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Your search keyword '"Cecere, F"' showing total 6 results
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6 results on '"Cecere, F"'

1. Real-world outcomes according to treatment strategies in ALK-rearranged non-small-cell lung cancer (NSCLC) patients: an Italian retrospective study

Author

Gobbini, E., primary, Chiari, R., additional, Pizzutillo, P., additional, Bordi, P., additional, Ghilardi, L., additional, Pilotto, S., additional, Osman, G., additional, Cappuzzo, F., additional, Cecere, F., additional, Riccardi, F., additional, Scotti, V., additional, Martelli, O., additional, Borra, G., additional, Maiello, E., additional, Rossi, A., additional, Graziano, P., additional, Gregorc, V., additional, Casartelli, C., additional, Sergi, C., additional, Del Conte, A., additional, Delmonte, A., additional, Bareggi, C., additional, Cortinovis, D., additional, Rizzo, P., additional, Tabbò, F., additional, Rossi, G., additional, Bria, E., additional, Galetta, D., additional, Tiseo, M., additional, Di Maio, M., additional, and Novello, S., additional

Published
2019
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2. Chemotherapy-induced nausea and vomiting (CINV) in patients with advanced lung cancer during the first-line treatment: assessment by physicians, nurses, and patients from an Italian multicenter survey

Author

Carnio, S., primary, Galetta, D., additional, Scotti, V., additional, Cortinovis, D. L., additional, Antonuzzo, A., additional, Pisconti, S., additional, Rossi, A., additional, Martelli, O., additional, Cecere, F. L., additional, Lunghi, A., additional, Del Conte, A., additional, Montagna, E. S., additional, Topulli, J., additional, Pelizzoni, D., additional, Rapetti, S. G., additional, Gianetta, M., additional, Pacchiana, M. V., additional, Pegoraro, V., additional, Cataldo, N., additional, Bria, E., additional, and Novello, S., additional

Published
2017
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4. Second- and third-generation aromatase inhibitors as first-line endocrine therapy in postmenopausal metastatic breast cancer patients: a pooled analysis of the randomised trials

Author

Ferretti, G, primary, Bria, E, additional, Giannarelli, D, additional, Felici, A, additional, Papaldo, P, additional, Fabi, A, additional, Di Cosimo, S, additional, Ruggeri, E M, additional, Milella, M, additional, Ciccarese, M, additional, Cecere, F L, additional, Gelibter, A, additional, Nuzzo, C, additional, Cognetti, F, additional, Terzoli, E, additional, and Carlini, P, additional

Published
2006
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6. Zfp57 inactivation illustrates the role of ICR methylation in imprinted gene expression during neural differentiation of mouse ESCs

Author

Claudia Angelini, Ankit Verma, Basilia Acurzio, Carlo Giaccari, Floriana Della Ragione, Francesco Cecere, Andrea Riccio, Robert Feil, Flavia Cerrato, Annalisa Fico, Alessia Polito, Salvatore Fioriniello, Acurzio, B., Verma, A., Polito, A., Giaccari, C., Cecere, F., Fioriniello, S., Della Ragione, F., Fico, A., Cerrato, F., Angelini, C., Feil, R., Riccio, A., Institut de Génétique Moléculaire de Montpellier (IGMM), and Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)

Subjects
nervous system development, wildtype, Mutant, Zfp57, Mice, 0302 clinical medicine, Neural Stem Cells, Neural Stem Cell, Imprinting (psychology), cell mutant, [SDV.BDD]Life Sciences [q-bio]/Development Biology, Regulation of gene expression, 0303 health sciences, Multidisciplinary, allele, article, Gene Expression Regulation, Developmental, Mouse Embryonic Stem Cells, Imprinting, Cell Differentiation, Methylation, protein function, ORIGIN-SPECIFIC EXPRESSIONDNA METHYLATIONDISTAL CHROMOSOME-7STEM-CELLSIDENTIFICATIONMULTIPLEMECHANISMSCHROMATINMAINTAINSTRANSIENT, Cell biology, DNA methylation, Medicine, Epigenetics, Science, Biology, Chromosome, Chromosomes, Genomic Imprinting, 03 medical and health sciences, hybrid mouse strain, Genetics, Animals, controlled study, [SDV.BBM]Life Sciences [q-bio]/Biochemistry, Molecular Biology, Gene, 030304 developmental biology, cell culture, [SDV.GEN]Life Sciences [q-bio]/Genetics, ES-derived neural progenitor cells, Animal, Mouse Embryonic Stem Cell, DNA Methylation, Repressor Proteins, JB1, methylation, Genomic imprinting, Zfp57, Genetics, Epigenetics, Imprinting, allele, article, cell culture, cell mutant, chromosome, controlled study, hybrid mouse strain, methylation, mouse embryonic stem cell, nervous system development, protein function, ES-derived neural progenitor cells, JB1, wildtype, Zfp57, 030217 neurology & neurosurgery
Abstract

ZFP57 is required to maintain the germline-marked differential methylation at imprinting control regions (ICRs) in mouse embryonic stem cells (ESCs). Although DNA methylation has a key role in genomic imprinting, several imprinted genes are controlled by different mechanisms, and a comprehensive study of the relationship between DMR methylation and imprinted gene expression is lacking. To address the latter issue, we differentiated wild-type and Zfp57-/- hybrid mouse ESCs into neural precursor cells (NPCs) and evaluated allelic expression of imprinted genes. In mutant NPCs, we observed a reduction of allelic bias of all the 32 genes that were imprinted in wild-type cells, demonstrating that ZFP57-dependent methylation is required for maintaining or acquiring imprinted gene expression during differentiation. Analysis of expression levels showed that imprinted genes expressed from the non-methylated chromosome were generally up-regulated, and those expressed from the methylated chromosome were down-regulated in mutant cells. However, expression levels of several imprinted genes acquiring biallelic expression were not affected, suggesting the existence of compensatory mechanisms that control their RNA level. Since neural differentiation was partially impaired in Zfp57-mutant cells, this study also indicates that imprinted genes and/or non-imprinted ZFP57-target genes are required for proper neurogenesis in cultured ESCs.

Published
2021

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