1. Association between farnesoid X receptor expression and cell proliferation in estrogen receptor-positive luminal-like breast cancer from postmenopausal patients
- Author
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Fabrice Journe, Denis Nonclercq, Jean-Jacques Body, Christos Sotiriou, Carole Chaboteaux, Guy Laurent, Virginie Durbecq, Denis Larsimont, Ghizlane Rouas, Institut Jules Bordet [Bruxelles], Faculté de Médecine [Bruxelles] (ULB), Université libre de Bruxelles (ULB)-Université libre de Bruxelles (ULB), Laboratory of Histology, Faculty of Medicine and Pharmacy, and Université de Mons-Hainaut
- Subjects
Cancer Research ,Fluorescent Antibody Technique ,Receptors, Cytoplasmic and Nuclear ,Estrogen receptor ,Immunoenzyme Techniques ,Breast cancer ,0302 clinical medicine ,Tumor Cells, Cultured ,Aromatase ,Receptor ,Aged, 80 and over ,0303 health sciences ,Reverse Transcriptase Polymerase Chain Reaction ,Middle Aged ,Immunohistochemistry ,3. Good health ,DNA-Binding Proteins ,Postmenopause ,Oncology ,030220 oncology & carcinogenesis ,Ki-67 ,Female ,Breast disease ,Adult ,medicine.medical_specialty ,Blotting, Western ,Breast Neoplasms ,Biology ,Chenodeoxycholic Acid ,03 medical and health sciences ,Gastrointestinal Agents ,Internal medicine ,medicine ,Humans ,Immunoprecipitation ,Neoplasm Invasiveness ,RNA, Messenger ,Aged ,Cell Proliferation ,030304 developmental biology ,Estrogen Receptor alpha ,Cancer ,medicine.disease ,Bile acids ,NR1H4 ,Endocrinology ,Nuclear receptor ,biology.protein ,Farnesoid X receptor ,Transcription Factors - Abstract
International audience; The farnesoid X receptor (FXR, NR1H4), a member of the nuclear receptor superfamily of ligand-dependent transcription factors, is normally produced in the liver and the gastrointestinal tract, where it acts as a bile acid sensor. It has been recently detected in breast cancer cell lines and tissue specimens. The expression of FXR was scored (0–8) by immunohistochemistry on 204 breast cancer samples and correlated with established cancer biomarkers. Moreover, the effect of the FXR activator chenodeoxycholic acid (CDCA) was determined on cell proliferation and estrogen receptor regulation/activation in breast cancer cell lines. FXR was detected in 82.4% of samples with a high median expression score of 5. FXR expression significantly correlated with estrogen receptor (ER) expression ( = 0.009) and luminal-like markers. In ER-positive tumors, FXR expression was significantly correlated with the proliferation marker Ki-67 (
- Published
- 2008
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