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Your search keyword '"Carmelo Luci"' showing total 2 results
Start Over Author "Carmelo Luci" Publisher springer science and business media llc
2 results on '"Carmelo Luci"'

1. Mechanisms of NK cell activation: CD4+ T cells enter the scene

Author

Claire Germain, Carmelo Luci, Franck Bihl, Veronique M. Braud, Institut de pharmacologie moléculaire et cellulaire (IPMC), Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Centre National de la Recherche Scientifique (CNRS), Faculté de Médecine Pasteur, and Institut National de la Santé et de la Recherche Médicale (INSERM)

Subjects
MESH: Interleukin-12, MESH: Killer Cells, Natural, CD4-Positive T-Lymphocytes, Antigen-Presenting Cells, Biology, Lymphocyte Activation, 03 medical and health sciences, Cellular and Molecular Neuroscience, Interleukin 21, 0302 clinical medicine, NK-92, Humans, MESH: Lymphocyte Activation, Antigen-presenting cell, Molecular Biology, 030304 developmental biology, Pharmacology, 0303 health sciences, MESH: Humans, Lymphokine-activated killer cell, MESH: Antigen-Presenting Cells, IL-2, Janus kinase 3, MESH: CD4-Positive T-Lymphocytes, NK receptors, MESH: Interleukin-2, Cell Biology, Natural killer T cell, Interleukin-12, CD4+ T cells, Cell biology, Killer Cells, Natural, IL-12, Myeloid-derived Suppressor Cell, Interleukin 12, Natural killer cells, [SDV.IMM]Life Sciences [q-bio]/Immunology, Interleukin-2, Molecular Medicine, 030215 immunology
Abstract

International audience; Natural killer (NK) cells are innate lymphocytes involved in immunosurveillance through their cytotoxic activity and their capacity to secrete inflammatory cytokines. NK cell activation is necessary to initiate effector functions and results from a complex series of molecular and cellular events. We review here the signals that trigger NK cells and discuss recent findings showing that, besides antigen-presenting cells, T cells can play a central role in the initiation of NK cell activation in lymph nodes.

Published
2011
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2. Influence of the transcription factor RORγt on the development of NKp46+ cell populations in gut and skin

Author

Carmelo Luci, Dan R. Littman, Ana Reynders, Céline Cognet, Esperanza Anguiano, Jean Hardwigsen, Eric Vivier, Ivaylo I. Ivanov, Marc Dalod, Elena Tomasello, Laurent Chiche, Damien Chaussabel, Lionel Chasson, Jacques Banchereau, Immunité muqueuse et vaccination, Université Nice Sophia Antipolis (1965 - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-IFR50-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Côte d'Azur (UCA), Centre d'Immunologie de Marseille - Luminy (CIML), Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Rostov State University, Centre de Biochimie Structurale [Montpellier] (CBS), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Hôpital de la Conception [CHU - APHM] (LA CONCEPTION), Baylor Institute for Immunology Research (BIIR), Baylor College of Medecine, New York University School of Medicine (NYU), The Kimmel Center for Biology and Medicine at the Skirball Institute and Howard Hughes Medical Institute, Hôpital de la Timone [CHU - APHM] (TIMONE), Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-IFR50-Université Côte d'Azur (UCA)-Institut National de la Santé et de la Recherche Médicale (INSERM), and Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Institut National de la Santé et de la Recherche Médicale (INSERM)

Subjects
MESH: Interleukins, MESH: Antigens, CD3, MESH: Mice, Mutant Strains, MESH: Interferon-gamma, MESH: Natural Cytotoxicity Triggering Receptor 1, CD3, Immunology, Biology, Interleukin 22, 03 medical and health sciences, 0302 clinical medicine, Dermis, MESH: Mice, Inbred C57BL, medicine, Immunology and Allergy, MESH: Animals, MESH: Receptors, Thyroid Hormone, MESH: Lymphocyte Activation, MESH: Mice, 030304 developmental biology, MESH: Receptors, Retinoic Acid, 0303 health sciences, Lamina propria, MESH: Humans, Innate immune system, Lymphokine-activated killer cell, MESH: Transcription Factors, MESH: Dermis, Natural killer T cell, Cell biology, Lymphatic system, medicine.anatomical_structure, MESH: Natural Killer T-Cells, MESH: Intestinal Mucosa, biology.protein, MESH: Peyer's Patches, MESH: Cell Division, [SDV.IMM]Life Sciences [q-bio]/Immunology, 030215 immunology
Abstract

International audience; NKp46+CD3- natural killer lymphocytes isolated from blood, lymphoid organs, lung, liver and uterus can produce granule-dependent cytotoxicity and interferon-gamma. Here we identify in dermis, gut lamina propria and cryptopatches distinct populations of NKp46+CD3- cells with a diminished capacity to degranulate and produce interferon-gamma. In the gut, expression of the transcription factor RORgammat, which is involved in the development of lymphoid tissue-inducer cells, defined a previously unknown subset of NKp46+CD3- lymphocytes. Unlike RORgammat- lamina propria and dermis natural killer cells, gut RORgammat+NKp46+ cells produced interleukin 22. Our data show that lymphoid tissue-inducer cells and natural killer cells shared unanticipated similarities and emphasize the heterogeneity of NKp46+CD3- cells in innate immunity, lymphoid organization and local tissue repair.

Published
2008
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