of green feed in the production of nutraceutical molecules, whose levels might be enhanced also in milk.

Published
2023

15. SGLT-2 inhibitors and in-stent restenosis-related events after acute myocardial infarction: an observational study in patients with type 2 diabetes

Author

Raffaele Marfella, Celestino Sardu, Nunzia D’Onofrio, Carlo Fumagalli, Lucia Scisciola, Ferdinando Carlo Sasso, Mario Siniscalchi, Ludovica Vittoria Marfella, Davide D’Andrea, Fabio Minicucci, Giuseppe Signoriello, Arturo Cesaro, Maria Consiglia Trotta, Chiara Frigé, Francesco Prattichizzo, Maria Luisa Balestrieri, Antonio Ceriello, Paolo Calabrò, Ciro Mauro, Luca del Viscovo, Giuseppe Paolisso, Marfella, Raffaele, Sardu, Celestino, D'Onofrio, Nunzia, Fumagalli, Carlo, Scisciola, Lucia, Sasso, Ferdinando Carlo, Siniscalchi, Mario, Marfella, Ludovica Vittoria, D'Andrea, Davide, Minicucci, Fabio, Signoriello, Giuseppe, Cesaro, Arturo, Trotta, Maria Consiglia, Frigé, Chiara, Prattichizzo, Francesco, Balestrieri, Maria Luisa, Ceriello, Antonio, Calabrò, Paolo, Mauro, Ciro, Del Viscovo, Luca, and Paolisso, Giuseppe

Subjects
Glycemic control, Major adverse cardiovascular event, SGLT-2 inhibitor, Restenosi, Type 2 diabetes, General Medicine
Abstract

Background No study evaluated the incidence of intra-stent restenosis (ISR)-related events in patients with type 2 diabetes (T2DM) and acute myocardial infarction (AMI) treated or not with sodium/glucose cotransporter 2 inhibitors (SGLT2i). Methods We recruited 377 patients with T2DM and AMI undergoing percutaneous coronary intervention (PCI). Among them, 177 T2DM were treated with SGLT2 inhibitors before PCI. The primary outcome was major adverse cardiovascular events (MACE) defined as cardiac death, re-infarction, and heart failure related to ISR. In patients without ISR, minimal lumen area and minimal lumen diameter were assessed by coronary CT-angiography at 1-year follow-up. Results Glycemic control was similar in SGLT2i-treated patients and never SGLT2i-users. The incidence of ISR-related MACE was higher in never SGLT2i-users compared with SGLT2i-treated patients, an effect independent of glycemic status (HR = 0.418, 95% CI = 0.241–0.725, P = 0.002) and observed also in the subgroup of patients with HbA1c < 7% (HR = 0.393, 95% CI = 0.157–0.984, P = 0.027). In patients without the event, the stent patency was greater in SGLT2i-treated patients compared with never SGLT2i-users at 1-year follow-up. Conclusions SGLT2i treatment in T2DM is associated with a reduced incidence of ISR-related events, independently of glycemic control.

Published
2023

16. Glycaemic control is associated with SARS-CoV-2 breakthrough infections in vaccinated patients with type 2 diabetes

Author

Raffaele Marfella, Celestino Sardu, Nunzia D’Onofrio, Francesco Prattichizzo, Lucia Scisciola, Vincenzo Messina, Rosalba La Grotta, Maria Luisa Balestrieri, Paolo Maggi, Claudio Napoli, Antonio Ceriello, Giuseppe Paolisso, Marfella, Raffaele, Sardu, Celestino, D'Onofrio, Nunzia, Prattichizzo, Francesco, Scisciola, Lucia, Messina, Vincenzo, La Grotta, Rosalba, Balestrieri, Maria Luisa, Maggi, Paolo, Napoli, Claudio, Ceriello, Antonio, and Paolisso, Giuseppe

Subjects
Glycated Hemoglobin, COVID-19 Vaccines, Glycated Hemoglobin A, Multidisciplinary, SARS-CoV-2, COVID-19 Vaccine, COVID-19, General Physics and Astronomy, Glycemic Control, General Chemistry, General Biochemistry, Genetics and Molecular Biology, Diabetes Mellitus, Type 2, Humans, Female, RNA, Messenger, BNT162 Vaccine, Human
Abstract

Patients with type 2 diabetes (T2D) are characterized by blunted immune responses, which are affected by glycaemic control. Whether glycaemic control influences the response to COVID-19 vaccines and the incidence of SARS-CoV-2 breakthrough infections is unknown. Here we show that poor glycaemic control, assessed as mean HbA1c in the post-vaccination period, is associated with lower immune responses and an increased incidence of SARS-CoV-2 breakthrough infections in T2D patients vaccinated with mRNA-BNT162b2. We report data from a prospective observational study enroling healthcare and educator workers with T2D receiving the mRNA-BNT162b2 vaccine in Campania (Italy) and followed for one year (5 visits, follow-up 346 ± 49 days) after one full vaccination cycle. Considering the 494 subjects completing the study, patients with good glycaemic control (HbA1c one-year mean < 7%) show a higher virus-neutralizing antibody capacity and a better CD4 + T/cytokine response, compared with those with poor control (HbA1c one-year mean ≥ 7%). The one-year mean of HbA1c is linearly associated with the incidence of breakthrough infections (Beta = 0.068; 95% confidence interval [CI], 0.032-0.103; p p = 0.008). Among other factors, only smoking (HR = 0.290, CI 0.146-0.576 for non-smokers; p p

Published
2022

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