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Start Over Author "Chu, Tong" Publisher springer science and business media llc
10 results on '"Chu, Tong"'

3. Divergent projections of the prelimbic cortex mediate autism- and anxiety-like behaviors

Author

Yi-Fan Luo, Lu Lu, Heng-Yi Song, Han Xu, Zhi-Wei Zheng, Zhou-Yue Wu, Chen-Chen Jiang, Chu Tong, Hao-Yang Yuan, Xiu-Xiu Liu, Xiang Chen, Mei-ling Sun, Ya-Min Tang, Heng-Yu Fan, Feng Han, and Ying-Mei Lu

Subjects
Cellular and Molecular Neuroscience, Psychiatry and Mental health, Molecular Biology
Abstract

The comorbidity of autism spectrum disorder and anxiety is common, but the underlying circuitry is poorly understood. Here, Tmem74-/- mice showed autism- and anxiety-like behaviors along with increased excitability of pyramidal neurons (PNs) in the prelimbic cortex (PL), which were reversed by Tmem74 re-expression and chemogenetic inhibition in PNs of the PL. To determine the underlying circuitry, we performed conditional deletion of Tmem74 in the PNs of PL of mice, and we found that alterations in the PL projections to fast-spiking interneurons (FSIs) in the dorsal striatum (dSTR) (PLPNs–dSTRFSIs) mediated the hyperexcitability of FSIs and autism-like behaviors and that alterations in the PL projections to the PNs of the basolateral amygdaloid nucleus (BLA) (PLPNs–BLAPNs) mediated the hyperexcitability of PNs and anxiety-like behaviors. However, the two populations of PNs in the PL had different spatial locations, optogenetic manipulations revealed that alterations in the activity in the PL–dSTR or PL–BLA circuits led to autism- or anxiety-like behaviors, respectively. Collectively, these findings highlight that the hyperactivity of the two populations of PNs in the PL mediates autism and anxiety comorbidity through the PL–dSTR and PL–BLA circuits, which may lead to the development of new therapeutics for the autism and anxiety comorbidity.

Published
2023

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